Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review

Hossam Mohamed; Houda Almansour; Dalal Alsaadoun; Mariam Almansour; Sawsan Samy; Yasmin Almansour

doi:doi:10.11648/j.frontiers.20220201.14

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Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review

Hossam Mohamed, Houda Almansour, Dalal Alsaadoun, Mariam Almansour, Sawsan Samy, Yasmin Almansour

Published in Frontiers (Volume 2, Issue 1)

Received: 4 January 2022 Accepted: 20 January 2022 Published: 28 January 2022

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Abstract

Mitochondria are the powerhouse of the cells. They are linked only to energy production and some very rare cases of maternal diseases. Recent studies at Harvard University show that there is a cross-talk between the mitochondria and nucleus that is responsible for longevity and rejuvenation. These studies postulate that the talk is mainly done via an antegrade pathway through 3 genes namely Sirtuin, mTOR, and LINE-1. Meanwhile, a group of granted US patents (US9,757,583), (US9,452,297), (US9,579,520), (US9,433,798), (US9,795,802) had issued and discussed different methods of stimulation of the mitochondria. They claimed that there is another retrograde axis of the cross-talk. This axis depends on a mild increase of the nitric oxide (NO) that enhances the mitochondrial enzymes. The above patents also claimed that the retrograde axis has the upper hand over that of the antegrade axis in controlling the cross-talk process. It is believed that fighting the aging process could be much easier and accessible by the stimulation of the 2-way axes together.

Published in	Frontiers (Volume 2, Issue 1)
DOI	10.11648/j.frontiers.20220201.14
Page(s)	34-45
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

MCU, VDAC, Autophagy, Apoptosis, mTOR, LINE-1 Gene, Sirtuin

References

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APA Style

Hossam Mohamed, Houda Almansour, Dalal Alsaadoun, Mariam Almansour, Sawsan Samy, et al. (2022). Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review. Frontiers, 2(1), 34-45. https://doi.org/10.11648/j.frontiers.20220201.14

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ACS Style

Hossam Mohamed; Houda Almansour; Dalal Alsaadoun; Mariam Almansour; Sawsan Samy, et al. Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review. Frontiers. 2022, 2(1), 34-45. doi: 10.11648/j.frontiers.20220201.14

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AMA Style

Hossam Mohamed, Houda Almansour, Dalal Alsaadoun, Mariam Almansour, Sawsan Samy, et al. Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review. Frontiers. 2022;2(1):34-45. doi: 10.11648/j.frontiers.20220201.14

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@article{10.11648/j.frontiers.20220201.14,
  author = {Hossam Mohamed and Houda Almansour and Dalal Alsaadoun and Mariam Almansour and Sawsan Samy and Yasmin Almansour},
  title = {Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review},
  journal = {Frontiers},
  volume = {2},
  number = {1},
  pages = {34-45},
  doi = {10.11648/j.frontiers.20220201.14},
  url = {https://doi.org/10.11648/j.frontiers.20220201.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.frontiers.20220201.14},
  abstract = {Mitochondria are the powerhouse of the cells. They are linked only to energy production and some very rare cases of maternal diseases. Recent studies at Harvard University show that there is a cross-talk between the mitochondria and nucleus that is responsible for longevity and rejuvenation. These studies postulate that the talk is mainly done via an antegrade pathway through 3 genes namely Sirtuin, mTOR, and LINE-1. Meanwhile, a group of granted US patents (US9,757,583), (US9,452,297), (US9,579,520), (US9,433,798), (US9,795,802) had issued and discussed different methods of stimulation of the mitochondria. They claimed that there is another retrograde axis of the cross-talk. This axis depends on a mild increase of the nitric oxide (NO) that enhances the mitochondrial enzymes. The above patents also claimed that the retrograde axis has the upper hand over that of the antegrade axis in controlling the cross-talk process. It is believed that fighting the aging process could be much easier and accessible by the stimulation of the 2-way axes together.},
 year = {2022}
}

