Introduction: Respiratory distress syndrome (RDS) previously known as hyaline membrane disease (HMD), is one of the most common respiratory disorders in preterm neonates, appearing in the first few hours or immediately after delivery. The lack of pulmonary surfactant caused by immaturity of the lung is the etiology of RDS. Risk factors of RDS include maternal (sociodemographic and obstetric abnormalities), intrapartum and fetal factors. Objectives: To know the risk factors of RDS in preterm neonates at Prof. DR. I. G. N. G. Ngoerah Hopital Denpasar, Bali. Methods: This study was a retrospective study with design of case control study that conducted from January 2021 until February 2022. Samples of this study is neonates born prematurely with diagnosed of RDS at Prof. DR. I. G. N. G. Ngoerah Hopital during this study periode. All the data were analyzed by SPSS version 25. Result: The total sample of this study was 170 subjects, consisting of 85 subjects with RDS and 85 subjects as control. Multivariate analysis with logistic regression showed that gestational age < 34 weeks (OR 4.6; 95% CI 1.882-11.346; p = 0.001), APGAR score < 7 (OR 2.7; 95% CI 1.216-6.295; p = 0.015) and maternal preeclampsia (OR 3.58; 95% CI 1.09-11.75; p = 0.03) were statistically significant as the risk factors of RDS. Conclusion: Respiratory Distress Syndrome still occurs often in preterm newborns younger than 34 weeks of gestation. The incidence of RDS in preterm newborns was significantly increased by gestational age less than 34 weeks, APGAR score less than 7, and maternal preeclampsia. In particular, prospective cohort studies with bigger, more focused sample sizes are required in order to generate more accurate study.
| Published in | American Journal of Pediatrics (Volume 8, Issue 4) |
| DOI | 10.11648/j.ajp.20220804.15 |
| Page(s) | 218-224 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Respiratory Distress Syndrome, Risk Factor, Preterm Neonates
| [1] | Gomela TL, Eyal FG, Mohammed FB. Gomella’s Neonatology Management, Procedures, on-call problems, diseases and drugs, 8th ed. US: McGraw Hill Education. 2020: 1043-1050. |
| [2] | Birihane BM, Bayih WA, Alemu AY, Belay DM, Demis A. The Burden of Hyaline Membrane Disease, Mortality and Its Determinant Factors among Preterm Neonates Admitted at Debre Tabor General Hospital, North Central Ethiopia : A Retrospective Follow Up Study. Plos One. 2021; 1-10. doi: https://doi.org/10.1371/journal.pone.0249365 |
| [3] | Yadav S, Lee B, Kamity R. Neonatal Respiratory Distress Syndrome. Treasure Island: StatPearls Publishing LLC. 2022: 1-10. |
| [4] | Permana I, Judistiani RTD, Bakhtiar, Alia A, Yuniati T, Setiabudiawan B. Incidence of Respiratory Distress Syndrome and Its Associated Factors Among Preterm Neonates: Study From West Java Tertiary Hospital. Int. J. Trop. Vet. Biomed. Res. 2022; 7: 1-7. doi: http://dx.doi.org/10.21157/ijtvbr.v7i1.27043 |
| [5] | Ndour DD, M Gueye. 2018. Diagnostic and Management of Hyaline Membrane Disease. EC Pediatrics. 2018; 7: 810-819. |
| [6] | Wang, X, Zhang, Y, Mei H, An C, Liu C, et al. Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants. Frontiers in Pediatrics. 2020; 8: 1-5. doi: https://doi.org/10.3389/fped.2020.00081 |
| [7] | Tochie JK, Sibetcheu AT, Danwang C, Mbonda AN, Kamla I, et all. The Epidemiology, Risk Factors, Mortality Rate, Diagnosis, Etiologies and Treatment of Neonatal Respiratory Distress: A Scoping Review. Research square. 2020: 1-22. doi: http://dx.doi.org/10.21203/rs.3.rs-131366/v1 |
