Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone

Nakul Kumar Datta; Krishna Priya Das; Mohammad Mamun Mia

doi:doi:10.11648/j.ajim.20200806.20

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Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone

Nakul Kumar Datta, Krishna Priya Das, Mohammad Mamun Mia

Published in American Journal of Internal Medicine (Volume 8, Issue 6)

Received: 31 October 2020 Accepted: 16 November 2020 Published: 4 December 2020

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Abstract

Cystic lesions include Simple bone cyst and Aneurysmal bone cyst, and among cyst like lesions studied Giant cell tumor, fibrous dysplasia and Non-ossifying fibroma. This prospective interventional study was conducted in the Department of orthopaedic surgery Bangubandhu Sheikh Mujib Mdical university (BSMMU) and Biomedical research division, Atomic energy centre Savar, Dhaka Bangladesh from January 2004 to December 2019. Out of 155 Cysts and cysts like lesions were operated, among which cystic lesions were 73 (47.10%), among cystic lesions SBC was 51 (69.86%), and ABC-22 (30.14%) and cyst like lesions were 82 (52.90%), among cyst like lesions GCT was 68 (82.92%), FD was 12 (14.63%) & NOF was 2 (2.43%). All cases were operated by thorough curettage and cavity filled with Lyophilized radiation sterilized bone allograft impregnated with autogenous bone marrow for children and mixed bone graft in adult. Clinical and radiological evaluation was done in all cases in which 61 (83.56%) out of 73 cystic lesions were healed and 12 (16.44%) lesions were recurred, on the other hand 58 (70.73%) out of 82 cyst like lesions were healed and 24 (29.27%) lesions were recurred. Out of 155 cysts and cyst like lesions 119 (76.78%) were healed / satisfactory and 36 (23.22%) were recurred. Follow up period were 9 month to 15 years. P value is <.001. Main aims to evaluate the complete healing of cystic and cyst like lesions of bone with in corporation of allograft. Bone marrow impregnated Lyophilized radiation sterilized bone allograft and mixed bone graft is useful graft material for healing of the lesional area and restoring structural integrity as well as function for management of cysts and cyst like lesions in bone.

Published in	American Journal of Internal Medicine (Volume 8, Issue 6)
DOI	10.11648/j.ajim.20200806.20
Page(s)	304-311
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Bone Allograft, Autogenous Bone Marrow and Mixed Graft, Cysts and Cyst Like Lesions

