Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma

Lali Bugadze; Nino Manjavidze; Lia Jor Joliani

doi:doi:10.11648/j.ass.20210902.12

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Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani

Published in Advances in Surgical Sciences (Volume 9, Issue 2)

Received: 27 May 2021 Accepted: 30 July 2021 Published: 12 October 2021

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Abstract

Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.

Published in	Advances in Surgical Sciences (Volume 9, Issue 2)
DOI	10.11648/j.ass.20210902.12
Page(s)	20-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Vitamin D, Children, Uncontrolled Asthma, Prick-test, Spirometry, IgE

References

[1]	Seasonal variation of asthma control, lung function tests and allergic inflammation in relation to vitamin D levels: a prospective annual study. Batmaz SB, Arıkoğlu T, Tamer L, Eskandari G, Kuyucu S. Postepy Dermatol Alergol. 2018 Feb; 35 (1): 99-105. doi: 10.5114/ada.2017.71421. Epub 2018 Feb 20. PMID: 29599679 (Free PMC Article).
[2]	Correlation of vitamin D receptor with bronchial asthma in children. Hou C, Zhu X, Chang X. Exp Ther Med. 2018 Mar; 15 (3): 2773-2776. doi: 10.3892/etm.2018.5739. Epub 2018 Jan 11. PMID: 29456680 (Free PMC Article).
[3]	Serum levels of vitamin A and 25-hydroxyvitamin D3 (25OHD3) as reflectors of pulmonary function and quality of life (QOL) in children with stable asthma: A case-control study. Bai YJ, Dai RJ. Medicine (Baltimore). 2018 Feb; 97 (7): e9830. doi: 10.1097/MD.0000000000009830.PMID: 29443744 (Free PMC Article).
[4]	Association between the oxidative status, Vitamin D levels and respiratory function in asthmatic children. Igde M, Baran P, Oksuz BG, Topcuoglu S, Karatekin G. Niger J Clin Pract. 2018 Jan; 21 (1): 63-68. doi: 10.4103/njcp.njcp_373_16.PMID: 29411726.
[5]	Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis. Shen SY, Xiao WQ, Lu JH, Yuan MY, He JR, Xia HM, Qiu X, Cheng KK, Lam KBH. BMC Pulm Med. 2018 Jul 20; 18 (1): 120. doi: 10.1186/s12890-018-0679-4. PMID: 30029599.
[6]	Vitamin D Status, Lung Function and Atopy in Children with Asthma. Ozdogan S, Sari G, Aktan IH, Aydin B, Irmak C, Cavdar S. J Coll Physicians Surg Pak. 2017 May; 27 (5): 292-295. PMID: 28599691.
[7]	Association between vitamin D status and asthma control: A meta-analysis of randomized trials. Wang M, Liu M, Wang C, Xiao Y, An T, Zou M, Cheng G. Respir Med. 2019 Apr; 150: 85-94. doi: 10.1016/j.rmed.2019.02.016. Epub 2019 Feb 21. PMID: 30961957.
[8]	Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children. Mirzakhani H, Carey VJ, Zeiger R, Bacharier LB, O'Connor GT, Schatz MX, Laranjo N, Weiss ST, Litonjua AA. Clin Exp Allergy. 2019 Apr; 49 (4): 419-429. doi: 10.1111/cea.13320. Epub 2019 Jan 3. PMID: 30461089.
[9]	Vitamin D for secondary prevention of acute wheeze attacks in preschool and school-age children. Stefanidis C, Martineau AR, Nwokoro C, Griffiths CJ, Bush A. Thorax. 2019 Oct; 74 (10): 977-985. doi: 10.1136/thoraxjnl-2019-213278. Epub 2019 Jul 5. PMID: 31278171.
[10]	Serum 25-hydroxyvitamin D status and wheezing in pre-school children, Kuwait. AbdelKader AM, Nassar MF. East Mediterr Health J. 2019 Apr 25; 25 (3): 197-204. doi: 10.26719/emhj.18.031. PMID: 31054230.
[11]	Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, Saglani S. Am J Respir Crit Care Med. 2011 Dec 15; 184 (12): 1342-9. doi: 10.1164/rccm.201107-1239OC. Epub 2011 Sep 8. PMID: 21908411.
[12]	Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK. Jolliffe DA, Kilpin K, MacLaughlin BD, Greiller CL, Hooper RL, Barnes NC, Timms PM, Rajakulasingam RK, Bhowmik A, Choudhury AB, Simcock DE, Hyppönen E, Corrigan CJ, Walton RT, Griffiths CJ, Martineau AR. J Steroid Biochem Mol Biol. 2018 Jan; 175: 88-96. doi: 10.1016/j.jsbmb.2016.11.004. Epub 2016 Nov 5. PMID: 27825992.
[13]	Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction. Litonjua AA, Carey VJ, Laranjo N, Stubbs BJ, Mirzakhani H, O'Connor GT, Sandel M, Beigelman A, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST. N Engl J Med. 2020 Feb 6; 382 (6): 525-533. doi: 10.1056/NEJMoa1906137. PMID: 32023372.
[14]	25-hydroxy Vitamin D Levels in Pediatric Asthma Patients and its Link with Asthma Severity. Ozturk Thomas G, Tutar E, Tokuc G, Oktem S. Cureus. 2019 Mar 22; 11 (3): e4302. doi: 10.7759/cureus.4302. PMID: 31183282.
[15]	Association of serum 25-OH vitamin D₃ with serum IgE and the Pediatric Asthma Severity Score in patients with pediatric asthma. Mohammadzadeh I, Darvish S, Qujeq D, Hajiahmadi M, Vaghari-Tabari M. Allergy Asthma Proc. 2020 Mar 1; 41 (2): 126-133. doi: 10.2500/aap.2020.41.190025. PMID: 32122449.
[16]	Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma. Galvão AA, de Araújo Sena F, Andrade Belitardo EMM, de Santana MBR, Costa GNO, Cruz ÁA, Barreto ML, Costa RDS, Alcantara-Neves NM, Figueiredo CA. Allergy Asthma Clin Immunol. 2020 Jul 9; 16: 62. doi: 10.1186/s13223-020-00460-y. eCollection 2020. PMID: 32834827.

