Papillary Tumor of the Pineal Region: A Case Report and Literature Review

Peng Lilin; Zhong Lijuan; Yang Bo; Lu Yuanzhi

doi:doi:10.11648/j.ajcem.20231102.11

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Papillary Tumor of the Pineal Region: A Case Report and Literature Review

Peng Lilin, Zhong Lijuan, Yang Bo, Lu Yuanzhi

Published in American Journal of Clinical and Experimental Medicine (Volume 11, Issue 2)

Received: 7 February 2023 Accepted: 1 March 2023 Published: 20 March 2023

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Abstract

Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented with intermittent dizziness and headache with vomiting for more than 2 months. The imaging revealed a mass in the region of the pineal region with obstructive hydrocephalus. After the hospitalization, the patient underwent a microscopic excision of the pineal mass, and the tissue was sent for histopathological examination and available immunohistochemical tests, which resulted in a definitive diagnosis of a papillary tumor of the pineal region. He had undergone several radiation treatments during his hospitalization and remained recurrence-free until the latest follow-up visit. This article highlights the similarities between this case and the PTPR described in WHO 2021 in terms of clinical presentation, imaging, and histopathological features. Therefore, this case report completes the sample database of PTPRs. By reviewing the literature related to PTPRs, we hope that this report will be helpful to improve the understanding of clinicians and pathologists about this rare tumor. However, more relevant studies are needed to clarify the pathogenesis, prognosis, and optimal treatment options to achieve early diagnosis, early treatment, and improved prognosis.

Published in	American Journal of Clinical and Experimental Medicine (Volume 11, Issue 2)
DOI	10.11648/j.ajcem.20231102.11
Page(s)	29-32
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Papillary Tumor of the Pineal Region, PTPR, Pineal Parenchymal Tumor, Diagnosis

