Influence of Birth Season Climate on Adult Total Serum IgE Levels

John Kelly Smith

doi:doi:10.11648/j.ajp.20220802.25

| Peer-Reviewed

Influence of Birth Season Climate on Adult Total Serum IgE Levels

John Kelly Smith

Published in American Journal of Pediatrics (Volume 8, Issue 2)

Received: 22 May 2022 Accepted: 10 June 2022 Published: 16 June 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: The effect of birth season climate on adult IgE-mediated respiratory disease is an important public health issue. Objective: To determine the effect of birth season climate on adult total serum IgE (TSIgE) levels. Study design: The study is a retrospective chart review with the following inclusion criteria: TSIgE measurement, age ≥ 16, and northeastern Tennessee birthplace. Main outcome measures include TSIgE levels, birth season climatic conditions, and regional pollen-producing plant and pollen counts. Results: The records of 1,274 women (mean age 40.8 ± 17.5, age range 16-96) and 762 men (mean age 38.1 ± 17, age range 16-82) seen in our Allergy Clinic were reviewed. Persons born in the spring and summer, the seasons with the highest pollen counts and the most favorable climatic conditions for plant growth, had nearly twice the odds of having TSIgE levels > 1σ above the mean of the study group when compared to those born in the fall or winter (odds ratio (OR) 1.75, 95% confidence interval (CI) 0.96-3.17 and OR 1.93, 95% CI 1.04-3.57, respectively); odds were highest for those born in March (OR 2.55, 95% CI 1.37-4.74) and July (OR 2.38, 95% CI 1.25-4.51) and lowest for those born in November (OR 0.11, 95% CI 0.0068-1.79). When averaged over the 95-years of study and five 30-year climate cycles TSIgE levels increased linearly as the seasons progressed from fall to summer (r² = 0.9475, P = 0.0266). Of the climatic factors, TSIgE levels correlated most strongly with levels of precipitation (r² = 0.9145, P = 0.0437). Conclusion: Climatic conditions that increase birth season exposure to environmental allergens may have a life-long effect on TSIgE production.

Published in	American Journal of Pediatrics (Volume 8, Issue 2)
DOI	10.11648/j.ajp.20220802.25
Page(s)	137-140
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Total Serum IgE, Birth Month, Birth Season, Birth Climate, Neonates, Allergy

