Aim: To determine the effects of simultaneously ingesting glucose and fat on postchallenge glycemia and lipidemia in 12 healthy young Japanese women. Methods: Three test trials were administered in a randomized crossover design: glucose (1 g/kg, G trial); fat cream (0.35 g/kg as fat; F trial); glucose + fat cream (GF trial). Blood samples were taken before and at 0.5, 1, 2, 4, and 6 h post-ingestion. Results: The GF trial's serum glucose peak value was lower than the G trial's, and its remnant lipoprotein-cholesterol (RLP-C) increase was less than the F trial's. The GF trial's apolipoprotein (Apo) B48 increase happened faster than the F trial's. The G and GF trials' insulinogenic index (I/G30) values were negatively correlated with the area under the curve (AUC) of glucose for 2 h. Fasting insulin level and HOMA-IR were positively (and QUICKI and I/G30 were negatively) correlated with the AUC of insulin for 2 h. The F and GF trials' fasting TG, RLP-C, ApoB48, and ApoC-III levels were positively correlated with the AUC of TG and RLP-C for 6 h. The fasting ApoB48 level predicted the AUC of ApoB48 for 6 h. Conclusion: The glucose peak was ameliorated by co-ingesting fat. I/G30 predicted an early postchallenge (0–2 h) glucose rise. The fasting insulin level, HOMA-IR, QUICKI, and I/G30 predicted an insulin rise. The RLP-C rise by fat ingestion was ameliorated by co-ingesting glucose. Fasting TG, RLP-C, ApoB48, and ApoC-III levels predicted postchallenge TG and RLP-C rises. The fasting ApoB48 level predicted postchallenge apoB48, i.e., a rise in intestinal lipoprotein.
| Published in | Journal of Food and Nutrition Sciences (Volume 9, Issue 6) |
| DOI | 10.11648/j.jfns.20210906.13 |
| Page(s) | 153-162 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Remnant Lipoprotein-Cholesterol, Apolipoprotein B48, Apolipoprotein C-III, Insulin Sensitivity, Insulin Resistance
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APA Style
Kaori Kuzawa, Yukino Morita, Natsuko Ichikawa, Michitaka Naito. (2021). Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women. Journal of Food and Nutrition Sciences, 9(6), 153-162. https://doi.org/10.11648/j.jfns.20210906.13
ACS Style
Kaori Kuzawa; Yukino Morita; Natsuko Ichikawa; Michitaka Naito. Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women. J. Food Nutr. Sci. 2021, 9(6), 153-162. doi: 10.11648/j.jfns.20210906.13
AMA Style
Kaori Kuzawa, Yukino Morita, Natsuko Ichikawa, Michitaka Naito. Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women. J Food Nutr Sci. 2021;9(6):153-162. doi: 10.11648/j.jfns.20210906.13
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Download@article{10.11648/j.jfns.20210906.13,
author = {Kaori Kuzawa and Yukino Morita and Natsuko Ichikawa and Michitaka Naito},
title = {Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women},
journal = {Journal of Food and Nutrition Sciences},
volume = {9},
number = {6},
pages = {153-162},
doi = {10.11648/j.jfns.20210906.13},
url = {https://doi.org/10.11648/j.jfns.20210906.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20210906.13},
abstract = {Aim: To determine the effects of simultaneously ingesting glucose and fat on postchallenge glycemia and lipidemia in 12 healthy young Japanese women. Methods: Three test trials were administered in a randomized crossover design: glucose (1 g/kg, G trial); fat cream (0.35 g/kg as fat; F trial); glucose + fat cream (GF trial). Blood samples were taken before and at 0.5, 1, 2, 4, and 6 h post-ingestion. Results: The GF trial's serum glucose peak value was lower than the G trial's, and its remnant lipoprotein-cholesterol (RLP-C) increase was less than the F trial's. The GF trial's apolipoprotein (Apo) B48 increase happened faster than the F trial's. The G and GF trials' insulinogenic index (I/G30) values were negatively correlated with the area under the curve (AUC) of glucose for 2 h. Fasting insulin level and HOMA-IR were positively (and QUICKI and I/G30 were negatively) correlated with the AUC of insulin for 2 h. The F and GF trials' fasting TG, RLP-C, ApoB48, and ApoC-III levels were positively correlated with the AUC of TG and RLP-C for 6 h. The fasting ApoB48 level predicted the AUC of ApoB48 for 6 h. Conclusion: The glucose peak was ameliorated by co-ingesting fat. I/G30 predicted an early postchallenge (0–2 h) glucose rise. The fasting insulin level, HOMA-IR, QUICKI, and I/G30 predicted an insulin rise. The RLP-C rise by fat ingestion was ameliorated by co-ingesting glucose. Fasting TG, RLP-C, ApoB48, and ApoC-III levels predicted postchallenge TG and RLP-C rises. The fasting ApoB48 level predicted postchallenge apoB48, i.e., a rise in intestinal lipoprotein.},
year = {2021}
}
TY - JOUR T1 - Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women AU - Kaori Kuzawa AU - Yukino Morita AU - Natsuko Ichikawa AU - Michitaka Naito Y1 - 2021/12/10 PY - 2021 N1 - https://doi.org/10.11648/j.jfns.20210906.13 DO - 10.11648/j.jfns.20210906.13 T2 - Journal of Food and Nutrition Sciences JF - Journal of Food and Nutrition Sciences JO - Journal of Food and Nutrition Sciences SP - 153 EP - 162 PB - Science Publishing Group SN - 2330-7293 UR - https://doi.org/10.11648/j.jfns.20210906.13 AB - Aim: To determine the effects of simultaneously ingesting glucose and fat on postchallenge glycemia and lipidemia in 12 healthy young Japanese women. Methods: Three test trials were administered in a randomized crossover design: glucose (1 g/kg, G trial); fat cream (0.35 g/kg as fat; F trial); glucose + fat cream (GF trial). Blood samples were taken before and at 0.5, 1, 2, 4, and 6 h post-ingestion. Results: The GF trial's serum glucose peak value was lower than the G trial's, and its remnant lipoprotein-cholesterol (RLP-C) increase was less than the F trial's. The GF trial's apolipoprotein (Apo) B48 increase happened faster than the F trial's. The G and GF trials' insulinogenic index (I/G30) values were negatively correlated with the area under the curve (AUC) of glucose for 2 h. Fasting insulin level and HOMA-IR were positively (and QUICKI and I/G30 were negatively) correlated with the AUC of insulin for 2 h. The F and GF trials' fasting TG, RLP-C, ApoB48, and ApoC-III levels were positively correlated with the AUC of TG and RLP-C for 6 h. The fasting ApoB48 level predicted the AUC of ApoB48 for 6 h. Conclusion: The glucose peak was ameliorated by co-ingesting fat. I/G30 predicted an early postchallenge (0–2 h) glucose rise. The fasting insulin level, HOMA-IR, QUICKI, and I/G30 predicted an insulin rise. The RLP-C rise by fat ingestion was ameliorated by co-ingesting glucose. Fasting TG, RLP-C, ApoB48, and ApoC-III levels predicted postchallenge TG and RLP-C rises. The fasting ApoB48 level predicted postchallenge apoB48, i.e., a rise in intestinal lipoprotein. VL - 9 IS - 6 ER -
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