Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State

Mogtaba Ahmed Mohammed; Alaa Abdalla Ibrahim; Ranya Adel Hamad; Jasim Mohamed Adam; Misson Shamsalfalah Ahmed; Musab Alsiddig Altayb; Mohammed Alhendi Ali; Amasi Abbas Idrees; Alaaeldeen Balal Ahmed

doi:doi:10.11648/j.bs.20230903.12

Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State

Mogtaba Ahmed Mohammed, Alaa Abdalla Ibrahim, Ranya Adel Hamad, Jasim Mohamed Adam, Misson Shamsalfalah Ahmed, Musab Alsiddig Altayb, Mohammed Alhendi Ali, Amasi Abbas Idrees, Alaaeldeen Balal Ahmed

Published in Biomedical Sciences (Volume 9, Issue 3)

Received: 6 April 2023 Accepted: 14 August 2023 Published: 28 August 2023

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Abstract

Introduction: Coronavirus disease 2019 (COVID-19) predominantly affects the pulmonary tract, causing mainly respiratory symptoms with some involvement of other organ systems. Liver injury has frequently been reported in COVID-19 patients. The clinical relevance of liver injury related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection remains unclear, with a need for studies on the impact of liver function tests (LFTs) abnormalities at baseline. Methods: This cross-sectional study aimed to detect an association of LFTs with COVID-19 among Sudanese patients in Khartoum State, the Republic of Sudan's national capital city, from August to December 2021. A total of 90 patients with COVID-19 confirmed by real-time polymerase chain reaction (RT-PCR) were enrolled; their ages ranged from 20 to 80. 5 ml of venous blood samples were collected from each participant by standard venipuncture and placed into a heparin container for chemical analysis. The Mindray device was used to analyze the plasma, and the results were shown on a sizable color liquid crystal display (LCD). Results: The results showed that there was a significant difference (p. value ≤ 0.05) between levels of liver function tests according to the different categories of COVID-19 cases (mild, moderate, and severe). Also, the results indicated that there was an insignificant difference (p. value ˃ 0.05) between levels of liver function tests according to gender. Moreover, the results found that there was no correlation between liver function parameters and age. Conclusions: The present study concluded that the levels of liver function tests were affected by the severity of COVID-19 infection.

Published in	Biomedical Sciences (Volume 9, Issue 3)
DOI	10.11648/j.bs.20230903.12
Page(s)	60-63
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

COVID-19, LFTs, Acute Respiratory Distress Syndrome

References

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[11]	Wei Xu. Dynamic Changes in Liver Function Tests and Their Correlation with Illness Severity and Mortality in Patients with COVID-19: A Retrospective Cohort Study. 2021; 102- 122, 140-147.
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Mogtaba Ahmed Mohammed, Alaa Abdalla Ibrahim, Ranya Adel Hamad, Jasim Mohamed Adam, Misson Shamsalfalah Ahmed, et al. (2023). Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State. Biomedical Sciences, 9(3), 60-63. https://doi.org/10.11648/j.bs.20230903.12

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ACS Style

Mogtaba Ahmed Mohammed; Alaa Abdalla Ibrahim; Ranya Adel Hamad; Jasim Mohamed Adam; Misson Shamsalfalah Ahmed, et al. Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State. Biomed. Sci. 2023, 9(3), 60-63. doi: 10.11648/j.bs.20230903.12

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AMA Style

Mogtaba Ahmed Mohammed, Alaa Abdalla Ibrahim, Ranya Adel Hamad, Jasim Mohamed Adam, Misson Shamsalfalah Ahmed, et al. Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State. Biomed Sci. 2023;9(3):60-63. doi: 10.11648/j.bs.20230903.12

