Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization

Nidenori Negoro; Keiichi Kumasawa; Eri Akita; Toshihiko Tomiyam a; Takeshi Taniguchi

doi:doi:10.11648/j.jgo.20210902.11

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Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization

Nidenori Negoro, Keiichi Kumasawa, Eri Akita, Toshihiko Tomiyam a, Takeshi Taniguchi

Published in Journal of Gynecology and Obstetrics (Volume 9, Issue 2)

Received: 25 January 2021 Accepted: 18 February 2021 Published: 4 March 2021

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Abstract

Artificial reproductive technology (ART) has become a standard treatment for patients with infertility. However the cost is burdensome to infertile patients in some countries. Moreover aging is a critical factor for infertile patients and is accompanied by higher risk of condition and counts of oocytes. In planning ART for a patient, there are two patterns of oocyte pick-up (OPU) method: One is to transfer all the embros which are obtained from one OPU. Then next OPU will be performed when she fails to get pregnant despite using up all embryos. The other method is to repeat several consecutive OPUs until sufficient stock of embryos. The sufficiency depends on age, serum AMH level, etc. This study investigates the deviation in the number of oocytes collected by OPU in infertile patients who received multiple OPU within 1 year. The number of oocytes increased as the average number of oocytes increased. However, the ratio of standard deviation/average decreased. The frequency of required OPU depends on the pregnancy rate per embryo, the background of the patient, and the number of eggs collected at the first or second OPU. Thus, the analysis will reduce their mental and economic burden. Further studies with large-scale data are needed to determine the ideal frequency of OPU.

Published in	Journal of Gynecology and Obstetrics (Volume 9, Issue 2)
DOI	10.11648/j.jgo.20210902.11
Page(s)	31-35
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Infertility, Artificial Reproductive Technology (ART), Oocyte Pick up (OPU), Cost, Variation of Oocyte Count

References

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[3]	S. L. Broer, F. J. Broekmans, J. S. Laven, B. C. Fauser, Anti-Mullerian hormone: ovarian reserve testing and its potential clinical implications, Hum Reprod Update 20 (5) (2014) 688-701.
[4]	N A. Dennis, L. A. Houghton, G. T. Jones, A. M. van Rij, K. Morgan, I. S. McLennan, The level of serum anti-Mullerian hormone correlates with vitamin D status in men and women but not in boys, J Clin Endocrinol Metab 97 (7) (2012) 2450-5.
[5]	N. Suzuki, N. Yoshioka, S. Takae, Y. Sugishita, M. Tamura, S. Hashimoto, Y. Morimoto, K. Kawamura, Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency, Hum Reprod 30 (3) (2015) 608-15.
[6]	I. A. van Rooij, F. J. Broekmans, E. R. te Velde, B. C. Fauser, L. F. Bancsi, F. H. de Jong, A. P. Themmen, Serum anti-Mullerian hormone levels: a novel measure of ovarian reserve, Hum Reprod 17 (12) (2002) 3065-71.
[7]	T. Piltonen, L. Morin-Papunen, R. Koivunen, A. Perheentupa, A. Ruokonen, J. S. Tapanainen, Serum anti-Mullerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome, Hum Reprod 20 (7) (2005) 1820-6.
[8]	F. Magri, L. Schena, V. Capelli, M. Gaiti, F. Zerbini, E. Brambilla, M. Rotondi, M. De Amici, A. Spinillo, R. E. Nappi, L. Chiovato, Anti-Mullerian hormone as a predictor of ovarian reserve in ART protocols: the hidden role of thyroid autoimmunity, Reprod Biol Endocrinol 13 (1) (2015) 106.
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[11]	Kumasawa, K., Yasui, Yuri. Nakamura, Hitomi., Kimura Tadashi. Increased Anti-mullerian Hormone (AMH) After Delivery: Case Report, Journal of Gynecology and Obstetrics 2016; 4 (3): 17-18.
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APA Style

Nidenori Negoro, Keiichi Kumasawa, Eri Akita, Toshihiko Tomiyam a, Takeshi Taniguchi. (2021). Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization. Journal of Gynecology and Obstetrics, 9(2), 31-35. https://doi.org/10.11648/j.jgo.20210902.11

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ACS Style

Nidenori Negoro; Keiichi Kumasawa; Eri Akita; Toshihiko Tomiyam a; Takeshi Taniguchi. Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization. J. Gynecol. Obstet. 2021, 9(2), 31-35. doi: 10.11648/j.jgo.20210902.11

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AMA Style

Nidenori Negoro, Keiichi Kumasawa, Eri Akita, Toshihiko Tomiyam a, Takeshi Taniguchi. Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization. J Gynecol Obstet. 2021;9(2):31-35. doi: 10.11648/j.jgo.20210902.11

