Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars

Pdiangty Giri Mawlong; Surabhi Dayal; Nishant Bisht

doi:doi:10.11648/j.ijcd.20210402.11

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Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars

Pdiangty Giri Mawlong, Surabhi Dayal, Nishant Bisht

Published in International Journal of Clinical Dermatology (Volume 4, Issue 2)

Received: 25 August 2021 Accepted: 8 September 2021 Published: 14 September 2021

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Abstract

Introduction: Atrophic acne scars are dermal depressions resulting from destruction of collagen after inflammatory acne which can lead to poor self-image and treating them can help improve patients’ self-esteem. Objectives: This study compared the efficacy and safety of combination of microneedling using dermaroller with topical application of autologous platelet rich plasma versus microneedling using dermaroller alone in facial atrophic acne scars. Methods: Patients with atrophic acne scars were randomized into 2 groups of 20 patients each and treated with either dermaroller alone or with a combination of dermaroller and topical application of autologous PRP at 4 weeks intervals for 16 weeks. Final response was evaluated at 4 weeks after the last sitting. Goodman and Baron’s qualitative acne scarring grading system, Goodman and Baron’s quantitative acne scar grading system, physician’s global assessment (PGA) and visual analogue scale were used to evaluate the treatment outcome in both the groups. Side effects were also noted at each visit. Results: At the end of treatment, improvement in Goodman and Baron’s qualitative acne scar grades, decrease in mean Goodman and Baron’s quantitative acne scar scores, percentage decrease in mean Goodman and Baron’s quantitative acne scar scores, physician global assessment and visual analogue scale were significantly higher in patients treated with dermaroller in combination with topical autologous PRP as compared to patients treated with dermaroller alone without much adverse effects. Conclusion: The combination approach using dermaroller and PRP was a better treatment option compared to dermaroller alone in atrophic acne scars with similar safety profile.

Published in	International Journal of Clinical Dermatology (Volume 4, Issue 2)
DOI	10.11648/j.ijcd.20210402.11
Page(s)	10-15
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Acne Scars, Dermaroller, Platelet Rich Plasma

References

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[3]	El-Domyati M, Barakat M, Awad S, Medhat W, El-Fakahany H, Farag H. Microneedling Therapy for Atrophic Acne Scars: An Objective Evaluation. J Clin Aesthet Dermatol 2015; 8: 36-42.
[4]	Jacob CI, Dover JS, Kaminer MS. Acne scarring: a classification system and review of treatment options 2001; 19: 109-17.
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[6]	Doddaballapur S. Microneedling with Dermaroller. J Cutan Aesthet Surg 2009; 2: 110-11.
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[8]	Leo MS, Kumar AS, Kirit R, konathan R, Sivamani RK. Systematic review of the use of platelet-rich plasma in aesthetic dermatology. J Cosmet Dermatol 2015; 14: 315-23.
[9]	Saeed M, Elethawi A, Al-Ani Z, Abdullah R. Application of fractional microneedling radio-frequency and autologous platelet in managing facial Acne scars. Br J Med Med Res 2016; 14: 1-18.
[10]	Chawla S. Split face comparative study of microneedling with PRP versus microneedling with vitamin C in treating atrophic post acne scars. J Cutan Aesthet Surg 2014; 7: 209-12.
[11]	Fabbrocini G, De Vita V, Pastore F, Panariello L, Fardella N, Sepulveres R, et al. Combined use of skin needling and platelet-rich plasma in acne scarring treatment. Cosmet Dermatol 2011; 24: 177-83.
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[16]	Yaseen U, Shah S, Bashir A. Combination of platelet rich plasma and microneedling in the management of atrophic acne scars. Int J Res Dermatol 2017; 3 (3): 346-50.
[17]	Porwal S, Chahar YS, Singh PK. A comparative study of combined dermaroller and platelet-rich plasma versus dermaroller alone in acne scars and assessment of quality of life before and after treatment. Indian J Dermatol 2018; 63: 403-8.
[18]	Ibrahim MK, Ibrahim SM, Salem AM. Skin microneedling plus platelet-rich plasma versus skin microneedling alone in the treatment of atrophic post acne scars: a split face comparative study. J Dermatolog Treat 2018; 63: 403-8.
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[20]	Majid I. Microneedling Therapy in Atrophic Facial Scars: An Objective Assessment. J Cutan Aesthet Surg 2009; 2: 26-3.

