Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo)

Eouani Levy Max Emery; Buambo Gauthier Regis Jostin; Mouhingou Belmar Nick-Desy; Mokoko Jules Cesar; Potokoue Mpia Sekangue Samantha Nuelly; Itoua Clautaire; Iloki Leon Herve

doi:doi:10.11648/j.jgo.20221002.20

Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo)

Eouani Levy Max Emery, Buambo Gauthier Regis Jostin, Mouhingou Belmar Nick-Desy, Mokoko Jules Cesar, Potokoue Mpia Sekangue Samantha Nuelly, Itoua Clautaire, Iloki Leon Herve

Published in Journal of Gynecology and Obstetrics (Volume 10, Issue 2)

Received: 21 March 2022 Accepted: 7 April 2022 Published: 14 April 2022

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Abstract

Preeclampsia is a serious obstetric situation, responsible for high maternal and perinatal morbidity and mortality. Its diagnosis is clinical and biological, with confirmation either by proteinuria on the urine dipstick or by 24-hour proteinuria constituting the gold standard. Current revisions to the definition of preeclampsia tend to free themselves from reliance on proteinuria for diagnosis. They are oriented towards a broader model where the involvement of a target organ concomitant with gestational hypertension is sufficient to make the diagnosis of preeclampsia. Late positivity of proteinuria after the onset of arterial hypertension (HTA) has been reported, contrasting with the precocity of angiogenic factors such as soluble Fms tyrosine kinase type 1 (sFlt-1) and placental growth factor (PlGF). Objective. To evaluate the performance of the sFLT-1/PLGF ratio in the diagnosis of preeclampsia. Methods. Cross-sectional multicenter analytical study conducted from October 17 to December 17, 2020 including hypertensive pregnant women, treated or not, with more than 20 weeks of amenorrhea. These all benefited from the Elisa assay of sFLT-1 and PlGF after carrying out the proteinuria on the urine dipstick during the consultation. Preeclampsia was defined by the double positivity of proteinuria on the urine dipstick associated with high blood pressure (Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg). SPSS software was used for statistical analysis and calculation of performance indices (Se; Sp; PPV; NPV; Youden “J” index, AUC). The p-value of the probability was considered significant for a value < 0.05. Results. Pregnant women were mostly multiparous with a median age of 31 years (24-35). Preeclampsia was noted in 69.2% of cases. sFLT-1 was significantly higher in preeclamptic pregnant women (409±18.9 vs 194.6±12.9; p<0.05). No significant difference was noted for PlGF (11.9 vs 13.6; p< 0.05). The sFlt-1/PlGF ratio was higher in case of preeclampsia (39.3 vs 14.6; p< 0.05). The threshold for the sFlt-/PlGF ratio retained was 18.5 (Se=86.4%; Sp=84.6%; PPV=90.5%; NPV=78.6%; J = 0.7; AUC =0.9). Conclusion. The sFlt-1/PlGF ratio was effective in the diagnosis of preeclampsia.

Published in	Journal of Gynecology and Obstetrics (Volume 10, Issue 2)
DOI	10.11648/j.jgo.20221002.20
Page(s)	126-130
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Preeclampsia, sFLT-1/PLGF Ratio, Diagnostic, Brazzaville

References

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APA Style

Eouani Levy Max Emery, Buambo Gauthier Regis Jostin, Mouhingou Belmar Nick-Desy, Mokoko Jules Cesar, Potokoue Mpia Sekangue Samantha Nuelly, et al. (2022). Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo). Journal of Gynecology and Obstetrics, 10(2), 126-130. https://doi.org/10.11648/j.jgo.20221002.20

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ACS Style

Eouani Levy Max Emery; Buambo Gauthier Regis Jostin; Mouhingou Belmar Nick-Desy; Mokoko Jules Cesar; Potokoue Mpia Sekangue Samantha Nuelly, et al. Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo). J. Gynecol. Obstet. 2022, 10(2), 126-130. doi: 10.11648/j.jgo.20221002.20

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AMA Style

Eouani Levy Max Emery, Buambo Gauthier Regis Jostin, Mouhingou Belmar Nick-Desy, Mokoko Jules Cesar, Potokoue Mpia Sekangue Samantha Nuelly, et al. Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo). J Gynecol Obstet. 2022;10(2):126-130. doi: 10.11648/j.jgo.20221002.20