| [8] | Riga PR, Boutsikou T, Kouis P, Kinni P, Krokou M, et al. Maternal and Neonatal Risk Factors for Neonatal Respiratory Distress Syndrome in Term Neonates in Cyprus: A Prospective Case–Control Study. Italian Journal of Pediatrics. 2021; 47 (129): 1-9. doi: https://doi.org/10.1186/s13052-021-01086-5 |
| [9] | Aynalem YA, Mekonen H, Akalu TY, Habtewold TD., Endalamaw A, et al. Incidence of Respiratory Distress and Its Predictors Among Neonates Admitted to The Neonatal Intensive Care Unit, Black Lion Specialized Hospital, Addis Ababa, Ethiopia. Plos one. 2020; 15 (7): 1-14. doi: https://doi.org/10.1371/journal.pone.0235544 |
| [10] | Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E. European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update. Neonatology. 2019; 115: 432-450. doi: https://doi.org/10.1159/000499361 |
| [11] | Zhou R, Zheng YN, Zhang XY, Cheng YY. A Meta-Analysis of The Risk Factors of Persistent Pulmonary Hypertension In Newborns. Frontiers in pediatrics. 2021; 9: 1-6. doi: https://doi.org/10.3389/fped.2021.659137 |
| [12] | Zhao D, Zou L, Lei X, Zhang Y. Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins. Scientific report. 2017; 7 (8736): 1-6. doi: https://doi.org/10.1038/s41598-017-08951-6 |
| [13] | Cutland CL, Lackritz EM, Mallett-Moore T, Bardaji A, Chandrasekaran R, et al. Low Birth Weight: Case Definition & Guidelines For Data Collection, Analysis, and Presentation of Maternal Immunization Safety Data. Vaccine. 2017; 35: 6492-6500. doi: https://doi.org/10.1016/j.vaccine.2017.01.049 |
| [14] | Nam NT, Dem PV, Tam NT, Dung NT. Preterm Birth and Low Birth Weight in Neonates With Postnatal Respiratory Failure at A Tertiary Hospital in Vietnam. Biomedical Research and Therapy. 2020; 7 (9): 4010-4015. doi: http://dx.doi.org/10.15419/bmrat.v7i9.633 |
| [15] | Altman M, Vanpee M, Cnattingius S, Norman M. Risk Factors for Acute Respiratory Morbidity in Moderately Preterm Infants. Paediatric and Perinatal Epidemiology. 2013; 27: 172-181. doi: https://doi.org/10.1111/ppe.12035 |
| [16] | Wang J, Yan J, Han JY, Ning Y, Yan C. Risk Factors for Respiratory Distress Syndrome among Chinese Infants of 34–42 Weeks Gestational Age: A Multi-Center Observational Study. Int J Clin Exp Med. 2019. 12 (4): 1-6. |
| [17] | Gagrani S, Mehrotra G, Mulye S, Shrivastav A. Effect of Gender and Gestational Age on Short Term Morbidities and Mortality in Extremely Low Birth Neonates. International Journal of Contemporary Pediatrics. 2017; 4 (3): 993-998. doi: https://dx.doi.org/10.18203/2349-3291.ijcp20171714 |
| [18] | Kim YJ, Kim BK, Kim YH. Association between Thyroid Stimulating Hormone and Respiratory Distress Syndrome of Newborn in the Preterm Infants. Research square. 2020: 1-16. doi: https://doi.org/10.21203/rs.3.rs-40381/v1 |
| [19] | Seikku L, Gissler M, Andersson S, Rahkonen P, Stefanovic V, et al. Asphyxia, Neurologic Morbidity, and Perinatal Mortality in Early-Term and Postterm Birth. Pediatrics, 2016; 137 (6): 1-9. doi: https://doi.org/10.1542/peds.2015-3334 |
| [20] | Iliodromiti S, Mackay DF, Smith GCS, Pell JP, Nelson SM. Apgar Score and The Risk of Cause-Specific Infant Mortality: A Population-Based Cohort Study. The Lancet, 2014; 6736 (14): 1-7. doi: https://doi.org/10.1016/s0140-6736(14)61135-1 |
