Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2<sup>*</sup> Method

Nga Thi Ho Nguyen; Phuoc Van Le; Phuoc Thanh Bui; Dung Van Le; Lam Hoang Nguyen; Van Bich Thi Le; Pham Van Bui

doi:doi:10.11648/j.ijmi.20231101.14

| Peer-Reviewed

Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2^* Method

Nga Thi Ho Nguyen, Phuoc Van Le, Phuoc Thanh Bui, Dung Van Le, Lam Hoang Nguyen, Van Bich Thi Le, Pham Van Bui

Published in International Journal of Medical Imaging (Volume 11, Issue 1)

Received: 17 March 2023 Accepted: 1 April 2023 Published: 18 April 2023

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

β-Thalassemia major often results in an excess of iron in the body due to frequent blood transfusions and enhanced absorption of iron in the gastrointestinal tract. Early detection of this condition and administering sufficient iron chelator therapy can significantly decrease the risk of complications and fatalities resulting from iron overload. MRI (Magnetic Resonance Imaging) T2^* is an accurate non-invasive method for assessing organ iron overload in β-Thalassaemia major patients. This study evaluated the correlation between serum ferritin and iron overload of liver, spleen, and heart in β -Thalassaemia major patients by MRI T2^* method. The design was a cross-section, descriptive study. We used MRI-T2^* to evaluate the correlation between serum ferritin and iron overload of liver, spleen, and heart in 24 Thalassaemia major patients admitted in Cho Ray hospital from 10/2013 to 1/2014, using a 1.5T MRI system (Siemens) with a body coil. T2^* measurements were taken in the liver, spleen, and myocardium using different gradient echo pulse sequences. T2^* values were calculated within homogeneous regions of interest (ROI) in the liver avoiding major blood vessels, spleen, and the entire thickness of the interventricular septum in the myocardium. Pearson correlation coefficient was used to evaluate correlations in the study with a significance threshold of p < 0.05 using SPSS 16.0 software. As results, moderate negative correlation between serum ferritin and liver, spleen MRI T2^* relaxation time (r = 0.57 and 0.755) and a weak negative correlation between serum ferritin and heart MRI T2^* relaxation time (r = 0.303). Liver and heart MRI T2^* readings were poorly correlated (r = 0.28). In conclusion, MRI T2^* is useful to evaluate the iron overload status in β thalassemia patients.

Published in	International Journal of Medical Imaging (Volume 11, Issue 1)
DOI	10.11648/j.ijmi.20231101.14
Page(s)	21-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Serum Ferritin, MRI T2^*, β -Thalassemia Major