References

[1]	Saitoh Y, Dake Y, Shimazu S, et. al. Month of birth, atopic disease, and atopic sensitization. J Investig Allergol Clin Immunol 2001; 11; 183-187.
[2]	Guerra S, Sherrill DL, Cottini M, Michetti G, Allegra L. On the association between date of birth and pollen sensitization: is age an effect modifier? Allergy Asthma Proc 2002; 23; 303-10.
[3]	Zhumambayeva S, Rozenson R, Tawfik A, Awadalla NJ, Zhumambayeva R. Date of birth and hay fever risk in children and adolescents of Kazakhstan. Int J Pediatr Otorhinolaryngol 2014; 78; 214-217.
[4]	Graf N, Johansen P, Schindler C et. al. Analysis of the relationship between pollinosis and date of birth in Switzerland. Int Arch Allergy Immunol 2007; 143; 269-275.
[5]	Yoo Y, Yu J, Kang H, Kim DK, Koh YY, Kim CK. Birth month and sensitization to house dust mites in asthmatic children. Allergy 2005; 60: 1327–30. [PubMed: 16135003].
[6]	Knudson TB, Thomsen SF, Ulrik CS, Fenger M, Nepper-Christensen S, Backer V. Season of birth and risk of atopic disease among children and adolescents. J Asthma 2007; 44; 257-260.
[7]	Yokomichi H, Mochizuki M, Tsuchida A, Kojima R, Horiuchi S, Ooka, T, et. al. Association of the incidence of atopic dermatitis until 3 years old with birth month and with sunshine duration and humidity in the first 6 months of life: Japan environmental and children’s study. BMJ Open 2021, 11, e047226. Doi 10.1136bmjopen-2020-047226.
[8]	Shuk-Mei H. Environmental epigenetics of asthma – an update. J Allergy Clin Immunol 2010; 126; 453-465.
[9]	Harb H, Renz H. Update on epigenetics in allergic disease. J Allergy Clin Immunol 2015; 135; 15-24.
[10]	Lovinsky-Desir S. Epigenetics, asthma, and allergic diseases: a review of the latest advancements. Curr Allergy Asthma Rep 2012; 12; 211-220.
[11]	National Climatic Data Center, Asheville, North Carolina. https://www.archives.gov/research/guide-fed-records/groups/027.html.
[12]	NOAA National Centers for Environmental Information. https://www.ncdc.noaa.gov/cag/.
[13]	Weather Spark. https://weatherspark.com/y/1630.
[14]	Harvey Broome Group. Vegetation. In: Cherokee National Forest Hiking Guide, 2^nd edition, Skelton W H (ed), University of Tennessee Press, Knoxville, TN, pp 17-29.
[15]	Holt P. Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period. Environ Health Perspect 106 (Suppl 3) 1998; 795-800.
[16]	Prescott SL, Macaubas C, Holt BJ, et al. Transplacental priming of the human immune system to environmental allergens. Universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 1998; 4730-4737.
[17]	Debock I, Flamand V. Unbalanced neonatal CD4+ T-cell immunity. Front Immunol 2014; 393; 1-6.
[18]	Lin H, Mosmann TR, Guilbert L, Tuntipopipat S, Wegmann TG. Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J Immunol 1993; 151; 4562-4573.
[19]	Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. J Exp Med 1996; 184; 539-548.
[20]	Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today 1993; 14; 353-356.
[21]	Björkstein B. Risk factors in early childhood for the development of atopic diseases. Allergy 1994; 49; 400-407.
[22]	Davidson A, Fairchild R, Lakkis F, Hancock W, Holmdahl R, Turka LA. Allergy and allergic diseases. In: Janeway’s Immunobiology, Murphy K (ed), Garland Science, Taylor & Francis Group, LLC, London 2012; pp 571-610.
[23]	Lockett GA, Soto-Ramirez N, Ray MA, et al. Association of season of birth with DNA methylation and allergic disease. Allergy 2016; 71; 1314-1324.
[24]	Potaczek DP and Kabesch M. Current concepts of IgE regulation and impact of genetic determinants. Clin & Exper Allergy 2012; 42; 852-871.
[25]	Hollinger SE, Angel JR. Weather and crops. In: Nafzinger E, ed. Illinois Agronomy Handbook, 24^th edition. University of Illinois, Urbana Champaign, Illinois; 2009: Chapter 1.
[26]	Arlien LG. Water balance and humidity requirements for house dust mites. Appl Acarol 1992; 16; 1-2; 14-35.
[27]	Fairely P, Chandra S, Moyer N. Mold growth. http://www.fsec.ucf.edu/en/consumer/buildings/basics/moldgrowth.htm.
[28]	White A. Why extreme rains are getting worse. Nature 2018; 563; 458-460.
[29]	D’Amato G, Holgate ST, Pawankar R, Ledford DK, Cecchi L, Al-Ahmad M, et. al. Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization. World Allergy Organ J 2015; 8; 25. doi: 10.1186/s40413-015-0073-0.

Cite This Article

Plain Text BibTeX RIS

APA Style

John Kelly Smith. (2022). Influence of Birth Season Climate on Adult Total Serum IgE Levels. American Journal of Pediatrics, 8(2), 137-140. https://doi.org/10.11648/j.ajp.20220802.25

Copy | Download

ACS Style

John Kelly Smith. Influence of Birth Season Climate on Adult Total Serum IgE Levels. Am. J. Pediatr. 2022, 8(2), 137-140. doi: 10.11648/j.ajp.20220802.25

Copy | Download

AMA Style

John Kelly Smith. Influence of Birth Season Climate on Adult Total Serum IgE Levels. Am J Pediatr. 2022;8(2):137-140. doi: 10.11648/j.ajp.20220802.25

