Hypospadias is a very common congenital anomaly in which the urethra opens onto the ventral aspect of the penis rather than at the tip. It has an incidence of less than 1% of live male births. In humans, anogenital distance (AGD) is a sexually dimorphic measure of genital development. In this study, we intended to examine the association between AGD and hypospadias using a homogenous group of patients. The same investigator examined all male newborns in our hospital, and anthropometric measurements of the anogenital distance were recorded. All the measurements were made in millimeters (mm) with a sliding digital caliper (graduated in millimeters) used for measuring the distance between the base of the scrotum to the center of the anus; defined as AGD. During the period Jan 2015 to December 2019 (both inclusive), there were 28,426 (14,615 males and 13,811 females) full-term live births in our hospital. The gestational age of the newborns ranged from 37 to 42 weeks. The mean AGD was 21.06±5.57 (range 12.11 to 33.14) mm in newborns without hypospadias, 9.92±1.90 (range 8.0 – 13.9) in newborns with proximal hypospadias and 17.03±1.95 (range 14.0 to 19.9) mm with distal hypospadias. In humans, hypospadias is associated with reduced anogenital distance. AGD further decreases with the severity of hypospadias.
| Published in | American Journal of Pediatrics (Volume 7, Issue 1) |
| DOI | 10.11648/j.ajp.20210701.15 |
| Page(s) | 19-22 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Anogenital Distance, Hypospadias, Newborns
| [1] | Snodgrass WT & Bush NC. Hypospadias. In Wein AJ, Kavoussi LR, Partin AW & Peters CA Ed. Campbell-Walsh Urology, 11th ed., Elsevier, Philadelphia. 2016 p 3399. |
| [2] | Baskin LS. Hypospadias and urethral development. J Urol. 2000; 163: 951-56. |
| [3] | Yucel S, Dravis C, Garcia N, Henkemeyer M, Baker LA. Hypospadias and anorectal malformations mediated by defective Eph/ephrin signaling. Journal of pediatric urology. 2007; 3 (5): 354-63. |
| [4] | Holmes N, Miller W, Baskin L. Lack of defects in androgen production in children with hypospadias. J Clin Endocrinol Metab 2004; 89: 2811–2816. |
| [5] | McIntyre BS, Barlow NJ, Foster PM. Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. Toxicol Sci 2001; 62: 236–249. |
| [6] | Bowman CJ, Barlow NJ, Turner KJ, Wallace DJ, Foster PM. Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci 2003; 74: 393–406. |
| [7] | Nerli RB, Ghagane SC, Hiremath MB, Dixit NS, Neelagund S. Anogenital distance in males attending assisted reproduction center. Journal of the Scientific Society. 2018; 45 (2): 72. |
| [8] | Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev 2015; 36: E1–E150. |
| [9] | Papadopoulou E, Vafeiadi M, Agramunt S, et al. Anogenital distances in newborns and children from Spain and Greece: predictors, tracking and reliability. Paediatr Perinat Epidemiol 2013; 27: 89–99. |
| [10] | Sathyanarayana S, Grady R, Redmon JB, et al. Anogenital distance and penile width measurements in The Infant Development and the Environment Study (TIDES): methods and predictors. J Pediatr Urol 2015; 11: 76 e71–76. |
| [11] | Fowler PA, Filis P, Bhattacharya S, et al. Human anogenital distance: an update on fetal smoke-exposure and integration of the perinatal literature on sex differences. Hum Reprod 2016; 31: 463–472. |
| [12] | Welsh M, Saunders PT, Fisken M, Scott HM, et al. Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest 2008; 118: 1479–1490. |
| [13] | Macleod DJ, Sharpe RM, Welsh M, et al. Androgen action in the masculinization programming window and development of male reproductive organs. Int J Androl 2010; 33: 279–287. |
| [14] | van den Driesche S, Scott HM, MacLeod DJ, Fisken M, Walker M, Sharpe RM. Relative importance of prenatal and postnatal androgen action in determining growth of the penis and anogenital distance in the rat before, during and after puberty. Int J Androl 2011; 34: e578–e586. |
| [15] | Thankamony A, Ong KK, Dunger DB, et al. Anogenital distance from birth to 2 years: a population study. Environ Health Perspect. 2009; 117: 1786-90. |
| [16] | Orish C, Didia B. Anogenital distance in human male and female newborns: A look at a cross section of a Nigerian population. Internet J Biol Anthropol. 2008; 3 (2): e1-4. |
| [17] | Salazar-Martinez E, Romano-Riquer P, Yanez-Marquez E, et al. Anogenital distance in human male and female newborns: A descriptive, cross-sectional study. Environ Health 2004; 3: 8. |
| [18] | Ozkan B, Konak B, Cayir A, et al. Anogenital Distance in Turkish Newborns. J Clin Res Ped Endo 2011; 3 (3): 122-125. |
| [19] | Hsieh MH, Breyer BN, Eisenberg ML, Baskin LS (2008) Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption. Curr Urol 2008; 9: 137-42. |
| [20] | Gilboa Y, Perlman S, Kivilevitch Z, et al. Prenatal Anogenital Distance Is Shorter in Fetuses with Hypospadias. J Ultrasound Med 2017; 36: 175–182. |
