Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of <i>Moringa Oleifera</i> Found in Sokoto Metropolis Using Albino Rats Models

Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez; Halima Ibrahim Yusuf; Umar Aliyu Dikko; Bulama Ibrahim; Adama Musa Abdullahi

doi:doi:10.11648/j.bmb.20210601.12

Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models

Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, Halima Ibrahim Yusuf, Umar Aliyu Dikko, Bulama Ibrahim, Adama Musa Abdullahi

Published in Biochemistry and Molecular Biology (Volume 6, Issue 1)

Received: 22 May 2020 Accepted: 4 June 2020 Published: 23 February 2021

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Abstract

Epidemiological studies have indicated that Moringa oleifera leaves are good source of nutrition and exhibit antioxidant activities. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on physiological vital parameters, Including Temperature, Respiratory rate and Heart rate. Twenty adult Wistar albino rats were used for this study. Animals were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and was administered distilled water; the experimental groups B, C and D were administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 1000mg/kg and 500mg/kg orally for period of twenty four hours. The vital parameters were monitored and recorded after every two hours for the first eight hours and there after four hour interval for twenty four hours. The result of this study shows slight variation in body temperature between the control group and the group exposed to different concentration of the crude extract. There was significant changes in the Heart and respiratory rate of the rats in the treated groups compare to the control group. Extract from this plant can be used as anti-hypertensive agent.

Published in	Biochemistry and Molecular Biology (Volume 6, Issue 1)
DOI	10.11648/j.bmb.20210601.12
Page(s)	7-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Anti-hypertensive Agent, Crude Extract, Heart Rate, Moringa oleifera, Respiratory Rate and Temperature

References

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[2]	MASIH, L. P., Singh, S., Elamathi, S., Anandhi, P., & Abraham, T. (2019). Moringa: A Multipurpose Potential Crop-A Review. Proceedings of the Indian National Science Academy, 85 (3), 589-601.
[3]	Balusamy, S. R., Perumalsamy, H., Ranjan, A., Park, S., & Ramani, S. (2019). A dietary vegetable, Moringa oleifera leaves (drumstick tree) induced fat cell apoptosis by inhibiting adipogenesis in 3T3-L1 adipocytes. Journal of Functional Foods, 59, 251-260.
[4]	Tété-Bénissan, A., Quashie, M. A., Lawson-Evi, K., Gnandi, K., Kokou, K., & Gbeassor, M. (2013). Influence of Moringa oleifera leaves on atherogenic lipids and glycaemia evolution in HIV-infected and uninfected malnourished patients. Journal of Applied Biosciences, 62, 4610-4619.
[5]	Ezzat, S. M., El Bishbishy, M. H., Aborehab, N. M., Salama, M. M., Hasheesh, A., Motaal, A. A., ... & Metwally, F. M. (2020). Upregulation of MC4R and PPAR-α expression mediates the anti-obesity activity of Moringa oleifera Lam. in high-fat diet-induced obesity in rats. Journal of Ethnopharmacology, 112541.
[6]	Jacques, A. S., Arnaud, S. S., Fr&ejus, O. O., & Jacques, D. T. (2020). Review on biological and immunomodulatory properties of Moringa oleifera in animal and human nutrition. Journal of Pharmacognosy and Phytotherapy, 12 (1), 1-9.
[7]	Aponso, M., Patti, A., & Bennett, L. E. (2020). Dose-related effects of inhaled essential oils on behavioural measures of anxiety and depression and biomarkers of oxidative stress. Journal of Ethnopharmacology, 250, 112469.
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[9]	Alawode, A. R., Dauda, M., Adegbola, A. G., & Babatunde, O. R. (2020). Biochemical and Hematological Effect of Cordyla pinnata Following Acute and Sub-Acute Exposure to Rattus norvegicus. Iranian Journal of Toxicology, 14 (1), 43-50.
[10]	Arunsi, U. O., Chinyere, G. C., Ngwogu, K. O., Ngwogu, A. C., Atasie, O. C., Oti, U. A., ... & Ibe, C. (2020). Evaluation of the biochemical, haematological and histopathological parameters of female Wistar rats fed with aqueous and ethanol extracts of Aspilia africana leaves. Journal of Herbmed Pharmacology, 9 (3).
[11]	Schwachtje, J., Whitcomb, S. J., Firmino, A. A. P., Zuther, E., Hincha, D. K., & Kopka, J. (2019). Induced, Imprinted and Primed Metabolic Responses of Plants to Changing Environments: Do Plants Store and Process Information by Metabolic Imprinting and Metabolic Priming. Frontiers in plant science, 10, 106.
[12]	Randriamboavonjy, J. I., Loirand, G., Vaillant, N., Lauzier, B., Derbré, S., Michalet, S., ... & Tesse, A. (2016). Cardiac protective effects of Moringa oleifera seeds in spontaneous hypertensive rats. American journal of hypertension, 29 (7), 873-881.
[13]	Minatel, I. O., Borges, C. V., Ferreira, M. I., Gomez, H. A. G., Chen, C. Y. O., & Lima, G. P. P. (2017). Phenolic compounds: Functional properties, impact of processing and bioavailability. Phenolic Compounds Biological Activity. Ed. InTech. Rijeka, Croatia, 1-24.