References

[1]	Friedlaender GE. 1987. current concepts review: Bone graft the basic science rationale for clinical applications. J Bone Joint surg. 69: 786-789.
[2]	Samuel LT. 1984. orthopaedics: principles and Their Application. 4^th edn. Vol. 1. pp. 31-100. Lippincort company, New work.
[3]	Kreuz FP. Hyatt GW, Turner JGTC and Bassett JGAL, 1951. The preservation and clinical use of freeze-dried bone. J Bone Joint Surg. 33: 863-872.
[4]	Urist MR, Silverman BF, Buring CG, Klas JC, Dubuc FL. and Rosenberg JM. 1967. The Bone induction principle. Clin Orthop. 53: 243-283.
[5]	Nade G and Burwell RG. 1977. Decalcified bone as a substrate for osteogenesis. J Bone Joint Surg. 59: 189-196.
[6]	Spence KF, Sell KW and Brown RH. 1969. Solitary bone cyst: Treatment with freeze dried cancellous bone allograft. J Bone Joint Surg. 51: 87-96.
[7]	Andrew H, Crenshaw (Jr) AH Surgical techniques and approaches (bone grafting). In: canale ST editor Campbell’s operative orthopaedics. Vol. 1, 9^th edn. New work, Mosby. 1998: 29-47.
[8]	Zasacki W. 1991. The efficacy of application of lyophilized, radiation sterilized bone graft in orthopaedic surgery. Clin Orthro Relt Res. 272: 82-87.
[9]	Conrad EU, Ericksen DP, Tencer AF, Strong DM, Mackenzie AP. The effects of freeze drying and rehydration on Cancellous Bone. Clin Ortho Relt Res 1993; 290: 279-84.
[10]	Broder HM. Possible precursor of unicameral bone cyst. JBJS Am. 1968; 50: 503–507.
[11]	Cohen J. Etiology of simple bone cyst. JBJS Am. 1970; 52: 1493–1497.
[12]	Jaffe HL, Lichtenstein L. Solitary unicameral bone cyst with emphasis on the roentgen picture, the pathologic appearance, and the pathogenesis. Arch Surg. 1942; 44: 1004–1025.
[13]	Weissel A, Hecht HL. Development of a unicameral bone cyst. JBJS Am. 1980; 62: 664–666.
[14]	Moore TE, King AR. Post traumatic cyst and cyst-like lesion of bone. Skelet Radiol. 1989; 18: 93–97.
[15]	Morton KS. The pathogenesis of unicameral bone cyst. Can J Surg. 1964; 7: 140–150.
[16]	Fechner RE, Mills SE, editors. Tumors of bones and joints. Armed Forces Institute For Pathology; 1993; Washington DC. pp. 173–186.
[17]	Baker M. Benign unicameral bone cyst. Clin Orthop. 1970; 71: 140–151.
[18]	Campanacci M, Capanna R. Unicameral and aneurysmal bone cyst. Skeletal Radiol. 1968; 204: 25–36.
[19]	Neer CS II, Francis KC, Marcove RC, Terz J and Carbonara PN. Treatment of unicameral bone cyst. A follow up study of one hundred seventy-five cases. JBJS Am. 1966; 48: 731–745.
[20]	Goldber RP, Genant HK. Case report 67. Solitary bone cyst of the right ilium. skeletal Radiol. 1978; 3: 118–121.
[21]	Capanna R, Van Horn J. Epiphyseal involvement in unicameral bone cyst. Skeletal radiol. 1986; 15: 428–432.
[22]	Lichten L. Aneurysmal bone cysts, further observation. cancer 1953; 6: 1228-37.
[23]	Sheman RS, Soong KY. Aneurysmal bone cyst: its roentgen diagnosis. Radiology 1957; 68: 54-64.
[24]	H. L. Jaffe and L. Lichtenstein, “Solitary unicameral bone cyst: with emphasis on the roentgen picture, the pathologic appearance and the pathogenesis,” Archives of Surgery, vol. 44, no. 6, pp. 1004–1025, 1942.
[25]	H. J. Mankin, F. J. Hornicek, E. Ortiz-Cruz, J. Villafuerte, and M. C. Gebhardt, “Aneurysmal bone cyst: a review of 150 patients,” Journal of Clinical Oncology, vol. 23, no. 27, pp. 6756–6762, 2005.