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@article{10.11648/j.jgo.20221002.20,
  author = {Eouani Levy Max Emery and Buambo Gauthier Regis Jostin and Mouhingou Belmar Nick-Desy and Mokoko Jules Cesar and Potokoue Mpia Sekangue Samantha Nuelly and Itoua Clautaire and Iloki Leon Herve},
  title = {Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo)},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {10},
  number = {2},
  pages = {126-130},
  doi = {10.11648/j.jgo.20221002.20},
  url = {https://doi.org/10.11648/j.jgo.20221002.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20221002.20},
  abstract = {Preeclampsia is a serious obstetric situation, responsible for high maternal and perinatal morbidity and mortality. Its diagnosis is clinical and biological, with confirmation either by proteinuria on the urine dipstick or by 24-hour proteinuria constituting the gold standard. Current revisions to the definition of preeclampsia tend to free themselves from reliance on proteinuria for diagnosis. They are oriented towards a broader model where the involvement of a target organ concomitant with gestational hypertension is sufficient to make the diagnosis of preeclampsia. Late positivity of proteinuria after the onset of arterial hypertension (HTA) has been reported, contrasting with the precocity of angiogenic factors such as soluble Fms tyrosine kinase type 1 (sFlt-1) and placental growth factor (PlGF). Objective. To evaluate the performance of the sFLT-1/PLGF ratio in the diagnosis of preeclampsia. Methods. Cross-sectional multicenter analytical study conducted from October 17 to December 17, 2020 including hypertensive pregnant women, treated or not, with more than 20 weeks of amenorrhea. These all benefited from the Elisa assay of sFLT-1 and PlGF after carrying out the proteinuria on the urine dipstick during the consultation. Preeclampsia was defined by the double positivity of proteinuria on the urine dipstick associated with high blood pressure (Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg). SPSS software was used for statistical analysis and calculation of performance indices (Se; Sp; PPV; NPV; Youden “J” index, AUC). The p-value of the probability was considered significant for a value Results. Pregnant women were mostly multiparous with a median age of 31 years (24-35). Preeclampsia was noted in 69.2% of cases. sFLT-1 was significantly higher in preeclamptic pregnant women (409±18.9 vs 194.6±12.9; pConclusion. The sFlt-1/PlGF ratio was effective in the diagnosis of preeclampsia.},
 year = {2022}
}

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TY - JOUR
T1 - Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo)
AU - Eouani Levy Max Emery
AU - Buambo Gauthier Regis Jostin
AU - Mouhingou Belmar Nick-Desy
AU - Mokoko Jules Cesar
AU - Potokoue Mpia Sekangue Samantha Nuelly
AU - Itoua Clautaire
AU - Iloki Leon Herve
Y1 - 2022/04/14
PY - 2022
N1 - https://doi.org/10.11648/j.jgo.20221002.20
DO - 10.11648/j.jgo.20221002.20
T2 - Journal of Gynecology and Obstetrics
JF - Journal of Gynecology and Obstetrics
JO - Journal of Gynecology and Obstetrics
SP - 126
EP - 130
PB - Science Publishing Group
SN - 2376-7820
UR - https://doi.org/10.11648/j.jgo.20221002.20
AB - Preeclampsia is a serious obstetric situation, responsible for high maternal and perinatal morbidity and mortality. Its diagnosis is clinical and biological, with confirmation either by proteinuria on the urine dipstick or by 24-hour proteinuria constituting the gold standard. Current revisions to the definition of preeclampsia tend to free themselves from reliance on proteinuria for diagnosis. They are oriented towards a broader model where the involvement of a target organ concomitant with gestational hypertension is sufficient to make the diagnosis of preeclampsia. Late positivity of proteinuria after the onset of arterial hypertension (HTA) has been reported, contrasting with the precocity of angiogenic factors such as soluble Fms tyrosine kinase type 1 (sFlt-1) and placental growth factor (PlGF). Objective. To evaluate the performance of the sFLT-1/PLGF ratio in the diagnosis of preeclampsia. Methods. Cross-sectional multicenter analytical study conducted from October 17 to December 17, 2020 including hypertensive pregnant women, treated or not, with more than 20 weeks of amenorrhea. These all benefited from the Elisa assay of sFLT-1 and PlGF after carrying out the proteinuria on the urine dipstick during the consultation. Preeclampsia was defined by the double positivity of proteinuria on the urine dipstick associated with high blood pressure (Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg). SPSS software was used for statistical analysis and calculation of performance indices (Se; Sp; PPV; NPV; Youden “J” index, AUC). The p-value of the probability was considered significant for a value Results. Pregnant women were mostly multiparous with a median age of 31 years (24-35). Preeclampsia was noted in 69.2% of cases. sFLT-1 was significantly higher in preeclamptic pregnant women (409±18.9 vs 194.6±12.9; pConclusion. The sFlt-1/PlGF ratio was effective in the diagnosis of preeclampsia.
VL - 10
IS - 2
ER -