References

[1]	Cuccia F, Mortellaro G, Cespuglio D, et al. A Case Report of Adult Pineoblastoma Occurring in a Pregnant Woman. Anticancer Res. 2019; 39 (5): 2627-2631. doi: 10.21873/anticanres.13386.
[2]	Jouvet A, Saint-Pierre G, Fauchon F, et al. Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol. 2000; 10 (1): 49-60. doi: 10.1111/j.1750-3639.2000.tb00242.x.
[3]	Yamaki VN, Solla DJF, Ribeiro RR, et al. Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors. Neurosurgery. 2019; 85 (3): E420-e429. doi: 10.1093/neuros/nyz062.
[4]	Jouvet A, Fauchon F, Liberski P, et al. Papillary tumor of the pineal region. Am J Surg Pathol. 2003; 27 (4): 505-512. doi: 10.1097/00000478-200304000-00011.
[5]	Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007; 114 (2): 97-109. doi: 10.1007/s00401-007-0243-4.
[6]	WHO Classification of Tumours Editorial Board. World Health Organization Classification of Tumours of the Central Nervous System. 5th ed. Lyon: International Agency for Research on Cancer; 2021.
[7]	Goschzik T, Gessi M, Denkhaus D, et al. PTEN mutations and activation of the PI3K/Akt/mTOR signaling pathway in papillary tumors of the pineal region. J Neuropathol Exp Neurol. 2014; 73 (8): 747-751. doi: 10.1097/nen.0000000000000093.
[8]	Hasselblatt M, Blümcke I, Jeibmann A, et al. Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region. Neuropathol Appl Neurobiol. 2006; 32 (3): 278-283. doi: 10.1111/j.1365-2990.2006.00723.x.
[9]	Assi HI, Kakati RT, Berro J, et al. PTEN R130Q Papillary Tumor of the Pineal Region (PTPR) with Chromosome 10 Loss Successfully Treated with Everolimus: A Case Report. Curr Oncol. 2021; 28 (2): 1274-1279. doi: 10.3390/curroncol28020121.
[10]	Fèvre Montange M, Vasiljevic A, Champier J, et al. Papillary tumor of the pineal region: Histopathological characterization and review of the literature. Neurochirurgie. 2015; 61 (2-3): 138-142. doi: 10.1016/j.neuchi.2013.04.011.
[11]	Fauchon F, Hasselblatt M, Jouvet A, et al. Role of surgery, radiotherapy and chemotherapy in papillary tumors of the pineal region: a multicenter study. J Neurooncol. 2013; 112 (2): 223-231. doi: 10.1007/s11060-013-1050-5.
[12]	Reni M, Brandes AA. Current management and prognostic factors for adult ependymoma. Expert Rev Anticancer Ther. 2002; 2 (5): 537-545. doi: 10.1586/14737140.2.5.537.
[13]	Matyja E, Grajkowska W, Nauman P, et al. Histopathological patterns of papillary tumour of the pineal region. Folia Neuropathol. 2011; 49 (3): 181-190.
[14]	Lechapt-Zalcman E, Chapon F, Guillamo JS, et al. Long-term clinicopathological observations on a papillary tumour of the pineal region. Neuropathol Appl Neurobiol. 2011; 37 (4): 431-435. doi: 10.1111/j.1365-2990.2010.01133.x.
[15]	Poulgrain K, Gurgo R, Winter C, et al. Papillary tumour of the pineal region. J Clin Neurosci. 2011; 18 (8): 1007-1017. doi: 10.1016/j.jocn.2010.12.027.
[16]	Júnior GV, Dellaretti M, de Carvalho GT, et al. Papillary tumor of the pineal region. Brain Tumor Pathol. 2011; 28 (4): 329-334. doi: 10.1007/s10014-011-0040-6.
[17]	Amemiya S, Shibahara J, Aoki S, et al. Recently established entities of central nervous system tumors: review of radiological findings. J Comput Assist Tomogr. 2008; 32 (2): 279-285. doi: 10.1097/RCT.0b013e31814ce981.
[18]	Patel SK, Tomei KL, Christiano LD, et al. Complete regression of papillary tumor of the pineal region after radiation therapy: case report and review of the literature. J Neurooncol. 2012; 107 (2): 427-434. doi: 10.1007/s11060-011-0764-5.
[19]	Vaghela V, Radhakrishnan N, Radhakrishnan VV, et al. Advanced magnetic resonance imaging with histopathological correlation in papillary tumor of pineal region: report of a case and review of literature. Neurol India. 2010; 58 (6): 928-932. doi: 10.4103/0028-3886.73750.
[20]	Chang AH, Fuller GN, Debnam JM, et al. MR imaging of papillary tumor of the pineal region. AJNR Am J Neuroradiol. 2008; 29 (1): 187-189. doi: 10.3174/ajnr.A0784.
[21]	Shibahara J, Todo T, Morita A, et al. Papillary neuroepithelial tumor of the pineal region. A case report. Acta Neuropathol. 2004; 108 (4): 337-340. doi: 10.1007/s00401-004-0898-z.
[22]	Sato TS, Kirby PA, Buatti JM, et al. Papillary tumor of the pineal region: report of a rapidly progressive tumor with possible multicentric origin. Pediatr Radiol. 2009; 39 (2): 188-190. doi: 10.1007/s00247-008-1060-1.
[23]	Rickard KA, Parker JR, Vitaz TW, et al. Papillary tumor of the pineal region: two case studies and a review of the literature. Ann Clin Lab Sci. 2011; 41 (2): 174-181.
[24]	Fèvre-Montange M, Vasiljevic A, Champier J, et al. Histopathology of tumors of the pineal region. Future Oncol. 2010; 6 (5): 791-809. doi: 10.2217/fon.10.28.
[25]	Favero G, Bonomini F, Rezzani R. Pineal Gland Tumors: A Review. Cancers (Basel). 2021; 13 (7). doi: 10.3390/cancers13071547.

