Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines

Guohong Zhou; Xiaozhong Shen; Zhendong Zhao; Renliang Yan; Peihao Huang; Ruqin Tan; Shuibo Liang; Yanting Zhi; Jiaqi Li

doi:doi:10.11648/j.jdmp.20210704.12

| Peer-Reviewed

Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines

Guohong Zhou, Xiaozhong Shen, Zhendong Zhao, Renliang Yan, Peihao Huang, Ruqin Tan, Shuibo Liang, Yanting Zhi, Jiaqi Li

Published in Journal of Diseases and Medicinal Plants (Volume 7, Issue 4)

Received: 19 October 2021 Accepted: 4 November 2021 Published: 12 November 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Charred traditional Chinese medicines have been used to stop bleeding since ancient times. To date, they are often applied to treat purpura, metrorrhagia, upper gastrointestinal bleeding, postoperative hemorrhage of mixed hemorrhoids, and hemorrhoids bleeding. Conventional oral decoction is still a predominate application form. It is noteworthy that a new and original application form of charred herbs has occurred in the treatment of upper gastrointestinal bleeding. Different from the conventional oral decoction, the micron-sized rhei radix et rhizome carbonisatus was sprayed on the surface of the lesion through gastroscopy to stop upper gastrointestinal bleeding. Active tannins, calcium ions, flavonoids and anthraquinones play a role in a part of charred herbs to stop bleeding. The emergence or increase of active components may lead charred herbs to significantly better haemostatic effects than uncharred ones, especially the emergence of activated carbon and novel carbon dots. This underlines a big need to char herbs at first before their clinical use. It leads to a new issue how to char herbs properly for maximum active components, which is related to the quality control of charred herbs. Hence, the optimum charring methods should be explored in depth for different herbs in the future. Furthermore, modern research indicates the haemostatic mechanisms of charred herbs are related to their ability to activate coagulation pathways, enhance platelet systems and/or inhibit fibrinolysis systems.

Published in	Journal of Diseases and Medicinal Plants (Volume 7, Issue 4)
DOI	10.11648/j.jdmp.20210704.12
Page(s)	98-108
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Charred Herbs, Carbonized Herbs, Haemostatic Effects, Stop Bleeding, Carbon Dots

