Objective: To investigate the etiological mechanisms, treatment and oral manifestations of inflammatory bowel disease (IBD) in relation to recurrent aphthous ulcer (RAU). Materials and Methods: By summarizing and reviewing the research in the literature on the etiological mechanisms and treatment of RAU and IBD in the past decade in China and abroad. By summarizing and reviewing the research in the literature on the etiological mechanisms and treatment of RAU and IBD in the past decade in China and abroad. To explore the interaction between oral and intestinal lesions. Results: Some specific bacteria in the oral cavity may translocate and colonize the intestine, affecting the microecological balance of the gut and interfering with the disease process of IBD. Also, in patients with IBD, their oral salivary microbiome is altered and may show extraintestinal manifestations such as oral mucosal lesions. The occurrence of RAU may aggravate the dysbiosis and immune abnormalities of the intestinal mucosal flora that will be indirectly caused by patients with IBD, as well as malnutrition. Conclusion: Patients with IBD and RAU can affect the microecology of the oral-intestinal axis. patients with IBD are at increased risk of oral mucosal disease and oral symptoms and are associated with the activity of IBD. Due to the complex pathogenic interactions between RAU and IBD. It is recommended that dentists and gastroenterologists should be aware of the bidirectional association between the two diseases for early recognition and multidisciplinary medical management.
| Published in | Clinical Medicine Research (Volume 11, Issue 6) |
| DOI | 10.11648/j.cmr.20221106.14 |
| Page(s) | 172-177 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Recurrent Aphthous Ulcers, Inflammatory Bowel Disease, Dysbiosis, Immune Dysregulation
| [1] | Queiroz, Salomão Israel Monteiro Lourenço, et al. "Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis." Anais brasileiros de dermatologia 93 (2018): 341-346. |
| [2] | Ernst, Benjamin, et al. "Investigations concerning the impact of consumption of hot beverages on acute cytotoxic and genotoxic effects in oral mucosa cells." Scientific Reports 11. 1 (2021): 1-10. |
| [3] | Cappello, Francesco, et al. "Probiotics can cure oral aphthous-like ulcers in inflammatory bowel disease patients: A review of the literature and a working hypothesis." International Journal of Molecular Sciences 20. 20 (2019): 5026. |
| [4] | Ribaldone, Davide Giuseppe, et al. "Oral manifestations of inflammatory bowel disease and the role of non-invasive surrogate markers of disease activity." Medicines 7. 6 (2020): 33. |
| [5] | Lauritano, Dorina, et al. "Prevalence of oral lesions and correlation with intestinal symptoms of inflammatory bowel disease: a systematic review." Diagnostics 9. 3 (2019): 77. |
| [6] | Laranjeira, Nuno, et al. "Oral mucosa lesions and oral symptoms in inflammatory bowel disease patients." Arquivos de gastroenterologia 52 (2015): 105-110. |
| [7] | Marzano, Angelo V., et al. "Cutaneous manifestations in patients with inflammatory bowel diseases: pathophysiology, clinical features, and therapy." Inflammatory bowel diseases 20. 1 (2014): 213-227. |
| [8] | Seedorf, Henning, et al. "Bacteria from diverse habitats colonize and compete in the mouse gut." Cell 159. 2 (2014): 253-266. |
| [9] | Lauritano, D., et al. "Periodontal pockets as a reservoir of Helicobacter pylori causing relapse of gastric ulcer: A review of the literature." J Biol Regul Homeost Agents 29. 3 Suppl 1 (2015): 123-6. |
| [10] | Shin, Na-Ri, Tae Woong Whon, and Jin-Woo Bae. "Proteobacteria: microbial signature of dysbiosis in gut microbiota." Trends in biotechnology 33. 9 (2015): 496-503. |