[26]	Sasaki, S. Nagano, H. Shimada et al., “Diagnosing and discriminating between primary and secondary aneurysmal bone cysts,” Oncology Letters, vol. 13, no. 4, pp. 2290–2296, 2017.
[27]	H. Y. Park, S. K. Yang, W. L. Sheppard et al., “Current management of aneurysmal bone cysts,” Current Reviews in Musculoskeletal Medicine, vol. 9, no. 4, pp. 435–444, 2016.
[28]	T. B. Rapp, J. P. Ward, and M. J. Alaia, “Aneurysmal bone cyst,” Journal of the American Academy of Orthopaedic Surgeons, vol. 20, no. 4, pp. 233–241, 2012. View at: Publisher Site \| Google Scholar.
[29]	A. M. Vergel De Dios, J. R. Bond, T. C. Shives, R. A. McLeod, and K. K. Unni, “Aneurysmal bone cyst. A clinicopathologic study of 238 cases,” Cancer, vol. 69, no. 12, pp. 2921–2931, 1992. View at: Publisher Site \| Google Scholar.
[30]	A. Leithner, R. Windhager, S. Lang, O. A. Haas, F. Kainberger, and R. Kotz, “Aneurysmal bone cyst. A population based epidemiologic study and literature review,” Clinical Orthopaedics and Related Research, vol. 363, pp. 176–179, 1999. View at: Publisher Site \| Google Scholar.
[31]	H. W. B. Schreuder, R. P. H. Veth, M. Pruszczynski, J. A. M. Lemmens, H. S. Koops, and W. M. Molenaar, “Aneurysmal bone cysts treated by curettage, cryotherapy and bone grafting,” Journal of Bone and Joint Surgery. British volume, vol. 79, no. 1, pp. 20–25, 1997. View at: Publisher Site \| Google Scholar.
[32]	P. Tsagozis and O. Brosjö, “Current strategies for the treatment of aneurysmal bone cysts,” Orthopedic Reviews, vol. 7, no. 4, p. 6182, 2015. View at: Publisher Site \| Google Scholar.
[33]	B. Erol, M. O. Topkar, E. Caliskan, and R. Erbolukbas, “Surgical treatment of active or aggressive aneurysmal bone cysts in children,” Journal of Pediatric Orthopaedics B, vol. 24, no. 5, pp. 461–468, 2015. View at: Publisher Site \| Google Scholar.
[34]	R. C. Marcove, D. S. Sheth, S. Takemoto, and J. H. Healey, “The treatment of aneurysmal bone cyst,” Clinical Orthopaedics and Related Research, vol. 311, pp. 157–163, 1995. View at: Google Scholar.
[35]	R. J. Steffner, C. Liao, G. Stacy et al., “Factors associated with recurrence of primary aneurysmal bone cysts: is argon beam coagulation an effective adjuvant treatment?” Journal Bone and Joint Surgery-American Volume, vol. 93, no. 21, pp. e122 (1)–e122 (9), 2011. View at: Publisher Site \| Google Scholarof.
[36]	H. Aiba, M. Kobayashi, Y. Waguri-Nagaya et al., “Treatment of aneurysmal bone cysts using endoscopic curettage,” BMC Musculoskeletal Disorders, vol. 19, no. 1, p. 268, 2018. View at: Publisher Site \| Google Scholar.
[37]	J. Syvänen, Y. Nietosvaara, I. Kohonen et al., “Treatment of aneurysmal bone cysts with bioactive glass in children,” Scandinavian Journal of Surgery, vol. 107, no. 1, pp. 76–81, 2018. View at: Publisher Site \| Google Scholar.
[38]	E. H. M. Wang, M. L. Marfori, M. V. T. Serrano, and D. A. Rubio, “Is curettage and high-speed burring sufficient treatment for aneurysmal bone cysts?” Clinical Orthopaedics and Related Research, vol. 472, no. 11, pp. 3483–3488, 2014. View at: Publisher Site \| Google Scholar.
[39]	S. Zhu, K. E. Hitchcock, and W. M. Mendenhall, “Radiation therapy for aneurysmal bone cysts,” American Journal of Clinical Oncology, vol. 40, no. 6, pp. 621–624, 2017. View at: Publisher Site \| Google Scholar.