Copy | Download

@article{10.11648/j.ajp.20220802.25,
  author = {John Kelly Smith},
  title = {Influence of Birth Season Climate on Adult Total Serum IgE Levels},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {2},
  pages = {137-140},
  doi = {10.11648/j.ajp.20220802.25},
  url = {https://doi.org/10.11648/j.ajp.20220802.25},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220802.25},
  abstract = {Background: The effect of birth season climate on adult IgE-mediated respiratory disease is an important public health issue. Objective: To determine the effect of birth season climate on adult total serum IgE (TSIgE) levels. Study design: The study is a retrospective chart review with the following inclusion criteria: TSIgE measurement, age ≥ 16, and northeastern Tennessee birthplace. Main outcome measures include TSIgE levels, birth season climatic conditions, and regional pollen-producing plant and pollen counts. Results: The records of 1,274 women (mean age 40.8 ± 17.5, age range 16-96) and 762 men (mean age 38.1 ± 17, age range 16-82) seen in our Allergy Clinic were reviewed. Persons born in the spring and summer, the seasons with the highest pollen counts and the most favorable climatic conditions for plant growth, had nearly twice the odds of having TSIgE levels > 1σ above the mean of the study group when compared to those born in the fall or winter (odds ratio (OR) 1.75, 95% confidence interval (CI) 0.96-3.17 and OR 1.93, 95% CI 1.04-3.57, respectively); odds were highest for those born in March (OR 2.55, 95% CI 1.37-4.74) and July (OR 2.38, 95% CI 1.25-4.51) and lowest for those born in November (OR 0.11, 95% CI 0.0068-1.79). When averaged over the 95-years of study and five 30-year climate cycles TSIgE levels increased linearly as the seasons progressed from fall to summer (r2 = 0.9475, P = 0.0266). Of the climatic factors, TSIgE levels correlated most strongly with levels of precipitation (r2 = 0.9145, P = 0.0437). Conclusion: Climatic conditions that increase birth season exposure to environmental allergens may have a life-long effect on TSIgE production.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Influence of Birth Season Climate on Adult Total Serum IgE Levels
AU  - John Kelly Smith
Y1  - 2022/06/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220802.25
DO  - 10.11648/j.ajp.20220802.25
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 137
EP  - 140
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220802.25
AB  - Background: The effect of birth season climate on adult IgE-mediated respiratory disease is an important public health issue. Objective: To determine the effect of birth season climate on adult total serum IgE (TSIgE) levels. Study design: The study is a retrospective chart review with the following inclusion criteria: TSIgE measurement, age ≥ 16, and northeastern Tennessee birthplace. Main outcome measures include TSIgE levels, birth season climatic conditions, and regional pollen-producing plant and pollen counts. Results: The records of 1,274 women (mean age 40.8 ± 17.5, age range 16-96) and 762 men (mean age 38.1 ± 17, age range 16-82) seen in our Allergy Clinic were reviewed. Persons born in the spring and summer, the seasons with the highest pollen counts and the most favorable climatic conditions for plant growth, had nearly twice the odds of having TSIgE levels > 1σ above the mean of the study group when compared to those born in the fall or winter (odds ratio (OR) 1.75, 95% confidence interval (CI) 0.96-3.17 and OR 1.93, 95% CI 1.04-3.57, respectively); odds were highest for those born in March (OR 2.55, 95% CI 1.37-4.74) and July (OR 2.38, 95% CI 1.25-4.51) and lowest for those born in November (OR 0.11, 95% CI 0.0068-1.79). When averaged over the 95-years of study and five 30-year climate cycles TSIgE levels increased linearly as the seasons progressed from fall to summer (r2 = 0.9475, P = 0.0266). Of the climatic factors, TSIgE levels correlated most strongly with levels of precipitation (r2 = 0.9145, P = 0.0437). Conclusion: Climatic conditions that increase birth season exposure to environmental allergens may have a life-long effect on TSIgE production.
VL  - 8
IS  - 2
ER  -

Copy | Download

Author Information

John Kelly Smith

Departments of Academic Affairs and Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, USA

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

John Kelly Smith. (2022). Influence of Birth Season Climate on Adult Total Serum IgE Levels. American Journal of Pediatrics, 8(2), 137-140. https://doi.org/10.11648/j.ajp.20220802.25

Copy | Download

ACS Style

John Kelly Smith. Influence of Birth Season Climate on Adult Total Serum IgE Levels. Am. J. Pediatr. 2022, 8(2), 137-140. doi: 10.11648/j.ajp.20220802.25