References

[1]	Zhu YY, Qiu Y, Liao LM (2015). Evaluation of hemostatic effects of carbonized hair-loaded poly(l-lactic) acid nanofabrics. J Nanosci Nanotechnol 6: 4193-9. https://doi.org/10.1166/jnn.2015.9799.
[2]	Ding Y, Sun XX, Bi XL et al (1994) Guidelines for TCM diagnosis and treatment of Henoch Schonlein purpura. Journal of Pediatrics of traditional Chinese Medicine 6: 1-4. https://doi.org/10.3969/j.issn.1673-4297.2011.06.001.
[3]	World Federation of Chinese Medicine Societies, China Association of Chinese Medicine (2021) International clinical practice guidelines of Chinese medicine metrorrhagia and metrostaxis. World Chinese Medicine 6: 870-877.
[4]	Shen WL (2014) Treatment of bloody fever delirium with combined western medicine of decarb Decoction and 60 cases of hypersensitivity purpura. Chinese Journal of Traditional Medical Science and Technology 6: 718. https://doi.org/CNKI:SUN:TJYY.0.2014-06-082.
[5]	Li YN, Wang J, Chen L et al (2019) Influing the curative effect of coagulation indicators and blood flow and study on the treatment of children allergic purpure with liangxue duocan decoction. Chinese Journal of Thrombosis and Hemostasis 4: 585-586+589. https://doi.org/CNKI:SUN:XSZX.0.2019-04-013.
[6]	Yang SK (2010) Treatment of 40 cases of Henoch Schonlein purpura with Xiaodian formula. Chinese Journal of Trauma and Disability Medicine 2: 74-75 https://doi.org/10.3969/j.issn.1673-6567.2010.02.062.
[7]	Yao HR (2015) Clinical effect of Carbonized catnip prescription combined with Tripterygium glycosides tablet in treatment of progressive pigmentary purpuric dermatosis. China Modern Medicine 26: 146-148 https://doi.org/CNKI:SUN:ZGUD.0.2015-26-050.
[8]	Dan X, Zhai XX (2013) Jingjie tanfang combined with Tripterygium wilfordii polyglycoside tablets in the treatment of 37 cases of progressive pigmented purpura dermatosis. Fujian Journal of Traditional Chinese Medicine 5: 29-30. https://doi.org/10.13260/j.cnki.jfjtcm.011392.
[9]	Gao SY (2000) Therapeutic effect of "three carbon syrup" and heparin calcium on 36 cases of purpura nephritis. Shandong Journal of traditional Chinese Medicine 12: 722-724. https://doi.org/10.3969/j.issn.0257-358X.2000.12.009.
[10]	Qi SQ (2019) Treatment of allergic purpura with 23 cases using three char Decoction hegongpi decoction. Gansu traditional Chinese Medicine 1: 19 https://doi.org/10.3969/j.issn.1004-6852.2005.01.014.
[11]	Kai JL, Liu H (2001) Journal of Ningxia Medical University. Gansu traditional Chinese Medicine 2: 20-21 https://doi.org/10.3969/j.issn.1004-6852.2004.02.012.
[12]	Li YF (2014) Treatment of 56 cases of metrorrhagia and metrorrhagia with Shitan Decoction. Journal of Practical Traditional Chinese Medicine 10: 926-927 https://doi.org/10.3969/j.issn.1004-2814.2014.10.022.
[13]	Han M (2011) 100 cases of dysfunctional uterine bleeding were treated with integrated traditional Chinese and Western medicine. Clinical research of traditional Chinese Medicine 13: 95 https://doi.org/CNKI:SUN:ZYLY.0.2011-13-062.
[14]	Yan Y, Lei X, Ye LZ et al (2011) Clinical observation on 56 cases of adolescent dysfunctional uterine bleeding treated with traditional Chinese Medicine. Journal of Sichuan of Traditional Chinese Medicine 1: 100-101 https://doi.org/CNKI:SUN:SCZY.0.2011-01-052.
[15]	Xing JX (2005) 125 cases of metrorrhagia and metrorrhagia treated with Ercao Wutan Decoction. Shaanxi Journal of Traditional Chinese Medicine 10: 1012-1013 https://doi.org/10.3969/j.issn.1000-7369.2005.10.016.
[16]	Xia ML, Miao T, Xu WB et al (2018) Effect of Wutan decoction on 60 cases with per-menopausal dysfunctional uterine bleeding. Clinical medical research and Practice 27: 142-143 https://doi.org/10.19347/j.cnki.2096-1413.201827063.
[17]	Cui HY (2011) The treatment of postoperative bleeding after induced abortion by Quyu hemostatic Decoction (56 cases). Journal of Practical Traditional Chinese Medicine 2: 89. https://doi.org/10.3969/j.issn.1004-2814.2011.02.010.
[18]	Zhang GA (2013) Peony tonga reduced treatment of dysfunctional uterine bleeding 50 cases. Guangming Journal of Chinese Medicine 7: 1381-1382. https://doi.org/CNKI:SUN:GMZY.0.2013-07-053.
