The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia

Mohammad Daaboul; Ahamad Chreitah; Ali Mohamed

doi:doi:10.11648/j.ajp.20210703.15

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The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia

Mohammad Daaboul, Ahamad Chreitah, Ali Mohamed

Published in American Journal of Pediatrics (Volume 7, Issue 3)

Received: 14 June 2021 Accepted: 23 June 2021 Published: 10 July 2021

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Abstract

Background: Short stature is a public health problem that, by definition, affects 2.5% of the population around the world, and higher rates in some areas. Celiac disease is one of the causes of short stature, it occurs with multiple mechanisms. And it is one of the causes that can be treated and thus the final length improvement, especially with the early start of treatment. Detection of celiac disease serologically is easy and cost-effective. Aims: To determine the prevalence of antiTTG-IGA antibody positivity in patients who meet the standard definition of short stature. Methods: A cross-sectional study that included 132 short children over two years of age attending the Pediatric endocrinology Clinic at Tishreen University Hospital from the beginning of 2016 until the end of 2019. The data of the patients attending the clinic with complaints of short stature was reviewed and the patients with antiTTG-IGA antibodies were identified and their data related to anemia and clinical symptoms were analyzed. Results: The number of short children included in the study was 132 children (69 males and 63 females), 10 of whom had positive antiTTG-IGA antibodies that were 7.6%. Digestive symptoms or anemia were not statistically significant in predicting the presence of celiac disease. It was found that the near-normal BMI and the absence of severe weight growth failure do not exclude the presence of celiac disease. Conclusion: Celiac disease is an important cause of short stature that is difficult to predict through clinical symptoms, which requires for titration of antiTTG-IGA antibodies in all children with short stature.

Published in	American Journal of Pediatrics (Volume 7, Issue 3)
DOI	10.11648/j.ajp.20210703.15
Page(s)	117-120
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Celiac Disease, Short Stature, Failure to Thrive, Body Mass Index, Anti Tissue Transglutaminase

References

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[2]	Green, P. H., & Cellier, C. (2007). Celiac disease. New england journal of medicine, 357 (17), 1731-1743.
[3]	Cataldo, F., & Montalto, G. (2007). Celiac disease in the developing countries: a new and challenging public health problem. World journal of gastroenterology: WJG, 13 (15), 2153.
[4]	van Rijn JC, Grote FK, Oostdijk W, Wit JM. Short stature and theprobability of celiac disease, in the absence of gastrointestinalsymptoms. Arch Dis Child. 2004; 89: 882–3.
[5]	Bhadada, S. K., Bhansali, A., Kochhar, R., Menon, A. S., Sinha, S. K., Dutta, P., & Nain, C. K. (2008). Does every short stature child need screening for celiac disease?. Journal of gastroenterology and hepatology, 23 (8pt2), e353-e356.
[6]	Al-Jurayyan, N. A., Al Nemri, A. M., Al Jurayyan, A. N., & Assiri, A. M. (2013). Celiac disease in children with short stature: A hospital based study. Journal of Taibah University Medical Sciences, 8 (2), 93-96.
[7]	Queiroz, M. S., Nery, M., Cancado, E. L., Gianella-Neto, D., & Liberman, B. (2004). Prevalence of celiac disease in Brazilian children of short stature. Brazilian journal of medical and biological research, 37 (1), 55-60.
[8]	Nusier, M. K., Brodtkorb, H. K., Rein, S. E., Odeh, A., Radaideh, A. M., & Klungland, H. (2010). Serological screening for celiac disease in schoolchildren in Jordan. Is height and weight affected when seropositive?. Italian journal of pediatrics, 36 (1), 1-6.‏
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[10]	Krupa-Kozak, U. (2014). Pathologic bone alterations in celiac disease: etiology, epidemiology, and treatment. Nutrition, 30 (1), 16-24.‏
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[12]	Boersma, B., Houwen, R. H. J., Blum, W. F., Van Doorn, J., & Wit, J. M. (2002). Catch-up growth and endocrine changes in childhood celiac disease. Hormone Research in Paediatrics, 58 (Suppl. 1), 57-65.
[13]	Rostami, K., Steegers, E. A. P., Wong, W. Y., Braat, D. D., & Steegers-Theunissen, R. P. M. (2001). Coeliac disease and reproductive disorders: a neglected association. European Journal of Obstetrics & Gynecology and Reproductive Biology, 96 (2), 146-149.
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APA Style

