Fever as an Adverse Drug Reaction of Different Therapeutic Groups

Sergey Postnikov; Natalia Teplova; Aleksey Ermilin; Marya Kostyleva; Anna Gratzyanskaya; Yulia Eremina; Galina Chervyakova

doi:doi:10.11648/j.ajp.20200604.28

Fever as an Adverse Drug Reaction of Different Therapeutic Groups

Sergey Postnikov, Natalia Teplova, Aleksey Ermilin, Marya Kostyleva, Anna Gratzyanskaya, Yulia Eremina, Galina Chervyakova

Published in American Journal of Pediatrics (Volume 6, Issue 4)

Received: 16 November 2020 Accepted: 4 December 2020 Published: 16 December 2020

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Abstract

Fever (t>38°C) developed in association with drug usage is rare but sometimes severe side effect (SE). It could manifest as single symptom or as a part of such life-threatening syndromes like malignant hyperthermia (MH), serotonin syndrome (SS), neuroleptic malignant syndrome (NMS). Fever could be caused by different therapeutic groups of drugs but the leading positions are occupied by antibiotics (mainly beta-lactams), substances acting on central nervous system (CNS) and chemotherapeutic agents. Main mechanisms are allergic and receptive. Curative measures include discontinuation of the suspected drug, introduction of agents blocking the action of the trigger factor - dantrolene (МН), bromocriptine (NMS), cyproheptadine (SS). Purpose of this review: to present the global and Russian data concerning fever as a drug-induced side effect. To distinguish the groups of patients and drugs of the highest risk. To evaluate aid measures. Results: fever as monosymptom of drug allergy is a difficult condition to be diagnosed and there are only few things that could help to recognize it such as temporal association with the suspected drug use and manifestation of fever along with the following resolution after suspected drug discontinuation and recurrence fever after suspected drug re-challenge. Among four syndromes described in this review such as serum sickness-like reaction (SSLR), NMS, SS and MH just fever at MH is not only a sign like in case of three others but it is significant and life-threatening manifestation and therefore requires additional curative methods (in addition to pharmacological support with dantrolene) – rapid cooling measures: ice-water nasogastric and rectal lavage, infusion of crystalloid solutions cooled up to 4°C, ice packs placing on main blood vessels and liver area, ventilatory measurements.

Published in	American Journal of Pediatrics (Volume 6, Issue 4)
DOI	10.11648/j.ajp.20200604.28
Page(s)	495-503
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Children, Drug Fever, Malignant Hyperthermia, Serotonin Syndrome, Neuroleptic Malignant Syndrome

References

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APA Style

Sergey Postnikov, Natalia Teplova, Aleksey Ermilin, Marya Kostyleva, Anna Gratzyanskaya, et al. (2020). Fever as an Adverse Drug Reaction of Different Therapeutic Groups. American Journal of Pediatrics, 6(4), 495-503. https://doi.org/10.11648/j.ajp.20200604.28

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ACS Style

Sergey Postnikov; Natalia Teplova; Aleksey Ermilin; Marya Kostyleva; Anna Gratzyanskaya, et al. Fever as an Adverse Drug Reaction of Different Therapeutic Groups. Am. J. Pediatr. 2020, 6(4), 495-503. doi: 10.11648/j.ajp.20200604.28

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AMA Style

Sergey Postnikov, Natalia Teplova, Aleksey Ermilin, Marya Kostyleva, Anna Gratzyanskaya, et al. Fever as an Adverse Drug Reaction of Different Therapeutic Groups. Am J Pediatr. 2020;6(4):495-503. doi: 10.11648/j.ajp.20200604.28

