Neonatal lupus erythematosus is a rare acquired disease involving the fetus and the newborn. It is caused by autoantibodies (mainly anti-SSA/Ro and anti-SSB/La antibodies) in the mother entering the fetus through the placenta to cause autoimmune reactions, The most common clinical manifestations of neonatal lupus erythematosus include skin involvement and congenital heart block, as well as blood, respiratory, neurological, and digestive system abnormalities. Patients often go to pediatrics or dermatology with rash as the first symptom. Because the rash is atypical, there is often a risk of misdiagnosis or missed diagnosis. We report a case of 2-month-old baby. Physical examination showed that dark red infiltrating macula was scattered on forehead and plantar. ANA positive, anti-SSA/Ro antibody positive, anti-SSB/La antibody positive, no involvement of the heart or other organ systems was found. Her mother was a patient with lupus erythematosus. The diagnosis of neonatal lupus erythematosus was made according to the history and clinical manifestations, symptomatic treatment was given to the rash site, and after 4 months, the rash disappeared at a follow-up visit. ANA, Anti SSA/Ro antibodies and anti SSB/La antibodies all turned negative. The etiology, clinical manifestation, prevention and treatment of neonatal lupus erythematosus were discussed in combination with existing literature. It was emphasized that autoantibody testing should be carried out for women and pregnant women with reproductive requirements in order to detect and prevent neonatal lupus erythematosus in time. For unexplained skin rashes of infants, if the mother has a history of connective tissue disease, the possibility of neonatal lupus erythematosus should be considered.
| Published in | American Journal of Pediatrics (Volume 9, Issue 2) |
| DOI | 10.11648/j.ajp.20230902.11 |
| Page(s) | 59-62 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Erythematosus, Neonatal Lupus, Anti-SSA/Ro, Anti-SSB/La, Prognosis
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APA Style
Runchao Wang, Haixia Jing, Tingting Chen, Rui Wu, Wentao Liu. (2023). Neonatal Lupus Erythematosus in a 2-Month-Old Girl: A Case Report. American Journal of Pediatrics, 9(2), 59-62. https://doi.org/10.11648/j.ajp.20230902.11
ACS Style
Runchao Wang; Haixia Jing; Tingting Chen; Rui Wu; Wentao Liu. Neonatal Lupus Erythematosus in a 2-Month-Old Girl: A Case Report. Am. J. Pediatr. 2023, 9(2), 59-62. doi: 10.11648/j.ajp.20230902.11
AMA Style
Runchao Wang, Haixia Jing, Tingting Chen, Rui Wu, Wentao Liu. Neonatal Lupus Erythematosus in a 2-Month-Old Girl: A Case Report. Am J Pediatr. 2023;9(2):59-62. doi: 10.11648/j.ajp.20230902.11
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Download@article{10.11648/j.ajp.20230902.11,
author = {Runchao Wang and Haixia Jing and Tingting Chen and Rui Wu and Wentao Liu},
title = {Neonatal Lupus Erythematosus in a 2-Month-Old Girl: A Case Report},
journal = {American Journal of Pediatrics},
volume = {9},
number = {2},
pages = {59-62},
doi = {10.11648/j.ajp.20230902.11},
url = {https://doi.org/10.11648/j.ajp.20230902.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230902.11},
abstract = {Neonatal lupus erythematosus is a rare acquired disease involving the fetus and the newborn. It is caused by autoantibodies (mainly anti-SSA/Ro and anti-SSB/La antibodies) in the mother entering the fetus through the placenta to cause autoimmune reactions, The most common clinical manifestations of neonatal lupus erythematosus include skin involvement and congenital heart block, as well as blood, respiratory, neurological, and digestive system abnormalities. Patients often go to pediatrics or dermatology with rash as the first symptom. Because the rash is atypical, there is often a risk of misdiagnosis or missed diagnosis. We report a case of 2-month-old baby. Physical examination showed that dark red infiltrating macula was scattered on forehead and plantar. ANA positive, anti-SSA/Ro antibody positive, anti-SSB/La antibody positive, no involvement of the heart or other organ systems was found. Her mother was a patient with lupus erythematosus. The diagnosis of neonatal lupus erythematosus was made according to the history and clinical manifestations, symptomatic treatment was given to the rash site, and after 4 months, the rash disappeared at a follow-up visit. ANA, Anti SSA/Ro antibodies and anti SSB/La antibodies all turned negative. The etiology, clinical manifestation, prevention and treatment of neonatal lupus erythematosus were discussed in combination with existing literature. It was emphasized that autoantibody testing should be carried out for women and pregnant women with reproductive requirements in order to detect and prevent neonatal lupus erythematosus in time. For unexplained skin rashes of infants, if the mother has a history of connective tissue disease, the possibility of neonatal lupus erythematosus should be considered.},
year = {2023}
}
TY - JOUR T1 - Neonatal Lupus Erythematosus in a 2-Month-Old Girl: A Case Report AU - Runchao Wang AU - Haixia Jing AU - Tingting Chen AU - Rui Wu AU - Wentao Liu Y1 - 2023/04/15 PY - 2023 N1 - https://doi.org/10.11648/j.ajp.20230902.11 DO - 10.11648/j.ajp.20230902.11 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 59 EP - 62 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20230902.11 AB - Neonatal lupus erythematosus is a rare acquired disease involving the fetus and the newborn. It is caused by autoantibodies (mainly anti-SSA/Ro and anti-SSB/La antibodies) in the mother entering the fetus through the placenta to cause autoimmune reactions, The most common clinical manifestations of neonatal lupus erythematosus include skin involvement and congenital heart block, as well as blood, respiratory, neurological, and digestive system abnormalities. Patients often go to pediatrics or dermatology with rash as the first symptom. Because the rash is atypical, there is often a risk of misdiagnosis or missed diagnosis. We report a case of 2-month-old baby. Physical examination showed that dark red infiltrating macula was scattered on forehead and plantar. ANA positive, anti-SSA/Ro antibody positive, anti-SSB/La antibody positive, no involvement of the heart or other organ systems was found. Her mother was a patient with lupus erythematosus. The diagnosis of neonatal lupus erythematosus was made according to the history and clinical manifestations, symptomatic treatment was given to the rash site, and after 4 months, the rash disappeared at a follow-up visit. ANA, Anti SSA/Ro antibodies and anti SSB/La antibodies all turned negative. The etiology, clinical manifestation, prevention and treatment of neonatal lupus erythematosus were discussed in combination with existing literature. It was emphasized that autoantibody testing should be carried out for women and pregnant women with reproductive requirements in order to detect and prevent neonatal lupus erythematosus in time. For unexplained skin rashes of infants, if the mother has a history of connective tissue disease, the possibility of neonatal lupus erythematosus should be considered. VL - 9 IS - 2 ER -
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