[19]	Wang HY (2011) Treatment of 54 cases of climacteric metrorrhagia and leakage with sancan rengen Decoction. Hunan Journal of Traditional Chinese Medicine 2: 85-86. https://doi.org/CNKI:SUN:HNZO.0.2011-02-050.
[20]	Lin YX (2014) Metrorrhagia and Metrostaxis; Clinical observation; Yin deficiency and blood heat; zhen qian particles. Beijing University of Chinese Medicine.
[21]	Pang JY, Chen H (2016) Clinical observation of ten grey powder on the treatment of acute non varicose upper gastrointestinal bleeding. Journal of Liaoning University of Traditional Chinese Medicine 8: 205-207. https://doi.org/10.13194/j.issn.1673-842x.2016.08.064.
[22]	Li C, Li YQ, Wang YF (2013) Clinical observation of pantoprazole combined with Shihui powder in the treatment of 100 cases of post-stroke stress gastrointestinal bleeding. Introduction to traditional Chinese Medicine 1: 49-50 https://doi.org/10.13862/j.cnki.cn43-1446/r.2013.01.066.
[23]	Lin SW, (2011) Treatment of acute nonvariceal upper gastrointestinal bleeding with decagray powder. Guangzhou University of traditional Chinese Medicine. https://doi.org/CNKI:CDMD:2.1011.136094.
[24]	Wang BM (2015) Effect of oral administration combined with gastroscope spraying micron rhubarb charcoal on gastric ulcer bleeding. Contemporary Medicine Forum 12: 186-187. https://doi.org/CNKI:SUN:QYWA.0.2015-12-160.
[25]	Yu GP (2013) Spraying rhubarb charcoal particles under gastroscope in the treatment of 53 cases of upper gastrointestinal bleeding. China Pharmaceuticals 6: 102-103 https://doi.org/CNKI:SUN:YYGZ.0.2013-06-063.
[26]	Song JK, Li HY, Li JM et al (2009) Clinical analysis of spraying rhubarb charcoal particles under gastroscope in the treatment of nonvariceal upper gastrointestinal bleeding. Chinese Journal of Misdiagnostics 19: 4615-4616. https://doi.org/CNKI:SUN:ZWZX.0.2009-19-071.
[27]	Shi ZH, Zhang S, Hu w et al (2007) Clinical observation on spraying micron rhubarb charcoal through gastroscopy for hemorrhagic peptic ulcer. Journal of Internal Medicine 3: 134-135. https://doi.org/10.3969/j.issn.1007-1024.2007.03.009.
[28]	He ZJ, Li RX (2014) Treatment of 63 cases of acute upper gastrointestinal bleeding with Zhixue powder combined with Western Medicine. Shaanxi traditional Chinese Medicine 09: 1119-1121 https://doi.org/10.3969/j.issn.1000-7369.2014.09.008.
[29]	Ge XD, Li XH, Cui JJ et al (2020) Clinical study of Shihui powder in the treatment of postoperative bleeding of mixed hemorrhoids. Hebei Traditional Chinese Medicine 9: 1330-1332.
[30]	Li CG, Sun ZH, Liu HY et al (2016) Prevention of primary anastomotic bleeding after PPH of circular mixed hemorrhoids with modified Shihui powder. Shanxi Traditional Chinese Medicine 1: 37-38 https://doi.org/10.3969/j.issn.1000-7156.2016.01.020.
[31]	Liu HY, Li CG (2015) One hundred and fifty casses of anastomotic bleeding after pph prevented by flavored shihui powder. Henan University of Chinese Medicine 10: 2467-2468. https://doi.org/10.16367/j.issn.1003-5028.2015.10.1053.
[32]	Li XJ, Wang D, Wang HS et al (2015) Clinical study of Shihui powder combined with external stripping and internal ligation and aggravated skin bridge construction in the treatment of circular mixed hemorrhoids. Journal of traditional Chinese Medicine 2: 199-201 https://doi.org/10.16368/j.issn.1674-8999.2015.02.067.
[33]	Jiang DP, Luo Y, Zhang XL et al (2017) Self controlled trial of Qinji Liangxue mixture in the treatment of early hemorrhagic hemorrhoids. Journal of Changchun University of traditional Chinese Medicine 03: 448-450 https://doi.org/10.13463/j.cnki.cczyy.2017.03.034.
[34]	Wang DS, Lu QG, Li XH (2016) Clinical observation of Shihui powder in the treatment of early internal hemorrhoids and hematochezia. Hebei Journal of Traditional Chinese Medicine 38: 95-97. https://doi.org/10.3969/j.issn.1002-2619.2016.01.029.
[35]	Chen YQ (2014) Clinical observation on treating 36 cases of epistaxis with Zhizi Baiji Oujie decoction. Clinical Journal of Chinese Medicine 11: 111-112.
[36]	Sheng FS (2012) Observation on 36 cases of epistaxis treated with rhubarb charcoal cuttlebone powder. Hainan Medical College 5: 94. https://doi.org/10.3969/j.issn.1003-6350.2012.05.042.
