Arthritis is an autoimmune disease characterized by joint inflammation, the treatment of this disease requires the use of non-steroidal or steroidal anti-inflammatory drugs. Given the many side effects associated with conventional anti-inflammatory drugs, the use of herbal medicines would benefit patients. Mitracarpus scaber (Rubiaceae), is a herb whose leaves are used to treat skin conditions and relieve pain in the limbs. To elucidate the traditional use of the aerial parts of M. scaber, the present study was conducted on arthritic rats induced by Freund's complete adjuvant. Arthritis was induced in Wistar rats by injecting Freund's complete adjuvant solution into the right hind leg. Diclofenac and Celebrex were chosen as reference molecules. Administration of Diclofenac (5 mg/kg body weight) and Celebrex (10 mg/kg body weight) and the aqueous extract of the aerial parts of M. scaber at doses of 200; 400 and 800 mg/kg body weight began the day after injection and continued for 20 days. Leg swelling, biochemical and hematological parameters as well as fibrinogen levels were evaluated. Oral administration of the extract significantly suppressed inflammatory responses in the joints of arthritic rats. It did not cause liver damage in the rats during the twenty (20) days of treatment. These results indicate that the aqueous extract of the aerial parts of M. scaber prevents the pathological development of arthritis in rats. The active ingredients present in the extract could be potential agents for the treatment of inflammation and arthritis.
| Published in | Journal of Diseases and Medicinal Plants (Volume 7, Issue 1) |
| DOI | 10.11648/j.jdmp.20210701.14 |
| Page(s) | 22-29 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Mitracarpus scaber, Arthritis, Anti-inflammatory
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APA Style
Georges Abizi, Ouattara-Soro Fatou Scherazade, Ernest Zougrou N’guessan, John Kouadio Kouakou, Emile Begbin Kouassi, et al. (2021). Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar. Journal of Diseases and Medicinal Plants, 7(1), 22-29. https://doi.org/10.11648/j.jdmp.20210701.14
ACS Style
Georges Abizi; Ouattara-Soro Fatou Scherazade; Ernest Zougrou N’guessan; John Kouadio Kouakou; Emile Begbin Kouassi, et al. Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar. J. Dis. Med. Plants 2021, 7(1), 22-29. doi: 10.11648/j.jdmp.20210701.14
AMA Style
Georges Abizi, Ouattara-Soro Fatou Scherazade, Ernest Zougrou N’guessan, John Kouadio Kouakou, Emile Begbin Kouassi, et al. Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar. J Dis Med Plants. 2021;7(1):22-29. doi: 10.11648/j.jdmp.20210701.14
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Download@article{10.11648/j.jdmp.20210701.14,
author = {Georges Abizi and Ouattara-Soro Fatou Scherazade and Ernest Zougrou N’guessan and John Kouadio Kouakou and Emile Begbin Kouassi and Sévérin Koffi and Jean-Jacques Kablan Kassi and Alassane Koné},
title = {Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar},
journal = {Journal of Diseases and Medicinal Plants},
volume = {7},
number = {1},
pages = {22-29},
doi = {10.11648/j.jdmp.20210701.14},
url = {https://doi.org/10.11648/j.jdmp.20210701.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20210701.14},
abstract = {Arthritis is an autoimmune disease characterized by joint inflammation, the treatment of this disease requires the use of non-steroidal or steroidal anti-inflammatory drugs. Given the many side effects associated with conventional anti-inflammatory drugs, the use of herbal medicines would benefit patients. Mitracarpus scaber (Rubiaceae), is a herb whose leaves are used to treat skin conditions and relieve pain in the limbs. To elucidate the traditional use of the aerial parts of M. scaber, the present study was conducted on arthritic rats induced by Freund's complete adjuvant. Arthritis was induced in Wistar rats by injecting Freund's complete adjuvant solution into the right hind leg. Diclofenac and Celebrex were chosen as reference molecules. Administration of Diclofenac (5 mg/kg body weight) and Celebrex (10 mg/kg body weight) and the aqueous extract of the aerial parts of M. scaber at doses of 200; 400 and 800 mg/kg body weight began the day after injection and continued for 20 days. Leg swelling, biochemical and hematological parameters as well as fibrinogen levels were evaluated. Oral administration of the extract significantly suppressed inflammatory responses in the joints of arthritic rats. It did not cause liver damage in the rats during the twenty (20) days of treatment. These results indicate that the aqueous extract of the aerial parts of M. scaber prevents the pathological development of arthritis in rats. The active ingredients present in the extract could be potential agents for the treatment of inflammation and arthritis.},
year = {2021}
}
TY - JOUR T1 - Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar AU - Georges Abizi AU - Ouattara-Soro Fatou Scherazade AU - Ernest Zougrou N’guessan AU - John Kouadio Kouakou AU - Emile Begbin Kouassi AU - Sévérin Koffi AU - Jean-Jacques Kablan Kassi AU - Alassane Koné Y1 - 2021/03/26 PY - 2021 N1 - https://doi.org/10.11648/j.jdmp.20210701.14 DO - 10.11648/j.jdmp.20210701.14 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 22 EP - 29 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20210701.14 AB - Arthritis is an autoimmune disease characterized by joint inflammation, the treatment of this disease requires the use of non-steroidal or steroidal anti-inflammatory drugs. Given the many side effects associated with conventional anti-inflammatory drugs, the use of herbal medicines would benefit patients. Mitracarpus scaber (Rubiaceae), is a herb whose leaves are used to treat skin conditions and relieve pain in the limbs. To elucidate the traditional use of the aerial parts of M. scaber, the present study was conducted on arthritic rats induced by Freund's complete adjuvant. Arthritis was induced in Wistar rats by injecting Freund's complete adjuvant solution into the right hind leg. Diclofenac and Celebrex were chosen as reference molecules. Administration of Diclofenac (5 mg/kg body weight) and Celebrex (10 mg/kg body weight) and the aqueous extract of the aerial parts of M. scaber at doses of 200; 400 and 800 mg/kg body weight began the day after injection and continued for 20 days. Leg swelling, biochemical and hematological parameters as well as fibrinogen levels were evaluated. Oral administration of the extract significantly suppressed inflammatory responses in the joints of arthritic rats. It did not cause liver damage in the rats during the twenty (20) days of treatment. These results indicate that the aqueous extract of the aerial parts of M. scaber prevents the pathological development of arthritis in rats. The active ingredients present in the extract could be potential agents for the treatment of inflammation and arthritis. VL - 7 IS - 1 ER -
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