The relationship between sperm DNA fragmentation and in vitro fertilization (IVF) outcome was uncertain today. In the past, researchers studying the pregnancy outcome of IVF, mainly base on fresh embryo transplantation cycle, recently, cumulative live birth rate was consider as a new indicator of IVF successful rate which is used to evaluate the pregnancy outcome by fresh or thawed transferred embryos until live birth or use up all embryos in one oocyte collection cycle, is more comprehensive. The purpose of this research is to investigate the relationship between sperm DNA fragmentation and cumulative live birth rate. 1019 couples who were assisted by IVF in our center from Jan 2012 to Dec 2016 were studied according to inclusive criteria, and divided into four groups by DNA fragmentation index (DFI), which were determined by sperm chrome structure assay (SCSA), then the fertilization rate, No. of Embryo available and cumulative live birth rate between the groups were analyzed. Cumulative live birth curve was plotted to study the time to reach live birth, and Cox regression model was used in order to find out the factors affecting pregnancy outcome. Study results showed no significant difference in cumulative live birth rate between the four groups, but DFI ≥40% group were significantly lower than the other three groups. In the cumulative live birth curve figure, except the high DFI group, the curve of the other three groups is relatively close. Cox regression model suggest that DFI was not the main factor affecting pregnancy outcome. Further studies in these patients with oligozoospermia showed that when DFI increase, a decrease trend was appeared in cumulative live birth rate, and spend more time to reach live birth studied by the live birth curve. Cox model showed that DFI was the impact factor of pregnancy outcome in oligozoospermia patients. In conclusion, abnormal sperm DNA fragmentation have a negative impact on cumulative live birth rate in patients with oligozoospermia, but further research was still needed.
| Published in | Clinical Medicine Research (Volume 10, Issue 3) |
| DOI | 10.11648/j.cmr.20211003.17 |
| Page(s) | 105-111 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Sperm DNA Fragmentation, Cumulative Live Birth Rate, IVF-ET, ICSI, Oligospermia
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APA Style
Liang Xiaodong, Duan Rubing, Ji Peng, Shen Binglian, Mo Ganwen, et al. (2021). Sperm DNA Fragmentation Has a Negative Impact on Cumulative Live Birth Rate of IVF-ET/ICSI in Patients with Oligozoospermia. Clinical Medicine Research, 10(3), 105-111. https://doi.org/10.11648/j.cmr.20211003.17
ACS Style
Liang Xiaodong; Duan Rubing; Ji Peng; Shen Binglian; Mo Ganwen, et al. Sperm DNA Fragmentation Has a Negative Impact on Cumulative Live Birth Rate of IVF-ET/ICSI in Patients with Oligozoospermia. Clin. Med. Res. 2021, 10(3), 105-111. doi: 10.11648/j.cmr.20211003.17
AMA Style
Liang Xiaodong, Duan Rubing, Ji Peng, Shen Binglian, Mo Ganwen, et al. Sperm DNA Fragmentation Has a Negative Impact on Cumulative Live Birth Rate of IVF-ET/ICSI in Patients with Oligozoospermia. Clin Med Res. 2021;10(3):105-111. doi: 10.11648/j.cmr.20211003.17
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Download@article{10.11648/j.cmr.20211003.17,
author = {Liang Xiaodong and Duan Rubing and Ji Peng and Shen Binglian and Mo Ganwen and Guo Jianghua and Liao Yongbin},
title = {Sperm DNA Fragmentation Has a Negative Impact on Cumulative Live Birth Rate of IVF-ET/ICSI in Patients with Oligozoospermia},
journal = {Clinical Medicine Research},
volume = {10},
number = {3},
pages = {105-111},
doi = {10.11648/j.cmr.20211003.17},
url = {https://doi.org/10.11648/j.cmr.20211003.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20211003.17},