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Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. (2021). Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models. Biochemistry and Molecular Biology, 6(1), 7-10. https://doi.org/10.11648/j.bmb.20210601.12

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ACS Style

Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez, et al. Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models. Biochem. Mol. Biol. 2021, 6(1), 7-10. doi: 10.11648/j.bmb.20210601.12

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AMA Style

Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models. Biochem Mol Biol. 2021;6(1):7-10. doi: 10.11648/j.bmb.20210601.12

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@article{10.11648/j.bmb.20210601.12,
  author = {Ibrahim Maina Hassan and Bashir Saidu and Ja’afaru Abdullahi Ishaq and Ashiru Dahiru and Nafisat Abdulazeez and Halima Ibrahim Yusuf and Umar Aliyu Dikko and Bulama Ibrahim and Adama Musa Abdullahi},
  title = {Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models},
  journal = {Biochemistry and Molecular Biology},
  volume = {6},
  number = {1},
  pages = {7-10},
  doi = {10.11648/j.bmb.20210601.12},
  url = {https://doi.org/10.11648/j.bmb.20210601.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20210601.12},
  abstract = {Epidemiological studies have indicated that Moringa oleifera leaves are good source of nutrition and exhibit antioxidant activities. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on physiological vital parameters, Including Temperature, Respiratory rate and Heart rate. Twenty adult Wistar albino rats were used for this study. Animals were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and was administered distilled water; the experimental groups B, C and D were administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 1000mg/kg and 500mg/kg orally for period of twenty four hours. The vital parameters were monitored and recorded after every two hours for the first eight hours and there after four hour interval for twenty four hours. The result of this study shows slight variation in body temperature between the control group and the group exposed to different concentration of the crude extract. There was significant changes in the Heart and respiratory rate of the rats in the treated groups compare to the control group. Extract from this plant can be used as anti-hypertensive agent.},
 year = {2021}
}

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TY  - JOUR
T1  - Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models
AU  - Ibrahim Maina Hassan
AU  - Bashir Saidu
AU  - Ja’afaru Abdullahi Ishaq
AU  - Ashiru Dahiru
AU  - Nafisat Abdulazeez
AU  - Halima Ibrahim Yusuf
AU  - Umar Aliyu Dikko
AU  - Bulama Ibrahim
AU  - Adama Musa Abdullahi
Y1  - 2021/02/23
PY  - 2021
N1  - https://doi.org/10.11648/j.bmb.20210601.12
DO  - 10.11648/j.bmb.20210601.12
T2  - Biochemistry and Molecular Biology
JF  - Biochemistry and Molecular Biology
JO  - Biochemistry and Molecular Biology
SP  - 7
EP  - 10
PB  - Science Publishing Group
SN  - 2575-5048
UR  - https://doi.org/10.11648/j.bmb.20210601.12
AB  - Epidemiological studies have indicated that Moringa oleifera leaves are good source of nutrition and exhibit antioxidant activities. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on physiological vital parameters, Including Temperature, Respiratory rate and Heart rate. Twenty adult Wistar albino rats were used for this study. Animals were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and was administered distilled water; the experimental groups B, C and D were administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 1000mg/kg and 500mg/kg orally for period of twenty four hours. The vital parameters were monitored and recorded after every two hours for the first eight hours and there after four hour interval for twenty four hours. The result of this study shows slight variation in body temperature between the control group and the group exposed to different concentration of the crude extract. There was significant changes in the Heart and respiratory rate of the rats in the treated groups compare to the control group. Extract from this plant can be used as anti-hypertensive agent.
VL  - 6
IS  - 1
ER  -