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APA Style

Pdiangty Giri Mawlong, Surabhi Dayal, Nishant Bisht. (2021). Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars. International Journal of Clinical Dermatology, 4(2), 10-15. https://doi.org/10.11648/j.ijcd.20210402.11

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ACS Style

Pdiangty Giri Mawlong; Surabhi Dayal; Nishant Bisht. Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars. Int. J. Clin. Dermatol. 2021, 4(2), 10-15. doi: 10.11648/j.ijcd.20210402.11

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AMA Style

Pdiangty Giri Mawlong, Surabhi Dayal, Nishant Bisht. Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars. Int J Clin Dermatol. 2021;4(2):10-15. doi: 10.11648/j.ijcd.20210402.11

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@article{10.11648/j.ijcd.20210402.11,
  author = {Pdiangty Giri Mawlong and Surabhi Dayal and Nishant Bisht},
  title = {Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars},
  journal = {International Journal of Clinical Dermatology},
  volume = {4},
  number = {2},
  pages = {10-15},
  doi = {10.11648/j.ijcd.20210402.11},
  url = {https://doi.org/10.11648/j.ijcd.20210402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcd.20210402.11},
  abstract = {Introduction: Atrophic acne scars are dermal depressions resulting from destruction of collagen after inflammatory acne which can lead to poor self-image and treating them can help improve patients’ self-esteem. Objectives: This study compared the efficacy and safety of combination of microneedling using dermaroller with topical application of autologous platelet rich plasma versus microneedling using dermaroller alone in facial atrophic acne scars. Methods: Patients with atrophic acne scars were randomized into 2 groups of 20 patients each and treated with either dermaroller alone or with a combination of dermaroller and topical application of autologous PRP at 4 weeks intervals for 16 weeks. Final response was evaluated at 4 weeks after the last sitting. Goodman and Baron’s qualitative acne scarring grading system, Goodman and Baron’s quantitative acne scar grading system, physician’s global assessment (PGA) and visual analogue scale were used to evaluate the treatment outcome in both the groups. Side effects were also noted at each visit. Results: At the end of treatment, improvement in Goodman and Baron’s qualitative acne scar grades, decrease in mean Goodman and Baron’s quantitative acne scar scores, percentage decrease in mean Goodman and Baron’s quantitative acne scar scores, physician global assessment and visual analogue scale were significantly higher in patients treated with dermaroller in combination with topical autologous PRP as compared to patients treated with dermaroller alone without much adverse effects. Conclusion: The combination approach using dermaroller and PRP was a better treatment option compared to dermaroller alone in atrophic acne scars with similar safety profile.},
 year = {2021}
}

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TY  - JOUR
T1  - Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars
AU  - Pdiangty Giri Mawlong
AU  - Surabhi Dayal
AU  - Nishant Bisht
Y1  - 2021/09/14
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcd.20210402.11
DO  - 10.11648/j.ijcd.20210402.11
T2  - International Journal of Clinical Dermatology
JF  - International Journal of Clinical Dermatology
JO  - International Journal of Clinical Dermatology
SP  - 10
EP  - 15
PB  - Science Publishing Group
SN  - 2995-1305
UR  - https://doi.org/10.11648/j.ijcd.20210402.11
AB  - Introduction: Atrophic acne scars are dermal depressions resulting from destruction of collagen after inflammatory acne which can lead to poor self-image and treating them can help improve patients’ self-esteem. Objectives: This study compared the efficacy and safety of combination of microneedling using dermaroller with topical application of autologous platelet rich plasma versus microneedling using dermaroller alone in facial atrophic acne scars. Methods: Patients with atrophic acne scars were randomized into 2 groups of 20 patients each and treated with either dermaroller alone or with a combination of dermaroller and topical application of autologous PRP at 4 weeks intervals for 16 weeks. Final response was evaluated at 4 weeks after the last sitting. Goodman and Baron’s qualitative acne scarring grading system, Goodman and Baron’s quantitative acne scar grading system, physician’s global assessment (PGA) and visual analogue scale were used to evaluate the treatment outcome in both the groups. Side effects were also noted at each visit. Results: At the end of treatment, improvement in Goodman and Baron’s qualitative acne scar grades, decrease in mean Goodman and Baron’s quantitative acne scar scores, percentage decrease in mean Goodman and Baron’s quantitative acne scar scores, physician global assessment and visual analogue scale were significantly higher in patients treated with dermaroller in combination with topical autologous PRP as compared to patients treated with dermaroller alone without much adverse effects. Conclusion: The combination approach using dermaroller and PRP was a better treatment option compared to dermaroller alone in atrophic acne scars with similar safety profile.
VL  - 4
IS  - 2
ER  -

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Author Information

Pdiangty Giri Mawlong

Dermatology Department, Government Medical College, Haldwani, India
Surabhi Dayal

Dermatology Department, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India
Nishant Bisht

Surgery Department, Government Medical College, Haldwani, India

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APA Style

Pdiangty Giri Mawlong, Surabhi Dayal, Nishant Bisht. (2021). Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars. International Journal of Clinical Dermatology, 4(2), 10-15. https://doi.org/10.11648/j.ijcd.20210402.11