[37]	Zhou XR, Wan MB, Li J (2012) Chinese medicine treated 27 cases of diabetic under-eye bleeding. Journal of Practical Traditional Chinese Medicine 9: 747. https://doi.org/10.3969/j.issn.1004-2814.2012.09.013.
[38]	Zhang ZL, Zhou Y, Huang XF (2008) Study of the hemostatic components of seschlot charcoal. Chinese Traditional Patent Medicine 12: 1803-1805. https://doi.org/10.3969/j.issn.1001-1528.2007.12.029.
[39]	Jiang ZG, Jiang QC (2001) Effect of residual blood charcoal on rapid hemostasis and prevention of dry socket in tooth extraction wound. Journal of Ningxia Medical University 08: 796-797 https://doi.org/10.16050/j.cnki.issn1674-6309.2011.08.007.
[40]	Chen Z, Ye SY, Yang Y et al (2019) A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect. Pharmaceutical biology 1: 498-506. https://doi.org/10.1080/13880209.2019.1645700.
[41]	Zhao H, Zhang XS, Dai YP et al (2018) The effect of the preparation on the content of the enamel components and the coagulation effect in the earth's crucifiium. Shandong Agricultural Sciences 12: 127-131. https://doi.org/10.14083/j.issn.1001-4942.2018.12.026.
[42]	Gong YX, Lu XL (1991) Study on trace elements in the dissolution solution of 20 traditional Chinese medicines before and after charcoal frying. Chinese Journal of traditional Chinese Medicine 2: 85-87+126-127.
[43]	Dan MQ (2013) Study on drying of Platycladi Cacumen and hemostatic mechanism after carbonized. Nanjing University of Chinese Medicine. https://doi.org/10.27253/d.cnki.gnjzu.2013.000003.
[44]	Chen Q (2014) Investigation on the basis of hemostatic pharmacodynamic substances and the mechanism of hemostatic synergism of Chinese artichoke char. Beijing University of Chinese medicine.
[45]	Zhang ZL, Lian B, Liu YM (2002) The chemical eye pill treated 108 cases of under-eye bleeding. Shandong Journal of Traditional Chinese Medicine 3: 149-150. https://doi.org/CNKI:SUN:SDZY.0.2002-03-012.
[46]	Luo J, Zhang ML, Cheng JJ et al (2018) Hemostatic effect of novel carbon dots derived from cirsium setosum carbonisata. RSC adv 66: 37707-37714. https://doi.org/10.1039/C8RA06340K.
[47]	Wang YZ, Kong H, Liu XM, et al (2018) Novel carbon dots derived from cirsii japonici herba carbonisata and their haemostatic effect. J Biomed Nanotechnol 9: 1635-1644. https://doi.org/10.1166/jbn.2018.2613.
[48]	Pan LL, Liu J, Huang X, (2017) Dicussion on cooling blood for hemostasis and processing mechanism of carbonized gardeniae fructus. Chinese Journal of Experimental Prescriptions 23: 1-6. https://doi.org/10.13422/j.cnki.syfjx.2017230001.
[49]	Yao L (2014) The study on the Material Basis of Gardenia Jasminoides fried into carbon. China Academy of Traditional Chinese Medicine.
[50]	Ma HF (2005) Study on Chemical Constituents of Puhuang Charcoal. Beijing University of Chinese Medicine.
[51]	He YY (2009) Study on hemostatic mechanism and quality standard of white grass root charcoal. Nanjing University of traditional Chinese Medicine https://doi.org/10.7666/d.y1646371.
[52]	Yang HL, Huang DF, Nong HN et al (2018) Influence on chemical components contents and hemostasis of Malusdoumeri (Bois.) Chev under Stir-fry to Scorch preparation. Pharmacology and Clinics of Chinese Materia Medica 6: 129-133 https://doi.org/10.13412/j.cnki.zyyl.2018.06.031.
[53]	Cui J (2004) Investigation on the material basis of hemostatic effect of 10 gray powder. Jiangsu Journal of Traditional Chinese Medicine 2: 46-48. https://doi.org/10.3969/j.issn.1672-397X.2004.02.027.
[54]	Zhao H (2019) Preliminary study on the basis of carbon hemostatic substances based on grey correlation analysis. Shandong University of Traditional Chinese Medicine.
[55]	Yu H, Mao BB, Liu HZ et al (2014) Effect of charcoal on the quality and hemorrhage effect of the molyes in the earth' cocoon. Chinese Traditional Patent Medicine 6: 1317-1320. https://doi.org/10.3969/j.issn.1001-1528.2014.06.048.
[56]	Yang L, Wen Y, Liu Y et al (2020) Study on relationship between color characteristics of rhubarb charcoal in heating process and contents of 14 chemical components. China Journal of Chinese Materia Medica 17: 4230-4237 https://doi.org/10.19540/j.cnki.cjcmm.20200622.307.