| [21] | Shen CL, Zhang Q, Hudson JM, Cole S, Wambach JA. Genetic Factors Contribute To Risk for Neonatal Respiratory Distress Syndrome among Moderately Preterm, Late Preterm, and Term Infants. The Journal of pediatrics, 2016. 172: 1-8. doi: https://doi.org/10.1016/j.jpeds.2016.01.031 |
| [22] | Tochie JN, Choukem SP, Langmia RN, Barla E, Ndombo PK. Neonatal Respiratory Distress in A Reference Neonatal Unit in Cameroon: An Analysis of Prevalence, Predictors, Etiologies and Outcomes. Pan African Medical Journal. 2016; 24 (152): 1-10. doi: https://doi.org/10.11604/pamj.2016.24.152.7066 |
| [23] | Sabol BA, Caughey AB. Acidemia in Neonates With A 5-Minute Apgar Score of 7 Or Greater–What Are The Outcomes? AJOG. 2016; 215 (4): 1-23. doi: https://doi.org/10.1016/j.ajog.2016.05.035 |
| [24] | Chang EY, Menard MK, Vermillion ST, Hulsey T, Ebeling M. The Association between Hyaline Membrane Disease and Preeclampsia. AJOG. 2004; 191: 1414-7. doi: https://doi.org/10.1016/J.AJOG.2004.06.097 |
| [25] | Wen YH, Yang HI, Chou HC, Chen CY, Hsieh WS, et al. Association of Maternal Preeclampsia with Neonatal Respiratory Distress Syndrome in Very-Low-Birth-Weight Infants. Scientific reports. 2019; (9); 13212: 1-8. doi: https://doi.org/10.1038/s41598-019-49561-8 |
| [26] | Li L, Li H, Jiang Y, Yu B, Wang X, Zhang W. The Relationship between Antenatal Corticosteroid Administration-To-Delivery Intervals and Neonatal Resoiratory Distress Syndrome and Respiratory Support. Journal of Healthcare Engineering. 2022: 1-7. doi: https://doi.org/10.1155/2022/2310080 |
APA Style
Maria Angela Yustina Fernandez, I Made Sukmawati, I Made Kardana, I Wayan Dharma Artana, Putu Junara Putra, et al. (2022). Risk Factors of Respiratory Distress Syndrome in Premature Infants at Prof Dr. I. G. N. G Ngoerah Hospital, Denpasar, Bali. American Journal of Pediatrics, 8(4), 218-224. https://doi.org/10.11648/j.ajp.20220804.15
ACS Style
Maria Angela Yustina Fernandez; I Made Sukmawati; I Made Kardana; I Wayan Dharma Artana; Putu Junara Putra, et al. Risk Factors of Respiratory Distress Syndrome in Premature Infants at Prof Dr. I. G. N. G Ngoerah Hospital, Denpasar, Bali. Am. J. Pediatr. 2022, 8(4), 218-224. doi: 10.11648/j.ajp.20220804.15
AMA Style
Maria Angela Yustina Fernandez, I Made Sukmawati, I Made Kardana, I Wayan Dharma Artana, Putu Junara Putra, et al. Risk Factors of Respiratory Distress Syndrome in Premature Infants at Prof Dr. I. G. N. G Ngoerah Hospital, Denpasar, Bali. Am J Pediatr. 2022;8(4):218-224. doi: 10.11648/j.ajp.20220804.15
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Download@article{10.11648/j.ajp.20220804.15,
author = {Maria Angela Yustina Fernandez and I Made Sukmawati and I Made Kardana and I Wayan Dharma Artana and Putu Junara Putra and Putu Mas Vina Paramitha Cempaka},
title = {Risk Factors of Respiratory Distress Syndrome in Premature Infants at Prof Dr. I. G. N. G Ngoerah Hospital, Denpasar, Bali},
journal = {American Journal of Pediatrics},
volume = {8},
number = {4},
pages = {218-224},
doi = {10.11648/j.ajp.20220804.15},
url = {https://doi.org/10.11648/j.ajp.20220804.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220804.15},
