The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma

Ying Li; Feng Zhou; Chao Shen; Yi Su; Yanxia Li; Cuicui Wang; Ruixia Yan; Guiran Yang; Zhenjiang Hou

doi:doi:10.11648/j.ajcem.20210906.15

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The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma

Ying Li, Feng Zhou, Chao Shen, Yi Su, Yanxia Li, Cuicui Wang, Ruixia Yan, Guiran Yang, Zhenjiang Hou

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6)

Received: 15 November 2021 Accepted: 6 December 2021 Published: 7 December 2021

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Abstract

Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: To explore the expression and clinical significance of interleukin-4 (IL-4) and interleukin-13 (IL-13) in the tissues and serum of patients with papillary thyroid carcinoma (PTC). Method: 120 cases of PTC patients were randomly selected as the experimental group, who underwent radical mastectomy at the Thyroid and Breast Surgery Department of Cangzhou Central Hospital from January 2018 to April 2019, and the PTC tissues and their adjacent tissues and serum samples were collected. 120 healthy people were matched 1:1 as the control group in the hospital physical examination center during the same period, according to the gender, age and body mass index of the experimental group, and serum samples were collected. The immunohisto chemical SP method is adopted to test the expression of IL-4 and IL-13 in the tissues, and the ELISA is adopted to test the serum levels of IL-4 and IL-13. Analyze the relationship between IL-4 and IL-13 expression and clinicopathological characteristics in PTC. Result: It was significantly higher with the positive expression rate of IL-4 and IL-13 in PTC tissues than that in adjacent tissues (P<0.05), and it was a significant positive correlation between IL-4 and IL-13 expressed in PTC tissues (r=0.375, P=0.002); It was significantly higher in the serum levels of IL-4 and IL-13 in PTC patients, than that in healthy subjects (P<0.05), and it was a significant positive correlation between IL-4 and IL-13 expressed in the serum of PTC patients (r=0.381, P<0.01); The expression of IL-4 and IL-13 was related to the maximum tumor diameter, TNM stage, degree of differentiation, and lymphatic metastasis in PTC (P<0.05). Conclusion: IL-4 and IL-13 were highly expressed in PTC, and the expression level may become a reference indicator for predicting the occurrence and development of PTC.

Published in	American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6)
DOI	10.11648/j.ajcem.20210906.15
Page(s)	215-222
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Papillary Thyroid Carcinoma, Interleukin-4, Interleukin-13, Clinical Significance

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APA Style

Ying Li, Feng Zhou, Chao Shen, Yi Su, Yanxia Li, et al. (2021). The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma. American Journal of Clinical and Experimental Medicine, 9(6), 215-222. https://doi.org/10.11648/j.ajcem.20210906.15

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ACS Style

Ying Li; Feng Zhou; Chao Shen; Yi Su; Yanxia Li, et al. The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma. Am. J. Clin. Exp. Med. 2021, 9(6), 215-222. doi: 10.11648/j.ajcem.20210906.15

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AMA Style

Ying Li, Feng Zhou, Chao Shen, Yi Su, Yanxia Li, et al. The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma. Am J Clin Exp Med. 2021;9(6):215-222. doi: 10.11648/j.ajcem.20210906.15

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@article{10.11648/j.ajcem.20210906.15,
  author = {Ying Li and Feng Zhou and Chao Shen and Yi Su and Yanxia Li and Cuicui Wang and Ruixia Yan and Guiran Yang and Zhenjiang Hou},
  title = {The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {6},
  pages = {215-222},
  doi = {10.11648/j.ajcem.20210906.15},
  url = {https://doi.org/10.11648/j.ajcem.20210906.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.15},
  abstract = {Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: To explore the expression and clinical significance of interleukin-4 (IL-4) and interleukin-13 (IL-13) in the tissues and serum of patients with papillary thyroid carcinoma (PTC). Method: 120 cases of PTC patients were randomly selected as the experimental group, who underwent radical mastectomy at the Thyroid and Breast Surgery Department of Cangzhou Central Hospital from January 2018 to April 2019, and the PTC tissues and their adjacent tissues and serum samples were collected. 120 healthy people were matched 1:1 as the control group in the hospital physical examination center during the same period, according to the gender, age and body mass index of the experimental group, and serum samples were collected. The immunohisto chemical SP method is adopted to test the expression of IL-4 and IL-13 in the tissues, and the ELISA is adopted to test the serum levels of IL-4 and IL-13. Analyze the relationship between IL-4 and IL-13 expression and clinicopathological characteristics in PTC. Result: It was significantly higher with the positive expression rate of IL-4 and IL-13 in PTC tissues than that in adjacent tissues (PConclusion: IL-4 and IL-13 were highly expressed in PTC, and the expression level may become a reference indicator for predicting the occurrence and development of PTC.},
 year = {2021}
}