| [21] | Hua XG, Hu R, Hu CY, et al. Associations between hypospadias, cryptorchidism and anogenital distance: systematic review and meta-analysis. Andrologia 2018; 50 (10): e 13152. |
| [22] | Cox K, Kyriakou A, Amjad B et al. Shorter anogenital and anoscrotal distances correlate with the severity of hypospadias: a prospective study. J Paed Urol 2017; 13: 57. e1-57. e5. |
| [23] | Hsieh MH, Eisenberg ML, Hittelman AB, et al. Caucasian male infants and boys with hypospadias exhibit reduced anogenital distance. Hum Reprod 2012; 27: 1577–1580. |
APA Style
Shashank Patil, Shridhar Ghagane, Manas Sharma, Nerli Rajendra, Nitin Pingale, et al. (2021). Anogenital Distance in Newborns with Hypospadias. American Journal of Pediatrics, 7(1), 19-22. https://doi.org/10.11648/j.ajp.20210701.15
ACS Style
Shashank Patil; Shridhar Ghagane; Manas Sharma; Nerli Rajendra; Nitin Pingale, et al. Anogenital Distance in Newborns with Hypospadias. Am. J. Pediatr. 2021, 7(1), 19-22. doi: 10.11648/j.ajp.20210701.15
AMA Style
Shashank Patil, Shridhar Ghagane, Manas Sharma, Nerli Rajendra, Nitin Pingale, et al. Anogenital Distance in Newborns with Hypospadias. Am J Pediatr. 2021;7(1):19-22. doi: 10.11648/j.ajp.20210701.15
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Download@article{10.11648/j.ajp.20210701.15,
author = {Shashank Patil and Shridhar Ghagane and Manas Sharma and Nerli Rajendra and Nitin Pingale and Pulkit Gupta},
title = {Anogenital Distance in Newborns with Hypospadias},
journal = {American Journal of Pediatrics},
volume = {7},
number = {1},
pages = {19-22},
doi = {10.11648/j.ajp.20210701.15},
url = {https://doi.org/10.11648/j.ajp.20210701.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20210701.15},
abstract = {Hypospadias is a very common congenital anomaly in which the urethra opens onto the ventral aspect of the penis rather than at the tip. It has an incidence of less than 1% of live male births. In humans, anogenital distance (AGD) is a sexually dimorphic measure of genital development. In this study, we intended to examine the association between AGD and hypospadias using a homogenous group of patients. The same investigator examined all male newborns in our hospital, and anthropometric measurements of the anogenital distance were recorded. All the measurements were made in millimeters (mm) with a sliding digital caliper (graduated in millimeters) used for measuring the distance between the base of the scrotum to the center of the anus; defined as AGD. During the period Jan 2015 to December 2019 (both inclusive), there were 28,426 (14,615 males and 13,811 females) full-term live births in our hospital. The gestational age of the newborns ranged from 37 to 42 weeks. The mean AGD was 21.06±5.57 (range 12.11 to 33.14) mm in newborns without hypospadias, 9.92±1.90 (range 8.0 – 13.9) in newborns with proximal hypospadias and 17.03±1.95 (range 14.0 to 19.9) mm with distal hypospadias. In humans, hypospadias is associated with reduced anogenital distance. AGD further decreases with the severity of hypospadias.},
year = {2021}
}
TY - JOUR T1 - Anogenital Distance in Newborns with Hypospadias AU - Shashank Patil AU - Shridhar Ghagane AU - Manas Sharma AU - Nerli Rajendra AU - Nitin Pingale AU - Pulkit Gupta Y1 - 2021/03/04 PY - 2021 N1 - https://doi.org/10.11648/j.ajp.20210701.15 DO - 10.11648/j.ajp.20210701.15 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 19 EP - 22 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20210701.15 AB - Hypospadias is a very common congenital anomaly in which the urethra opens onto the ventral aspect of the penis rather than at the tip. It has an incidence of less than 1% of live male births. In humans, anogenital distance (AGD) is a sexually dimorphic measure of genital development. In this study, we intended to examine the association between AGD and hypospadias using a homogenous group of patients. The same investigator examined all male newborns in our hospital, and anthropometric measurements of the anogenital distance were recorded. All the measurements were made in millimeters (mm) with a sliding digital caliper (graduated in millimeters) used for measuring the distance between the base of the scrotum to the center of the anus; defined as AGD. During the period Jan 2015 to December 2019 (both inclusive), there were 28,426 (14,615 males and 13,811 females) full-term live births in our hospital. The gestational age of the newborns ranged from 37 to 42 weeks. The mean AGD was 21.06±5.57 (range 12.11 to 33.14) mm in newborns without hypospadias, 9.92±1.90 (range 8.0 – 13.9) in newborns with proximal hypospadias and 17.03±1.95 (range 14.0 to 19.9) mm with distal hypospadias. In humans, hypospadias is associated with reduced anogenital distance. AGD further decreases with the severity of hypospadias. VL - 7 IS - 1 ER -
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