Mycosis Fongoïde is a rare T cell lymphoma. The mean age of onset is about sixty year old, mostly in masculin population. The clinical presentation is dominated by cutaneous signs. We report the case of a 78 year old patient, with a history of erythroderma with pruritus non ameliorated by corticosteroid topics, who was readmitted four years later for osteomyelopathy. At physical examination, he had bilateral axillary lymph nodes. We also noted dry generalized erythroderma with no interval of healthy skin and at the neurologic exam, there was ataxia on walking and a bilateral pyramidal syndrome majorated on the right. The blood count showed hyperleukocytosis with hyperlymphocytosis and chronic hypereosinophilia. The blood smear showed Sezary cells of the order of 2000. The CT scan has confirmed the presence of axillary adenopathies, left breast nodules not found on breast ultrasound, and bilateral adenomegaly of the external iliac and inguinal chains. The first cutaneous biopsy was not conclusive. Axillary node biopsy, 6th skin biopsy and Immunophenotyping of circulating CD4+ T lymphoctes allowed to retain Mycosis fungoides. He was treated with Methotrexate for a year with improvement. Mycosis Fungoides is a rare disease with diagnostic and therapeutic difficulties due to the non contribution of confirmatory examinations wich may delay the diagnostic and with a possibility of atypical presentation.
| Published in | International Journal of Clinical Dermatology (Volume 5, Issue 2) |
| DOI | 10.11648/j.ijcd.20220502.11 |
| Page(s) | 11-14 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Cutaneous Lymphoma, Epidermotropic Lymphoma, Mycosis Fungoides, Sezary's Syndrome
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APA Style
Roua Mankai, Fatma Daoud, Imene Rachdi, Fatma Khanchel, Mehdi Somai, et al. (2022). Mycosis Fungoïdes in an Old Patient: A Diagnostic Challenge. International Journal of Clinical Dermatology, 5(2), 11-14. https://doi.org/10.11648/j.ijcd.20220502.11
ACS Style
Roua Mankai; Fatma Daoud; Imene Rachdi; Fatma Khanchel; Mehdi Somai, et al. Mycosis Fungoïdes in an Old Patient: A Diagnostic Challenge. Int. J. Clin. Dermatol. 2022, 5(2), 11-14. doi: 10.11648/j.ijcd.20220502.11
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Download@article{10.11648/j.ijcd.20220502.11,
author = {Roua Mankai and Fatma Daoud and Imene Rachdi and Fatma Khanchel and Mehdi Somai and Hana Zoubeidi and Besma Ben Dhaou and Zohra Aydi and Aschraf Chadli Debbiche and Anissa Zaouak and Fatma Boussema},
title = {Mycosis Fungoïdes in an Old Patient: A Diagnostic Challenge},
journal = {International Journal of Clinical Dermatology},
volume = {5},
number = {2},
pages = {11-14},
doi = {10.11648/j.ijcd.20220502.11},
url = {https://doi.org/10.11648/j.ijcd.20220502.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcd.20220502.11},
abstract = {Mycosis Fongoïde is a rare T cell lymphoma. The mean age of onset is about sixty year old, mostly in masculin population. The clinical presentation is dominated by cutaneous signs. We report the case of a 78 year old patient, with a history of erythroderma with pruritus non ameliorated by corticosteroid topics, who was readmitted four years later for osteomyelopathy. At physical examination, he had bilateral axillary lymph nodes. We also noted dry generalized erythroderma with no interval of healthy skin and at the neurologic exam, there was ataxia on walking and a bilateral pyramidal syndrome majorated on the right. The blood count showed hyperleukocytosis with hyperlymphocytosis and chronic hypereosinophilia. The blood smear showed Sezary cells of the order of 2000. The CT scan has confirmed the presence of axillary adenopathies, left breast nodules not found on breast ultrasound, and bilateral adenomegaly of the external iliac and inguinal chains. The first cutaneous biopsy was not conclusive. Axillary node biopsy, 6th skin biopsy and Immunophenotyping of circulating CD4+ T lymphoctes allowed to retain Mycosis fungoides. He was treated with Methotrexate for a year with improvement. Mycosis Fungoides is a rare disease with diagnostic and therapeutic difficulties due to the non contribution of confirmatory examinations wich may delay the diagnostic and with a possibility of atypical presentation.},
year = {2022}
}
TY - JOUR T1 - Mycosis Fungoïdes in an Old Patient: A Diagnostic Challenge AU - Roua Mankai AU - Fatma Daoud AU - Imene Rachdi AU - Fatma Khanchel AU - Mehdi Somai AU - Hana Zoubeidi AU - Besma Ben Dhaou AU - Zohra Aydi AU - Aschraf Chadli Debbiche AU - Anissa Zaouak AU - Fatma Boussema Y1 - 2022/09/29 PY - 2022 N1 - https://doi.org/10.11648/j.ijcd.20220502.11 DO - 10.11648/j.ijcd.20220502.11 T2 - International Journal of Clinical Dermatology JF - International Journal of Clinical Dermatology JO - International Journal of Clinical Dermatology SP - 11 EP - 14 PB - Science Publishing Group SN - 2995-1305 UR - https://doi.org/10.11648/j.ijcd.20220502.11 AB - Mycosis Fongoïde is a rare T cell lymphoma. The mean age of onset is about sixty year old, mostly in masculin population. The clinical presentation is dominated by cutaneous signs. We report the case of a 78 year old patient, with a history of erythroderma with pruritus non ameliorated by corticosteroid topics, who was readmitted four years later for osteomyelopathy. At physical examination, he had bilateral axillary lymph nodes. We also noted dry generalized erythroderma with no interval of healthy skin and at the neurologic exam, there was ataxia on walking and a bilateral pyramidal syndrome majorated on the right. The blood count showed hyperleukocytosis with hyperlymphocytosis and chronic hypereosinophilia. The blood smear showed Sezary cells of the order of 2000. The CT scan has confirmed the presence of axillary adenopathies, left breast nodules not found on breast ultrasound, and bilateral adenomegaly of the external iliac and inguinal chains. The first cutaneous biopsy was not conclusive. Axillary node biopsy, 6th skin biopsy and Immunophenotyping of circulating CD4+ T lymphoctes allowed to retain Mycosis fungoides. He was treated with Methotrexate for a year with improvement. Mycosis Fungoides is a rare disease with diagnostic and therapeutic difficulties due to the non contribution of confirmatory examinations wich may delay the diagnostic and with a possibility of atypical presentation. VL - 5 IS - 2 ER -
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