| [11] | Segata, Nicola, et al. "Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples." Genome biology 13. 6 (2012): 1-18. |
| [12] | Olsen, Ingar, and Kazuhisa Yamazaki. "Can oral bacteria affect the microbiome of the gut?." Journal of oral microbiology 11. 1 (2019): 1586422. |
| [13] | Kitamoto, S., et al. "The bacterial connection between the oral cavity and the gut diseases." Journal of dental research 99. 9 (2020): 1021-1029. |
| [14] | Auchtung, Thomas A., et al. "Investigating colonization of the healthy adult gastrointestinal tract by fungi." MSphere 3. 2 (2018): e00092-18. |
| [15] | Human Microbiome Project Consortium. "Huttenhower C, Gevers D, Knight R, Abubucker S, Badger JH, et al." Structure, function and diversity of the healthy human microbiome. Nature 486. 7402 (2012): 207-14. |
| [16] | David, Lawrence A., et al. "Diet rapidly and reproducibly alters the human gut microbiome." Nature 505. 7484 (2014): 559-563. |
| [17] | Rosier, B. T., P. D. Marsh, and A. Mira. "Resilience of the oral microbiota in health: mechanisms that prevent dysbiosis." Journal of dental research 97. 4 (2018): 371-380. |
| [18] | Zaura, Egija, et al. "Acquiring and maintaining a normal oral microbiome: current perspective." Frontiers in cellular and infection microbiology 4 (2014): 85. |
| [19] | Elmaghrawy, Khalid, Séamus Hussey, and Gary P. Moran. "The oral microbiome in pediatric IBD: a source of pathobionts or biomarkers?" Frontiers in Pediatrics 8 (2021): 620254. |
| [20] | Slebioda, Zuzanna et al. “Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review.” Archivum immunologiae et therapiae experimentalis vol. 62, 3 (2014): 205-15. |
| [21] | Chiang, Chun-Pin, et al. "Recurrent aphthous stomatitis–Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management." Journal of the Formosan Medical Association 118. 9 (2019): 1279-1289. |
| [22] | Aksit Bıcak, Damla et al. “The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints.” BMC oral health vol. 17, 1 67. 21 Mar. 2017, doi: 10.1186/s12903-017-0361-x. |
| [23] | Shi, Lu, et al. "Qingwei San treats oral ulcer subjected to stomach heat syndrome in db/db mice by targeting TLR4/MyD88/NF-κB pathway." Chinese Medicine 17. 1 (2022): 1-16. |
| [24] | "Human skin is the largest epithelial surface for interaction with microbes." Journal of Investigative Dermatology 137. 6 (2017): 1213-1214. |
| [25] | Binienda, Agata, et al. "Dietary Carbohydrates and Lipids in the Pathogenesis of Leaky Gut Syndrome: An Overview." International Journal of Molecular Sciences 21. 21 (2020): 8368. |
| [26] | Said, Heba S., et al. "Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers." DNA research 21. 1 (2014): 15-25. |
| [27] | Xun, Zhe, et al. "Dysbiosis and ecotypes of the salivary microbiome associated with inflammatory bowel diseases and the assistance in diagnosis of diseases using oral bacterial profiles." Frontiers in microbiology 9 (2018): 1136. |
| [28] | Edgar, Natalie Rose, Dahlia Saleh, and Richard A. Miller. "Recurrent aphthous stomatitis: a review." The Journal of clinical and aesthetic dermatology 10. 3 (2017): 26. |
| [29] | Yaşar, Sirin, Bülent Yaşar, and Evren Abut. "Clinical importance of celiac disease in patients with recurrent aphthous stomatitis." The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology 23. 1 (2012): 14-18. |
| [30] | Beguerie, Julieta Ruiz, and Mariana Sabas. "Recurrent aphthous stomatitis: An update on etiopathogenia and treatment." Journal of the Dermatology Nurses' Association 7. 1 (2015): 8-12. |
| [31] | Feller, Liviu, Razia AG Khammissa, and Johan Lemmer. "Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease?" Journal of Oral Pathology & Medicine 46. 10 (2017): 859-863. |