[40]	G. Rossi, A. F. Mavrogenis, G. Facchini et al., “How effective is embolization with N-2-butyl-cyanoacrylate for aneurysmal bone cysts?” International Orthopaedics, vol. 41, no. 8, pp. 1685–1692, 2017. View at: Publisher Site \| Google Scholar.
[41]	G. Rossi, E. Rimondi, T. Bartalena et al., “Selective arterial embolization of 36 aneurysmal bone cysts of the skeleton with N-2-butyl cyanoacrylate,” Skeletal Radiology, vol. 39, no. 2, pp. 161–167, 2010. View at: Publisher Site \| Google Scholar.
[42]	S. Terzi, A. Gasbarrini, M. Fuiano et al., “Efficacy and safety of selective arterial embolization in the treatment of aneurysmal bone cyst of the mobile spine,” SPINE, vol. 42, no. 15, pp. 1130–1138, 2017. View at: Publisher Site \| Google Scholar.
[43]	J. Cottalorda and S. Bourelle, “Modern concepts of primary aneurysmal bone cyst,” Archives of Orthopaedic and Trauma Surgery, vol. 127, no. 2, pp. 105–114, 2007. View at: Publisher Site \| Google Scholar.
[44]	E. Mascard, A. Gomez-Brouchet, and K. Lambot, “Bone cysts: unicameral and aneurysmal bone cyst,” Orthopaedics & Traumatology: Surgery & Research, vol. 101, no. 1, pp. S119–S127, 2015. View at: Publisher Site \| Google Scholar.
[45]	O. Hauschild, M. Lüdemann, M. Engelhardt et al., “Aneurysmal bone cyst (ABC): treatment options and proposal of a follow-up regime,” Acta Orthopaedica Belgica, vol. 82, no. 3, pp. 474–483, 2016. View at: Google Scholar.
[46]	A. R. Ramírez and R. P. Stanton, “Aneurysmal bone cyst in 29 children,” Journal of Pediatric Orthopaedics, vol. 22, no. 4, pp. 533–539, 2002. View at: Publisher Site \| Google Scholar.
[47]	C. P. Gibbs, M. C. Hefele, T. D. Peabody, A. G. Montag, V. Aithal, and M. A. Simon, “Aneurysmal bone cyst of the extremities. Factors related to local recurrence after curettage with a high-speed burr,” Journal of Bone & Joint Surgery, vol. 81, no. 12, pp. 1671–1678, 1999. View at: Publisher Site \| Google Scholar.
[48]	P. Flont, M. Kolacinska-Flont, and K. Niedzielski, “A comparison of cyst wall curettage and en bloc excision in the treatment of aneurysmal bone cysts,” World Journal of Surgical Oncology, vol. 11, no. 1, p. 109, 2013. View at: Publisher Site \| Google Scholar.
[49]	J. E. Cummings, R. A. Smith, and R. K. Heck, “Argon beam coagulation as adjuvant treatment after curettage of aneurysmal bone cysts: a preliminary study,” Clinical Orthopaedics and Related Research®, vol. 468, no. 1, pp. 231–237, 2010. View at: Publisher Site \| Google Scholar.
[50]	S. P. Peeters, I. C. M. Van der Geest, J. W. J. de Rooy, R. P. H. Veth, and H. W. B. Schreuder, “Aneurysmal bone cyst: the role of cryosurgery as local adjuvant treatment,” Journal of Surgical Oncology, vol. 100, no. 8, pp. 719–724, 2009. View at: Publisher Site \| Google Scholar.
[51]	J. P. Dormans, B. G. Hanna, D. R. Johnston, and J. S. Khurana, “Surgical treatment and recurrence rate of aneurysmal bone cysts in children,” Clinical Orthopaedics and Related Research, vol. 421, pp. 205–211, 2004. View at: Publisher Site \| Google Scholar.
[52]	Carnesale PG, Benign (occasionally malignant) tumor’s of bone. In: Canale ST editor Campbell’s operative orthopaedics. Vol. 1 9^th edn. New York, Mosby 1998; 703-13.
[53]	Jafee HL, Tumors and timorous condition of the bones and joints. Philadelphia, Lea and Febigen, 1958; 18-43.
[54]	Heek (Jr.) RK. Benign (occasionally aggressive) tumors of bone. In: Canale ST Daugherty K & Jones L, eds, Campbell’s operative orthopaedics 10^th edn. Vol. 1, Mosby, Philadelphia, 2003; 813-17.