[57]	Li X, Wei XL, Zhao XL et al (2011) The changes of chemical components of peony bark before and after charcoal frying were compared. Chinese Journal of experimental prescriptions 23: 32-35. https://doi.org/10.13422/j.cnki.syfjx.2011.23.020.
[58]	Zhao XL (2009) Research on the process and quality standards of danpi carbon concocting. Nanjing University of Chinese Medicine. https://doi.org/10.7666/d.y1646370.
[59]	Wei XJ, Li XY, Zhao HB et al (2015) Influence of processing on the hemostation and the content of gallic acid in Acalypha australis. West China Journal of Pharmaceutical Sciences 4: 478-480 https://doi.org/10.13375/j.cnki.wcjps.2015.04.032.
[60]	Li XY, Zhao HB, Sun XH et al (2015) Effects of different charcoal frying methods on hemostasis and gallic acid content of iron amaranth. Shizhen national medicine 3: 621-622 https://doi.org/CNKI:SUN:SZGY.0.2015-03-040.
[61]	Yao XD (2009) Study on quality standard and hemostatic mechanism of Cacumen Platycladi Carbonisatum. Nanjing University of Chinese Medicine https://doi.org/10.7666/d.y1646352.
[62]	Li SJ, Jia SJ, Yang L et al (2019) Changes of microstructure and coagulation components of Hawthorn before and after charcoal frying. Shizhen national medicine 6: 1352-1354.
[63]	Xia MQ (2019) On the hemostatic material basis of hawthorn before and after charcoal processing with the theory"the red can be stopped by black medicines". Southwest Jiaotong University https://doi.org/10.27414/d.cnki.gxnju.2019.001663.
[64]	Xu LY, Pan X, Xu K et al (2011) Study on the relationship between tannins, organic acids of mume-carbon and blood coagulation. Chinese Journal of Hospital Pharmacy 7: 535-537. https://doi.org/CNKI:SUN:ZGYZ.0.2011-07-006.
[65]	Huang Q, Meng J, Wu DL et al (2013) Comparison of tannin content and carbon adsorption capacity of Scutellaria baicalensis before and after charcoal frying. Chinese Journal of experimental prescriptions 22: 82-84. https://doi.org/10.11653/syfj2013220082.
[66]	Yao L, Meng J, Zhang C et al (2014) Content of the Tanning and Absorption Capacity of Carbon in Different Processed Gardenia Slices. Chinese Journal of Experimental Traditional Medical Formulae 4: 45-48 https://doi.org/10.11653/syfj2014040045.
[67]	Chen C, Shan MQ, Ding AW (2009) Comparison of sorption of lateral cortex leaves and lateral cortex drinkers. Journal of Jiangsu Traditional Chinese Medicine 3: 57-78. https://doi.org/10.3969/j.issn.1672-397X.2009.03.036.
[68]	Li X, Zhang H, Ding AW et al (2011) Comparative study on changes of adsorption capacity of peony bark before and after charcoal frying. Journal of traditional Chinese Medicine 08: 959-960 https://doi.org/10.16368/j.issn.1674-8999.2011.08.040.
[69]	Zhao YS, Zhao JL, Liu CY et al (2020) Study on the correlation between jaundice charcoal hemostatic effect and adsorption. Yunnan Journal of Traditional Chinese Medicine and Materia Medica 7: 72-76.
[70]	Wang CL, Zhang XL (2010) Determination of hyperoside and quercetin in different processed products of Nelumbins Receptaculum by HPLC. Chinese Patent Drug 10: 1729-1733. https://doi.org/CNKI:SUN:ZCYA.0.2010-10-026.
[71]	Chen YQ (2016) Study on the correlation between transformation of flavonoids in Liangxue hemostatic medicine and its hemostatic activity. Nanjing University of Chinese Medicine.
[72]	Zhao Y, Guo J, Liu T et al (2010) Pharmacological study of new hemostatic components after the production of charcoal. China Journal of Chinese Materia Medica 17: 2346-2349. https://doi.org/10.4268/cjcmm20101729.
[73]	Shi DH, Dai YP, Su BZ et al (2020) Preliminary Study on the Scientific Connotation “carbonizing retains characteristics” of Platycladi Cacumen. Chinese Medicinal Herb 23: 5963-5971. https://doi.org/10.7501/j.issn.0253-2670.2020.23.008.
[74]	Li K (2016) Study on quality control and hemostatic effect of lotus leaf and lotus leaf charcoal. Shanxi College of traditional Chinese Medicine https://doi.org/CNKI:CDMD:2.1016.316169.
[75]	Guo DY, Wang M, Tang ZS et al (2010) Experimental study on changes of chemical components and hemostatic effect of rhubarb before and after charcoal frying. Shizhen national medicine 12: 3152-3153. https://doi.org/10.3969/j.issn.1008-0805.2010.12.053.