| [32] | Tavakoli, P., et al. "A review of inflammatory bowel disease: a model of microbial, immune and neuropsychological integration." Public Health Reviews 42 (2021): 1603990. |
| [33] | Mimura, Maria Angela Martins, et al. "Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic." Journal of Oral Pathology & Medicine 46. 9 (2017): 821-828. |
| [34] | Buc, M. "Crohns disease and ulcerative colitis-current view on genetic determination, immunopathogenesis and biologic therapy." Epidemiologie, Mikrobiologie, Imunologie: Casopis Spolecnosti pro Epidemiologii a Mikrobiologii Ceske Lekarske Spolecnosti JE Purkyne 66. 4 (2017): 189-197. |
| [35] | Wu, Rui-Qing, et al. "The mucosal immune system in the oral cavity—an orchestra of T cell diversity." International journal of oral science 6. 3 (2014): 125-132. |
| [36] | Najafi, Shamsolmoulouk, et al. "Interleukin-4 and interleukin-4 receptor alpha gene polymorphisms in recurrent aphthous stomatitis." Immunological Investigations 47. 7 (2018): 680-688. |
| [37] | Zdravkovic, Natasa D., et al. "Potential dual immunomodulatory role of VEGF in ulcerative colitis and colorectal carcinoma." International journal of medical sciences 11. 9 (2014): 936. |
| [38] | Nijakowski, Kacper, and Anna Surdacka. "Salivary biomarkers for diagnosis of inflammatory bowel diseases: A systematic review." International journal of molecular sciences 21. 20 (2020): 7477. |
| [39] | Sun, Boyang, et al. "Metagenomic analysis of saliva reveals disease-associated microbiotas in patients with periodontitis and Crohn’s disease-associated periodontitis." Frontiers in cellular and infection microbiology 11 (2021). |
| [40] | Szczeklik, Katarzyna, et al. "Proinflammatory cytokines in the saliva of patients with active and nonactive Crohn's disease." Polskie Archiwum Medycyny Wewnętrznej= Polish Archives of Internal Medicine 122. 5 (2012). |
| [41] | Chen, H., et al. "Impact of haematologic deficiencies on recurrent aphthous ulceration: a meta-analysis." British Dental Journal 218. 4 (2015): E8-E8. |
| [42] | Bischoff, Stephan C., et al. "ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease." Clinical Nutrition 39. 3 (2020): 632-653. |
| [43] | Muhvić-Urek, Miranda, Marija Tomac-Stojmenović, and Brankica Mijandrušić-Sinčić. "Oral pathology in inflammatory bowel disease." World journal of gastroenterology 22. 25 (2016): 5655. |
| [44] | France, Katherine, and Alessandro Villa. "Acuteorallesions." Dermatologic Clinics 38. 4 (2020): 441-450. |
| [45] | Manu, Peter, et al. "Pharmacological management of peptic ulcer: a century of expert opinions in cecil textbook of medicine." American Journal of Therapeutics 28. 5 (2021): e552. |
| [46] | Chandan, J. S., and T. Thomas. "Inflammatory bowel disease and oral health." Bdj Team 4.5 (2017): 17083. |
APA Style
Xiang Guo, Jing-Yi Zhong, Sunchuri Diwas, Meng-Fei Zhou, Long Lian, et al. (2022). Bidirectional Study of Oral Recurrent Aphthous Ulcers and Inflammatory Bowel Disease. Clinical Medicine Research, 11(6), 172-177. https://doi.org/10.11648/j.cmr.20221106.14
ACS Style
Xiang Guo; Jing-Yi Zhong; Sunchuri Diwas; Meng-Fei Zhou; Long Lian, et al. Bidirectional Study of Oral Recurrent Aphthous Ulcers and Inflammatory Bowel Disease. Clin. Med. Res. 2022, 11(6), 172-177. doi: 10.11648/j.cmr.20221106.14
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Download@article{10.11648/j.cmr.20221106.14,
author = {Xiang Guo and Jing-Yi Zhong and Sunchuri Diwas and Meng-Fei Zhou and Long Lian and Si-Yu Tao and Zhu-Ling Guo},
title = {Bidirectional Study of Oral Recurrent Aphthous Ulcers and Inflammatory Bowel Disease},
journal = {Clinical Medicine Research},
volume = {11},
number = {6},
pages = {172-177},
doi = {10.11648/j.cmr.20221106.14},
url = {https://doi.org/10.11648/j.cmr.20221106.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20221106.14},
