Determination of Ferrous Iron in Ferric Chloride Hexahydrate

Bai Xiaoguang; Wang Zhengda; Wu Xudong; Duan Shufen; Liu Aihua; Cheng Xiao

doi:doi:10.11648/j.ijpc.20210701.11

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Determination of Ferrous Iron in Ferric Chloride Hexahydrate

Bai Xiaoguang, Wang Zhengda, Wu Xudong, Duan Shufen, Liu Aihua, Cheng Xiao

Published in International Journal of Pharmacy and Chemistry (Volume 7, Issue 1)

Received: 25 March 2019 Accepted: 24 June 2020 Published: 10 February 2021

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Abstract

Objective: As a pharmaceutical raw material, ferric chloride hexahydrate has been included in the British Pharmacopoeia, the European Pharmacopoeia (2008) and the United States Pharmacopoeia (2015), and there are detailed discussions on quality standards and testing methods. Ferric chloride hexahydrate has not been included in the Chinese Pharmacopoeia. This study is the part of research to establish a spectrophotometric method for the determination of ferrous iron in ferric chloride hexahydrate. In this study, the two methods were discussed in detail, and the spectrophotometric method for detecting the content of ferrous iron in ferric chloride hexahydrate was proposed. Methods: The detection method on ferrous iron in ferric chloride hexahydrate among European pharmacopoeia, United States pharmacopoeia and Chemical Reagent Ferric Chloride Hexahydrate (HG/T3474-2014) of China's Chemical Industry were compared. The last two methods were not easy to operation. On the basis of the European pharmacopoeia, a method was proposed that after Fe³⁺ were screened with H₃PO₄, Fe²⁺ was measured by spectrophotometry, and the method was verified by experiments. Results and Conclusion: The spectrophotometry method is easy to operate and has good reproducibility. The content of ferrous iron can be calculated semi-quantitatively by masking ferric iron with H₃PO₄ and spectrophotometric determination of ferrous ion content. Therefore, the method established in this study can more clearly detect whether the ferrous content in ferric chloride hexahydrate is up to standard.

Published in	International Journal of Pharmacy and Chemistry (Volume 7, Issue 1)
DOI	10.11648/j.ijpc.20210701.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Ferrous Ion, Ferric Chloride Hexahydrate, Spectrophotometry, Quality Control

References

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[8]	Yang Shizhong, Zhang Lianyi and Baharguly Kahar, Determination of Vitamin C Utilizing the Reaction of Fe²⁺ and K₃[Fe(CN)₆] [J]. Journal of Analytical Science, 2005 (05).
[9]	Zhang Suijuan, Li Qiongfang and Mo Haihong, Catalytic Spectrophotometric Determination of Trace Mercury with K₄[Fe(CN)₆]-K₃[Fe(CN)₆] system [J]. Chinese Journal of Analytical Laboratory, 2007, 26 (3): 80-83.
[10]	Б. В. Некрасов, General Chemistry Course (Volume 2) [M]. Beijing: Higher Education Press, 1955: 816.
[11]	Piao Fengyu, Zhang Jing’ai, Yu Zheqia, Wu Xinzi, and Jin Dacheng, Identification and Content Determination an the Resultant of Potassium Ferricyanide and Ferric Chloride [J]. Journal of Yanbian University (Natural Science Edition), 1996.
[12]	Zheng Liqing, Li Jing, Fan Shunli, Gao Xiaolin and Li Quanmin, Spectrophotometric Determination of Terbutaline Using K₃[Fe(CN)₆]-FeCl₃ [J]. Chemical Research and Application, 2010, 22 (7).
[13]	HG/T3474-2014, chemical reagent ferric chloride hexahydrate (ferric chloride) [S].
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[15]	Stumm W, Morgan JJ. Aquatic Chemistry; Chemical Equilibria and Rates in Natural Waters [J]. Wiley: New York, 1996 (260).

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APA Style

Bai Xiaoguang, Wang Zhengda, Wu Xudong, Duan Shufen, Liu Aihua, et al. (2021). Determination of Ferrous Iron in Ferric Chloride Hexahydrate. International Journal of Pharmacy and Chemistry, 7(1), 1-4. https://doi.org/10.11648/j.ijpc.20210701.11

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ACS Style

Bai Xiaoguang; Wang Zhengda; Wu Xudong; Duan Shufen; Liu Aihua, et al. Determination of Ferrous Iron in Ferric Chloride Hexahydrate. Int. J. Pharm. Chem. 2021, 7(1), 1-4. doi: 10.11648/j.ijpc.20210701.11