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APA Style

Peng Lilin, Zhong Lijuan, Yang Bo, Lu Yuanzhi. (2023). Papillary Tumor of the Pineal Region: A Case Report and Literature Review. American Journal of Clinical and Experimental Medicine, 11(2), 29-32. https://doi.org/10.11648/j.ajcem.20231102.11

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ACS Style

Peng Lilin; Zhong Lijuan; Yang Bo; Lu Yuanzhi. Papillary Tumor of the Pineal Region: A Case Report and Literature Review. Am. J. Clin. Exp. Med. 2023, 11(2), 29-32. doi: 10.11648/j.ajcem.20231102.11

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AMA Style

Peng Lilin, Zhong Lijuan, Yang Bo, Lu Yuanzhi. Papillary Tumor of the Pineal Region: A Case Report and Literature Review. Am J Clin Exp Med. 2023;11(2):29-32. doi: 10.11648/j.ajcem.20231102.11

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@article{10.11648/j.ajcem.20231102.11,
  author = {Peng Lilin and Zhong Lijuan and Yang Bo and Lu Yuanzhi},
  title = {Papillary Tumor of the Pineal Region: A Case Report and Literature Review},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {11},
  number = {2},
  pages = {29-32},
  doi = {10.11648/j.ajcem.20231102.11},
  url = {https://doi.org/10.11648/j.ajcem.20231102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20231102.11},
  abstract = {Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented with intermittent dizziness and headache with vomiting for more than 2 months. The imaging revealed a mass in the region of the pineal region with obstructive hydrocephalus. After the hospitalization, the patient underwent a microscopic excision of the pineal mass, and the tissue was sent for histopathological examination and available immunohistochemical tests, which resulted in a definitive diagnosis of a papillary tumor of the pineal region. He had undergone several radiation treatments during his hospitalization and remained recurrence-free until the latest follow-up visit. This article highlights the similarities between this case and the PTPR described in WHO 2021 in terms of clinical presentation, imaging, and histopathological features. Therefore, this case report completes the sample database of PTPRs. By reviewing the literature related to PTPRs, we hope that this report will be helpful to improve the understanding of clinicians and pathologists about this rare tumor. However, more relevant studies are needed to clarify the pathogenesis, prognosis, and optimal treatment options to achieve early diagnosis, early treatment, and improved prognosis.},
 year = {2023}
}

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TY  - JOUR
T1  - Papillary Tumor of the Pineal Region: A Case Report and Literature Review
AU  - Peng Lilin
AU  - Zhong Lijuan
AU  - Yang Bo
AU  - Lu Yuanzhi
Y1  - 2023/03/20
PY  - 2023
N1  - https://doi.org/10.11648/j.ajcem.20231102.11
DO  - 10.11648/j.ajcem.20231102.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 29
EP  - 32
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20231102.11
AB  - Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented with intermittent dizziness and headache with vomiting for more than 2 months. The imaging revealed a mass in the region of the pineal region with obstructive hydrocephalus. After the hospitalization, the patient underwent a microscopic excision of the pineal mass, and the tissue was sent for histopathological examination and available immunohistochemical tests, which resulted in a definitive diagnosis of a papillary tumor of the pineal region. He had undergone several radiation treatments during his hospitalization and remained recurrence-free until the latest follow-up visit. This article highlights the similarities between this case and the PTPR described in WHO 2021 in terms of clinical presentation, imaging, and histopathological features. Therefore, this case report completes the sample database of PTPRs. By reviewing the literature related to PTPRs, we hope that this report will be helpful to improve the understanding of clinicians and pathologists about this rare tumor. However, more relevant studies are needed to clarify the pathogenesis, prognosis, and optimal treatment options to achieve early diagnosis, early treatment, and improved prognosis.
VL  - 11
IS  - 2
ER  -

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Author Information

Peng Lilin

Department of Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China
Zhong Lijuan