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ACS Style

Pdiangty Giri Mawlong; Surabhi Dayal; Nishant Bisht. Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars. Int. J. Clin. Dermatol. 2021, 4(2), 10-15. doi: 10.11648/j.ijcd.20210402.11

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AMA Style

Pdiangty Giri Mawlong, Surabhi Dayal, Nishant Bisht. Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars. Int J Clin Dermatol. 2021;4(2):10-15. doi: 10.11648/j.ijcd.20210402.11

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@article{10.11648/j.ijcd.20210402.11,
  author = {Pdiangty Giri Mawlong and Surabhi Dayal and Nishant Bisht},
  title = {Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars},
  journal = {International Journal of Clinical Dermatology},
  volume = {4},
  number = {2},
  pages = {10-15},
  doi = {10.11648/j.ijcd.20210402.11},
  url = {https://doi.org/10.11648/j.ijcd.20210402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcd.20210402.11},
  abstract = {Introduction: Atrophic acne scars are dermal depressions resulting from destruction of collagen after inflammatory acne which can lead to poor self-image and treating them can help improve patients’ self-esteem. Objectives: This study compared the efficacy and safety of combination of microneedling using dermaroller with topical application of autologous platelet rich plasma versus microneedling using dermaroller alone in facial atrophic acne scars. Methods: Patients with atrophic acne scars were randomized into 2 groups of 20 patients each and treated with either dermaroller alone or with a combination of dermaroller and topical application of autologous PRP at 4 weeks intervals for 16 weeks. Final response was evaluated at 4 weeks after the last sitting. Goodman and Baron’s qualitative acne scarring grading system, Goodman and Baron’s quantitative acne scar grading system, physician’s global assessment (PGA) and visual analogue scale were used to evaluate the treatment outcome in both the groups. Side effects were also noted at each visit. Results: At the end of treatment, improvement in Goodman and Baron’s qualitative acne scar grades, decrease in mean Goodman and Baron’s quantitative acne scar scores, percentage decrease in mean Goodman and Baron’s quantitative acne scar scores, physician global assessment and visual analogue scale were significantly higher in patients treated with dermaroller in combination with topical autologous PRP as compared to patients treated with dermaroller alone without much adverse effects. Conclusion: The combination approach using dermaroller and PRP was a better treatment option compared to dermaroller alone in atrophic acne scars with similar safety profile.},
 year = {2021}
}

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TY  - JOUR
T1  - Comparative Study of Efficacy and Safety of Microneedling with Topical Autologous Platelet Rich Plasma Versus Microneedling Alone in Facial Atrophic Acne Scars
AU  - Pdiangty Giri Mawlong
AU  - Surabhi Dayal
AU  - Nishant Bisht
Y1  - 2021/09/14
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcd.20210402.11
DO  - 10.11648/j.ijcd.20210402.11
T2  - International Journal of Clinical Dermatology
JF  - International Journal of Clinical Dermatology
JO  - International Journal of Clinical Dermatology
SP  - 10
EP  - 15
PB  - Science Publishing Group
SN  - 2995-1305
UR  - https://doi.org/10.11648/j.ijcd.20210402.11
AB  - Introduction: Atrophic acne scars are dermal depressions resulting from destruction of collagen after inflammatory acne which can lead to poor self-image and treating them can help improve patients’ self-esteem. Objectives: This study compared the efficacy and safety of combination of microneedling using dermaroller with topical application of autologous platelet rich plasma versus microneedling using dermaroller alone in facial atrophic acne scars. Methods: Patients with atrophic acne scars were randomized into 2 groups of 20 patients each and treated with either dermaroller alone or with a combination of dermaroller and topical application of autologous PRP at 4 weeks intervals for 16 weeks. Final response was evaluated at 4 weeks after the last sitting. Goodman and Baron’s qualitative acne scarring grading system, Goodman and Baron’s quantitative acne scar grading system, physician’s global assessment (PGA) and visual analogue scale were used to evaluate the treatment outcome in both the groups. Side effects were also noted at each visit. Results: At the end of treatment, improvement in Goodman and Baron’s qualitative acne scar grades, decrease in mean Goodman and Baron’s quantitative acne scar scores, percentage decrease in mean Goodman and Baron’s quantitative acne scar scores, physician global assessment and visual analogue scale were significantly higher in patients treated with dermaroller in combination with topical autologous PRP as compared to patients treated with dermaroller alone without much adverse effects. Conclusion: The combination approach using dermaroller and PRP was a better treatment option compared to dermaroller alone in atrophic acne scars with similar safety profile.
VL  - 4
IS  - 2
ER  -

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