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Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions

Received: 31 October 2017     Accepted: 13 November 2017     Published: 27 December 2017
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Abstract

The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melting Point and Conductivity Measurements. On the basis of this study, it is proven that Acetaminophen acts as a bidentate ligand coordinated to the metal ions through phenol and carbonyl oxygen atom. The acute toxic effect was carried out by the method and the rats were found to be moderately toxic and slightly toxic. The test complexes in general showed maximum inhibition percentage at about 3 hours, after 4 hours it goes on reducing and reaches a minimum at about 5 hours.

Published in International Journal of Biomedical Materials Research (Volume 5, Issue 6)
DOI 10.11648/j.ijbmr.20170506.13
Page(s) 78-83
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Acetaminophen, Anti-inflammatory, Acute Toxicity, Metal Complexes

References
[1] A. M. Larson, J. Polson, R. J. Fontana, T. J. Davern, E. Lalani, L. S. Hynan and W. M. Lee, (2005), Acetaminophen‐induced acute liver failure: results of a United States multicenter, prospective study. Hepatology, 42 (6), 1364-1372.
[2] A. Ottani, S. Leone, M. Sandrini, A. Ferrari, and A. Bertolini (2006), "The analgesic activity of paracetamol” European Journal of Pharmacology. 531 (1-3): 280–281.
[3] A. A. Osowale, O. Agbaje, B. O Ojo (2014) synthesis, spectroscopic characterization and antibacterial properties of some heteroleptic metal (II) mixed ligand complexes of paracetamol and Vanillin. Asian journal of pharmaceutical and clinical Research.
[4] Shraddha Shukla and A. S Mishra, (2014), Metal complexes used as anti-inflammatory agents: Synthesis, characterization and anti-inflammatory action of VO (II)-complexes, Arabian Journal of Chemistry.
[5] B. A. Oluwatoosin, M. W Sherifat, Aderoju A. Osowole (2014) Synthesis, spectroscopic characterisation and antimicrobial activities of some mixed drug meta l (II) complexes of Sulfamethoxazole and Paracetamol, Asian journal of pharmaceutical and clinical Research.
[6] M. S. Refat, A. Sabry, El-Korashy and A. H. Mostafa (2013), Ligational, Spectroscopic (Infrared and Electronic) and Thermal Studies on the Mn (II), Co (II), Fe (II) and Cu (II) Complexes with Analgesic Drugs, Canadian Chemical Transactions.
[7] D. Lorke (1983). A new approach to practical acute toxicity testing. Archives of toxicology, 54 (4), 275-287.
[8] C. A. Winter, E. A. Risley, and G. W. Nuss (1962), Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Experimental Biology and Medicine, 111 (3), 544-547.
[9] J. Coates, (2000). Interpretation of infrared spectra, a practical approach. Encyclopedia of analytical chemistry.
[10] F. M. Gulam, and V. L. Manohar, (2014). Synthesis of Ferrocene Based Organometallic Compounds & Antimicrobial Activity, Journal of Applied Chemistry. 7 (1). 27-32.
[11] P. Kavitha, M Saritha, R. Laxma (2013), Synthesis, structural characterization, fluorescence, antimicrobial, antioxidant and DNA cleavage studies of Cu (II) complexes of formyl chromone Schiff bases, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, (102). 159-161.
[12] A. Hodge, and B. Sterner (2005), Toxicity classes in: Canadian Centre for occupational health and Safety. Copyright@ 1997–2010.
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    John Akwu Faruna, Elaoyi David Paul, Yakubu Ali Dallatu. (2017). Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions. International Journal of Biomedical Materials Research, 5(6), 78-83. https://doi.org/10.11648/j.ijbmr.20170506.13

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    ACS Style

    John Akwu Faruna; Elaoyi David Paul; Yakubu Ali Dallatu. Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions. Int. J. Biomed. Mater. Res. 2017, 5(6), 78-83. doi: 10.11648/j.ijbmr.20170506.13

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    AMA Style

    John Akwu Faruna, Elaoyi David Paul, Yakubu Ali Dallatu. Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions. Int J Biomed Mater Res. 2017;5(6):78-83. doi: 10.11648/j.ijbmr.20170506.13

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  • @article{10.11648/j.ijbmr.20170506.13,
      author = {John Akwu Faruna and Elaoyi David Paul and Yakubu Ali Dallatu},
      title = {Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions},
      journal = {International Journal of Biomedical Materials Research},
      volume = {5},
      number = {6},
      pages = {78-83},
      doi = {10.11648/j.ijbmr.20170506.13},
      url = {https://doi.org/10.11648/j.ijbmr.20170506.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20170506.13},
      abstract = {The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melting Point and Conductivity Measurements. On the basis of this study, it is proven that Acetaminophen acts as a bidentate ligand coordinated to the metal ions through phenol and carbonyl oxygen atom. The acute toxic effect was carried out by the method and the rats were found to be moderately toxic and slightly toxic. The test complexes in general showed maximum inhibition percentage at about 3 hours, after 4 hours it goes on reducing and reaches a minimum at about 5 hours.},
     year = {2017}
    }
    

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    T1  - Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions
    AU  - John Akwu Faruna
    AU  - Elaoyi David Paul
    AU  - Yakubu Ali Dallatu
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    DO  - 10.11648/j.ijbmr.20170506.13
    T2  - International Journal of Biomedical Materials Research
    JF  - International Journal of Biomedical Materials Research
    JO  - International Journal of Biomedical Materials Research
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    EP  - 83
    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.ijbmr.20170506.13
    AB  - The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melting Point and Conductivity Measurements. On the basis of this study, it is proven that Acetaminophen acts as a bidentate ligand coordinated to the metal ions through phenol and carbonyl oxygen atom. The acute toxic effect was carried out by the method and the rats were found to be moderately toxic and slightly toxic. The test complexes in general showed maximum inhibition percentage at about 3 hours, after 4 hours it goes on reducing and reaches a minimum at about 5 hours.
    VL  - 5
    IS  - 6
    ER  - 

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Author Information
  • Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria

  • Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria

  • Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria

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