[76]	Zhang ZL, Huang XF, Zhang CS et al (2008) Comparison of pharmacological effects before and after the fried charcoal of madder drink tablets. China Journal of Traditional Chinese Medicine and Pharmacy 10: 879-881. https://doi.org/CNKI:SUN:BXYY.0.2008-10-011.
[77]	Zhang WH, Zhang ZL, Huang XF et al (2006) Comparison of hemostatic mechanism before and after the fried charcoal of madder drink tablets. China Journal of Traditional Chinese Medicine and Pharmacy 3: 160-162. https://doi.org/10.3969/j.issn.1673-1727.2006.03.008.
[78]	Liu XM (2018) Study on Hemostatic Effect of Phellodendron chinense Charcoal and Its Mechanism. Beijing University of Chinese Medicine.
[79]	Liu XM, Wang YZ, Yan X et al (2018) Novel phellodendri cortex (huang bo)-derived carbon dots and their hemostatic effect. Nanomedicine 4: 391-405. https://doi.org/10.2217/nnm-2017-0297.
[80]	Wang YZ (2018) Study on hemostatic material basis and action mechanism of artichoke charcoal. Beijing University of traditional Chinese Medicine.
[81]	Luo J, Hu J, Liu YH et al (2021) The effect Moutan coetex carbonisata nan-components on the blood-cooling and hemostatic. Acta Pharmaceutica Sinica 1: 15. https://doi.org/10.16438/j.0513-4870.2021-0676.
[82]	Luo J, Zhao Y, Cheng JJ et al (2019) Nanoparticles derived from lotus Leaf Carbonisatus and their hemostatic effect. northwest pharmaceutical journal 4: 499-504.
[83]	Cheng JJ (2019) Investigation on the material basis of "" hemostasis and treatment of epilepsy "" with blood carbon and its mechanism of action. Beijing University of Chinese medicine. https://doi.org/10.26973/d.cnki.gbjzu.2019.000003.
[84]	Zhang ML (2018) Study on the basis of Jing mustard hemostatic substance and its mechanism of action. Beijing University of Chinese Medicine.
[85]	Zhang ML, Zhao Y, Cheng JJ et al (2018). Novel carbon dots derived from Schizonepetae Herba Carbonisata and investigation of their haemostatic efficacy. Artif Cells Nanomed Biotechnol 8: 1562-1571. https://doi.org/10.1080/21691401.2017.1379015.
[86]	Sun ZW, Lu F, Cheng JJ (2018) Haemostatic bioactivity of novel schizonepetae spica carbonisata-derived carbon dots via platelet counts elevation. Artif Cells Nanomed Biotechnol 46 (sup3): S308-S317. https://doi.org/10.1080/21691401.2018.1492419.
[87]	Xiong W, Zhao Y, Cheng JJ et al (2019) Novel carbon dots derived from Dryopteridis Crassirhizomatis Rhizoma Carbonisatum and their hemostatic effect. Chinese Traditional and Herbal Drugs 6: 1388-1394 https://doi.org/CNKI:SUN:ZCYO.0.2019-06-019.
[88]	Cheng JJ, Zhang ML, Sun ZW et al (2019) Hemostatic and hepatoprotective bioactivity of junci medulla carbonisata-derived carbon dots. Nanomedicine 4: 431-446. https://doi.org/10.2217/nnm-2018-0285.
[89]	Yan X, Zhao Y, Luo J et al (2017) Hemostatic bioactivity of novel pollen typhae carbonisata-derived carbon quantum dots. J Nanobiotechnology 1: 60. https://doi.org/10.1186/s12951-017-0296-z.
[90]	Zhang DJ, Zhao X, Sun L et al (2020) Study on the change of cold blood hemostatic effect before and after honeysuckle fried charcoal. Lishizhen Medicine and Materia Medica Research 3: 603-605. https://doi.org/10.3969/j.issn.1008-0805.2020.03.028.
[91]	Wang B (2020) Research on between “effects of hemostasis with epartly preservation”and carbonizing crafts of Rehmanniae Radix charcoal. Shanxi University of traditional Chinese Medicine. https://doi.org/10.27820/d.cnki.gszxy.2020.000099.
[92]	Yang RF, Wu SH, Wei SH et al (2015) Effects of Selaginella Selaginella charcoal frying on bleeding time and coagulation time in mice. Traditional Chinese Medicinal Research 12: 70-73 https://doi.org/10.3969/j.issn.1001-6910.2015.12.32.
[93]	Cui J (2004) Discussion on mechanism of hemorrhage and blood coagulation of shihui powder. Journal of Shandong University of Traditional Chinese Medicine 6: 463-466. https://doi.org/10.16294/j.cnki.1007-659x.2004.06.024.
[94]	Zhang S (2007) Clinical and experimental studies of micron large rheum to treat peptic ulcer bleeding. Hubei University of Chinese Medicine. https://doi.org/10.3969/j.issn.1007-1024.2007.03.009.
[95]	Wang RQ (2007) Clinical observation of micron rhubarb charcoal in the treatment of peptic ulcer bleeding and the mechanism of platelet system. Hubei University of Chinese Medicine.