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TY  - JOUR
T1  - The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma
AU  - Ying Li
AU  - Feng Zhou
AU  - Chao Shen
AU  - Yi Su
AU  - Yanxia Li
AU  - Cuicui Wang
AU  - Ruixia Yan
AU  - Guiran Yang
AU  - Zhenjiang Hou
Y1  - 2021/12/07
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210906.15
DO  - 10.11648/j.ajcem.20210906.15
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 215
EP  - 222
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210906.15
AB  - Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: To explore the expression and clinical significance of interleukin-4 (IL-4) and interleukin-13 (IL-13) in the tissues and serum of patients with papillary thyroid carcinoma (PTC). Method: 120 cases of PTC patients were randomly selected as the experimental group, who underwent radical mastectomy at the Thyroid and Breast Surgery Department of Cangzhou Central Hospital from January 2018 to April 2019, and the PTC tissues and their adjacent tissues and serum samples were collected. 120 healthy people were matched 1:1 as the control group in the hospital physical examination center during the same period, according to the gender, age and body mass index of the experimental group, and serum samples were collected. The immunohisto chemical SP method is adopted to test the expression of IL-4 and IL-13 in the tissues, and the ELISA is adopted to test the serum levels of IL-4 and IL-13. Analyze the relationship between IL-4 and IL-13 expression and clinicopathological characteristics in PTC. Result: It was significantly higher with the positive expression rate of IL-4 and IL-13 in PTC tissues than that in adjacent tissues (PConclusion: IL-4 and IL-13 were highly expressed in PTC, and the expression level may become a reference indicator for predicting the occurrence and development of PTC.
VL  - 9
IS  - 6
ER  -

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Author Information

Ying Li

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Feng Zhou

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Chao Shen

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Yi Su

Thyroid and Breast Surgical Department, People's Hospital of Nanpi County, Cangzhou, China
Yanxia Li

Department of Rheumatology and Immunology, Cangzhou Central Hospital, Cangzhou, China
Cuicui Wang

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Ruixia Yan

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Guiran Yang

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Zhenjiang Hou

Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

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APA Style

Ying Li, Feng Zhou, Chao Shen, Yi Su, Yanxia Li, et al. (2021). The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma. American Journal of Clinical and Experimental Medicine, 9(6), 215-222. https://doi.org/10.11648/j.ajcem.20210906.15

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ACS Style

Ying Li; Feng Zhou; Chao Shen; Yi Su; Yanxia Li, et al. The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma. Am. J. Clin. Exp. Med. 2021, 9(6), 215-222. doi: 10.11648/j.ajcem.20210906.15

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AMA Style

Ying Li, Feng Zhou, Chao Shen, Yi Su, Yanxia Li, et al. The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma. Am J Clin Exp Med. 2021;9(6):215-222. doi: 10.11648/j.ajcem.20210906.15

Copy | Download

@article{10.11648/j.ajcem.20210906.15,
  author = {Ying Li and Feng Zhou and Chao Shen and Yi Su and Yanxia Li and Cuicui Wang and Ruixia Yan and Guiran Yang and Zhenjiang Hou},
  title = {The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {6},
  pages = {215-222},
  doi = {10.11648/j.ajcem.20210906.15},
  url = {https://doi.org/10.11648/j.ajcem.20210906.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.15},
  abstract = {Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: To explore the expression and clinical significance of interleukin-4 (IL-4) and interleukin-13 (IL-13) in the tissues and serum of patients with papillary thyroid carcinoma (PTC). Method: 120 cases of PTC patients were randomly selected as the experimental group, who underwent radical mastectomy at the Thyroid and Breast Surgery Department of Cangzhou Central Hospital from January 2018 to April 2019, and the PTC tissues and their adjacent tissues and serum samples were collected. 120 healthy people were matched 1:1 as the control group in the hospital physical examination center during the same period, according to the gender, age and body mass index of the experimental group, and serum samples were collected. The immunohisto chemical SP method is adopted to test the expression of IL-4 and IL-13 in the tissues, and the ELISA is adopted to test the serum levels of IL-4 and IL-13. Analyze the relationship between IL-4 and IL-13 expression and clinicopathological characteristics in PTC. Result: It was significantly higher with the positive expression rate of IL-4 and IL-13 in PTC tissues than that in adjacent tissues (PConclusion: IL-4 and IL-13 were highly expressed in PTC, and the expression level may become a reference indicator for predicting the occurrence and development of PTC.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma
AU  - Ying Li
AU  - Feng Zhou
AU  - Chao Shen
AU  - Yi Su
AU  - Yanxia Li
AU  - Cuicui Wang
AU  - Ruixia Yan
AU  - Guiran Yang
AU  - Zhenjiang Hou
Y1  - 2021/12/07
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210906.15
DO  - 10.11648/j.ajcem.20210906.15
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 215
EP  - 222
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210906.15
AB  - Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: To explore the expression and clinical significance of interleukin-4 (IL-4) and interleukin-13 (IL-13) in the tissues and serum of patients with papillary thyroid carcinoma (PTC). Method: 120 cases of PTC patients were randomly selected as the experimental group, who underwent radical mastectomy at the Thyroid and Breast Surgery Department of Cangzhou Central Hospital from January 2018 to April 2019, and the PTC tissues and their adjacent tissues and serum samples were collected. 120 healthy people were matched 1:1 as the control group in the hospital physical examination center during the same period, according to the gender, age and body mass index of the experimental group, and serum samples were collected. The immunohisto chemical SP method is adopted to test the expression of IL-4 and IL-13 in the tissues, and the ELISA is adopted to test the serum levels of IL-4 and IL-13. Analyze the relationship between IL-4 and IL-13 expression and clinicopathological characteristics in PTC. Result: It was significantly higher with the positive expression rate of IL-4 and IL-13 in PTC tissues than that in adjacent tissues (PConclusion: IL-4 and IL-13 were highly expressed in PTC, and the expression level may become a reference indicator for predicting the occurrence and development of PTC.
VL  - 9
IS  - 6
ER  -

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