The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis

Wan-Yun Lin; Lin-Han Wu; Xiang-Qiong Chen; Hai-Long Zheng; Zheng-Rou Wang; Pin-Xin Zhan; Sunchuri Diwas; Zhu-Ling Guo

doi:doi:10.11648/j.cmr.20221101.11

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The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis

Wan-Yun Lin, Lin-Han Wu, Xiang-Qiong Chen, Hai-Long Zheng, Zheng-Rou Wang, Pin-Xin Zhan, Sunchuri Diwas, Zhu-Ling Guo

Published in Clinical Medicine Research (Volume 11, Issue 1)

Received: 14 December 2021 Accepted: 31 December 2021 Published: 8 January 2022

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Abstract

Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.

Published in	Clinical Medicine Research (Volume 11, Issue 1)
DOI	10.11648/j.cmr.20221101.11
Page(s)	1-5
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress

References

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APA Style

Wan-Yun Lin, Lin-Han Wu, Xiang-Qiong Chen, Hai-Long Zheng, Zheng-Rou Wang, et al. (2022). The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis. Clinical Medicine Research, 11(1), 1-5. https://doi.org/10.11648/j.cmr.20221101.11

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ACS Style

Wan-Yun Lin; Lin-Han Wu; Xiang-Qiong Chen; Hai-Long Zheng; Zheng-Rou Wang, et al. The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis. Clin. Med. Res. 2022, 11(1), 1-5. doi: 10.11648/j.cmr.20221101.11

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AMA Style

Wan-Yun Lin, Lin-Han Wu, Xiang-Qiong Chen, Hai-Long Zheng, Zheng-Rou Wang, et al. The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis. Clin Med Res. 2022;11(1):1-5. doi: 10.11648/j.cmr.20221101.11

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@article{10.11648/j.cmr.20221101.11,
  author = {Wan-Yun Lin and Lin-Han Wu and Xiang-Qiong Chen and Hai-Long Zheng and Zheng-Rou Wang and Pin-Xin Zhan and Sunchuri Diwas and Zhu-Ling Guo},
  title = {The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis},
  journal = {Clinical Medicine Research},
  volume = {11},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.cmr.20221101.11},
  url = {https://doi.org/10.11648/j.cmr.20221101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20221101.11},
  abstract = {Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.},
 year = {2022}
}

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TY  - JOUR
T1  - The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis
AU  - Wan-Yun Lin
AU  - Lin-Han Wu
AU  - Xiang-Qiong Chen
AU  - Hai-Long Zheng
AU  - Zheng-Rou Wang
AU  - Pin-Xin Zhan
AU  - Sunchuri Diwas
AU  - Zhu-Ling Guo
Y1  - 2022/01/08
PY  - 2022
N1  - https://doi.org/10.11648/j.cmr.20221101.11
DO  - 10.11648/j.cmr.20221101.11
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20221101.11
AB  - Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.
VL  - 11
IS  - 1
ER  -

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Author Information

Wan-Yun Lin

School of Dentistry, Hainan Medical University, Haikou, PR China
Lin-Han Wu

School of Dentistry, Hainan Medical University, Haikou, PR China
Xiang-Qiong Chen

Department of Dentistry, the First Affiliated Hospital of Hainan Medical University, Haikou, PR China
Hai-Long Zheng

Department of Dentistry, the First Affiliated Hospital of Hainan Medical University, Haikou, PR China
Zheng-Rou Wang

School of Dentistry, Hainan Medical University, Haikou, PR China
Pin-Xin Zhan

School of Dentistry, Hainan Medical University, Haikou, PR China
Sunchuri Diwas

School of International Education, Hainan Medical University, Haikou, PR China
Zhu-Ling Guo

School of Dentistry, Hainan Medical University, Haikou, PR China

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APA Style

Wan-Yun Lin, Lin-Han Wu, Xiang-Qiong Chen, Hai-Long Zheng, Zheng-Rou Wang, et al. (2022). The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis. Clinical Medicine Research, 11(1), 1-5. https://doi.org/10.11648/j.cmr.20221101.11

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ACS Style

Wan-Yun Lin; Lin-Han Wu; Xiang-Qiong Chen; Hai-Long Zheng; Zheng-Rou Wang, et al. The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis. Clin. Med. Res. 2022, 11(1), 1-5. doi: 10.11648/j.cmr.20221101.11

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AMA Style

Wan-Yun Lin, Lin-Han Wu, Xiang-Qiong Chen, Hai-Long Zheng, Zheng-Rou Wang, et al. The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis. Clin Med Res. 2022;11(1):1-5. doi: 10.11648/j.cmr.20221101.11

Copy | Download

@article{10.11648/j.cmr.20221101.11,
  author = {Wan-Yun Lin and Lin-Han Wu and Xiang-Qiong Chen and Hai-Long Zheng and Zheng-Rou Wang and Pin-Xin Zhan and Sunchuri Diwas and Zhu-Ling Guo},
  title = {The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis},
  journal = {Clinical Medicine Research},
  volume = {11},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.cmr.20221101.11},
  url = {https://doi.org/10.11648/j.cmr.20221101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20221101.11},
  abstract = {Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis
AU  - Wan-Yun Lin
AU  - Lin-Han Wu
AU  - Xiang-Qiong Chen
AU  - Hai-Long Zheng
AU  - Zheng-Rou Wang
AU  - Pin-Xin Zhan
AU  - Sunchuri Diwas
AU  - Zhu-Ling Guo
Y1  - 2022/01/08
PY  - 2022
N1  - https://doi.org/10.11648/j.cmr.20221101.11
DO  - 10.11648/j.cmr.20221101.11
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20221101.11
AB  - Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.
VL  - 11
IS  - 1
ER  -

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