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@article{10.11648/j.jgo.20210902.11,
  author = {Nidenori Negoro and Keiichi Kumasawa and Eri Akita and Toshihiko Tomiyam a and Takeshi Taniguchi},
  title = {Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {9},
  number = {2},
  pages = {31-35},
  doi = {10.11648/j.jgo.20210902.11},
  url = {https://doi.org/10.11648/j.jgo.20210902.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20210902.11},
  abstract = {Artificial reproductive technology (ART) has become a standard treatment for patients with infertility. However the cost is burdensome to infertile patients in some countries. Moreover aging is a critical factor for infertile patients and is accompanied by higher risk of condition and counts of oocytes. In planning ART for a patient, there are two patterns of oocyte pick-up (OPU) method: One is to transfer all the embros which are obtained from one OPU. Then next OPU will be performed when she fails to get pregnant despite using up all embryos. The other method is to repeat several consecutive OPUs until sufficient stock of embryos. The sufficiency depends on age, serum AMH level, etc. This study investigates the deviation in the number of oocytes collected by OPU in infertile patients who received multiple OPU within 1 year. The number of oocytes increased as the average number of oocytes increased. However, the ratio of standard deviation/average decreased. The frequency of required OPU depends on the pregnancy rate per embryo, the background of the patient, and the number of eggs collected at the first or second OPU. Thus, the analysis will reduce their mental and economic burden. Further studies with large-scale data are needed to determine the ideal frequency of OPU.},
 year = {2021}
}

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TY - JOUR
T1 - Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization
AU - Nidenori Negoro
AU - Keiichi Kumasawa
AU - Eri Akita
AU - Toshihiko Tomiyam a
AU - Takeshi Taniguchi
Y1 - 2021/03/04
PY - 2021
N1 - https://doi.org/10.11648/j.jgo.20210902.11
DO - 10.11648/j.jgo.20210902.11
T2 - Journal of Gynecology and Obstetrics
JF - Journal of Gynecology and Obstetrics
JO - Journal of Gynecology and Obstetrics
SP - 31
EP - 35
PB - Science Publishing Group
SN - 2376-7820
UR - https://doi.org/10.11648/j.jgo.20210902.11
AB - Artificial reproductive technology (ART) has become a standard treatment for patients with infertility. However the cost is burdensome to infertile patients in some countries. Moreover aging is a critical factor for infertile patients and is accompanied by higher risk of condition and counts of oocytes. In planning ART for a patient, there are two patterns of oocyte pick-up (OPU) method: One is to transfer all the embros which are obtained from one OPU. Then next OPU will be performed when she fails to get pregnant despite using up all embryos. The other method is to repeat several consecutive OPUs until sufficient stock of embryos. The sufficiency depends on age, serum AMH level, etc. This study investigates the deviation in the number of oocytes collected by OPU in infertile patients who received multiple OPU within 1 year. The number of oocytes increased as the average number of oocytes increased. However, the ratio of standard deviation/average decreased. The frequency of required OPU depends on the pregnancy rate per embryo, the background of the patient, and the number of eggs collected at the first or second OPU. Thus, the analysis will reduce their mental and economic burden. Further studies with large-scale data are needed to determine the ideal frequency of OPU.
VL - 9
IS - 2
ER -

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Author Information

Nidenori Negoro

Taniguchi Hospital, Osaka, Japan
Keiichi Kumasawa

The Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
Eri Akita

Taniguchi Hospital, Osaka, Japan
Toshihiko Tomiyam a

Taniguchi Hospital, Osaka, Japan
Takeshi Taniguchi

Taniguchi Hospital, Osaka, Japan

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Plain Text BibTeX RIS

APA Style

Nidenori Negoro, Keiichi Kumasawa, Eri Akita, Toshihiko Tomiyam a, Takeshi Taniguchi. (2021). Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization. Journal of Gynecology and Obstetrics, 9(2), 31-35. https://doi.org/10.11648/j.jgo.20210902.11

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ACS Style

Nidenori Negoro; Keiichi Kumasawa; Eri Akita; Toshihiko Tomiyam a; Takeshi Taniguchi. Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization. J. Gynecol. Obstet. 2021, 9(2), 31-35. doi: 10.11648/j.jgo.20210902.11

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AMA Style

Nidenori Negoro, Keiichi Kumasawa, Eri Akita, Toshihiko Tomiyam a, Takeshi Taniguchi. Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization. J Gynecol Obstet. 2021;9(2):31-35. doi: 10.11648/j.jgo.20210902.11

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@article{10.11648/j.jgo.20210902.11,
  author = {Nidenori Negoro and Keiichi Kumasawa and Eri Akita and Toshihiko Tomiyam a and Takeshi Taniguchi},
  title = {Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {9},
  number = {2},
  pages = {31-35},
  doi = {10.11648/j.jgo.20210902.11},
  url = {https://doi.org/10.11648/j.jgo.20210902.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20210902.11},
  abstract = {Artificial reproductive technology (ART) has become a standard treatment for patients with infertility. However the cost is burdensome to infertile patients in some countries. Moreover aging is a critical factor for infertile patients and is accompanied by higher risk of condition and counts of oocytes. In planning ART for a patient, there are two patterns of oocyte pick-up (OPU) method: One is to transfer all the embros which are obtained from one OPU. Then next OPU will be performed when she fails to get pregnant despite using up all embryos. The other method is to repeat several consecutive OPUs until sufficient stock of embryos. The sufficiency depends on age, serum AMH level, etc. This study investigates the deviation in the number of oocytes collected by OPU in infertile patients who received multiple OPU within 1 year. The number of oocytes increased as the average number of oocytes increased. However, the ratio of standard deviation/average decreased. The frequency of required OPU depends on the pregnancy rate per embryo, the background of the patient, and the number of eggs collected at the first or second OPU. Thus, the analysis will reduce their mental and economic burden. Further studies with large-scale data are needed to determine the ideal frequency of OPU.},
 year = {2021}
}

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