[55]	Adams JC & Hamblen DL, Outline of orthopaedics, 13 th edn. Churchill Livingstone, New work, 2001; 82-86.
[56]	Turcotte RE. Giant cell tumor of bone. Orthop, Clin North AM. 2006; 37: 35-51.
[57]	Rao PT. Management of giant cell tumor of bone. Kini memorial oration. Indian J. Orthop. 1993; 27: 96-100.
[58]	Sung, HW, Kuo DP, Chai YB, Liu CC, Li SM. Giant cell tumor of bone: Analysis of two hundred and eight cases in Chinese patients. J. Bone Joint Surg. Am. 1982; 64: 755-61.
[59]	Solomon L, Warwick DJ, Nayagam S; Apley’s system of orthopaedics and fracture, 8^th edition, London Arnold. 2001; 167-199.
[60]	Randall RL and Hoang BH, Mu sculoskeletal oncology. In: Skinner HB editor. Current Diagnosis & treatment in orthopaedics, 4^th edn. New Work, McGraw Hill Companies. 2006; 298-323.
[61]	Sim FH, Dahlin DC and Beabout JW. Multicentric giant cell tumor of bone. J Bone Joint Surg. 1977; 59A: 1052.
[62]	Sybrandy S, and De La Fuente AA. Multiple giant cell tumor of bone. Report of a case. J Bone Joint Surg. 1973; 55B: 350.
[63]	Tornberg DN and, Dick HM and Johnston A, Multicentric giant cell tomors in the long bones. J Bone Joint Surg. 1973; 57A: 429.
[64]	Turek SL. Orthopaedics principles and their application, Vol. 1. 4^th Edn, New work, JB. Lippincott company. 1984; 30-100.
[65]	Enneking W F, Gearen PF. Fibrous dysplasia of the femoral neck. Treatment by cortical bone grafting. J Bone Joint SurgAm. 1986; 68: 1415-1422.
[66]	Ippolito E, Bray EW, Corsi A etal. Natural history and treatment of fibrous dysplasia of bone: a multicentre Clinico-pathologic study promoted by the European Paediatric orthopaedic society. J pediatr orthop B2003; 12: 155-177.
[67]	Stanton RP. Surgery for fibrous dysplasia. J Bone Miner Res. 2006; 21 (supp 2): p105-109.
[68]	Stanton RP, Diamond L, surgical management of fibrous dysplasia in. Mc Cune-Albright syndrome pediatr. Endocrinol Rev. 2007; 4 (Suppl 4): 446-452.
[69]	Randall RL and Hoang BH. Musculoskeletal oncology. In: Skinner HB ed. Current Diagnostic & treatment in Orthopaedics. 4^th edn. New York: McGraw Hill companies; 2006. 298-323.
[70]	Carnesale PG. Benign Tumors of In: Canale ST ed. Campbell’s operative Orthopaedics. Vol. 1, 9^th edn. New York: Mosby; 1998. 683-99.
[71]	Gold RH & Marcove RC. Intraosseous spindle cell and collagen producing tumors, IN: Mirra JM ed. Bone tumors Diagnosis and treatments. Philadelphia: J B Lippincott company; 1980. 257-301.
[72]	Sontag LW and pyle SI. The appearance and nature of cyst like areas in the distal femoral metaphyses of children. Am J Roentgenol. Rad. Ther. Nucl. Med. 1941; 46-185.
[73]	Hatcher CH. The pathogenesis of localized fibrous lesions s in the metaphyses of long bones. Ann. Surg. 1945; 122: 1016.
[74]	Jaffe HL and Lichtenstein L. Non osteogenic fibroma of bone. Am J pathol. 1942; 18: 205.
[75]	Heiple KG, Chase SW and Herndon CHA. comparative study of the healing process following different types bone transplantation. The J Bone & Joint Surg. 1963; 45: 1593-1616.
[76]	Campanaeci M, Baldini N, Boriani S, and Sudanese A, Giant cell tumor of bone.. J Bone Joint Surg. 1987; 69: 106-13.
[77]	Goldenberg RR, Campbell CJ and Bonfiglio M: Giant cell tumor of bone. An Analysis of two hundred and eighteen cases. J Bone Joint Surg 1970; 52: 649-61.