References

[1]	Anderson LJ. Assessment of iron overload with T2^* magnetic resonance imaging. Progress in cardiovascular Diseases, 2011, 54: 287-294.
[2]	Anderson LJ et al. Cardiovascular T2^*magnetic resonance for early diagnosis of myocardial iron overload. European Heart Journal, 2001, 22: 2171-2179.
[3]	Andrew T2^*: an ROC study. The Internet Journal of Gastroenterology, 2009, 8 (2): 1528-1532.
[4]	Argyropoulou MI, Astrakas L. MRI evaluation of tissue iron burden in patients with β – Thalassaemia major. Pediatric Radiology, 2007, 37: 183-190.
[5]	Azarkeivan A et al. Relation between serum ferritin and liver and heart MRI T2* in β thalassaemia major patients. Eastern Mediterranean Health Journal, 2012, 19: 727-380.
[6]	Casey J. Brewer et al. Spleen R2 and R2^* in iron-overload patients with sickle cell disease and thalassemia major. J Magn Reson Imaging, 2009, 29 (2): 357-364.
[7]	Cohen AR et al. Thalassemia. Hematology (American society of Hematology Education Program). Washington DC, American Society of Hematology, 2004: 14-34.
[8]	Hamed EA, El Melegy NT. Renal functions in pediatric patients with β - thalassemia major: relation to chelation therapy: original prospective study. Italian Journal of Pediatrics, 2010, 6: 39.
[9]	Jane S Hankins, et al. R2^* magnetic resonance imaging of the liver in patients with iron overload. Blood, 2009, 113: 4853-4857.
[10]	Jonh-Paul Carpenter, et al. On T2^* magnetic resonance and cardia citron. Circulation, 2011, 1519-1528.
[11]	Kirk P et al. International reproducibility of single breath hold T2^* MR for cardiac and liver iron assessment among five thalassemia centers. Journal of Magnetic Resonance Imaging, 2010, 32: 315-319.
[12]	Kirk P et al. Cardiac T2^* magnetic resonance for the prediction of cardiac complications in thalassemia major. Circulation, 2009, 120: 1961-1968.
[13]	Leung AW et al. Magnetic resonance imaging assessment of cardiac and liver iron load in transfusion depend patients. Pediatric blood and cancer, 2009, 53: 1054-1059.
[14]	Ping Hou et al. A practical approach for a wide range of liver iron quantitation using a magnetic resonance imaging technique. Radiology research and practice, 2012, 2012: 2073-2082.
[15]	St pierre TG et al. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood, 2005, 105: 855-861.
[16]	Tanner MA et al. Thalassemia International Federation Heart T2^* Investigators. Multi-center validation of the transferability of the magnetic resonance T2^* technique for the quantification of tissue iron. Hematological, 2006, 91: 1388-1391.
[17]	Wood JC. Diagnosis and management of transfusion iron overload: the role of imaging. PMC, 2010, 82: 1132-1135.
[18]	Wood JC. Magnetic resonance imaging measurement of iron overload. Current Opinion Hematology, 2007, 14: 183-190.
[19]	Worwood M et al. Binding of serum ferritin to concanavalin A: patients with homozygous β thalassaemia and transfusion iron overload. British Journal of Haematology, 1980, 46: 409-416.
[20]	Yesilipek MA. Stem cell transplantation in hemoglobinopathies. Hemoglobin, 2007, 31: 251-256.

Cite This Article

Plain Text BibTeX RIS

APA Style

Nga Thi Ho Nguyen, Phuoc Van Le, Phuoc Thanh Bui, Dung Van Le, Lam Hoang Nguyen, et al. (2023). Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method. International Journal of Medical Imaging, 11(1), 21-24. https://doi.org/10.11648/j.ijmi.20231101.14

Copy | Download

ACS Style

Nga Thi Ho Nguyen; Phuoc Van Le; Phuoc Thanh Bui; Dung Van Le; Lam Hoang Nguyen, et al. Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method. Int. J. Med. Imaging 2023, 11(1), 21-24. doi: 10.11648/j.ijmi.20231101.14

Copy | Download

AMA Style

Nga Thi Ho Nguyen, Phuoc Van Le, Phuoc Thanh Bui, Dung Van Le, Lam Hoang Nguyen, et al. Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method. Int J Med Imaging. 2023;11(1):21-24. doi: 10.11648/j.ijmi.20231101.14