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@article{10.11648/j.bs.20230903.12,
  author = {Mogtaba Ahmed Mohammed and Alaa Abdalla Ibrahim and Ranya Adel Hamad and Jasim Mohamed Adam and Misson Shamsalfalah Ahmed and Musab Alsiddig Altayb and Mohammed Alhendi Ali and Amasi Abbas Idrees and Alaaeldeen Balal Ahmed},
  title = {Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {3},
  pages = {60-63},
  doi = {10.11648/j.bs.20230903.12},
  url = {https://doi.org/10.11648/j.bs.20230903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230903.12},
  abstract = {Introduction: Coronavirus disease 2019 (COVID-19) predominantly affects the pulmonary tract, causing mainly respiratory symptoms with some involvement of other organ systems. Liver injury has frequently been reported in COVID-19 patients. The clinical relevance of liver injury related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection remains unclear, with a need for studies on the impact of liver function tests (LFTs) abnormalities at baseline. Methods: This cross-sectional study aimed to detect an association of LFTs with COVID-19 among Sudanese patients in Khartoum State, the Republic of Sudan's national capital city, from August to December 2021. A total of 90 patients with COVID-19 confirmed by real-time polymerase chain reaction (RT-PCR) were enrolled; their ages ranged from 20 to 80. 5 ml of venous blood samples were collected from each participant by standard venipuncture and placed into a heparin container for chemical analysis. The Mindray device was used to analyze the plasma, and the results were shown on a sizable color liquid crystal display (LCD). Results: The results showed that there was a significant difference (p. value ≤ 0.05) between levels of liver function tests according to the different categories of COVID-19 cases (mild, moderate, and severe). Also, the results indicated that there was an insignificant difference (p. value ˃ 0.05) between levels of liver function tests according to gender. Moreover, the results found that there was no correlation between liver function parameters and age. Conclusions: The present study concluded that the levels of liver function tests were affected by the severity of COVID-19 infection.},
 year = {2023}
}

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TY  - JOUR
T1  - Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State
AU  - Mogtaba Ahmed Mohammed
AU  - Alaa Abdalla Ibrahim
AU  - Ranya Adel Hamad
AU  - Jasim Mohamed Adam
AU  - Misson Shamsalfalah Ahmed
AU  - Musab Alsiddig Altayb
AU  - Mohammed Alhendi Ali
AU  - Amasi Abbas Idrees
AU  - Alaaeldeen Balal Ahmed
Y1  - 2023/08/28
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230903.12
DO  - 10.11648/j.bs.20230903.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 60
EP  - 63
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230903.12
AB  - Introduction: Coronavirus disease 2019 (COVID-19) predominantly affects the pulmonary tract, causing mainly respiratory symptoms with some involvement of other organ systems. Liver injury has frequently been reported in COVID-19 patients. The clinical relevance of liver injury related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection remains unclear, with a need for studies on the impact of liver function tests (LFTs) abnormalities at baseline. Methods: This cross-sectional study aimed to detect an association of LFTs with COVID-19 among Sudanese patients in Khartoum State, the Republic of Sudan's national capital city, from August to December 2021. A total of 90 patients with COVID-19 confirmed by real-time polymerase chain reaction (RT-PCR) were enrolled; their ages ranged from 20 to 80. 5 ml of venous blood samples were collected from each participant by standard venipuncture and placed into a heparin container for chemical analysis. The Mindray device was used to analyze the plasma, and the results were shown on a sizable color liquid crystal display (LCD). Results: The results showed that there was a significant difference (p. value ≤ 0.05) between levels of liver function tests according to the different categories of COVID-19 cases (mild, moderate, and severe). Also, the results indicated that there was an insignificant difference (p. value ˃ 0.05) between levels of liver function tests according to gender. Moreover, the results found that there was no correlation between liver function parameters and age. Conclusions: The present study concluded that the levels of liver function tests were affected by the severity of COVID-19 infection.
VL  - 9
IS  - 3
ER  -

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Author Information

Mogtaba Ahmed Mohammed

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan
Alaa Abdalla Ibrahim

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, National University, Khartoum, Sudan
Ranya Adel Hamad

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Elrazi University, Khartoum, Sudan
Jasim Mohamed Adam

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, National University, Khartoum, Sudan
Misson Shamsalfalah Ahmed

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, National University, Khartoum, Sudan
Musab Alsiddig Altayb

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan
Mohammed Alhendi Ali

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Elrazi University, Khartoum, Sudan
Amasi Abbas Idrees

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Elrazi University, Khartoum, Sudan
Alaaeldeen Balal Ahmed

Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan

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APA Style

Mogtaba Ahmed Mohammed, Alaa Abdalla Ibrahim, Ranya Adel Hamad, Jasim Mohamed Adam, Misson Shamsalfalah Ahmed, et al. (2023). Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State. Biomedical Sciences, 9(3), 60-63. https://doi.org/10.11648/j.bs.20230903.12

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ACS Style

Mogtaba Ahmed Mohammed; Alaa Abdalla Ibrahim; Ranya Adel Hamad; Jasim Mohamed Adam; Misson Shamsalfalah Ahmed, et al. Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State. Biomed. Sci. 2023, 9(3), 60-63. doi: 10.11648/j.bs.20230903.12