Cite This Article

Plain Text BibTeX RIS

APA Style

Guohong Zhou, Xiaozhong Shen, Zhendong Zhao, Renliang Yan, Peihao Huang, et al. (2021). Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines. Journal of Diseases and Medicinal Plants, 7(4), 98-108. https://doi.org/10.11648/j.jdmp.20210704.12

Copy | Download

ACS Style

Guohong Zhou; Xiaozhong Shen; Zhendong Zhao; Renliang Yan; Peihao Huang, et al. Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines. J. Dis. Med. Plants 2021, 7(4), 98-108. doi: 10.11648/j.jdmp.20210704.12

Copy | Download

AMA Style

Guohong Zhou, Xiaozhong Shen, Zhendong Zhao, Renliang Yan, Peihao Huang, et al. Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines. J Dis Med Plants. 2021;7(4):98-108. doi: 10.11648/j.jdmp.20210704.12

Copy | Download

@article{10.11648/j.jdmp.20210704.12,
  author = {Guohong Zhou and Xiaozhong Shen and Zhendong Zhao and Renliang Yan and Peihao Huang and Ruqin Tan and Shuibo Liang and Yanting Zhi and Jiaqi Li},
  title = {Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {7},
  number = {4},
  pages = {98-108},
  doi = {10.11648/j.jdmp.20210704.12},
  url = {https://doi.org/10.11648/j.jdmp.20210704.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20210704.12},
  abstract = {Charred traditional Chinese medicines have been used to stop bleeding since ancient times. To date, they are often applied to treat purpura, metrorrhagia, upper gastrointestinal bleeding, postoperative hemorrhage of mixed hemorrhoids, and hemorrhoids bleeding. Conventional oral decoction is still a predominate application form. It is noteworthy that a new and original application form of charred herbs has occurred in the treatment of upper gastrointestinal bleeding. Different from the conventional oral decoction, the micron-sized rhei radix et rhizome carbonisatus was sprayed on the surface of the lesion through gastroscopy to stop upper gastrointestinal bleeding. Active tannins, calcium ions, flavonoids and anthraquinones play a role in a part of charred herbs to stop bleeding. The emergence or increase of active components may lead charred herbs to significantly better haemostatic effects than uncharred ones, especially the emergence of activated carbon and novel carbon dots. This underlines a big need to char herbs at first before their clinical use. It leads to a new issue how to char herbs properly for maximum active components, which is related to the quality control of charred herbs. Hence, the optimum charring methods should be explored in depth for different herbs in the future. Furthermore, modern research indicates the haemostatic mechanisms of charred herbs are related to their ability to activate coagulation pathways, enhance platelet systems and/or inhibit fibrinolysis systems.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines
AU  - Guohong Zhou
AU  - Xiaozhong Shen
AU  - Zhendong Zhao
AU  - Renliang Yan
AU  - Peihao Huang
AU  - Ruqin Tan
AU  - Shuibo Liang
AU  - Yanting Zhi
AU  - Jiaqi Li
Y1  - 2021/11/12
PY  - 2021
N1  - https://doi.org/10.11648/j.jdmp.20210704.12
DO  - 10.11648/j.jdmp.20210704.12
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 98
EP  - 108
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20210704.12
AB  - Charred traditional Chinese medicines have been used to stop bleeding since ancient times. To date, they are often applied to treat purpura, metrorrhagia, upper gastrointestinal bleeding, postoperative hemorrhage of mixed hemorrhoids, and hemorrhoids bleeding. Conventional oral decoction is still a predominate application form. It is noteworthy that a new and original application form of charred herbs has occurred in the treatment of upper gastrointestinal bleeding. Different from the conventional oral decoction, the micron-sized rhei radix et rhizome carbonisatus was sprayed on the surface of the lesion through gastroscopy to stop upper gastrointestinal bleeding. Active tannins, calcium ions, flavonoids and anthraquinones play a role in a part of charred herbs to stop bleeding. The emergence or increase of active components may lead charred herbs to significantly better haemostatic effects than uncharred ones, especially the emergence of activated carbon and novel carbon dots. This underlines a big need to char herbs at first before their clinical use. It leads to a new issue how to char herbs properly for maximum active components, which is related to the quality control of charred herbs. Hence, the optimum charring methods should be explored in depth for different herbs in the future. Furthermore, modern research indicates the haemostatic mechanisms of charred herbs are related to their ability to activate coagulation pathways, enhance platelet systems and/or inhibit fibrinolysis systems.
VL  - 7
IS  - 4
ER  -

Copy | Download

Author Information

Guohong Zhou

Chinese Medicine School, Guangdong Food and Drug Vocational College, Guangzhou, China
Xiaozhong Shen

Chinese Medicine School, Guangdong Food and Drug Vocational College, Guangzhou, China
Zhendong Zhao

Chinese Medicine School, Guangdong Food and Drug Vocational College, Guangzhou, China
Renliang Yan

Chinese Medicine School, Guangdong Food and Drug Vocational College, Guangzhou, China
Peihao Huang

Chinese Medicine School, Guangdong Food and Drug Vocational College, Guangzhou, China
Ruqin Tan

Chinese Medicine School, Guangdong Food and Drug Vocational College, Guangzhou, China
Shuibo Liang

Chinese Medicine School, Guangdong Food and Drug Vocational College, Guangzhou, China
Yanting Zhi