Copy | Download

@article{10.11648/j.ijmi.20231101.14,
  author = {Nga Thi Ho Nguyen and Phuoc Van Le and Phuoc Thanh Bui and Dung Van Le and Lam Hoang Nguyen and Van Bich Thi Le and Pham Van Bui},
  title = {Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method},
  journal = {International Journal of Medical Imaging},
  volume = {11},
  number = {1},
  pages = {21-24},
  doi = {10.11648/j.ijmi.20231101.14},
  url = {https://doi.org/10.11648/j.ijmi.20231101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20231101.14},
  abstract = {β-Thalassemia major often results in an excess of iron in the body due to frequent blood transfusions and enhanced absorption of iron in the gastrointestinal tract. Early detection of this condition and administering sufficient iron chelator therapy can significantly decrease the risk of complications and fatalities resulting from iron overload. MRI (Magnetic Resonance Imaging) T2* is an accurate non-invasive method for assessing organ iron overload in β-Thalassaemia major patients. This study evaluated the correlation between serum ferritin and iron overload of liver, spleen, and heart in β -Thalassaemia major patients by MRI T2* method. The design was a cross-section, descriptive study. We used MRI-T2* to evaluate the correlation between serum ferritin and iron overload of liver, spleen, and heart in 24 Thalassaemia major patients admitted in Cho Ray hospital from 10/2013 to 1/2014, using a 1.5T MRI system (Siemens) with a body coil. T2* measurements were taken in the liver, spleen, and myocardium using different gradient echo pulse sequences. T2* values were calculated within homogeneous regions of interest (ROI) in the liver avoiding major blood vessels, spleen, and the entire thickness of the interventricular septum in the myocardium. Pearson correlation coefficient was used to evaluate correlations in the study with a significance threshold of p * relaxation time (r = 0.57 and 0.755) and a weak negative correlation between serum ferritin and heart MRI T2* relaxation time (r = 0.303). Liver and heart MRI T2* readings were poorly correlated (r = 0.28). In conclusion, MRI T2* is useful to evaluate the iron overload status in β thalassemia patients.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method
AU  - Nga Thi Ho Nguyen
AU  - Phuoc Van Le
AU  - Phuoc Thanh Bui
AU  - Dung Van Le
AU  - Lam Hoang Nguyen
AU  - Van Bich Thi Le
AU  - Pham Van Bui
Y1  - 2023/04/18
PY  - 2023
N1  - https://doi.org/10.11648/j.ijmi.20231101.14
DO  - 10.11648/j.ijmi.20231101.14
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 21
EP  - 24
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20231101.14
AB  - β-Thalassemia major often results in an excess of iron in the body due to frequent blood transfusions and enhanced absorption of iron in the gastrointestinal tract. Early detection of this condition and administering sufficient iron chelator therapy can significantly decrease the risk of complications and fatalities resulting from iron overload. MRI (Magnetic Resonance Imaging) T2* is an accurate non-invasive method for assessing organ iron overload in β-Thalassaemia major patients. This study evaluated the correlation between serum ferritin and iron overload of liver, spleen, and heart in β -Thalassaemia major patients by MRI T2* method. The design was a cross-section, descriptive study. We used MRI-T2* to evaluate the correlation between serum ferritin and iron overload of liver, spleen, and heart in 24 Thalassaemia major patients admitted in Cho Ray hospital from 10/2013 to 1/2014, using a 1.5T MRI system (Siemens) with a body coil. T2* measurements were taken in the liver, spleen, and myocardium using different gradient echo pulse sequences. T2* values were calculated within homogeneous regions of interest (ROI) in the liver avoiding major blood vessels, spleen, and the entire thickness of the interventricular septum in the myocardium. Pearson correlation coefficient was used to evaluate correlations in the study with a significance threshold of p * relaxation time (r = 0.57 and 0.755) and a weak negative correlation between serum ferritin and heart MRI T2* relaxation time (r = 0.303). Liver and heart MRI T2* readings were poorly correlated (r = 0.28). In conclusion, MRI T2* is useful to evaluate the iron overload status in β thalassemia patients.
VL  - 11
IS  - 1
ER  -

Copy | Download

Author Information

Nga Thi Ho Nguyen

Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
Phuoc Van Le

Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
Phuoc Thanh Bui

Department of Surgery, Pham Ngoc Thach Medical University, Ho Chi Minh City, Vietnam
Dung Van Le

Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
Lam Hoang Nguyen

Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
Van Bich Thi Le

Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
Pham Van Bui

Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Nga Thi Ho Nguyen, Phuoc Van Le, Phuoc Thanh Bui, Dung Van Le, Lam Hoang Nguyen, et al. (2023). Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method. International Journal of Medical Imaging, 11(1), 21-24. https://doi.org/10.11648/j.ijmi.20231101.14

Copy | Download

ACS Style

Nga Thi Ho Nguyen; Phuoc Van Le; Phuoc Thanh Bui; Dung Van Le; Lam Hoang Nguyen, et al. Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method. Int. J. Med. Imaging 2023, 11(1), 21-24. doi: 10.11648/j.ijmi.20231101.14

Copy | Download

AMA Style

Nga Thi Ho Nguyen, Phuoc Van Le, Phuoc Thanh Bui, Dung Van Le, Lam Hoang Nguyen, et al. Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method. Int J Med Imaging. 2023;11(1):21-24. doi: 10.11648/j.ijmi.20231101.14