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AMA Style

Mogtaba Ahmed Mohammed, Alaa Abdalla Ibrahim, Ranya Adel Hamad, Jasim Mohamed Adam, Misson Shamsalfalah Ahmed, et al. Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State. Biomed Sci. 2023;9(3):60-63. doi: 10.11648/j.bs.20230903.12

Copy | Download

@article{10.11648/j.bs.20230903.12,
  author = {Mogtaba Ahmed Mohammed and Alaa Abdalla Ibrahim and Ranya Adel Hamad and Jasim Mohamed Adam and Misson Shamsalfalah Ahmed and Musab Alsiddig Altayb and Mohammed Alhendi Ali and Amasi Abbas Idrees and Alaaeldeen Balal Ahmed},
  title = {Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {3},
  pages = {60-63},
  doi = {10.11648/j.bs.20230903.12},
  url = {https://doi.org/10.11648/j.bs.20230903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230903.12},
  abstract = {Introduction: Coronavirus disease 2019 (COVID-19) predominantly affects the pulmonary tract, causing mainly respiratory symptoms with some involvement of other organ systems. Liver injury has frequently been reported in COVID-19 patients. The clinical relevance of liver injury related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection remains unclear, with a need for studies on the impact of liver function tests (LFTs) abnormalities at baseline. Methods: This cross-sectional study aimed to detect an association of LFTs with COVID-19 among Sudanese patients in Khartoum State, the Republic of Sudan's national capital city, from August to December 2021. A total of 90 patients with COVID-19 confirmed by real-time polymerase chain reaction (RT-PCR) were enrolled; their ages ranged from 20 to 80. 5 ml of venous blood samples were collected from each participant by standard venipuncture and placed into a heparin container for chemical analysis. The Mindray device was used to analyze the plasma, and the results were shown on a sizable color liquid crystal display (LCD). Results: The results showed that there was a significant difference (p. value ≤ 0.05) between levels of liver function tests according to the different categories of COVID-19 cases (mild, moderate, and severe). Also, the results indicated that there was an insignificant difference (p. value ˃ 0.05) between levels of liver function tests according to gender. Moreover, the results found that there was no correlation between liver function parameters and age. Conclusions: The present study concluded that the levels of liver function tests were affected by the severity of COVID-19 infection.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Impact of COVID-19 on Liver Function Tests Among Sudanese Patients: A Cross-Sectional Study of Khartoum State
AU  - Mogtaba Ahmed Mohammed
AU  - Alaa Abdalla Ibrahim
AU  - Ranya Adel Hamad
AU  - Jasim Mohamed Adam
AU  - Misson Shamsalfalah Ahmed
AU  - Musab Alsiddig Altayb
AU  - Mohammed Alhendi Ali
AU  - Amasi Abbas Idrees
AU  - Alaaeldeen Balal Ahmed
Y1  - 2023/08/28
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230903.12
DO  - 10.11648/j.bs.20230903.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 60
EP  - 63
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230903.12
AB  - Introduction: Coronavirus disease 2019 (COVID-19) predominantly affects the pulmonary tract, causing mainly respiratory symptoms with some involvement of other organ systems. Liver injury has frequently been reported in COVID-19 patients. The clinical relevance of liver injury related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection remains unclear, with a need for studies on the impact of liver function tests (LFTs) abnormalities at baseline. Methods: This cross-sectional study aimed to detect an association of LFTs with COVID-19 among Sudanese patients in Khartoum State, the Republic of Sudan's national capital city, from August to December 2021. A total of 90 patients with COVID-19 confirmed by real-time polymerase chain reaction (RT-PCR) were enrolled; their ages ranged from 20 to 80. 5 ml of venous blood samples were collected from each participant by standard venipuncture and placed into a heparin container for chemical analysis. The Mindray device was used to analyze the plasma, and the results were shown on a sizable color liquid crystal display (LCD). Results: The results showed that there was a significant difference (p. value ≤ 0.05) between levels of liver function tests according to the different categories of COVID-19 cases (mild, moderate, and severe). Also, the results indicated that there was an insignificant difference (p. value ˃ 0.05) between levels of liver function tests according to gender. Moreover, the results found that there was no correlation between liver function parameters and age. Conclusions: The present study concluded that the levels of liver function tests were affected by the severity of COVID-19 infection.
VL  - 9
IS  - 3
ER  -

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