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@article{10.11648/j.ajp.20200604.28,
  author = {Sergey Postnikov and Natalia Teplova and Aleksey Ermilin and Marya Kostyleva and Anna Gratzyanskaya and Yulia Eremina and Galina Chervyakova},
  title = {Fever as an Adverse Drug Reaction of Different Therapeutic Groups},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {4},
  pages = {495-503},
  doi = {10.11648/j.ajp.20200604.28},
  url = {https://doi.org/10.11648/j.ajp.20200604.28},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200604.28},
  abstract = {Fever (t>38°C) developed in association with drug usage is rare but sometimes severe side effect (SE). It could manifest as single symptom or as a part of such life-threatening syndromes like malignant hyperthermia (MH), serotonin syndrome (SS), neuroleptic malignant syndrome (NMS). Fever could be caused by different therapeutic groups of drugs but the leading positions are occupied by antibiotics (mainly beta-lactams), substances acting on central nervous system (CNS) and chemotherapeutic agents. Main mechanisms are allergic and receptive. Curative measures include discontinuation of the suspected drug, introduction of agents blocking the action of the trigger factor - dantrolene (МН), bromocriptine (NMS), cyproheptadine (SS). Purpose of this review: to present the global and Russian data concerning fever as a drug-induced side effect. To distinguish the groups of patients and drugs of the highest risk. To evaluate aid measures. Results: fever as monosymptom of drug allergy is a difficult condition to be diagnosed and there are only few things that could help to recognize it such as temporal association with the suspected drug use and manifestation of fever along with the following resolution after suspected drug discontinuation and recurrence fever after suspected drug re-challenge. Among four syndromes described in this review such as serum sickness-like reaction (SSLR), NMS, SS and MH just fever at MH is not only a sign like in case of three others but it is significant and life-threatening manifestation and therefore requires additional curative methods (in addition to pharmacological support with dantrolene) – rapid cooling measures: ice-water nasogastric and rectal lavage, infusion of crystalloid solutions cooled up to 4°C, ice packs placing on main blood vessels and liver area, ventilatory measurements.},
 year = {2020}
}

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TY  - JOUR
T1  - Fever as an Adverse Drug Reaction of Different Therapeutic Groups
AU  - Sergey Postnikov
AU  - Natalia Teplova
AU  - Aleksey Ermilin
AU  - Marya Kostyleva
AU  - Anna Gratzyanskaya
AU  - Yulia Eremina
AU  - Galina Chervyakova
Y1  - 2020/12/16
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200604.28
DO  - 10.11648/j.ajp.20200604.28
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 495
EP  - 503
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200604.28
AB  - Fever (t>38°C) developed in association with drug usage is rare but sometimes severe side effect (SE). It could manifest as single symptom or as a part of such life-threatening syndromes like malignant hyperthermia (MH), serotonin syndrome (SS), neuroleptic malignant syndrome (NMS). Fever could be caused by different therapeutic groups of drugs but the leading positions are occupied by antibiotics (mainly beta-lactams), substances acting on central nervous system (CNS) and chemotherapeutic agents. Main mechanisms are allergic and receptive. Curative measures include discontinuation of the suspected drug, introduction of agents blocking the action of the trigger factor - dantrolene (МН), bromocriptine (NMS), cyproheptadine (SS). Purpose of this review: to present the global and Russian data concerning fever as a drug-induced side effect. To distinguish the groups of patients and drugs of the highest risk. To evaluate aid measures. Results: fever as monosymptom of drug allergy is a difficult condition to be diagnosed and there are only few things that could help to recognize it such as temporal association with the suspected drug use and manifestation of fever along with the following resolution after suspected drug discontinuation and recurrence fever after suspected drug re-challenge. Among four syndromes described in this review such as serum sickness-like reaction (SSLR), NMS, SS and MH just fever at MH is not only a sign like in case of three others but it is significant and life-threatening manifestation and therefore requires additional curative methods (in addition to pharmacological support with dantrolene) – rapid cooling measures: ice-water nasogastric and rectal lavage, infusion of crystalloid solutions cooled up to 4°C, ice packs placing on main blood vessels and liver area, ventilatory measurements.
VL  - 6
IS  - 4
ER  -

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Author Information

Sergey Postnikov

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Natalia Teplova

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Aleksey Ermilin

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Marya Kostyleva

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Anna Gratzyanskaya

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Yulia Eremina

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Galina Chervyakova

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation

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APA Style

Sergey Postnikov, Natalia Teplova, Aleksey Ermilin, Marya Kostyleva, Anna Gratzyanskaya, et al. (2020). Fever as an Adverse Drug Reaction of Different Therapeutic Groups. American Journal of Pediatrics, 6(4), 495-503. https://doi.org/10.11648/j.ajp.20200604.28

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ACS Style

Sergey Postnikov; Natalia Teplova; Aleksey Ermilin; Marya Kostyleva; Anna Gratzyanskaya, et al. Fever as an Adverse Drug Reaction of Different Therapeutic Groups. Am. J. Pediatr. 2020, 6(4), 495-503. doi: 10.11648/j.ajp.20200604.28