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Author Information

Eouani Levy Max Emery

Obstetrics Gynecology Department, Loandjili General Hospital, Pointe Noire, Congo
Buambo Gauthier Regis Jostin

Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo
Mouhingou Belmar Nick-Desy

Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo
Mokoko Jules Cesar

Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo
Potokoue Mpia Sekangue Samantha Nuelly

Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo
Itoua Clautaire

Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo
Iloki Leon Herve

Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo

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APA Style

Eouani Levy Max Emery, Buambo Gauthier Regis Jostin, Mouhingou Belmar Nick-Desy, Mokoko Jules Cesar, Potokoue Mpia Sekangue Samantha Nuelly, et al. (2022). Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo). Journal of Gynecology and Obstetrics, 10(2), 126-130. https://doi.org/10.11648/j.jgo.20221002.20

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ACS Style

Eouani Levy Max Emery; Buambo Gauthier Regis Jostin; Mouhingou Belmar Nick-Desy; Mokoko Jules Cesar; Potokoue Mpia Sekangue Samantha Nuelly, et al. Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo). J. Gynecol. Obstet. 2022, 10(2), 126-130. doi: 10.11648/j.jgo.20221002.20

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AMA Style

Eouani Levy Max Emery, Buambo Gauthier Regis Jostin, Mouhingou Belmar Nick-Desy, Mokoko Jules Cesar, Potokoue Mpia Sekangue Samantha Nuelly, et al. Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo). J Gynecol Obstet. 2022;10(2):126-130. doi: 10.11648/j.jgo.20221002.20

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@article{10.11648/j.jgo.20221002.20,
  author = {Eouani Levy Max Emery and Buambo Gauthier Regis Jostin and Mouhingou Belmar Nick-Desy and Mokoko Jules Cesar and Potokoue Mpia Sekangue Samantha Nuelly and Itoua Clautaire and Iloki Leon Herve},
  title = {Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo)},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {10},
  number = {2},
  pages = {126-130},
  doi = {10.11648/j.jgo.20221002.20},
  url = {https://doi.org/10.11648/j.jgo.20221002.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20221002.20},
  abstract = {Preeclampsia is a serious obstetric situation, responsible for high maternal and perinatal morbidity and mortality. Its diagnosis is clinical and biological, with confirmation either by proteinuria on the urine dipstick or by 24-hour proteinuria constituting the gold standard. Current revisions to the definition of preeclampsia tend to free themselves from reliance on proteinuria for diagnosis. They are oriented towards a broader model where the involvement of a target organ concomitant with gestational hypertension is sufficient to make the diagnosis of preeclampsia. Late positivity of proteinuria after the onset of arterial hypertension (HTA) has been reported, contrasting with the precocity of angiogenic factors such as soluble Fms tyrosine kinase type 1 (sFlt-1) and placental growth factor (PlGF). Objective. To evaluate the performance of the sFLT-1/PLGF ratio in the diagnosis of preeclampsia. Methods. Cross-sectional multicenter analytical study conducted from October 17 to December 17, 2020 including hypertensive pregnant women, treated or not, with more than 20 weeks of amenorrhea. These all benefited from the Elisa assay of sFLT-1 and PlGF after carrying out the proteinuria on the urine dipstick during the consultation. Preeclampsia was defined by the double positivity of proteinuria on the urine dipstick associated with high blood pressure (Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg). SPSS software was used for statistical analysis and calculation of performance indices (Se; Sp; PPV; NPV; Youden “J” index, AUC). The p-value of the probability was considered significant for a value Results. Pregnant women were mostly multiparous with a median age of 31 years (24-35). Preeclampsia was noted in 69.2% of cases. sFLT-1 was significantly higher in preeclamptic pregnant women (409±18.9 vs 194.6±12.9; pConclusion. The sFlt-1/PlGF ratio was effective in the diagnosis of preeclampsia.},
 year = {2022}
}

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