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AMA Style

Bai Xiaoguang, Wang Zhengda, Wu Xudong, Duan Shufen, Liu Aihua, et al. Determination of Ferrous Iron in Ferric Chloride Hexahydrate. Int J Pharm Chem. 2021;7(1):1-4. doi: 10.11648/j.ijpc.20210701.11

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@article{10.11648/j.ijpc.20210701.11,
  author = {Bai Xiaoguang and Wang Zhengda and Wu Xudong and Duan Shufen and Liu Aihua and Cheng Xiao},
  title = {Determination of Ferrous Iron in Ferric Chloride Hexahydrate},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {7},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijpc.20210701.11},
  url = {https://doi.org/10.11648/j.ijpc.20210701.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20210701.11},
  abstract = {Objective: As a pharmaceutical raw material, ferric chloride hexahydrate has been included in the British Pharmacopoeia, the European Pharmacopoeia (2008) and the United States Pharmacopoeia (2015), and there are detailed discussions on quality standards and testing methods. Ferric chloride hexahydrate has not been included in the Chinese Pharmacopoeia. This study is the part of research to establish a spectrophotometric method for the determination of ferrous iron in ferric chloride hexahydrate. In this study, the two methods were discussed in detail, and the spectrophotometric method for detecting the content of ferrous iron in ferric chloride hexahydrate was proposed. Methods: The detection method on ferrous iron in ferric chloride hexahydrate among European pharmacopoeia, United States pharmacopoeia and Chemical Reagent Ferric Chloride Hexahydrate (HG/T3474-2014) of China's Chemical Industry were compared. The last two methods were not easy to operation. On the basis of the European pharmacopoeia, a method was proposed that after Fe3+ were screened with H3PO4, Fe2+ was measured by spectrophotometry, and the method was verified by experiments. Results and Conclusion: The spectrophotometry method is easy to operate and has good reproducibility. The content of ferrous iron can be calculated semi-quantitatively by masking ferric iron with H3PO4 and spectrophotometric determination of ferrous ion content. Therefore, the method established in this study can more clearly detect whether the ferrous content in ferric chloride hexahydrate is up to standard.},
 year = {2021}
}

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TY  - JOUR
T1  - Determination of Ferrous Iron in Ferric Chloride Hexahydrate
AU  - Bai Xiaoguang
AU  - Wang Zhengda
AU  - Wu Xudong
AU  - Duan Shufen
AU  - Liu Aihua
AU  - Cheng Xiao
Y1  - 2021/02/10
PY  - 2021
N1  - https://doi.org/10.11648/j.ijpc.20210701.11
DO  - 10.11648/j.ijpc.20210701.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20210701.11
AB  - Objective: As a pharmaceutical raw material, ferric chloride hexahydrate has been included in the British Pharmacopoeia, the European Pharmacopoeia (2008) and the United States Pharmacopoeia (2015), and there are detailed discussions on quality standards and testing methods. Ferric chloride hexahydrate has not been included in the Chinese Pharmacopoeia. This study is the part of research to establish a spectrophotometric method for the determination of ferrous iron in ferric chloride hexahydrate. In this study, the two methods were discussed in detail, and the spectrophotometric method for detecting the content of ferrous iron in ferric chloride hexahydrate was proposed. Methods: The detection method on ferrous iron in ferric chloride hexahydrate among European pharmacopoeia, United States pharmacopoeia and Chemical Reagent Ferric Chloride Hexahydrate (HG/T3474-2014) of China's Chemical Industry were compared. The last two methods were not easy to operation. On the basis of the European pharmacopoeia, a method was proposed that after Fe3+ were screened with H3PO4, Fe2+ was measured by spectrophotometry, and the method was verified by experiments. Results and Conclusion: The spectrophotometry method is easy to operate and has good reproducibility. The content of ferrous iron can be calculated semi-quantitatively by masking ferric iron with H3PO4 and spectrophotometric determination of ferrous ion content. Therefore, the method established in this study can more clearly detect whether the ferrous content in ferric chloride hexahydrate is up to standard.
VL  - 7
IS  - 1
ER  -

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Author Information

Bai Xiaoguang

Shanghai Gongji Chemical Co., Ltd., Shanghai, China
Wang Zhengda

Shanghai Gongji Chemical Co., Ltd., Shanghai, China
Wu Xudong

Shanghai Gongji Chemical Co., Ltd., Shanghai, China
Duan Shufen

Shanghai Gongji Chemical Co., Ltd., Shanghai, China
Liu Aihua

Shanghai Gongji Chemical Co., Ltd., Shanghai, China
Cheng Xiao

Qingdao Guofeng Pharmaceutical Co., Ltd, Qingdao, China

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APA Style

Bai Xiaoguang, Wang Zhengda, Wu Xudong, Duan Shufen, Liu Aihua, et al. (2021). Determination of Ferrous Iron in Ferric Chloride Hexahydrate. International Journal of Pharmacy and Chemistry, 7(1), 1-4. https://doi.org/10.11648/j.ijpc.20210701.11