abstract = {Objective: To investigate the etiological mechanisms, treatment and oral manifestations of inflammatory bowel disease (IBD) in relation to recurrent aphthous ulcer (RAU). Materials and Methods: By summarizing and reviewing the research in the literature on the etiological mechanisms and treatment of RAU and IBD in the past decade in China and abroad. By summarizing and reviewing the research in the literature on the etiological mechanisms and treatment of RAU and IBD in the past decade in China and abroad. To explore the interaction between oral and intestinal lesions. Results: Some specific bacteria in the oral cavity may translocate and colonize the intestine, affecting the microecological balance of the gut and interfering with the disease process of IBD. Also, in patients with IBD, their oral salivary microbiome is altered and may show extraintestinal manifestations such as oral mucosal lesions. The occurrence of RAU may aggravate the dysbiosis and immune abnormalities of the intestinal mucosal flora that will be indirectly caused by patients with IBD, as well as malnutrition. Conclusion: Patients with IBD and RAU can affect the microecology of the oral-intestinal axis. patients with IBD are at increased risk of oral mucosal disease and oral symptoms and are associated with the activity of IBD. Due to the complex pathogenic interactions between RAU and IBD. It is recommended that dentists and gastroenterologists should be aware of the bidirectional association between the two diseases for early recognition and multidisciplinary medical management.},
year = {2022}
}
TY - JOUR T1 - Bidirectional Study of Oral Recurrent Aphthous Ulcers and Inflammatory Bowel Disease AU - Xiang Guo AU - Jing-Yi Zhong AU - Sunchuri Diwas AU - Meng-Fei Zhou AU - Long Lian AU - Si-Yu Tao AU - Zhu-Ling Guo Y1 - 2022/12/15 PY - 2022 N1 - https://doi.org/10.11648/j.cmr.20221106.14 DO - 10.11648/j.cmr.20221106.14 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 172 EP - 177 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20221106.14 AB - Objective: To investigate the etiological mechanisms, treatment and oral manifestations of inflammatory bowel disease (IBD) in relation to recurrent aphthous ulcer (RAU). Materials and Methods: By summarizing and reviewing the research in the literature on the etiological mechanisms and treatment of RAU and IBD in the past decade in China and abroad. By summarizing and reviewing the research in the literature on the etiological mechanisms and treatment of RAU and IBD in the past decade in China and abroad. To explore the interaction between oral and intestinal lesions. Results: Some specific bacteria in the oral cavity may translocate and colonize the intestine, affecting the microecological balance of the gut and interfering with the disease process of IBD. Also, in patients with IBD, their oral salivary microbiome is altered and may show extraintestinal manifestations such as oral mucosal lesions. The occurrence of RAU may aggravate the dysbiosis and immune abnormalities of the intestinal mucosal flora that will be indirectly caused by patients with IBD, as well as malnutrition. Conclusion: Patients with IBD and RAU can affect the microecology of the oral-intestinal axis. patients with IBD are at increased risk of oral mucosal disease and oral symptoms and are associated with the activity of IBD. Due to the complex pathogenic interactions between RAU and IBD. It is recommended that dentists and gastroenterologists should be aware of the bidirectional association between the two diseases for early recognition and multidisciplinary medical management. VL - 11 IS - 6 ER -
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