Chinese Medicine School, Guangdong Food and Drug Vocational College, Guangzhou, China
Jiaqi Li

Chinese Medicine School, Guangdong Food and Drug Vocational College, Guangzhou, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Guohong Zhou, Xiaozhong Shen, Zhendong Zhao, Renliang Yan, Peihao Huang, et al. (2021). Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines. Journal of Diseases and Medicinal Plants, 7(4), 98-108. https://doi.org/10.11648/j.jdmp.20210704.12

Copy | Download

ACS Style

Guohong Zhou; Xiaozhong Shen; Zhendong Zhao; Renliang Yan; Peihao Huang, et al. Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines. J. Dis. Med. Plants 2021, 7(4), 98-108. doi: 10.11648/j.jdmp.20210704.12

Copy | Download

AMA Style

Guohong Zhou, Xiaozhong Shen, Zhendong Zhao, Renliang Yan, Peihao Huang, et al. Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines. J Dis Med Plants. 2021;7(4):98-108. doi: 10.11648/j.jdmp.20210704.12

Copy | Download

@article{10.11648/j.jdmp.20210704.12,
  author = {Guohong Zhou and Xiaozhong Shen and Zhendong Zhao and Renliang Yan and Peihao Huang and Ruqin Tan and Shuibo Liang and Yanting Zhi and Jiaqi Li},
  title = {Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {7},
  number = {4},
  pages = {98-108},
  doi = {10.11648/j.jdmp.20210704.12},
  url = {https://doi.org/10.11648/j.jdmp.20210704.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20210704.12},
  abstract = {Charred traditional Chinese medicines have been used to stop bleeding since ancient times. To date, they are often applied to treat purpura, metrorrhagia, upper gastrointestinal bleeding, postoperative hemorrhage of mixed hemorrhoids, and hemorrhoids bleeding. Conventional oral decoction is still a predominate application form. It is noteworthy that a new and original application form of charred herbs has occurred in the treatment of upper gastrointestinal bleeding. Different from the conventional oral decoction, the micron-sized rhei radix et rhizome carbonisatus was sprayed on the surface of the lesion through gastroscopy to stop upper gastrointestinal bleeding. Active tannins, calcium ions, flavonoids and anthraquinones play a role in a part of charred herbs to stop bleeding. The emergence or increase of active components may lead charred herbs to significantly better haemostatic effects than uncharred ones, especially the emergence of activated carbon and novel carbon dots. This underlines a big need to char herbs at first before their clinical use. It leads to a new issue how to char herbs properly for maximum active components, which is related to the quality control of charred herbs. Hence, the optimum charring methods should be explored in depth for different herbs in the future. Furthermore, modern research indicates the haemostatic mechanisms of charred herbs are related to their ability to activate coagulation pathways, enhance platelet systems and/or inhibit fibrinolysis systems.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines
AU  - Guohong Zhou
AU  - Xiaozhong Shen
AU  - Zhendong Zhao
AU  - Renliang Yan
AU  - Peihao Huang
AU  - Ruqin Tan
AU  - Shuibo Liang
AU  - Yanting Zhi
AU  - Jiaqi Li
Y1  - 2021/11/12
PY  - 2021
N1  - https://doi.org/10.11648/j.jdmp.20210704.12
DO  - 10.11648/j.jdmp.20210704.12
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 98
EP  - 108
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20210704.12
AB  - Charred traditional Chinese medicines have been used to stop bleeding since ancient times. To date, they are often applied to treat purpura, metrorrhagia, upper gastrointestinal bleeding, postoperative hemorrhage of mixed hemorrhoids, and hemorrhoids bleeding. Conventional oral decoction is still a predominate application form. It is noteworthy that a new and original application form of charred herbs has occurred in the treatment of upper gastrointestinal bleeding. Different from the conventional oral decoction, the micron-sized rhei radix et rhizome carbonisatus was sprayed on the surface of the lesion through gastroscopy to stop upper gastrointestinal bleeding. Active tannins, calcium ions, flavonoids and anthraquinones play a role in a part of charred herbs to stop bleeding. The emergence or increase of active components may lead charred herbs to significantly better haemostatic effects than uncharred ones, especially the emergence of activated carbon and novel carbon dots. This underlines a big need to char herbs at first before their clinical use. It leads to a new issue how to char herbs properly for maximum active components, which is related to the quality control of charred herbs. Hence, the optimum charring methods should be explored in depth for different herbs in the future. Furthermore, modern research indicates the haemostatic mechanisms of charred herbs are related to their ability to activate coagulation pathways, enhance platelet systems and/or inhibit fibrinolysis systems.
VL  - 7
IS  - 4
ER  -

Copy | Download