Department of Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China
Yang Bo

Department of Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China
Lu Yuanzhi

Department of Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China

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Plain Text BibTeX RIS

APA Style

Peng Lilin, Zhong Lijuan, Yang Bo, Lu Yuanzhi. (2023). Papillary Tumor of the Pineal Region: A Case Report and Literature Review. American Journal of Clinical and Experimental Medicine, 11(2), 29-32. https://doi.org/10.11648/j.ajcem.20231102.11

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ACS Style

Peng Lilin; Zhong Lijuan; Yang Bo; Lu Yuanzhi. Papillary Tumor of the Pineal Region: A Case Report and Literature Review. Am. J. Clin. Exp. Med. 2023, 11(2), 29-32. doi: 10.11648/j.ajcem.20231102.11

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AMA Style

Peng Lilin, Zhong Lijuan, Yang Bo, Lu Yuanzhi. Papillary Tumor of the Pineal Region: A Case Report and Literature Review. Am J Clin Exp Med. 2023;11(2):29-32. doi: 10.11648/j.ajcem.20231102.11

Copy | Download

@article{10.11648/j.ajcem.20231102.11,
  author = {Peng Lilin and Zhong Lijuan and Yang Bo and Lu Yuanzhi},
  title = {Papillary Tumor of the Pineal Region: A Case Report and Literature Review},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {11},
  number = {2},
  pages = {29-32},
  doi = {10.11648/j.ajcem.20231102.11},
  url = {https://doi.org/10.11648/j.ajcem.20231102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20231102.11},
  abstract = {Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented with intermittent dizziness and headache with vomiting for more than 2 months. The imaging revealed a mass in the region of the pineal region with obstructive hydrocephalus. After the hospitalization, the patient underwent a microscopic excision of the pineal mass, and the tissue was sent for histopathological examination and available immunohistochemical tests, which resulted in a definitive diagnosis of a papillary tumor of the pineal region. He had undergone several radiation treatments during his hospitalization and remained recurrence-free until the latest follow-up visit. This article highlights the similarities between this case and the PTPR described in WHO 2021 in terms of clinical presentation, imaging, and histopathological features. Therefore, this case report completes the sample database of PTPRs. By reviewing the literature related to PTPRs, we hope that this report will be helpful to improve the understanding of clinicians and pathologists about this rare tumor. However, more relevant studies are needed to clarify the pathogenesis, prognosis, and optimal treatment options to achieve early diagnosis, early treatment, and improved prognosis.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Papillary Tumor of the Pineal Region: A Case Report and Literature Review
AU  - Peng Lilin
AU  - Zhong Lijuan
AU  - Yang Bo
AU  - Lu Yuanzhi
Y1  - 2023/03/20
PY  - 2023
N1  - https://doi.org/10.11648/j.ajcem.20231102.11
DO  - 10.11648/j.ajcem.20231102.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 29
EP  - 32
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20231102.11
AB  - Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented with intermittent dizziness and headache with vomiting for more than 2 months. The imaging revealed a mass in the region of the pineal region with obstructive hydrocephalus. After the hospitalization, the patient underwent a microscopic excision of the pineal mass, and the tissue was sent for histopathological examination and available immunohistochemical tests, which resulted in a definitive diagnosis of a papillary tumor of the pineal region. He had undergone several radiation treatments during his hospitalization and remained recurrence-free until the latest follow-up visit. This article highlights the similarities between this case and the PTPR described in WHO 2021 in terms of clinical presentation, imaging, and histopathological features. Therefore, this case report completes the sample database of PTPRs. By reviewing the literature related to PTPRs, we hope that this report will be helpful to improve the understanding of clinicians and pathologists about this rare tumor. However, more relevant studies are needed to clarify the pathogenesis, prognosis, and optimal treatment options to achieve early diagnosis, early treatment, and improved prognosis.
VL  - 11
IS  - 2
ER  -

Copy | Download