@article{10.11648/j.ijec.20210501.11,
  author = {Uzma Jabbar and Mazhar Mushtaq and Javed Anver Qureshi},
  title = {Serum Nickel Levels Compromise the Oxidative Status and Lung Functions in Ceramic Workers},
  journal = {International Journal of Environmental Chemistry},
  volume = {5},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.ijec.20210501.11},
  url = {https://doi.org/10.11648/j.ijec.20210501.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijec.20210501.11},
  abstract = {Nickel, in the form of various alloys and compounds, has been in widespread commercial use for over 100 years. Several million workers worldwide are exposed to airborne fumes, dust, and mist containing nickel and its compounds. Further, exposures by inhalation, ingestion, or skin contact occur in nickel-producing industries, like mining, milling, melting, and refining, and in nickel-using industries, like electroplating, welding, and grinding. Insoluble nickel is the predominant exposure in nickel-producing industries, whereas soluble nickel is the predominant exposure in nickel-using industries like the ceramics industry. This study was designed to extrapolate the levels of serum nickel, antioxidant compounds, and stress markers and correlate them with lung function status in craft workers in the ceramics industry. The study included 50 fiber craft workers from the ceramics industry who met the inclusion criteria. The control group consisted of subjects from the general population with no disease. Blood samples from the workers were collected by a phlebotomist. The levels of nickel and biological antioxidants, i.e. serum glutathione (GSH) and stress marker malondialdehye (MDA), were determined. Estimation of oxidants and haptoglobin (Hp) levels were assessed. The level of nickel was measured by atomic absorption spectrophotometry. A spirometer was used to measure lung functions. The calculated levels of these parameters were compared with those in the control subjects. An overall increase in nickel and MDA levels and a decrease in GSH level were observed. When these workers were classified into groups, it was observed that prolonged employment in the ceramics industry was associated with an increased nickel concentration in the serum, which in turn increased oxidative stress biomarkers and thus decreased the antioxidant levels to the lower limit. The decrease in GSH level compromises lung function. Our findings of an increase the Hp level is noteworthy, as it increased by 89% in the group with over 10 years of service in the industry compared with the group working for less than 5 years. Prolonged exposure of nickel increases the oxidative stress, in terms of increased MDA level and decreased GSH level. These findings can compromise the lung function and increase the Hp level.},
 year = {2021}
}

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TY  - JOUR
T1  - Serum Nickel Levels Compromise the Oxidative Status and Lung Functions in Ceramic Workers
AU  - Uzma Jabbar
AU  - Mazhar Mushtaq
AU  - Javed Anver Qureshi
Y1  - 2021/03/30
PY  - 2021
N1  - https://doi.org/10.11648/j.ijec.20210501.11
DO  - 10.11648/j.ijec.20210501.11
T2  - International Journal of Environmental Chemistry
JF  - International Journal of Environmental Chemistry
JO  - International Journal of Environmental Chemistry
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2640-1460
UR  - https://doi.org/10.11648/j.ijec.20210501.11
AB  - Nickel, in the form of various alloys and compounds, has been in widespread commercial use for over 100 years. Several million workers worldwide are exposed to airborne fumes, dust, and mist containing nickel and its compounds. Further, exposures by inhalation, ingestion, or skin contact occur in nickel-producing industries, like mining, milling, melting, and refining, and in nickel-using industries, like electroplating, welding, and grinding. Insoluble nickel is the predominant exposure in nickel-producing industries, whereas soluble nickel is the predominant exposure in nickel-using industries like the ceramics industry. This study was designed to extrapolate the levels of serum nickel, antioxidant compounds, and stress markers and correlate them with lung function status in craft workers in the ceramics industry. The study included 50 fiber craft workers from the ceramics industry who met the inclusion criteria. The control group consisted of subjects from the general population with no disease. Blood samples from the workers were collected by a phlebotomist. The levels of nickel and biological antioxidants, i.e. serum glutathione (GSH) and stress marker malondialdehye (MDA), were determined. Estimation of oxidants and haptoglobin (Hp) levels were assessed. The level of nickel was measured by atomic absorption spectrophotometry. A spirometer was used to measure lung functions. The calculated levels of these parameters were compared with those in the control subjects. An overall increase in nickel and MDA levels and a decrease in GSH level were observed. When these workers were classified into groups, it was observed that prolonged employment in the ceramics industry was associated with an increased nickel concentration in the serum, which in turn increased oxidative stress biomarkers and thus decreased the antioxidant levels to the lower limit. The decrease in GSH level compromises lung function. Our findings of an increase the Hp level is noteworthy, as it increased by 89% in the group with over 10 years of service in the industry compared with the group working for less than 5 years. Prolonged exposure of nickel increases the oxidative stress, in terms of increased MDA level and decreased GSH level. These findings can compromise the lung function and increase the Hp level.
VL  - 5
IS  - 1
ER  - 

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