Copy | Download

@article{10.11648/j.ijmi.20231101.14,
  author = {Nga Thi Ho Nguyen and Phuoc Van Le and Phuoc Thanh Bui and Dung Van Le and Lam Hoang Nguyen and Van Bich Thi Le and Pham Van Bui},
  title = {Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method},
  journal = {International Journal of Medical Imaging},
  volume = {11},
  number = {1},
  pages = {21-24},
  doi = {10.11648/j.ijmi.20231101.14},
  url = {https://doi.org/10.11648/j.ijmi.20231101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20231101.14},
  abstract = {β-Thalassemia major often results in an excess of iron in the body due to frequent blood transfusions and enhanced absorption of iron in the gastrointestinal tract. Early detection of this condition and administering sufficient iron chelator therapy can significantly decrease the risk of complications and fatalities resulting from iron overload. MRI (Magnetic Resonance Imaging) T2* is an accurate non-invasive method for assessing organ iron overload in β-Thalassaemia major patients. This study evaluated the correlation between serum ferritin and iron overload of liver, spleen, and heart in β -Thalassaemia major patients by MRI T2* method. The design was a cross-section, descriptive study. We used MRI-T2* to evaluate the correlation between serum ferritin and iron overload of liver, spleen, and heart in 24 Thalassaemia major patients admitted in Cho Ray hospital from 10/2013 to 1/2014, using a 1.5T MRI system (Siemens) with a body coil. T2* measurements were taken in the liver, spleen, and myocardium using different gradient echo pulse sequences. T2* values were calculated within homogeneous regions of interest (ROI) in the liver avoiding major blood vessels, spleen, and the entire thickness of the interventricular septum in the myocardium. Pearson correlation coefficient was used to evaluate correlations in the study with a significance threshold of p * relaxation time (r = 0.57 and 0.755) and a weak negative correlation between serum ferritin and heart MRI T2* relaxation time (r = 0.303). Liver and heart MRI T2* readings were poorly correlated (r = 0.28). In conclusion, MRI T2* is useful to evaluate the iron overload status in β thalassemia patients.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method
AU  - Nga Thi Ho Nguyen
AU  - Phuoc Van Le
AU  - Phuoc Thanh Bui
AU  - Dung Van Le
AU  - Lam Hoang Nguyen
AU  - Van Bich Thi Le
AU  - Pham Van Bui
Y1  - 2023/04/18
PY  - 2023
N1  - https://doi.org/10.11648/j.ijmi.20231101.14
DO  - 10.11648/j.ijmi.20231101.14
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 21
EP  - 24
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20231101.14
AB  - β-Thalassemia major often results in an excess of iron in the body due to frequent blood transfusions and enhanced absorption of iron in the gastrointestinal tract. Early detection of this condition and administering sufficient iron chelator therapy can significantly decrease the risk of complications and fatalities resulting from iron overload. MRI (Magnetic Resonance Imaging) T2* is an accurate non-invasive method for assessing organ iron overload in β-Thalassaemia major patients. This study evaluated the correlation between serum ferritin and iron overload of liver, spleen, and heart in β -Thalassaemia major patients by MRI T2* method. The design was a cross-section, descriptive study. We used MRI-T2* to evaluate the correlation between serum ferritin and iron overload of liver, spleen, and heart in 24 Thalassaemia major patients admitted in Cho Ray hospital from 10/2013 to 1/2014, using a 1.5T MRI system (Siemens) with a body coil. T2* measurements were taken in the liver, spleen, and myocardium using different gradient echo pulse sequences. T2* values were calculated within homogeneous regions of interest (ROI) in the liver avoiding major blood vessels, spleen, and the entire thickness of the interventricular septum in the myocardium. Pearson correlation coefficient was used to evaluate correlations in the study with a significance threshold of p * relaxation time (r = 0.57 and 0.755) and a weak negative correlation between serum ferritin and heart MRI T2* relaxation time (r = 0.303). Liver and heart MRI T2* readings were poorly correlated (r = 0.28). In conclusion, MRI T2* is useful to evaluate the iron overload status in β thalassemia patients.
VL  - 11
IS  - 1
ER  -

Copy | Download