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Nakul Kumar Datta, Krishna Priya Das, Mohammad Mamun Mia. (2020). Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone. American Journal of Internal Medicine, 8(6), 304-311. https://doi.org/10.11648/j.ajim.20200806.20

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ACS Style

Nakul Kumar Datta; Krishna Priya Das; Mohammad Mamun Mia. Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone. Am. J. Intern. Med. 2020, 8(6), 304-311. doi: 10.11648/j.ajim.20200806.20

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AMA Style

Nakul Kumar Datta, Krishna Priya Das, Mohammad Mamun Mia. Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone. Am J Intern Med. 2020;8(6):304-311. doi: 10.11648/j.ajim.20200806.20

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@article{10.11648/j.ajim.20200806.20,
  author = {Nakul Kumar Datta and Krishna Priya Das and Mohammad Mamun Mia},
  title = {Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {6},
  pages = {304-311},
  doi = {10.11648/j.ajim.20200806.20},
  url = {https://doi.org/10.11648/j.ajim.20200806.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200806.20},
  abstract = {Cystic lesions include Simple bone cyst and Aneurysmal bone cyst, and among cyst like lesions studied Giant cell tumor, fibrous dysplasia and Non-ossifying fibroma. This prospective interventional study was conducted in the Department of orthopaedic surgery Bangubandhu Sheikh Mujib Mdical university (BSMMU) and Biomedical research division, Atomic energy centre Savar, Dhaka Bangladesh from January 2004 to December 2019. Out of 155 Cysts and cysts like lesions were operated, among which cystic lesions were 73 (47.10%), among cystic lesions SBC was 51 (69.86%), and ABC-22 (30.14%) and cyst like lesions were 82 (52.90%), among cyst like lesions GCT was 68 (82.92%), FD was 12 (14.63%) & NOF was 2 (2.43%). All cases were operated by thorough curettage and cavity filled with Lyophilized radiation sterilized bone allograft impregnated with autogenous bone marrow for children and mixed bone graft in adult. Clinical and radiological evaluation was done in all cases in which 61 (83.56%) out of 73 cystic lesions were healed and 12 (16.44%) lesions were recurred, on the other hand 58 (70.73%) out of 82 cyst like lesions were healed and 24 (29.27%) lesions were recurred. Out of 155 cysts and cyst like lesions 119 (76.78%) were healed / satisfactory and 36 (23.22%) were recurred. Follow up period were 9 month to 15 years. P value is <.001. Main aims to evaluate the complete healing of cystic and cyst like lesions of bone with in corporation of allograft. Bone marrow impregnated Lyophilized radiation sterilized bone allograft and mixed bone graft is useful graft material for healing of the lesional area and restoring structural integrity as well as function for management of cysts and cyst like lesions in bone.},
 year = {2020}
}

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TY  - JOUR
T1  - Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone
AU  - Nakul Kumar Datta
AU  - Krishna Priya Das
AU  - Mohammad Mamun Mia
Y1  - 2020/12/04
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200806.20
DO  - 10.11648/j.ajim.20200806.20
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 304
EP  - 311
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200806.20
AB  - Cystic lesions include Simple bone cyst and Aneurysmal bone cyst, and among cyst like lesions studied Giant cell tumor, fibrous dysplasia and Non-ossifying fibroma. This prospective interventional study was conducted in the Department of orthopaedic surgery Bangubandhu Sheikh Mujib Mdical university (BSMMU) and Biomedical research division, Atomic energy centre Savar, Dhaka Bangladesh from January 2004 to December 2019. Out of 155 Cysts and cysts like lesions were operated, among which cystic lesions were 73 (47.10%), among cystic lesions SBC was 51 (69.86%), and ABC-22 (30.14%) and cyst like lesions were 82 (52.90%), among cyst like lesions GCT was 68 (82.92%), FD was 12 (14.63%) & NOF was 2 (2.43%). All cases were operated by thorough curettage and cavity filled with Lyophilized radiation sterilized bone allograft impregnated with autogenous bone marrow for children and mixed bone graft in adult. Clinical and radiological evaluation was done in all cases in which 61 (83.56%) out of 73 cystic lesions were healed and 12 (16.44%) lesions were recurred, on the other hand 58 (70.73%) out of 82 cyst like lesions were healed and 24 (29.27%) lesions were recurred. Out of 155 cysts and cyst like lesions 119 (76.78%) were healed / satisfactory and 36 (23.22%) were recurred. Follow up period were 9 month to 15 years. P value is <.001. Main aims to evaluate the complete healing of cystic and cyst like lesions of bone with in corporation of allograft. Bone marrow impregnated Lyophilized radiation sterilized bone allograft and mixed bone graft is useful graft material for healing of the lesional area and restoring structural integrity as well as function for management of cysts and cyst like lesions in bone.
VL  - 8
IS  - 6
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Author Information

Nakul Kumar Datta

Department of Orthopaedic Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Krishna Priya Das

Department of Orthopaedic Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Mohammad Mamun Mia

Tissue Banking and Biomedical Research Unit, Atomic Energy Research Establishment (AERE), Dhaka, Bangladesh

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Nakul Kumar Datta, Krishna Priya Das, Mohammad Mamun Mia. (2020). Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone. American Journal of Internal Medicine, 8(6), 304-311. https://doi.org/10.11648/j.ajim.20200806.20

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Nakul Kumar Datta; Krishna Priya Das; Mohammad Mamun Mia. Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone. Am. J. Intern. Med. 2020, 8(6), 304-311. doi: 10.11648/j.ajim.20200806.20

