Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention

Abdalla Mostafa Kamal; Mona Fikry Fathy; Ghada Mahmoud Soltan

doi:doi:10.11648/j.ccr.20210502.12

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Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention

Abdalla Mostafa Kamal, Mona Fikry Fathy, Ghada Mahmoud Soltan

Published in Cardiology and Cardiovascular Research (Volume 5, Issue 2)

Received: 15 April 2021 Accepted: 3 May 2021 Published: 14 May 2021

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Abstract

Background: In myocardial infarction (MI) patients, myocardial reperfusion and subsequently, early infarct related artery (IRA) patency are very critical in this emergency situation. Recently, there is growing research on the ability of platelet to lymphocyte ratio (PLR) to be a predictor of outcome and its value as a marker for inflammation and coagulopathy detection. Our work aims at finding the relation between PLR and the prognosis of IRA in STEMI patients. Methodology: Two hundred cases presented with STEMI were included for the study. Patency of IRA was estimated by Thrombolysis in Myocardial Infarction (TIMI) grade. Patent IRA was defined as TIMI grade III flow and occluded IRA was defined as TIMI grade 0-II flow. Blood samples were withdrawn on admission at emergency department to calculate PLR. Results: Forty-one (20.5%) cases revealed TIMI 3 flow in IRA before pPCI. Occluded group showed significantly higher PLR than patent group with mean PLR 231.3±94.2 vs 100.95±37.7 respectively with P value <0.0001. Multivariate regression analysis demonstrated, both HTN [95% CI (- 0.135)-(-0.747)] & PLR ratio [95% CI (-0.001)-(-0.002)] together are the most independent predictors for TIMI flow in IRA (F-ratio=12.2, p<0.001). Conclusion: our results show that high Platelet lymphocyte ratio predicts patency of IRA independently in cases with STEMI before pPCI.

Published in	Cardiology and Cardiovascular Research (Volume 5, Issue 2)
DOI	10.11648/j.ccr.20210502.12
Page(s)	61-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

PLR, IRA, pPCI

References

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APA Style

Abdalla Mostafa Kamal, Mona Fikry Fathy, Ghada Mahmoud Soltan. (2021). Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention. Cardiology and Cardiovascular Research, 5(2), 61-66. https://doi.org/10.11648/j.ccr.20210502.12

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ACS Style

Abdalla Mostafa Kamal; Mona Fikry Fathy; Ghada Mahmoud Soltan. Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention. Cardiol. Cardiovasc. Res. 2021, 5(2), 61-66. doi: 10.11648/j.ccr.20210502.12

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AMA Style

Abdalla Mostafa Kamal, Mona Fikry Fathy, Ghada Mahmoud Soltan. Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention. Cardiol Cardiovasc Res. 2021;5(2):61-66. doi: 10.11648/j.ccr.20210502.12

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@article{10.11648/j.ccr.20210502.12,
  author = {Abdalla Mostafa Kamal and Mona Fikry Fathy and Ghada Mahmoud Soltan},
  title = {Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention},
  journal = {Cardiology and Cardiovascular Research},
  volume = {5},
  number = {2},
  pages = {61-66},
  doi = {10.11648/j.ccr.20210502.12},
  url = {https://doi.org/10.11648/j.ccr.20210502.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20210502.12},
  abstract = {Background: In myocardial infarction (MI) patients, myocardial reperfusion and subsequently, early infarct related artery (IRA) patency are very critical in this emergency situation. Recently, there is growing research on the ability of platelet to lymphocyte ratio (PLR) to be a predictor of outcome and its value as a marker for inflammation and coagulopathy detection. Our work aims at finding the relation between PLR and the prognosis of IRA in STEMI patients. Methodology: Two hundred cases presented with STEMI were included for the study. Patency of IRA was estimated by Thrombolysis in Myocardial Infarction (TIMI) grade. Patent IRA was defined as TIMI grade III flow and occluded IRA was defined as TIMI grade 0-II flow. Blood samples were withdrawn on admission at emergency department to calculate PLR. Results: Forty-one (20.5%) cases revealed TIMI 3 flow in IRA before pPCI. Occluded group showed significantly higher PLR than patent group with mean PLR 231.3±94.2 vs 100.95±37.7 respectively with P value <0.0001. Multivariate regression analysis demonstrated, both HTN [95% CI (- 0.135)-(-0.747)] & PLR ratio [95% CI (-0.001)-(-0.002)] together are the most independent predictors for TIMI flow in IRA (F-ratio=12.2, p<0.001). Conclusion: our results show that high Platelet lymphocyte ratio predicts patency of IRA independently in cases with STEMI before pPCI.},
 year = {2021}
}

