Worldwide, benign prostatic hyperplasia (BPH) is common in men over the age of 50. Hence there is a phytotherapy for BPH. In Mali, many medicinal plants are used in the traditional treatment of BPH. The current work aimed to characterize secondary metabolites and anti-radical constituents, to determine the acute toxicity and to evaluate the analgesic and anti-inflammatory activities of aqueous extracts from the leaves and stems of Flueggea virosa. Colour and precipitation reactions in tubes were performed to characterize the chemical constituents of the extracts. Anti-radical substances were determined through the free radical reduction method of 1,1 diphenyl, 2-picryl hydrazyl radical. The acute toxicity was performed in vivo using female mice. In vivo analgesic activity was determined through inhibition of induced pain in mice using 0.6% acetic acid. In vivo anti-inflammatory activity was determined by inhibiting inflammation caused with carrageenan in mice. The main chemical constituents of aqueous extracts were flavonoids, tannins and saponins. Polar extracts contained anti-radical substances. These extracts exhibited analgesic and anti-inflammatory activities. The decoction extracts administered orally in mice at the dose of 2000 mg/kg did not provoke toxic effects and mortality. The stem extract at 100 mg / kg exhibited the best analgesic activity with 64.82% inhibition and anti-inflammatory activity with 59.07% inhibition. These first results justify the traditional use of the plant in the medical management of BPH and will help to make data for the development of a new improved traditional medicine (ITM) based on the stems of Flueggea virosa.
| Published in | Journal of Diseases and Medicinal Plants (Volume 7, Issue 4) |
| DOI | 10.11648/j.jdmp.20210704.14 |
| Page(s) | 119-126 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Flueggea virosa, Analgesic and Anti-inflammatory, Anti-radical Substances, Benign Prostatic Hyperplasia, Mali
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APA Style
Adama Dénou, Mahamane Haïdara, Flacoro Diakité, Sékou Doumbia, Daouda Lassine Dembélé, et al. (2021). Phytochemicals and Biological Activities of Flueggea virosa (Phyllanthaceae) Used in the Traditional Treatment of Benign Prostatic Hyperplasia in Mali. Journal of Diseases and Medicinal Plants, 7(4), 119-126. https://doi.org/10.11648/j.jdmp.20210704.14
ACS Style
Adama Dénou; Mahamane Haïdara; Flacoro Diakité; Sékou Doumbia; Daouda Lassine Dembélé, et al. Phytochemicals and Biological Activities of Flueggea virosa (Phyllanthaceae) Used in the Traditional Treatment of Benign Prostatic Hyperplasia in Mali. J. Dis. Med. Plants 2021, 7(4), 119-126. doi: 10.11648/j.jdmp.20210704.14
AMA Style
Adama Dénou, Mahamane Haïdara, Flacoro Diakité, Sékou Doumbia, Daouda Lassine Dembélé, et al. Phytochemicals and Biological Activities of Flueggea virosa (Phyllanthaceae) Used in the Traditional Treatment of Benign Prostatic Hyperplasia in Mali. J Dis Med Plants. 2021;7(4):119-126. doi: 10.11648/j.jdmp.20210704.14
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Download@article{10.11648/j.jdmp.20210704.14,
author = {Adama Dénou and Mahamane Haïdara and Flacoro Diakité and Sékou Doumbia and Daouda Lassine Dembélé and Rokia Sanogo},
title = {Phytochemicals and Biological Activities of Flueggea virosa (Phyllanthaceae) Used in the Traditional Treatment of Benign Prostatic Hyperplasia in Mali},
journal = {Journal of Diseases and Medicinal Plants},
volume = {7},
number = {4},
pages = {119-126},
doi = {10.11648/j.jdmp.20210704.14},
url = {https://doi.org/10.11648/j.jdmp.20210704.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20210704.14},
abstract = {Worldwide, benign prostatic hyperplasia (BPH) is common in men over the age of 50. Hence there is a phytotherapy for BPH. In Mali, many medicinal plants are used in the traditional treatment of BPH. The current work aimed to characterize secondary metabolites and anti-radical constituents, to determine the acute toxicity and to evaluate the analgesic and anti-inflammatory activities of aqueous extracts from the leaves and stems of Flueggea virosa. Colour and precipitation reactions in tubes were performed to characterize the chemical constituents of the extracts. Anti-radical substances were determined through the free radical reduction method of 1,1 diphenyl, 2-picryl hydrazyl radical. The acute toxicity was performed in vivo using female mice. In vivo analgesic activity was determined through inhibition of induced pain in mice using 0.6% acetic acid. In vivo anti-inflammatory activity was determined by inhibiting inflammation caused with carrageenan in mice. The main chemical constituents of aqueous extracts were flavonoids, tannins and saponins. Polar extracts contained anti-radical substances. These extracts exhibited analgesic and anti-inflammatory activities. The decoction extracts administered orally in mice at the dose of 2000 mg/kg did not provoke toxic effects and mortality. The stem extract at 100 mg / kg exhibited the best analgesic activity with 64.82% inhibition and anti-inflammatory activity with 59.07% inhibition. These first results justify the traditional use of the plant in the medical management of BPH and will help to make data for the development of a new improved traditional medicine (ITM) based on the stems of Flueggea virosa.},
year = {2021}
}
TY - JOUR T1 - Phytochemicals and Biological Activities of Flueggea virosa (Phyllanthaceae) Used in the Traditional Treatment of Benign Prostatic Hyperplasia in Mali AU - Adama Dénou AU - Mahamane Haïdara AU - Flacoro Diakité AU - Sékou Doumbia AU - Daouda Lassine Dembélé AU - Rokia Sanogo Y1 - 2021/11/29 PY - 2021 N1 - https://doi.org/10.11648/j.jdmp.20210704.14 DO - 10.11648/j.jdmp.20210704.14 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 119 EP - 126 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20210704.14 AB - Worldwide, benign prostatic hyperplasia (BPH) is common in men over the age of 50. Hence there is a phytotherapy for BPH. In Mali, many medicinal plants are used in the traditional treatment of BPH. The current work aimed to characterize secondary metabolites and anti-radical constituents, to determine the acute toxicity and to evaluate the analgesic and anti-inflammatory activities of aqueous extracts from the leaves and stems of Flueggea virosa. Colour and precipitation reactions in tubes were performed to characterize the chemical constituents of the extracts. Anti-radical substances were determined through the free radical reduction method of 1,1 diphenyl, 2-picryl hydrazyl radical. The acute toxicity was performed in vivo using female mice. In vivo analgesic activity was determined through inhibition of induced pain in mice using 0.6% acetic acid. In vivo anti-inflammatory activity was determined by inhibiting inflammation caused with carrageenan in mice. The main chemical constituents of aqueous extracts were flavonoids, tannins and saponins. Polar extracts contained anti-radical substances. These extracts exhibited analgesic and anti-inflammatory activities. The decoction extracts administered orally in mice at the dose of 2000 mg/kg did not provoke toxic effects and mortality. The stem extract at 100 mg / kg exhibited the best analgesic activity with 64.82% inhibition and anti-inflammatory activity with 59.07% inhibition. These first results justify the traditional use of the plant in the medical management of BPH and will help to make data for the development of a new improved traditional medicine (ITM) based on the stems of Flueggea virosa. VL - 7 IS - 4 ER -
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