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AMA Style

Sergey Postnikov, Natalia Teplova, Aleksey Ermilin, Marya Kostyleva, Anna Gratzyanskaya, et al. Fever as an Adverse Drug Reaction of Different Therapeutic Groups. Am J Pediatr. 2020;6(4):495-503. doi: 10.11648/j.ajp.20200604.28

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@article{10.11648/j.ajp.20200604.28,
  author = {Sergey Postnikov and Natalia Teplova and Aleksey Ermilin and Marya Kostyleva and Anna Gratzyanskaya and Yulia Eremina and Galina Chervyakova},
  title = {Fever as an Adverse Drug Reaction of Different Therapeutic Groups},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {4},
  pages = {495-503},
  doi = {10.11648/j.ajp.20200604.28},
  url = {https://doi.org/10.11648/j.ajp.20200604.28},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200604.28},
  abstract = {Fever (t>38°C) developed in association with drug usage is rare but sometimes severe side effect (SE). It could manifest as single symptom or as a part of such life-threatening syndromes like malignant hyperthermia (MH), serotonin syndrome (SS), neuroleptic malignant syndrome (NMS). Fever could be caused by different therapeutic groups of drugs but the leading positions are occupied by antibiotics (mainly beta-lactams), substances acting on central nervous system (CNS) and chemotherapeutic agents. Main mechanisms are allergic and receptive. Curative measures include discontinuation of the suspected drug, introduction of agents blocking the action of the trigger factor - dantrolene (МН), bromocriptine (NMS), cyproheptadine (SS). Purpose of this review: to present the global and Russian data concerning fever as a drug-induced side effect. To distinguish the groups of patients and drugs of the highest risk. To evaluate aid measures. Results: fever as monosymptom of drug allergy is a difficult condition to be diagnosed and there are only few things that could help to recognize it such as temporal association with the suspected drug use and manifestation of fever along with the following resolution after suspected drug discontinuation and recurrence fever after suspected drug re-challenge. Among four syndromes described in this review such as serum sickness-like reaction (SSLR), NMS, SS and MH just fever at MH is not only a sign like in case of three others but it is significant and life-threatening manifestation and therefore requires additional curative methods (in addition to pharmacological support with dantrolene) – rapid cooling measures: ice-water nasogastric and rectal lavage, infusion of crystalloid solutions cooled up to 4°C, ice packs placing on main blood vessels and liver area, ventilatory measurements.},
 year = {2020}
}

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TY  - JOUR
T1  - Fever as an Adverse Drug Reaction of Different Therapeutic Groups
AU  - Sergey Postnikov
AU  - Natalia Teplova
AU  - Aleksey Ermilin
AU  - Marya Kostyleva
AU  - Anna Gratzyanskaya
AU  - Yulia Eremina
AU  - Galina Chervyakova
Y1  - 2020/12/16
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200604.28
DO  - 10.11648/j.ajp.20200604.28
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 495
EP  - 503
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200604.28
AB  - Fever (t>38°C) developed in association with drug usage is rare but sometimes severe side effect (SE). It could manifest as single symptom or as a part of such life-threatening syndromes like malignant hyperthermia (MH), serotonin syndrome (SS), neuroleptic malignant syndrome (NMS). Fever could be caused by different therapeutic groups of drugs but the leading positions are occupied by antibiotics (mainly beta-lactams), substances acting on central nervous system (CNS) and chemotherapeutic agents. Main mechanisms are allergic and receptive. Curative measures include discontinuation of the suspected drug, introduction of agents blocking the action of the trigger factor - dantrolene (МН), bromocriptine (NMS), cyproheptadine (SS). Purpose of this review: to present the global and Russian data concerning fever as a drug-induced side effect. To distinguish the groups of patients and drugs of the highest risk. To evaluate aid measures. Results: fever as monosymptom of drug allergy is a difficult condition to be diagnosed and there are only few things that could help to recognize it such as temporal association with the suspected drug use and manifestation of fever along with the following resolution after suspected drug discontinuation and recurrence fever after suspected drug re-challenge. Among four syndromes described in this review such as serum sickness-like reaction (SSLR), NMS, SS and MH just fever at MH is not only a sign like in case of three others but it is significant and life-threatening manifestation and therefore requires additional curative methods (in addition to pharmacological support with dantrolene) – rapid cooling measures: ice-water nasogastric and rectal lavage, infusion of crystalloid solutions cooled up to 4°C, ice packs placing on main blood vessels and liver area, ventilatory measurements.
VL  - 6
IS  - 4
ER  -

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