Copy | Download

AMA Style

John Kelly Smith. Influence of Birth Season Climate on Adult Total Serum IgE Levels. Am J Pediatr. 2022;8(2):137-140. doi: 10.11648/j.ajp.20220802.25

Copy | Download

@article{10.11648/j.ajp.20220802.25,
  author = {John Kelly Smith},
  title = {Influence of Birth Season Climate on Adult Total Serum IgE Levels},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {2},
  pages = {137-140},
  doi = {10.11648/j.ajp.20220802.25},
  url = {https://doi.org/10.11648/j.ajp.20220802.25},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220802.25},
  abstract = {Background: The effect of birth season climate on adult IgE-mediated respiratory disease is an important public health issue. Objective: To determine the effect of birth season climate on adult total serum IgE (TSIgE) levels. Study design: The study is a retrospective chart review with the following inclusion criteria: TSIgE measurement, age ≥ 16, and northeastern Tennessee birthplace. Main outcome measures include TSIgE levels, birth season climatic conditions, and regional pollen-producing plant and pollen counts. Results: The records of 1,274 women (mean age 40.8 ± 17.5, age range 16-96) and 762 men (mean age 38.1 ± 17, age range 16-82) seen in our Allergy Clinic were reviewed. Persons born in the spring and summer, the seasons with the highest pollen counts and the most favorable climatic conditions for plant growth, had nearly twice the odds of having TSIgE levels > 1σ above the mean of the study group when compared to those born in the fall or winter (odds ratio (OR) 1.75, 95% confidence interval (CI) 0.96-3.17 and OR 1.93, 95% CI 1.04-3.57, respectively); odds were highest for those born in March (OR 2.55, 95% CI 1.37-4.74) and July (OR 2.38, 95% CI 1.25-4.51) and lowest for those born in November (OR 0.11, 95% CI 0.0068-1.79). When averaged over the 95-years of study and five 30-year climate cycles TSIgE levels increased linearly as the seasons progressed from fall to summer (r2 = 0.9475, P = 0.0266). Of the climatic factors, TSIgE levels correlated most strongly with levels of precipitation (r2 = 0.9145, P = 0.0437). Conclusion: Climatic conditions that increase birth season exposure to environmental allergens may have a life-long effect on TSIgE production.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Influence of Birth Season Climate on Adult Total Serum IgE Levels
AU  - John Kelly Smith
Y1  - 2022/06/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220802.25
DO  - 10.11648/j.ajp.20220802.25
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 137
EP  - 140
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220802.25
AB  - Background: The effect of birth season climate on adult IgE-mediated respiratory disease is an important public health issue. Objective: To determine the effect of birth season climate on adult total serum IgE (TSIgE) levels. Study design: The study is a retrospective chart review with the following inclusion criteria: TSIgE measurement, age ≥ 16, and northeastern Tennessee birthplace. Main outcome measures include TSIgE levels, birth season climatic conditions, and regional pollen-producing plant and pollen counts. Results: The records of 1,274 women (mean age 40.8 ± 17.5, age range 16-96) and 762 men (mean age 38.1 ± 17, age range 16-82) seen in our Allergy Clinic were reviewed. Persons born in the spring and summer, the seasons with the highest pollen counts and the most favorable climatic conditions for plant growth, had nearly twice the odds of having TSIgE levels > 1σ above the mean of the study group when compared to those born in the fall or winter (odds ratio (OR) 1.75, 95% confidence interval (CI) 0.96-3.17 and OR 1.93, 95% CI 1.04-3.57, respectively); odds were highest for those born in March (OR 2.55, 95% CI 1.37-4.74) and July (OR 2.38, 95% CI 1.25-4.51) and lowest for those born in November (OR 0.11, 95% CI 0.0068-1.79). When averaged over the 95-years of study and five 30-year climate cycles TSIgE levels increased linearly as the seasons progressed from fall to summer (r2 = 0.9475, P = 0.0266). Of the climatic factors, TSIgE levels correlated most strongly with levels of precipitation (r2 = 0.9145, P = 0.0437). Conclusion: Climatic conditions that increase birth season exposure to environmental allergens may have a life-long effect on TSIgE production.
VL  - 8
IS  - 2
ER  -

Copy | Download