Ninety-eight patients with acutely decompensated systolic heart failure were admitted to the Hospital Universitario de Los Andes between 2005 and 2011, in Mérida, Venezuela. Medical Treatment: Protocol 1: Furosemide 20 mg IV every 8 hours (28 patients). Protocol 2: Furosemide 20 IV every 24 hours plus cautious uptitration of carvedilol (70 patients). Heart rate decreased from 99.19±12.38 to 67.64±11.27 (bpm) (p < 0.0001) with protocol 2. Daily weight changes were similar both protocols. Mean maximum dose of carvedilol was 59.37 mg, furosemide 240 mg for protocol 1 and 80 mg for protocol 2. For the whole group of patients, survival probability was close to 60% at fifty months of follow up. There were fourteen deaths with protocol 1 and eleven with protocol 2. Survival probability was significantly higher, in patients assigned to protocol 2 versus protocol 1 (72% vs 38%, p< 0.046). Cox multiple regression analysis indicated that, medical treatment with carvedilol, was significantly and independently associated to survival, only in those patients who were in sinus rhythm. Cautious uptitration of carvedilol, in still decompensated patients with sinus rhythm, increases long term survival.
| Published in | American Journal of Internal Medicine (Volume 9, Issue 4) |
| DOI | 10.11648/j.ajim.20210904.14 |
| Page(s) | 186-193 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Furosemide, Carvedilol, Acute Decompensated Systolic Heart Failure, Heart Rate, Survival Probability
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APA Style
Francisco Jose Sánchez Rivas, Jose Hipolito Donis Hernández, Carmen Mazzei De Dávila, Maite Alexandra González, Diego Fernando Dávila. (2021). Carvedilol in Patients with Acutely Decompensated Systolic Heart Failure: Effects on Survival. American Journal of Internal Medicine, 9(4), 186-193. https://doi.org/10.11648/j.ajim.20210904.14
ACS Style
Francisco Jose Sánchez Rivas; Jose Hipolito Donis Hernández; Carmen Mazzei De Dávila; Maite Alexandra González; Diego Fernando Dávila. Carvedilol in Patients with Acutely Decompensated Systolic Heart Failure: Effects on Survival. Am. J. Intern. Med. 2021, 9(4), 186-193. doi: 10.11648/j.ajim.20210904.14
AMA Style
Francisco Jose Sánchez Rivas, Jose Hipolito Donis Hernández, Carmen Mazzei De Dávila, Maite Alexandra González, Diego Fernando Dávila. Carvedilol in Patients with Acutely Decompensated Systolic Heart Failure: Effects on Survival. Am J Intern Med. 2021;9(4):186-193. doi: 10.11648/j.ajim.20210904.14
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Download@article{10.11648/j.ajim.20210904.14,
author = {Francisco Jose Sánchez Rivas and Jose Hipolito Donis Hernández and Carmen Mazzei De Dávila and Maite Alexandra González and Diego Fernando Dávila},
title = {Carvedilol in Patients with Acutely Decompensated Systolic Heart Failure: Effects on Survival},
journal = {American Journal of Internal Medicine},
volume = {9},
number = {4},
pages = {186-193},
doi = {10.11648/j.ajim.20210904.14},
url = {https://doi.org/10.11648/j.ajim.20210904.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210904.14},
abstract = {Ninety-eight patients with acutely decompensated systolic heart failure were admitted to the Hospital Universitario de Los Andes between 2005 and 2011, in Mérida, Venezuela. Medical Treatment: Protocol 1: Furosemide 20 mg IV every 8 hours (28 patients). Protocol 2: Furosemide 20 IV every 24 hours plus cautious uptitration of carvedilol (70 patients). Heart rate decreased from 99.19±12.38 to 67.64±11.27 (bpm) (p < 0.0001) with protocol 2. Daily weight changes were similar both protocols. Mean maximum dose of carvedilol was 59.37 mg, furosemide 240 mg for protocol 1 and 80 mg for protocol 2. For the whole group of patients, survival probability was close to 60% at fifty months of follow up. There were fourteen deaths with protocol 1 and eleven with protocol 2. Survival probability was significantly higher, in patients assigned to protocol 2 versus protocol 1 (72% vs 38%, p< 0.046). Cox multiple regression analysis indicated that, medical treatment with carvedilol, was significantly and independently associated to survival, only in those patients who were in sinus rhythm. Cautious uptitration of carvedilol, in still decompensated patients with sinus rhythm, increases long term survival.},
year = {2021}
}
TY - JOUR T1 - Carvedilol in Patients with Acutely Decompensated Systolic Heart Failure: Effects on Survival AU - Francisco Jose Sánchez Rivas AU - Jose Hipolito Donis Hernández AU - Carmen Mazzei De Dávila AU - Maite Alexandra González AU - Diego Fernando Dávila Y1 - 2021/07/09 PY - 2021 N1 - https://doi.org/10.11648/j.ajim.20210904.14 DO - 10.11648/j.ajim.20210904.14 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 186 EP - 193 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20210904.14 AB - Ninety-eight patients with acutely decompensated systolic heart failure were admitted to the Hospital Universitario de Los Andes between 2005 and 2011, in Mérida, Venezuela. Medical Treatment: Protocol 1: Furosemide 20 mg IV every 8 hours (28 patients). Protocol 2: Furosemide 20 IV every 24 hours plus cautious uptitration of carvedilol (70 patients). Heart rate decreased from 99.19±12.38 to 67.64±11.27 (bpm) (p < 0.0001) with protocol 2. Daily weight changes were similar both protocols. Mean maximum dose of carvedilol was 59.37 mg, furosemide 240 mg for protocol 1 and 80 mg for protocol 2. For the whole group of patients, survival probability was close to 60% at fifty months of follow up. There were fourteen deaths with protocol 1 and eleven with protocol 2. Survival probability was significantly higher, in patients assigned to protocol 2 versus protocol 1 (72% vs 38%, p< 0.046). Cox multiple regression analysis indicated that, medical treatment with carvedilol, was significantly and independently associated to survival, only in those patients who were in sinus rhythm. Cautious uptitration of carvedilol, in still decompensated patients with sinus rhythm, increases long term survival. VL - 9 IS - 4 ER -
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