Background: The autoimmunity associated with environmental pollutants such as heavy metals is a phenomenon that has been described previously. The aim of the present study investigated the relationship between autoimmunity and lead pollutants in a cohort of children who lived in a mining settlement. Methods: Children were studied clinically and serologically. The serum lead concentration was measured by atomic absorption spectrometry, and antinuclear antibodies were analysed by immunofluorescence, ELISA and Western blot. Results: None of the studied children displayed any autoimmune disease. The lead concentration in the control group was negligible, at 0.10 ± 011 μg. L-1. In contrast, the study group had values of 12.72 ± 0.5 μg. L-1. The differences between the groups were significant (p < 0.0001). In addition, control sera were negative for antinuclear antibodies (ANA), while the sera of children living near the mining settlement showed ANA-positive titres (p < 0.001). These autoantibodies mainly recognized antigens associated with dividing cells, such as the mitotic apparatus and centrioles. Conclusion: The present results show how metallic pollutants induce environmentally associated autoimmunity and are reflected by antinuclear antibodies. This research should prompt us to take greater caution and implement permanent monitoring to ensure a healthy environment.
| Published in | International Journal of Immunology (Volume 9, Issue 1) |
| DOI | 10.11648/j.iji.20210901.14 |
| Page(s) | 16-21 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Autoimmunity, Autoimmune Diseases, Autoantibodies, Antinuclear Antibodies, Enviromental Pollutants, Humoral Immunity
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APA Style
Deyanira Pacheco-Tovar, María-Guadalupe Pacheco-Tovar, Esperanza Avalos-Díaz, Juan-José Bollain-y-Goytia, María-Elena Pérez-Pérez, et al. (2021). Associated Autoimmunity and Lead Exposure in Childhood. International Journal of Immunology, 9(1), 16-21. https://doi.org/10.11648/j.iji.20210901.14
ACS Style
Deyanira Pacheco-Tovar; María-Guadalupe Pacheco-Tovar; Esperanza Avalos-Díaz; Juan-José Bollain-y-Goytia; María-Elena Pérez-Pérez, et al. Associated Autoimmunity and Lead Exposure in Childhood. Int. J. Immunol. 2021, 9(1), 16-21. doi: 10.11648/j.iji.20210901.14
AMA Style
Deyanira Pacheco-Tovar, María-Guadalupe Pacheco-Tovar, Esperanza Avalos-Díaz, Juan-José Bollain-y-Goytia, María-Elena Pérez-Pérez, et al. Associated Autoimmunity and Lead Exposure in Childhood. Int J Immunol. 2021;9(1):16-21. doi: 10.11648/j.iji.20210901.14
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Download@article{10.11648/j.iji.20210901.14,
author = {Deyanira Pacheco-Tovar and María-Guadalupe Pacheco-Tovar and Esperanza Avalos-Díaz and Juan-José Bollain-y-Goytia and María-Elena Pérez-Pérez and Roxana Ramírez-Sandoval and Argelia López-Luna and Rafael Herrera-Esparza},
title = {Associated Autoimmunity and Lead Exposure in Childhood},
journal = {International Journal of Immunology},
volume = {9},
number = {1},
pages = {16-21},
doi = {10.11648/j.iji.20210901.14},
url = {https://doi.org/10.11648/j.iji.20210901.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20210901.14},
abstract = {Background: The autoimmunity associated with environmental pollutants such as heavy metals is a phenomenon that has been described previously. The aim of the present study investigated the relationship between autoimmunity and lead pollutants in a cohort of children who lived in a mining settlement. Methods: Children were studied clinically and serologically. The serum lead concentration was measured by atomic absorption spectrometry, and antinuclear antibodies were analysed by immunofluorescence, ELISA and Western blot. Results: None of the studied children displayed any autoimmune disease. The lead concentration in the control group was negligible, at 0.10 ± 011 μg. L-1. In contrast, the study group had values of 12.72 ± 0.5 μg. L-1. The differences between the groups were significant (p < 0.0001). In addition, control sera were negative for antinuclear antibodies (ANA), while the sera of children living near the mining settlement showed ANA-positive titres (p < 0.001). These autoantibodies mainly recognized antigens associated with dividing cells, such as the mitotic apparatus and centrioles. Conclusion: The present results show how metallic pollutants induce environmentally associated autoimmunity and are reflected by antinuclear antibodies. This research should prompt us to take greater caution and implement permanent monitoring to ensure a healthy environment.},
year = {2021}
}
TY - JOUR T1 - Associated Autoimmunity and Lead Exposure in Childhood AU - Deyanira Pacheco-Tovar AU - María-Guadalupe Pacheco-Tovar AU - Esperanza Avalos-Díaz AU - Juan-José Bollain-y-Goytia AU - María-Elena Pérez-Pérez AU - Roxana Ramírez-Sandoval AU - Argelia López-Luna AU - Rafael Herrera-Esparza Y1 - 2021/03/26 PY - 2021 N1 - https://doi.org/10.11648/j.iji.20210901.14 DO - 10.11648/j.iji.20210901.14 T2 - International Journal of Immunology JF - International Journal of Immunology JO - International Journal of Immunology SP - 16 EP - 21 PB - Science Publishing Group SN - 2329-1753 UR - https://doi.org/10.11648/j.iji.20210901.14 AB - Background: The autoimmunity associated with environmental pollutants such as heavy metals is a phenomenon that has been described previously. The aim of the present study investigated the relationship between autoimmunity and lead pollutants in a cohort of children who lived in a mining settlement. Methods: Children were studied clinically and serologically. The serum lead concentration was measured by atomic absorption spectrometry, and antinuclear antibodies were analysed by immunofluorescence, ELISA and Western blot. Results: None of the studied children displayed any autoimmune disease. The lead concentration in the control group was negligible, at 0.10 ± 011 μg. L-1. In contrast, the study group had values of 12.72 ± 0.5 μg. L-1. The differences between the groups were significant (p < 0.0001). In addition, control sera were negative for antinuclear antibodies (ANA), while the sera of children living near the mining settlement showed ANA-positive titres (p < 0.001). These autoantibodies mainly recognized antigens associated with dividing cells, such as the mitotic apparatus and centrioles. Conclusion: The present results show how metallic pollutants induce environmentally associated autoimmunity and are reflected by antinuclear antibodies. This research should prompt us to take greater caution and implement permanent monitoring to ensure a healthy environment. VL - 9 IS - 1 ER -
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