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TY - JOUR
T1 - Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention
AU - Abdalla Mostafa Kamal
AU - Mona Fikry Fathy
AU - Ghada Mahmoud Soltan
Y1 - 2021/05/14
PY - 2021
N1 - https://doi.org/10.11648/j.ccr.20210502.12
DO - 10.11648/j.ccr.20210502.12
T2 - Cardiology and Cardiovascular Research
JF - Cardiology and Cardiovascular Research
JO - Cardiology and Cardiovascular Research
SP - 61
EP - 66
PB - Science Publishing Group
SN - 2578-8914
UR - https://doi.org/10.11648/j.ccr.20210502.12
AB - Background: In myocardial infarction (MI) patients, myocardial reperfusion and subsequently, early infarct related artery (IRA) patency are very critical in this emergency situation. Recently, there is growing research on the ability of platelet to lymphocyte ratio (PLR) to be a predictor of outcome and its value as a marker for inflammation and coagulopathy detection. Our work aims at finding the relation between PLR and the prognosis of IRA in STEMI patients. Methodology: Two hundred cases presented with STEMI were included for the study. Patency of IRA was estimated by Thrombolysis in Myocardial Infarction (TIMI) grade. Patent IRA was defined as TIMI grade III flow and occluded IRA was defined as TIMI grade 0-II flow. Blood samples were withdrawn on admission at emergency department to calculate PLR. Results: Forty-one (20.5%) cases revealed TIMI 3 flow in IRA before pPCI. Occluded group showed significantly higher PLR than patent group with mean PLR 231.3±94.2 vs 100.95±37.7 respectively with P value <0.0001. Multivariate regression analysis demonstrated, both HTN [95% CI (- 0.135)-(-0.747)] & PLR ratio [95% CI (-0.001)-(-0.002)] together are the most independent predictors for TIMI flow in IRA (F-ratio=12.2, p<0.001). Conclusion: our results show that high Platelet lymphocyte ratio predicts patency of IRA independently in cases with STEMI before pPCI.
VL - 5
IS - 2
ER -

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Author Information

Abdalla Mostafa Kamal

Cardiology Department, Faculty of Medicine, Menofia University, Al Minufya, Egypt
Mona Fikry Fathy

Cardiology Department, National Heart Institute, Cairo, Egypt
Ghada Mahmoud Soltan

Cardiology Department, Faculty of Medicine, Menofia University, Al Minufya, Egypt

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APA Style

Abdalla Mostafa Kamal, Mona Fikry Fathy, Ghada Mahmoud Soltan. (2021). Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention. Cardiology and Cardiovascular Research, 5(2), 61-66. https://doi.org/10.11648/j.ccr.20210502.12

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ACS Style

Abdalla Mostafa Kamal; Mona Fikry Fathy; Ghada Mahmoud Soltan. Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention. Cardiol. Cardiovasc. Res. 2021, 5(2), 61-66. doi: 10.11648/j.ccr.20210502.12

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AMA Style

Abdalla Mostafa Kamal, Mona Fikry Fathy, Ghada Mahmoud Soltan. Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention. Cardiol Cardiovasc Res. 2021;5(2):61-66. doi: 10.11648/j.ccr.20210502.12

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@article{10.11648/j.ccr.20210502.12,
  author = {Abdalla Mostafa Kamal and Mona Fikry Fathy and Ghada Mahmoud Soltan},
  title = {Platelet to Lymphocyte Ratio as a Predictor of Infarct-Related Artery Patency in Patients Undergoing Primary Percutaneous Coronary Intervention},
  journal = {Cardiology and Cardiovascular Research},
  volume = {5},
  number = {2},
  pages = {61-66},
  doi = {10.11648/j.ccr.20210502.12},
  url = {https://doi.org/10.11648/j.ccr.20210502.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20210502.12},
  abstract = {Background: In myocardial infarction (MI) patients, myocardial reperfusion and subsequently, early infarct related artery (IRA) patency are very critical in this emergency situation. Recently, there is growing research on the ability of platelet to lymphocyte ratio (PLR) to be a predictor of outcome and its value as a marker for inflammation and coagulopathy detection. Our work aims at finding the relation between PLR and the prognosis of IRA in STEMI patients. Methodology: Two hundred cases presented with STEMI were included for the study. Patency of IRA was estimated by Thrombolysis in Myocardial Infarction (TIMI) grade. Patent IRA was defined as TIMI grade III flow and occluded IRA was defined as TIMI grade 0-II flow. Blood samples were withdrawn on admission at emergency department to calculate PLR. Results: Forty-one (20.5%) cases revealed TIMI 3 flow in IRA before pPCI. Occluded group showed significantly higher PLR than patent group with mean PLR 231.3±94.2 vs 100.95±37.7 respectively with P value <0.0001. Multivariate regression analysis demonstrated, both HTN [95% CI (- 0.135)-(-0.747)] & PLR ratio [95% CI (-0.001)-(-0.002)] together are the most independent predictors for TIMI flow in IRA (F-ratio=12.2, p<0.001). Conclusion: our results show that high Platelet lymphocyte ratio predicts patency of IRA independently in cases with STEMI before pPCI.},
 year = {2021}
}

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