Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation

Akodu Busayo Odunayo; Fasuba Ilesanmi Kayode; Akawa Ayodeji Benjamin; Adu Isaac Adekola; Olasehinde Oluwaseun Ruth

doi:doi:10.11648/j.ijpc.20210702.11

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Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation

Akodu Busayo Odunayo, Fasuba Ilesanmi Kayode, Akawa Ayodeji Benjamin, Adu Isaac Adekola, Olasehinde Oluwaseun Ruth

Published in International Journal of Pharmacy and Chemistry (Volume 7, Issue 2)

Received: 17 February 2021 Accepted: 9 March 2021 Published: 30 March 2021

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Abstract

The binding property of five (5) commonly used binders in metronidazole granule and tablet formulations was studied. The binders studied included gelatin, polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), maize starch and guar gum. The binders were incorporated as 5%w/w of tablet weight in each case. The granules were formulated by the wet granulation technique while the tablets were prepared by compression. The properties of granules evaluated included flow rate, angle of repose, bulk and tapped densities, Hausner’s ratio, Carr’s index and moisture content. Tablet properties studied included weight uniformity, hardness, friability, thickness and diameter, disintegration time and dissolution rate. Results indicated that granules containing guar gum or PVP possessed flow properties superior to those of other binders, while those containing gelatin possessed the least flow property. In terms of packing characteristics, granules containing CMC were better than others. The mechanical strength of tablets containing gelatin, PVP or CMC was superior to those made with either guar gum or maize starch. In terms of release of metronidazole, tablets containing PVP, gelatin or guar gum were more efficient in releasing the drug, while those made with CMC was the least. On the basis of these, good metronidazole tablets could be formulated using PVP, gelatin or guar gum. On the other hand, maize starch or CMC may not be recommended as a binder for metronidazole tablets because of high friability or poor release respectively.

Published in	International Journal of Pharmacy and Chemistry (Volume 7, Issue 2)
DOI	10.11648/j.ijpc.20210702.11
Page(s)	22-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Binding Property, Metronidazole Granule, Polyvinylpyrrolidone, Carboxymethylcellulose, Tablet Formulations

References

[1]	Rehman, B. M., Wahed, M., Khondkar, P., Ahmed, M., Islam, R., Barman, R., Islam, M. A. (2018). Effect of Starch 1500 as a binder and disintegrant in Lamivudine tablets prepared by high shear wet granulation, Pakistan Journal of Pharmaceutical Sciences, 21 (23) 455-459.
[2]	Mohammed, B. B., Isah, A. B., Apeji, Y. E. (2011). The role of acid-hydrolysed cassava starch as binders in paracetamol tablets, Journal of Pharmaceutical Research and Innovation, 4 (6): 9-12.
[3]	Shailendra, P., Agrawal, S., Lodhi, B. S. (2012). Natural binding agents in tablet formation, International Journal of Pharmaceutical and Biological Archives 3 (3): 466-473.
[4]	Ronelle, R. (2004). Synthetic excipents challenges all natural organics offer advantages/ challenges to developers and formulators. Advenster Communications Inc 1: 38-50.
[5]	Mukesh, G. (2016). Tablet binder’s adhesives and granulating agent. Pharmainfo. Net, http://ww.pharmainfo.net/binders.
[6]	Alebiowu, G. (2010). Assesment of tapioca starches obtained after different steeping period as binders in a paracetamol tablet formulation, Farmacia 58 (45): 341-52.
[7]	Shivalingam, M. R., Kumaran, K., Jeslin, D., Reddy, Y. D., Tejaswini, M., Rao, C. M., Tejopavan, V. (2010). Cassiaroxburghii seed galactomannan: A potential binding agent in the tablet formulation, Journal of Biomedical Sciences Research 2 (23): 18-22.
[8]	Rubinstein, M. H. (2005). Tablets in Phamaceutics, the science of Dosage form design, Churchill Livingstone, London 34 (45) 457-463.
[9]	Alekha, K. D., Somnath, S., Tolman, J. (2014). Solid dosage forms in pharmaceutics basic principles and application to pharmacy practice, 1^st edition editors Elsevier Inc UK 987 (12): 161-162.
[10]	Enauyatifard, R., Azadbakht, M., Fadakar, Y. (2012). Assessment of Ferulagummosagum as binding agent in tablet formulations, Acta Poloniac Pharma, Drug Research 6 (9) 291-8.
[11]	Menon, S. S., Basavaraj, B. V., Bharath, S., Deveswaran, R., Madhaven, V. (2011). Formulation and evaluation of Ibuprofen tablets using Orange peel pectin as binding agent, Derm. PharmaciaLettre 3 (34) 241-7.
[12]	Symeko, C. and Rhodes, C. T. (2014). Binder functionality in Tablet System Drug development and Industrial Pharmacy 21 (9) 1091-1114.
[13]	Paul, J. J. and Eugene, L. P. (2016). Comparison of granules strenght and Tablet tensile strength. Journal of pharmaceutical sciences 72 (5): 530-531.
[14]	Elsabbagh, H. M., Ghanem, A. H., Abdel-Alim, H. M. (2017). The influence of binders and concentration on the physical characteristics of calcium carbonate granules and their corresponding tablets. Pubmed Publications 36 (8): 548-51.
[15]	Smith, J., Hong-Shum, K., Lily, L. (2011). Complex mixture of Phosphatidyl ethanolamine, Phosphatidyl inositol, Phosphatidyl acid, Glycolipids and Food additives data book 2^nd edition, Chichester, West Sussex Willey- Blackwell 334 (45) 23-32.
[16]	Okafor, I. S. (2011). The Rheological Properties of Grewiagum, Nigeria Journal of Polymer Science and Technology 2 (65) 169-175.
[17]	Ngwuluka, N. C., Idiakhoa, B. A., Nep, E. I., Ogaji, I., Okafor, I. S. (2010). Formulation and evaluation of Paracetamol tablets manufactured using the dried fruit of Phoenix dactylifera Linn as excipient Research in Pharmaceutical Biotechnology 2 (3) 25-32.
[18]	Agrawal, Y. K. and Prakasam, K. (2014). Effect of Binders on Sulfamethoxazole Tablets. Journal of Phamaceutical Sciences. 7 (10) 885-888.
[19]	Pifferi, G. and Restani, P. (2013). The safety of pharmaceutical excipients II Farmaco 58 (8): 541-550.
[20]	Alderborn, G. (2013). Tablets and compaction in Aulton’s Pharmaceutics. The design and manufacture of medicines, 4^th edition. Churchill Livingstone, London.
[21]	Canton, S. L., Augsburger, L. L., Hoag, S. W., Armin, G. (2018). Pharmaceutical granulation process, mechanism and the use of binders, research gate Publications 1 (54): 261-301.
[22]	Dilip, M. P. (2014). Handbook of Pharmaceutical graduation technology CRC press, Florida 2^nd edition.
[23]	Jones, D. (2018). Solid Dosage Forms1: Tablets in Pharmaceutics-The science of dosage form design, 1^st edition, Pharmaceutical press London. ISSN: 9780-85369-7640.
[24]	Karthik, V. V. (2016). Excipients used in the formulation of tablets research and reviews. Journal of Chemistry. 5 (2): 143-154.