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ACS Style

Bai Xiaoguang; Wang Zhengda; Wu Xudong; Duan Shufen; Liu Aihua, et al. Determination of Ferrous Iron in Ferric Chloride Hexahydrate. Int. J. Pharm. Chem. 2021, 7(1), 1-4. doi: 10.11648/j.ijpc.20210701.11

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AMA Style

Bai Xiaoguang, Wang Zhengda, Wu Xudong, Duan Shufen, Liu Aihua, et al. Determination of Ferrous Iron in Ferric Chloride Hexahydrate. Int J Pharm Chem. 2021;7(1):1-4. doi: 10.11648/j.ijpc.20210701.11

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@article{10.11648/j.ijpc.20210701.11,
  author = {Bai Xiaoguang and Wang Zhengda and Wu Xudong and Duan Shufen and Liu Aihua and Cheng Xiao},
  title = {Determination of Ferrous Iron in Ferric Chloride Hexahydrate},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {7},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijpc.20210701.11},
  url = {https://doi.org/10.11648/j.ijpc.20210701.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20210701.11},
  abstract = {Objective: As a pharmaceutical raw material, ferric chloride hexahydrate has been included in the British Pharmacopoeia, the European Pharmacopoeia (2008) and the United States Pharmacopoeia (2015), and there are detailed discussions on quality standards and testing methods. Ferric chloride hexahydrate has not been included in the Chinese Pharmacopoeia. This study is the part of research to establish a spectrophotometric method for the determination of ferrous iron in ferric chloride hexahydrate. In this study, the two methods were discussed in detail, and the spectrophotometric method for detecting the content of ferrous iron in ferric chloride hexahydrate was proposed. Methods: The detection method on ferrous iron in ferric chloride hexahydrate among European pharmacopoeia, United States pharmacopoeia and Chemical Reagent Ferric Chloride Hexahydrate (HG/T3474-2014) of China's Chemical Industry were compared. The last two methods were not easy to operation. On the basis of the European pharmacopoeia, a method was proposed that after Fe3+ were screened with H3PO4, Fe2+ was measured by spectrophotometry, and the method was verified by experiments. Results and Conclusion: The spectrophotometry method is easy to operate and has good reproducibility. The content of ferrous iron can be calculated semi-quantitatively by masking ferric iron with H3PO4 and spectrophotometric determination of ferrous ion content. Therefore, the method established in this study can more clearly detect whether the ferrous content in ferric chloride hexahydrate is up to standard.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Determination of Ferrous Iron in Ferric Chloride Hexahydrate
AU  - Bai Xiaoguang
AU  - Wang Zhengda
AU  - Wu Xudong
AU  - Duan Shufen
AU  - Liu Aihua
AU  - Cheng Xiao
Y1  - 2021/02/10
PY  - 2021
N1  - https://doi.org/10.11648/j.ijpc.20210701.11
DO  - 10.11648/j.ijpc.20210701.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20210701.11
AB  - Objective: As a pharmaceutical raw material, ferric chloride hexahydrate has been included in the British Pharmacopoeia, the European Pharmacopoeia (2008) and the United States Pharmacopoeia (2015), and there are detailed discussions on quality standards and testing methods. Ferric chloride hexahydrate has not been included in the Chinese Pharmacopoeia. This study is the part of research to establish a spectrophotometric method for the determination of ferrous iron in ferric chloride hexahydrate. In this study, the two methods were discussed in detail, and the spectrophotometric method for detecting the content of ferrous iron in ferric chloride hexahydrate was proposed. Methods: The detection method on ferrous iron in ferric chloride hexahydrate among European pharmacopoeia, United States pharmacopoeia and Chemical Reagent Ferric Chloride Hexahydrate (HG/T3474-2014) of China's Chemical Industry were compared. The last two methods were not easy to operation. On the basis of the European pharmacopoeia, a method was proposed that after Fe3+ were screened with H3PO4, Fe2+ was measured by spectrophotometry, and the method was verified by experiments. Results and Conclusion: The spectrophotometry method is easy to operate and has good reproducibility. The content of ferrous iron can be calculated semi-quantitatively by masking ferric iron with H3PO4 and spectrophotometric determination of ferrous ion content. Therefore, the method established in this study can more clearly detect whether the ferrous content in ferric chloride hexahydrate is up to standard.
VL  - 7
IS  - 1
ER  -

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