abstract = {The relationship between sperm DNA fragmentation and in vitro fertilization (IVF) outcome was uncertain today. In the past, researchers studying the pregnancy outcome of IVF, mainly base on fresh embryo transplantation cycle, recently, cumulative live birth rate was consider as a new indicator of IVF successful rate which is used to evaluate the pregnancy outcome by fresh or thawed transferred embryos until live birth or use up all embryos in one oocyte collection cycle, is more comprehensive. The purpose of this research is to investigate the relationship between sperm DNA fragmentation and cumulative live birth rate. 1019 couples who were assisted by IVF in our center from Jan 2012 to Dec 2016 were studied according to inclusive criteria, and divided into four groups by DNA fragmentation index (DFI), which were determined by sperm chrome structure assay (SCSA), then the fertilization rate, No. of Embryo available and cumulative live birth rate between the groups were analyzed. Cumulative live birth curve was plotted to study the time to reach live birth, and Cox regression model was used in order to find out the factors affecting pregnancy outcome. Study results showed no significant difference in cumulative live birth rate between the four groups, but DFI ≥40% group were significantly lower than the other three groups. In the cumulative live birth curve figure, except the high DFI group, the curve of the other three groups is relatively close. Cox regression model suggest that DFI was not the main factor affecting pregnancy outcome. Further studies in these patients with oligozoospermia showed that when DFI increase, a decrease trend was appeared in cumulative live birth rate, and spend more time to reach live birth studied by the live birth curve. Cox model showed that DFI was the impact factor of pregnancy outcome in oligozoospermia patients. In conclusion, abnormal sperm DNA fragmentation have a negative impact on cumulative live birth rate in patients with oligozoospermia, but further research was still needed.},
year = {2021}
}
TY - JOUR T1 - Sperm DNA Fragmentation Has a Negative Impact on Cumulative Live Birth Rate of IVF-ET/ICSI in Patients with Oligozoospermia AU - Liang Xiaodong AU - Duan Rubing AU - Ji Peng AU - Shen Binglian AU - Mo Ganwen AU - Guo Jianghua AU - Liao Yongbin Y1 - 2021/06/26 PY - 2021 N1 - https://doi.org/10.11648/j.cmr.20211003.17 DO - 10.11648/j.cmr.20211003.17 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 105 EP - 111 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20211003.17 AB - The relationship between sperm DNA fragmentation and in vitro fertilization (IVF) outcome was uncertain today. In the past, researchers studying the pregnancy outcome of IVF, mainly base on fresh embryo transplantation cycle, recently, cumulative live birth rate was consider as a new indicator of IVF successful rate which is used to evaluate the pregnancy outcome by fresh or thawed transferred embryos until live birth or use up all embryos in one oocyte collection cycle, is more comprehensive. The purpose of this research is to investigate the relationship between sperm DNA fragmentation and cumulative live birth rate. 1019 couples who were assisted by IVF in our center from Jan 2012 to Dec 2016 were studied according to inclusive criteria, and divided into four groups by DNA fragmentation index (DFI), which were determined by sperm chrome structure assay (SCSA), then the fertilization rate, No. of Embryo available and cumulative live birth rate between the groups were analyzed. Cumulative live birth curve was plotted to study the time to reach live birth, and Cox regression model was used in order to find out the factors affecting pregnancy outcome. Study results showed no significant difference in cumulative live birth rate between the four groups, but DFI ≥40% group were significantly lower than the other three groups. In the cumulative live birth curve figure, except the high DFI group, the curve of the other three groups is relatively close. Cox regression model suggest that DFI was not the main factor affecting pregnancy outcome. Further studies in these patients with oligozoospermia showed that when DFI increase, a decrease trend was appeared in cumulative live birth rate, and spend more time to reach live birth studied by the live birth curve. Cox model showed that DFI was the impact factor of pregnancy outcome in oligozoospermia patients. In conclusion, abnormal sperm DNA fragmentation have a negative impact on cumulative live birth rate in patients with oligozoospermia, but further research was still needed. VL - 10 IS - 3 ER -
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