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APA Style

Akodu Busayo Odunayo, Fasuba Ilesanmi Kayode, Akawa Ayodeji Benjamin, Adu Isaac Adekola, Olasehinde Oluwaseun Ruth. (2021). Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation. International Journal of Pharmacy and Chemistry, 7(2), 22-30. https://doi.org/10.11648/j.ijpc.20210702.11

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ACS Style

Akodu Busayo Odunayo; Fasuba Ilesanmi Kayode; Akawa Ayodeji Benjamin; Adu Isaac Adekola; Olasehinde Oluwaseun Ruth. Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation. Int. J. Pharm. Chem. 2021, 7(2), 22-30. doi: 10.11648/j.ijpc.20210702.11

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AMA Style

Akodu Busayo Odunayo, Fasuba Ilesanmi Kayode, Akawa Ayodeji Benjamin, Adu Isaac Adekola, Olasehinde Oluwaseun Ruth. Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation. Int J Pharm Chem. 2021;7(2):22-30. doi: 10.11648/j.ijpc.20210702.11

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@article{10.11648/j.ijpc.20210702.11,
  author = {Akodu Busayo Odunayo and Fasuba Ilesanmi Kayode and Akawa Ayodeji Benjamin and Adu Isaac Adekola and Olasehinde Oluwaseun Ruth},
  title = {Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {7},
  number = {2},
  pages = {22-30},
  doi = {10.11648/j.ijpc.20210702.11},
  url = {https://doi.org/10.11648/j.ijpc.20210702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20210702.11},
  abstract = {The binding property of five (5) commonly used binders in metronidazole granule and tablet formulations was studied. The binders studied included gelatin, polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), maize starch and guar gum. The binders were incorporated as 5%w/w of tablet weight in each case. The granules were formulated by the wet granulation technique while the tablets were prepared by compression. The properties of granules evaluated included flow rate, angle of repose, bulk and tapped densities, Hausner’s ratio, Carr’s index and moisture content. Tablet properties studied included weight uniformity, hardness, friability, thickness and diameter, disintegration time and dissolution rate. Results indicated that granules containing guar gum or PVP possessed flow properties superior to those of other binders, while those containing gelatin possessed the least flow property. In terms of packing characteristics, granules containing CMC were better than others. The mechanical strength of tablets containing gelatin, PVP or CMC was superior to those made with either guar gum or maize starch. In terms of release of metronidazole, tablets containing PVP, gelatin or guar gum were more efficient in releasing the drug, while those made with CMC was the least. On the basis of these, good metronidazole tablets could be formulated using PVP, gelatin or guar gum. On the other hand, maize starch or CMC may not be recommended as a binder for metronidazole tablets because of high friability or poor release respectively.},
 year = {2021}
}