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Author Information

Ibrahim Maina Hassan

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Bashir Saidu

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Ja’afaru Abdullahi Ishaq

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Ashiru Dahiru

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Nafisat Abdulazeez

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Halima Ibrahim Yusuf

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Umar Aliyu Dikko

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Bulama Ibrahim

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Borno, Nigeria
Adama Musa Abdullahi

Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Maiduguri, Borno, Nigeria

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APA Style

Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. (2021). Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models. Biochemistry and Molecular Biology, 6(1), 7-10. https://doi.org/10.11648/j.bmb.20210601.12

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ACS Style

Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez, et al. Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models. Biochem. Mol. Biol. 2021, 6(1), 7-10. doi: 10.11648/j.bmb.20210601.12

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AMA Style

Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models. Biochem Mol Biol. 2021;6(1):7-10. doi: 10.11648/j.bmb.20210601.12

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@article{10.11648/j.bmb.20210601.12,
  author = {Ibrahim Maina Hassan and Bashir Saidu and Ja’afaru Abdullahi Ishaq and Ashiru Dahiru and Nafisat Abdulazeez and Halima Ibrahim Yusuf and Umar Aliyu Dikko and Bulama Ibrahim and Adama Musa Abdullahi},
  title = {Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models},
  journal = {Biochemistry and Molecular Biology},
  volume = {6},
  number = {1},
  pages = {7-10},
  doi = {10.11648/j.bmb.20210601.12},
  url = {https://doi.org/10.11648/j.bmb.20210601.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20210601.12},
  abstract = {Epidemiological studies have indicated that Moringa oleifera leaves are good source of nutrition and exhibit antioxidant activities. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on physiological vital parameters, Including Temperature, Respiratory rate and Heart rate. Twenty adult Wistar albino rats were used for this study. Animals were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and was administered distilled water; the experimental groups B, C and D were administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 1000mg/kg and 500mg/kg orally for period of twenty four hours. The vital parameters were monitored and recorded after every two hours for the first eight hours and there after four hour interval for twenty four hours. The result of this study shows slight variation in body temperature between the control group and the group exposed to different concentration of the crude extract. There was significant changes in the Heart and respiratory rate of the rats in the treated groups compare to the control group. Extract from this plant can be used as anti-hypertensive agent.},
 year = {2021}
}

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TY  - JOUR
T1  - Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models
AU  - Ibrahim Maina Hassan
AU  - Bashir Saidu
AU  - Ja’afaru Abdullahi Ishaq
AU  - Ashiru Dahiru
AU  - Nafisat Abdulazeez
AU  - Halima Ibrahim Yusuf
AU  - Umar Aliyu Dikko
AU  - Bulama Ibrahim
AU  - Adama Musa Abdullahi
Y1  - 2021/02/23
PY  - 2021
N1  - https://doi.org/10.11648/j.bmb.20210601.12
DO  - 10.11648/j.bmb.20210601.12
T2  - Biochemistry and Molecular Biology
JF  - Biochemistry and Molecular Biology
JO  - Biochemistry and Molecular Biology
SP  - 7
EP  - 10
PB  - Science Publishing Group
SN  - 2575-5048
UR  - https://doi.org/10.11648/j.bmb.20210601.12
AB  - Epidemiological studies have indicated that Moringa oleifera leaves are good source of nutrition and exhibit antioxidant activities. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on physiological vital parameters, Including Temperature, Respiratory rate and Heart rate. Twenty adult Wistar albino rats were used for this study. Animals were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and was administered distilled water; the experimental groups B, C and D were administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 1000mg/kg and 500mg/kg orally for period of twenty four hours. The vital parameters were monitored and recorded after every two hours for the first eight hours and there after four hour interval for twenty four hours. The result of this study shows slight variation in body temperature between the control group and the group exposed to different concentration of the crude extract. There was significant changes in the Heart and respiratory rate of the rats in the treated groups compare to the control group. Extract from this plant can be used as anti-hypertensive agent.
VL  - 6
IS  - 1
ER  -

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