Mohammad Daaboul, Ahamad Chreitah, Ali Mohamed. (2021). The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia. American Journal of Pediatrics, 7(3), 117-120. https://doi.org/10.11648/j.ajp.20210703.15

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ACS Style

Mohammad Daaboul; Ahamad Chreitah; Ali Mohamed. The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia. Am. J. Pediatr. 2021, 7(3), 117-120. doi: 10.11648/j.ajp.20210703.15

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AMA Style

Mohammad Daaboul, Ahamad Chreitah, Ali Mohamed. The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia. Am J Pediatr. 2021;7(3):117-120. doi: 10.11648/j.ajp.20210703.15

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@article{10.11648/j.ajp.20210703.15,
  author = {Mohammad Daaboul and Ahamad Chreitah and Ali Mohamed},
  title = {The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia},
  journal = {American Journal of Pediatrics},
  volume = {7},
  number = {3},
  pages = {117-120},
  doi = {10.11648/j.ajp.20210703.15},
  url = {https://doi.org/10.11648/j.ajp.20210703.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20210703.15},
  abstract = {Background: Short stature is a public health problem that, by definition, affects 2.5% of the population around the world, and higher rates in some areas. Celiac disease is one of the causes of short stature, it occurs with multiple mechanisms. And it is one of the causes that can be treated and thus the final length improvement, especially with the early start of treatment. Detection of celiac disease serologically is easy and cost-effective. Aims: To determine the prevalence of antiTTG-IGA antibody positivity in patients who meet the standard definition of short stature. Methods: A cross-sectional study that included 132 short children over two years of age attending the Pediatric endocrinology Clinic at Tishreen University Hospital from the beginning of 2016 until the end of 2019. The data of the patients attending the clinic with complaints of short stature was reviewed and the patients with antiTTG-IGA antibodies were identified and their data related to anemia and clinical symptoms were analyzed. Results: The number of short children included in the study was 132 children (69 males and 63 females), 10 of whom had positive antiTTG-IGA antibodies that were 7.6%. Digestive symptoms or anemia were not statistically significant in predicting the presence of celiac disease. It was found that the near-normal BMI and the absence of severe weight growth failure do not exclude the presence of celiac disease. Conclusion: Celiac disease is an important cause of short stature that is difficult to predict through clinical symptoms, which requires for titration of antiTTG-IGA antibodies in all children with short stature.},
 year = {2021}
}

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TY  - JOUR
T1  - The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia
AU  - Mohammad Daaboul
AU  - Ahamad Chreitah
AU  - Ali Mohamed
Y1  - 2021/07/10
PY  - 2021
N1  - https://doi.org/10.11648/j.ajp.20210703.15
DO  - 10.11648/j.ajp.20210703.15
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 117
EP  - 120
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20210703.15
AB  - Background: Short stature is a public health problem that, by definition, affects 2.5% of the population around the world, and higher rates in some areas. Celiac disease is one of the causes of short stature, it occurs with multiple mechanisms. And it is one of the causes that can be treated and thus the final length improvement, especially with the early start of treatment. Detection of celiac disease serologically is easy and cost-effective. Aims: To determine the prevalence of antiTTG-IGA antibody positivity in patients who meet the standard definition of short stature. Methods: A cross-sectional study that included 132 short children over two years of age attending the Pediatric endocrinology Clinic at Tishreen University Hospital from the beginning of 2016 until the end of 2019. The data of the patients attending the clinic with complaints of short stature was reviewed and the patients with antiTTG-IGA antibodies were identified and their data related to anemia and clinical symptoms were analyzed. Results: The number of short children included in the study was 132 children (69 males and 63 females), 10 of whom had positive antiTTG-IGA antibodies that were 7.6%. Digestive symptoms or anemia were not statistically significant in predicting the presence of celiac disease. It was found that the near-normal BMI and the absence of severe weight growth failure do not exclude the presence of celiac disease. Conclusion: Celiac disease is an important cause of short stature that is difficult to predict through clinical symptoms, which requires for titration of antiTTG-IGA antibodies in all children with short stature.
VL  - 7
IS  - 3
ER  -

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Author Information

Mohammad Daaboul

Department of Pediatrics, Tishreen University Hospital, Lattakia, Syria
Ahamad Chreitah

