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Current Research Status and Progress in Kümmell’s Disease

Received: 31 August 2022    Accepted: 15 September 2022    Published: 27 September 2022
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Abstract

With the arrival of an aging society, the incidence of Kümmell’s disease (KD), one of the complications of osteoporotic vertebral compression fracture (OVCF), has gradually increased, because it easily leads to vertebral instability and causes intractable pain or neurological dysfunction, and the disability rate of the disease is high, placing a serious burden on society and families. Since Dr. Kümmell Hermann first reported Kümmell’s disease in 1895, more than 100 years later, the pathogenesis of this disease has not been elucidated, but many scholars generally believe that the presence of intravertebral vacuum cleft (IVC) sign on imaging is a specific sign of vertebral ischemic osteonecrosis and Kümmell’s disease should be highly suspected. About two-thirds of patients with Kümmell’s disease have no significant back pain symptoms in the early stages, resulting in patients rarely going to the hospital for relevant examinations. At the same time, trivial injuries are easily overlooked by patients, so it is difficult to make an early diagnosis of this disease. Progressive kyphosis due to vertebral collapse has already developed in this disease at the time of diagnosis, so treatment becomes difficult, and there is currently no uniform guideline for the treatment of this disease. The purpose of this review is to discuss the latest research progress of Kümmell’s disease and provide some reference for spinal surgeons.

Published in European Journal of Clinical and Biomedical Sciences (Volume 8, Issue 5)
DOI 10.11648/j.ejcbs.20220805.11
Page(s) 71-74
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Osteoporosis, Kümmell’s Disease, Vertebral Fracture, Osteonecrosis, Intravertebral Vacuum Cleft

References
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[6] Steel H H. Kümmell's disease. The American Journal of Surgery, 1951, 81 (2): 161-167.
[7] Adamska O, Modzelewski K, Stolarczyk A, et al. Is Kummell's Disease a Misdiagnosed and/or an Underreported Complication of Osteoporotic Vertebral Compression Fractures? A Pattern of the Condition and Available Treatment Modalities. J Clin Med, 2021, 10 (12).
[8] Laredo J. Expert’s comment concerning Grand Rounds case entitled “Kümmell’s disease: delayed post-traumatic osteonecrosis of the vertebral body” (by R. Ma, R. Chow, F. H. Shen). European Spine Journal, 2010, 19 (7): 1071-1072.
[9] Benedek T G, Nicholas J J. Delayed traumatic vertebral body compression fracture; part II: pathologic features. Semin Arthritis Rheum, 1981, 10 (4): 271-277.
[10] Kümmell H. Ueber die traumatischen Erkrankungen der Wirbelsäule 1). DMW - Deutsche Medizinische Wochenschrift, 1895, 21 (11): 180-181.
[11] Maldague B E, Noel H M, Malghem J J. The Intravertebral Vacuum Cleft: A Sign of Ischemic Vertebral Collapse. Radiology, 1978, 129 (1): 23-29.
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[14] Li H, Liang C, Shen C, et al. Decreases in fluid shear stress due to microcracks: A possible primary pathogenesis of Kümmell’s disease. Medical hypotheses, 2011, 77 (5): 897-899.
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[18] VAN EENENAAM D P, EL-KHOURY G Y. Delayed post-traumatic vertebral collapse (Kummell's disease): case report with serial radiographs, computed tomographic scans, and bone scans. Spine (Philadelphia, Pa. 1976), 1993, 18 (9): 1236-1241.
[19] Theodorou D J. The intravertebral vacuum cleft sign. Radiology, 2001, 221 (3): 787-788.
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Cite This Article
  • APA Style

    Yude Xu. (2022). Current Research Status and Progress in Kümmell’s Disease. European Journal of Clinical and Biomedical Sciences, 8(5), 71-74. https://doi.org/10.11648/j.ejcbs.20220805.11

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    ACS Style

    Yude Xu. Current Research Status and Progress in Kümmell’s Disease. Eur. J. Clin. Biomed. Sci. 2022, 8(5), 71-74. doi: 10.11648/j.ejcbs.20220805.11

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    AMA Style

    Yude Xu. Current Research Status and Progress in Kümmell’s Disease. Eur J Clin Biomed Sci. 2022;8(5):71-74. doi: 10.11648/j.ejcbs.20220805.11

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  • @article{10.11648/j.ejcbs.20220805.11,
      author = {Yude Xu},
      title = {Current Research Status and Progress in Kümmell’s Disease},
      journal = {European Journal of Clinical and Biomedical Sciences},
      volume = {8},
      number = {5},
      pages = {71-74},
      doi = {10.11648/j.ejcbs.20220805.11},
      url = {https://doi.org/10.11648/j.ejcbs.20220805.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20220805.11},
      abstract = {With the arrival of an aging society, the incidence of Kümmell’s disease (KD), one of the complications of osteoporotic vertebral compression fracture (OVCF), has gradually increased, because it easily leads to vertebral instability and causes intractable pain or neurological dysfunction, and the disability rate of the disease is high, placing a serious burden on society and families. Since Dr. Kümmell Hermann first reported Kümmell’s disease in 1895, more than 100 years later, the pathogenesis of this disease has not been elucidated, but many scholars generally believe that the presence of intravertebral vacuum cleft (IVC) sign on imaging is a specific sign of vertebral ischemic osteonecrosis and Kümmell’s disease should be highly suspected. About two-thirds of patients with Kümmell’s disease have no significant back pain symptoms in the early stages, resulting in patients rarely going to the hospital for relevant examinations. At the same time, trivial injuries are easily overlooked by patients, so it is difficult to make an early diagnosis of this disease. Progressive kyphosis due to vertebral collapse has already developed in this disease at the time of diagnosis, so treatment becomes difficult, and there is currently no uniform guideline for the treatment of this disease. The purpose of this review is to discuss the latest research progress of Kümmell’s disease and provide some reference for spinal surgeons.},
     year = {2022}
    }
    

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    T2  - European Journal of Clinical and Biomedical Sciences
    JF  - European Journal of Clinical and Biomedical Sciences
    JO  - European Journal of Clinical and Biomedical Sciences
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    AB  - With the arrival of an aging society, the incidence of Kümmell’s disease (KD), one of the complications of osteoporotic vertebral compression fracture (OVCF), has gradually increased, because it easily leads to vertebral instability and causes intractable pain or neurological dysfunction, and the disability rate of the disease is high, placing a serious burden on society and families. Since Dr. Kümmell Hermann first reported Kümmell’s disease in 1895, more than 100 years later, the pathogenesis of this disease has not been elucidated, but many scholars generally believe that the presence of intravertebral vacuum cleft (IVC) sign on imaging is a specific sign of vertebral ischemic osteonecrosis and Kümmell’s disease should be highly suspected. About two-thirds of patients with Kümmell’s disease have no significant back pain symptoms in the early stages, resulting in patients rarely going to the hospital for relevant examinations. At the same time, trivial injuries are easily overlooked by patients, so it is difficult to make an early diagnosis of this disease. Progressive kyphosis due to vertebral collapse has already developed in this disease at the time of diagnosis, so treatment becomes difficult, and there is currently no uniform guideline for the treatment of this disease. The purpose of this review is to discuss the latest research progress of Kümmell’s disease and provide some reference for spinal surgeons.
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Author Information
  • Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China

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