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AMA Style

Nakul Kumar Datta, Krishna Priya Das, Mohammad Mamun Mia. Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone. Am J Intern Med. 2020;8(6):304-311. doi: 10.11648/j.ajim.20200806.20

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@article{10.11648/j.ajim.20200806.20,
  author = {Nakul Kumar Datta and Krishna Priya Das and Mohammad Mamun Mia},
  title = {Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {6},
  pages = {304-311},
  doi = {10.11648/j.ajim.20200806.20},
  url = {https://doi.org/10.11648/j.ajim.20200806.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200806.20},
  abstract = {Cystic lesions include Simple bone cyst and Aneurysmal bone cyst, and among cyst like lesions studied Giant cell tumor, fibrous dysplasia and Non-ossifying fibroma. This prospective interventional study was conducted in the Department of orthopaedic surgery Bangubandhu Sheikh Mujib Mdical university (BSMMU) and Biomedical research division, Atomic energy centre Savar, Dhaka Bangladesh from January 2004 to December 2019. Out of 155 Cysts and cysts like lesions were operated, among which cystic lesions were 73 (47.10%), among cystic lesions SBC was 51 (69.86%), and ABC-22 (30.14%) and cyst like lesions were 82 (52.90%), among cyst like lesions GCT was 68 (82.92%), FD was 12 (14.63%) & NOF was 2 (2.43%). All cases were operated by thorough curettage and cavity filled with Lyophilized radiation sterilized bone allograft impregnated with autogenous bone marrow for children and mixed bone graft in adult. Clinical and radiological evaluation was done in all cases in which 61 (83.56%) out of 73 cystic lesions were healed and 12 (16.44%) lesions were recurred, on the other hand 58 (70.73%) out of 82 cyst like lesions were healed and 24 (29.27%) lesions were recurred. Out of 155 cysts and cyst like lesions 119 (76.78%) were healed / satisfactory and 36 (23.22%) were recurred. Follow up period were 9 month to 15 years. P value is <.001. Main aims to evaluate the complete healing of cystic and cyst like lesions of bone with in corporation of allograft. Bone marrow impregnated Lyophilized radiation sterilized bone allograft and mixed bone graft is useful graft material for healing of the lesional area and restoring structural integrity as well as function for management of cysts and cyst like lesions in bone.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone
AU  - Nakul Kumar Datta
AU  - Krishna Priya Das
AU  - Mohammad Mamun Mia
Y1  - 2020/12/04
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200806.20
DO  - 10.11648/j.ajim.20200806.20
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 304
EP  - 311
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200806.20
AB  - Cystic lesions include Simple bone cyst and Aneurysmal bone cyst, and among cyst like lesions studied Giant cell tumor, fibrous dysplasia and Non-ossifying fibroma. This prospective interventional study was conducted in the Department of orthopaedic surgery Bangubandhu Sheikh Mujib Mdical university (BSMMU) and Biomedical research division, Atomic energy centre Savar, Dhaka Bangladesh from January 2004 to December 2019. Out of 155 Cysts and cysts like lesions were operated, among which cystic lesions were 73 (47.10%), among cystic lesions SBC was 51 (69.86%), and ABC-22 (30.14%) and cyst like lesions were 82 (52.90%), among cyst like lesions GCT was 68 (82.92%), FD was 12 (14.63%) & NOF was 2 (2.43%). All cases were operated by thorough curettage and cavity filled with Lyophilized radiation sterilized bone allograft impregnated with autogenous bone marrow for children and mixed bone graft in adult. Clinical and radiological evaluation was done in all cases in which 61 (83.56%) out of 73 cystic lesions were healed and 12 (16.44%) lesions were recurred, on the other hand 58 (70.73%) out of 82 cyst like lesions were healed and 24 (29.27%) lesions were recurred. Out of 155 cysts and cyst like lesions 119 (76.78%) were healed / satisfactory and 36 (23.22%) were recurred. Follow up period were 9 month to 15 years. P value is <.001. Main aims to evaluate the complete healing of cystic and cyst like lesions of bone with in corporation of allograft. Bone marrow impregnated Lyophilized radiation sterilized bone allograft and mixed bone graft is useful graft material for healing of the lesional area and restoring structural integrity as well as function for management of cysts and cyst like lesions in bone.
VL  - 8
IS  - 6
ER  -

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