Department of Pediatrics, Tishreen University Hospital, Lattakia, Syria
Ali Mohamed

Department of Pediatrics, Tishreen University Hospital, Lattakia, Syria

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APA Style

Mohammad Daaboul, Ahamad Chreitah, Ali Mohamed. (2021). The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia. American Journal of Pediatrics, 7(3), 117-120. https://doi.org/10.11648/j.ajp.20210703.15

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ACS Style

Mohammad Daaboul; Ahamad Chreitah; Ali Mohamed. The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia. Am. J. Pediatr. 2021, 7(3), 117-120. doi: 10.11648/j.ajp.20210703.15

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AMA Style

Mohammad Daaboul, Ahamad Chreitah, Ali Mohamed. The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia. Am J Pediatr. 2021;7(3):117-120. doi: 10.11648/j.ajp.20210703.15

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@article{10.11648/j.ajp.20210703.15,
  author = {Mohammad Daaboul and Ahamad Chreitah and Ali Mohamed},
  title = {The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia},
  journal = {American Journal of Pediatrics},
  volume = {7},
  number = {3},
  pages = {117-120},
  doi = {10.11648/j.ajp.20210703.15},
  url = {https://doi.org/10.11648/j.ajp.20210703.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20210703.15},
  abstract = {Background: Short stature is a public health problem that, by definition, affects 2.5% of the population around the world, and higher rates in some areas. Celiac disease is one of the causes of short stature, it occurs with multiple mechanisms. And it is one of the causes that can be treated and thus the final length improvement, especially with the early start of treatment. Detection of celiac disease serologically is easy and cost-effective. Aims: To determine the prevalence of antiTTG-IGA antibody positivity in patients who meet the standard definition of short stature. Methods: A cross-sectional study that included 132 short children over two years of age attending the Pediatric endocrinology Clinic at Tishreen University Hospital from the beginning of 2016 until the end of 2019. The data of the patients attending the clinic with complaints of short stature was reviewed and the patients with antiTTG-IGA antibodies were identified and their data related to anemia and clinical symptoms were analyzed. Results: The number of short children included in the study was 132 children (69 males and 63 females), 10 of whom had positive antiTTG-IGA antibodies that were 7.6%. Digestive symptoms or anemia were not statistically significant in predicting the presence of celiac disease. It was found that the near-normal BMI and the absence of severe weight growth failure do not exclude the presence of celiac disease. Conclusion: Celiac disease is an important cause of short stature that is difficult to predict through clinical symptoms, which requires for titration of antiTTG-IGA antibodies in all children with short stature.},
 year = {2021}
}

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TY  - JOUR
T1  - The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia
AU  - Mohammad Daaboul
AU  - Ahamad Chreitah
AU  - Ali Mohamed
Y1  - 2021/07/10
PY  - 2021
N1  - https://doi.org/10.11648/j.ajp.20210703.15
DO  - 10.11648/j.ajp.20210703.15
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 117
EP  - 120
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20210703.15
AB  - Background: Short stature is a public health problem that, by definition, affects 2.5% of the population around the world, and higher rates in some areas. Celiac disease is one of the causes of short stature, it occurs with multiple mechanisms. And it is one of the causes that can be treated and thus the final length improvement, especially with the early start of treatment. Detection of celiac disease serologically is easy and cost-effective. Aims: To determine the prevalence of antiTTG-IGA antibody positivity in patients who meet the standard definition of short stature. Methods: A cross-sectional study that included 132 short children over two years of age attending the Pediatric endocrinology Clinic at Tishreen University Hospital from the beginning of 2016 until the end of 2019. The data of the patients attending the clinic with complaints of short stature was reviewed and the patients with antiTTG-IGA antibodies were identified and their data related to anemia and clinical symptoms were analyzed. Results: The number of short children included in the study was 132 children (69 males and 63 females), 10 of whom had positive antiTTG-IGA antibodies that were 7.6%. Digestive symptoms or anemia were not statistically significant in predicting the presence of celiac disease. It was found that the near-normal BMI and the absence of severe weight growth failure do not exclude the presence of celiac disease. Conclusion: Celiac disease is an important cause of short stature that is difficult to predict through clinical symptoms, which requires for titration of antiTTG-IGA antibodies in all children with short stature.
VL  - 7
IS  - 3
ER  -

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