abstract = {Introduction: Respiratory distress syndrome (RDS) previously known as hyaline membrane disease (HMD), is one of the most common respiratory disorders in preterm neonates, appearing in the first few hours or immediately after delivery. The lack of pulmonary surfactant caused by immaturity of the lung is the etiology of RDS. Risk factors of RDS include maternal (sociodemographic and obstetric abnormalities), intrapartum and fetal factors. Objectives: To know the risk factors of RDS in preterm neonates at Prof. DR. I. G. N. G. Ngoerah Hopital Denpasar, Bali. Methods: This study was a retrospective study with design of case control study that conducted from January 2021 until February 2022. Samples of this study is neonates born prematurely with diagnosed of RDS at Prof. DR. I. G. N. G. Ngoerah Hopital during this study periode. All the data were analyzed by SPSS version 25. Result: The total sample of this study was 170 subjects, consisting of 85 subjects with RDS and 85 subjects as control. Multivariate analysis with logistic regression showed that gestational age Conclusion: Respiratory Distress Syndrome still occurs often in preterm newborns younger than 34 weeks of gestation. The incidence of RDS in preterm newborns was significantly increased by gestational age less than 34 weeks, APGAR score less than 7, and maternal preeclampsia. In particular, prospective cohort studies with bigger, more focused sample sizes are required in order to generate more accurate study.},
year = {2022}
}
TY - JOUR T1 - Risk Factors of Respiratory Distress Syndrome in Premature Infants at Prof Dr. I. G. N. G Ngoerah Hospital, Denpasar, Bali AU - Maria Angela Yustina Fernandez AU - I Made Sukmawati AU - I Made Kardana AU - I Wayan Dharma Artana AU - Putu Junara Putra AU - Putu Mas Vina Paramitha Cempaka Y1 - 2022/10/18 PY - 2022 N1 - https://doi.org/10.11648/j.ajp.20220804.15 DO - 10.11648/j.ajp.20220804.15 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 218 EP - 224 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20220804.15 AB - Introduction: Respiratory distress syndrome (RDS) previously known as hyaline membrane disease (HMD), is one of the most common respiratory disorders in preterm neonates, appearing in the first few hours or immediately after delivery. The lack of pulmonary surfactant caused by immaturity of the lung is the etiology of RDS. Risk factors of RDS include maternal (sociodemographic and obstetric abnormalities), intrapartum and fetal factors. Objectives: To know the risk factors of RDS in preterm neonates at Prof. DR. I. G. N. G. Ngoerah Hopital Denpasar, Bali. Methods: This study was a retrospective study with design of case control study that conducted from January 2021 until February 2022. Samples of this study is neonates born prematurely with diagnosed of RDS at Prof. DR. I. G. N. G. Ngoerah Hopital during this study periode. All the data were analyzed by SPSS version 25. Result: The total sample of this study was 170 subjects, consisting of 85 subjects with RDS and 85 subjects as control. Multivariate analysis with logistic regression showed that gestational age Conclusion: Respiratory Distress Syndrome still occurs often in preterm newborns younger than 34 weeks of gestation. The incidence of RDS in preterm newborns was significantly increased by gestational age less than 34 weeks, APGAR score less than 7, and maternal preeclampsia. In particular, prospective cohort studies with bigger, more focused sample sizes are required in order to generate more accurate study. VL - 8 IS - 4 ER -
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