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TY - JOUR
T1 - Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review
AU - Hossam Mohamed
AU - Houda Almansour
AU - Dalal Alsaadoun
AU - Mariam Almansour
AU - Sawsan Samy
AU - Yasmin Almansour
Y1 - 2022/01/28
PY - 2022
N1 - https://doi.org/10.11648/j.frontiers.20220201.14
DO - 10.11648/j.frontiers.20220201.14
T2 - Frontiers
JF - Frontiers
JO - Frontiers
SP - 34
EP - 45
PB - Science Publishing Group
SN - 2994-7197
UR - https://doi.org/10.11648/j.frontiers.20220201.14
AB - Mitochondria are the powerhouse of the cells. They are linked only to energy production and some very rare cases of maternal diseases. Recent studies at Harvard University show that there is a cross-talk between the mitochondria and nucleus that is responsible for longevity and rejuvenation. These studies postulate that the talk is mainly done via an antegrade pathway through 3 genes namely Sirtuin, mTOR, and LINE-1. Meanwhile, a group of granted US patents (US9,757,583), (US9,452,297), (US9,579,520), (US9,433,798), (US9,795,802) had issued and discussed different methods of stimulation of the mitochondria. They claimed that there is another retrograde axis of the cross-talk. This axis depends on a mild increase of the nitric oxide (NO) that enhances the mitochondrial enzymes. The above patents also claimed that the retrograde axis has the upper hand over that of the antegrade axis in controlling the cross-talk process. It is believed that fighting the aging process could be much easier and accessible by the stimulation of the 2-way axes together.
VL - 2
IS - 1
ER -

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Author Information

Hossam Mohamed

Medical & Research Department, Huda Health INC, Ottawa, Canada
Houda Almansour

Medical & Research Department, Huda Health INC, Ottawa, Canada
Dalal Alsaadoun

Internal Medicine Department, College of Medicine, King Faisal University, Alahsa City, Saudi Arabia
Mariam Almansour

Department of Endocrinology, AlFaisalia Hospital, Alhafouf City, Saudi Arabia
Sawsan Samy

Medical & Research Department, Huda Health INC, Ottawa, Canada
Yasmin Almansour

Department of Palliative Care, Specialized King Fahad Hospital, Dammam City, Saudi Arabia

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APA Style

Hossam Mohamed, Houda Almansour, Dalal Alsaadoun, Mariam Almansour, Sawsan Samy, et al. (2022). Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review. Frontiers, 2(1), 34-45. https://doi.org/10.11648/j.frontiers.20220201.14

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ACS Style

Hossam Mohamed; Houda Almansour; Dalal Alsaadoun; Mariam Almansour; Sawsan Samy, et al. Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review. Frontiers. 2022, 2(1), 34-45. doi: 10.11648/j.frontiers.20220201.14

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AMA Style

Hossam Mohamed, Houda Almansour, Dalal Alsaadoun, Mariam Almansour, Sawsan Samy, et al. Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review. Frontiers. 2022;2(1):34-45. doi: 10.11648/j.frontiers.20220201.14

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@article{10.11648/j.frontiers.20220201.14,
  author = {Hossam Mohamed and Houda Almansour and Dalal Alsaadoun and Mariam Almansour and Sawsan Samy and Yasmin Almansour},
  title = {Hossam Retrograde Mitochondrial-Nuclear Axis is the Hidden Secret for Rejuvenation: Granted US Patents Review},
  journal = {Frontiers},
  volume = {2},
  number = {1},
  pages = {34-45},
  doi = {10.11648/j.frontiers.20220201.14},
  url = {https://doi.org/10.11648/j.frontiers.20220201.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.frontiers.20220201.14},
  abstract = {Mitochondria are the powerhouse of the cells. They are linked only to energy production and some very rare cases of maternal diseases. Recent studies at Harvard University show that there is a cross-talk between the mitochondria and nucleus that is responsible for longevity and rejuvenation. These studies postulate that the talk is mainly done via an antegrade pathway through 3 genes namely Sirtuin, mTOR, and LINE-1. Meanwhile, a group of granted US patents (US9,757,583), (US9,452,297), (US9,579,520), (US9,433,798), (US9,795,802) had issued and discussed different methods of stimulation of the mitochondria. They claimed that there is another retrograde axis of the cross-talk. This axis depends on a mild increase of the nitric oxide (NO) that enhances the mitochondrial enzymes. The above patents also claimed that the retrograde axis has the upper hand over that of the antegrade axis in controlling the cross-talk process. It is believed that fighting the aging process could be much easier and accessible by the stimulation of the 2-way axes together.},
 year = {2022}
}

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