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TY - JOUR
T1 - Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation
AU - Akodu Busayo Odunayo
AU - Fasuba Ilesanmi Kayode
AU - Akawa Ayodeji Benjamin
AU - Adu Isaac Adekola
AU - Olasehinde Oluwaseun Ruth
Y1 - 2021/03/30
PY - 2021
N1 - https://doi.org/10.11648/j.ijpc.20210702.11
DO - 10.11648/j.ijpc.20210702.11
T2 - International Journal of Pharmacy and Chemistry
JF - International Journal of Pharmacy and Chemistry
JO - International Journal of Pharmacy and Chemistry
SP - 22
EP - 30
PB - Science Publishing Group
SN - 2575-5749
UR - https://doi.org/10.11648/j.ijpc.20210702.11
AB - The binding property of five (5) commonly used binders in metronidazole granule and tablet formulations was studied. The binders studied included gelatin, polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), maize starch and guar gum. The binders were incorporated as 5%w/w of tablet weight in each case. The granules were formulated by the wet granulation technique while the tablets were prepared by compression. The properties of granules evaluated included flow rate, angle of repose, bulk and tapped densities, Hausner’s ratio, Carr’s index and moisture content. Tablet properties studied included weight uniformity, hardness, friability, thickness and diameter, disintegration time and dissolution rate. Results indicated that granules containing guar gum or PVP possessed flow properties superior to those of other binders, while those containing gelatin possessed the least flow property. In terms of packing characteristics, granules containing CMC were better than others. The mechanical strength of tablets containing gelatin, PVP or CMC was superior to those made with either guar gum or maize starch. In terms of release of metronidazole, tablets containing PVP, gelatin or guar gum were more efficient in releasing the drug, while those made with CMC was the least. On the basis of these, good metronidazole tablets could be formulated using PVP, gelatin or guar gum. On the other hand, maize starch or CMC may not be recommended as a binder for metronidazole tablets because of high friability or poor release respectively.
VL - 7
IS - 2
ER -

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Author Information

Akodu Busayo Odunayo

Department of Pharmaceutical Technology, University of Jos, Jos, Nigeria
Fasuba Ilesanmi Kayode

Department of Pharmaceutical Technology, University of Jos, Jos, Nigeria
Akawa Ayodeji Benjamin

Department of Medical Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria
Adu Isaac Adekola

Department of Medical Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria
Olasehinde Oluwaseun Ruth

Department of Medical Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria

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APA Style

Akodu Busayo Odunayo, Fasuba Ilesanmi Kayode, Akawa Ayodeji Benjamin, Adu Isaac Adekola, Olasehinde Oluwaseun Ruth. (2021). Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation. International Journal of Pharmacy and Chemistry, 7(2), 22-30. https://doi.org/10.11648/j.ijpc.20210702.11

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ACS Style

Akodu Busayo Odunayo; Fasuba Ilesanmi Kayode; Akawa Ayodeji Benjamin; Adu Isaac Adekola; Olasehinde Oluwaseun Ruth. Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation. Int. J. Pharm. Chem. 2021, 7(2), 22-30. doi: 10.11648/j.ijpc.20210702.11

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AMA Style

Akodu Busayo Odunayo, Fasuba Ilesanmi Kayode, Akawa Ayodeji Benjamin, Adu Isaac Adekola, Olasehinde Oluwaseun Ruth. Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation. Int J Pharm Chem. 2021;7(2):22-30. doi: 10.11648/j.ijpc.20210702.11

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@article{10.11648/j.ijpc.20210702.11,
  author = {Akodu Busayo Odunayo and Fasuba Ilesanmi Kayode and Akawa Ayodeji Benjamin and Adu Isaac Adekola and Olasehinde Oluwaseun Ruth},
  title = {Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {7},
  number = {2},
  pages = {22-30},
  doi = {10.11648/j.ijpc.20210702.11},
  url = {https://doi.org/10.11648/j.ijpc.20210702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20210702.11},
  abstract = {The binding property of five (5) commonly used binders in metronidazole granule and tablet formulations was studied. The binders studied included gelatin, polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), maize starch and guar gum. The binders were incorporated as 5%w/w of tablet weight in each case. The granules were formulated by the wet granulation technique while the tablets were prepared by compression. The properties of granules evaluated included flow rate, angle of repose, bulk and tapped densities, Hausner’s ratio, Carr’s index and moisture content. Tablet properties studied included weight uniformity, hardness, friability, thickness and diameter, disintegration time and dissolution rate. Results indicated that granules containing guar gum or PVP possessed flow properties superior to those of other binders, while those containing gelatin possessed the least flow property. In terms of packing characteristics, granules containing CMC were better than others. The mechanical strength of tablets containing gelatin, PVP or CMC was superior to those made with either guar gum or maize starch. In terms of release of metronidazole, tablets containing PVP, gelatin or guar gum were more efficient in releasing the drug, while those made with CMC was the least. On the basis of these, good metronidazole tablets could be formulated using PVP, gelatin or guar gum. On the other hand, maize starch or CMC may not be recommended as a binder for metronidazole tablets because of high friability or poor release respectively.},
 year = {2021}
}

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