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APA Style

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani. (2021). Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Advances in Surgical Sciences, 9(2), 20-24. https://doi.org/10.11648/j.ass.20210902.12

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ACS Style

Lali Bugadze; Nino Manjavidze; Lia Jor Joliani. Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Adv. Surg. Sci. 2021, 9(2), 20-24. doi: 10.11648/j.ass.20210902.12

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AMA Style

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani. Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Adv Surg Sci. 2021;9(2):20-24. doi: 10.11648/j.ass.20210902.12

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@article{10.11648/j.ass.20210902.12,
  author = {Lali Bugadze and Nino Manjavidze and Lia Jor Joliani},
  title = {Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma},
  journal = {Advances in Surgical Sciences},
  volume = {9},
  number = {2},
  pages = {20-24},
  doi = {10.11648/j.ass.20210902.12},
  url = {https://doi.org/10.11648/j.ass.20210902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20210902.12},
  abstract = {Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.},
 year = {2021}
}

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TY  - JOUR
T1  - Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma
AU  - Lali Bugadze
AU  - Nino Manjavidze
AU  - Lia Jor Joliani
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ass.20210902.12
DO  - 10.11648/j.ass.20210902.12
T2  - Advances in Surgical Sciences
JF  - Advances in Surgical Sciences
JO  - Advances in Surgical Sciences
SP  - 20
EP  - 24
PB  - Science Publishing Group
SN  - 2376-6182
UR  - https://doi.org/10.11648/j.ass.20210902.12
AB  - Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.
VL  - 9
IS  - 2
ER  -

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Author Information

Lali Bugadze

School of Medicine and Stomatology, David Aghmashenebeli University of Georgia, Tbilisi, Georgia
Nino Manjavidze

School of Medicine and Stomatology, David Aghmashenebeli University of Georgia, Tbilisi, Georgia
Lia Jor Joliani

School of Medicine and Stomatology, David Aghmashenebeli University of Georgia, Tbilisi, Georgia

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Plain Text BibTeX RIS

APA Style

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani. (2021). Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Advances in Surgical Sciences, 9(2), 20-24. https://doi.org/10.11648/j.ass.20210902.12

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ACS Style

Lali Bugadze; Nino Manjavidze; Lia Jor Joliani. Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Adv. Surg. Sci. 2021, 9(2), 20-24. doi: 10.11648/j.ass.20210902.12

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AMA Style

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani. Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Adv Surg Sci. 2021;9(2):20-24. doi: 10.11648/j.ass.20210902.12

Copy | Download

@article{10.11648/j.ass.20210902.12,
  author = {Lali Bugadze and Nino Manjavidze and Lia Jor Joliani},
  title = {Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma},
  journal = {Advances in Surgical Sciences},
  volume = {9},
  number = {2},
  pages = {20-24},
  doi = {10.11648/j.ass.20210902.12},
  url = {https://doi.org/10.11648/j.ass.20210902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20210902.12},
  abstract = {Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma
AU  - Lali Bugadze
AU  - Nino Manjavidze
AU  - Lia Jor Joliani
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ass.20210902.12
DO  - 10.11648/j.ass.20210902.12
T2  - Advances in Surgical Sciences
JF  - Advances in Surgical Sciences
JO  - Advances in Surgical Sciences
SP  - 20
EP  - 24
PB  - Science Publishing Group
SN  - 2376-6182
UR  - https://doi.org/10.11648/j.ass.20210902.12
AB  - Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.
VL  - 9
IS  - 2
ER  -

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