Diseases and infections are two of the most notable health challenges that humans are facing today; these have led to different health impairments, death and other economic damages. To combat these menaces, leaf and stem of Momordicaaugustisepala plant have been noted for their medicinal properties. Ethanol extract of Momordicaaugustisepala leaf and stem was investigated for their phytochemical constituents and antimicrobial activities. M. augustisepala leaf (MAL) andstem (MAS) was collected in Ogbomoso. Exactly 500 g of leafand stem was soaked in 4000 mL of ethanol. It was agitated for 1 hour at room temperature (27°C) in ultrasonic sonicator based on their polarity. The extract was then decanted, combined, filtered and concentrated using Rotary Evaporator at 40°C. The Fourier transforms infrared (FT-IR) spectra and ultraviolet-visible (UV-VIS) spectrophotometer was obtained on a Perkin Elmer Spectrum and Varian Cary ultraviolet-visible. Results of the phytochemical analysis of the Momordicaaugustisepala leaf and stem showed the presence of Alkaloids, Glycosides, Flavonoids, Terpenoids, Tannins, Saponins, Phenols, Steroids and Anthraquinones, and Momordicaaugustisepala stem revealed, Alkaloids, flavonoids, Anthraquinones, Glycoside, Steroids, terpenoids, Tannins, Saponins and Phenols, while reducing sugar and phlobatanins were absent. Maximum inhibition protein denaturation of 86.6% and 89.3%was observed at 500μg/ml for anti-inflammatory activities. As compared to Aspirin standard anti-inflammation drug which gave 85.9% at the same concentration. The results revealed that both seed and stem of M. augustisepala have potential for antimicrobial and anti- inflammatory activities which may be due to the presence of plant secondary metabolites.
| Published in | Modern Chemistry (Volume 8, Issue 4) |
| DOI | 10.11648/j.mc.20200804.12 |
| Page(s) | 54-63 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Phytochemical Constituents, Antimicrobial Activity, Anti-inflammatory, Momordicaaugustisepala, Ethanol Extract
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APA Style
Ezekiel Gbadebo Adeyeni, Ezekiel Temidayo Ayodele, Taofik Adewale Adedosu, Olusola Nathaniel Majolagbe, Ruth Adeola Adeyeni. (2020). Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria. Modern Chemistry, 8(4), 54-63. https://doi.org/10.11648/j.mc.20200804.12
ACS Style
Ezekiel Gbadebo Adeyeni; Ezekiel Temidayo Ayodele; Taofik Adewale Adedosu; Olusola Nathaniel Majolagbe; Ruth Adeola Adeyeni. Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria. Mod. Chem. 2020, 8(4), 54-63. doi: 10.11648/j.mc.20200804.12
AMA Style
Ezekiel Gbadebo Adeyeni, Ezekiel Temidayo Ayodele, Taofik Adewale Adedosu, Olusola Nathaniel Majolagbe, Ruth Adeola Adeyeni. Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria. Mod Chem. 2020;8(4):54-63. doi: 10.11648/j.mc.20200804.12
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Download@article{10.11648/j.mc.20200804.12,
author = {Ezekiel Gbadebo Adeyeni and Ezekiel Temidayo Ayodele and Taofik Adewale Adedosu and Olusola Nathaniel Majolagbe and Ruth Adeola Adeyeni},
title = {Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria},
journal = {Modern Chemistry},
volume = {8},
number = {4},
pages = {54-63},
doi = {10.11648/j.mc.20200804.12},
url = {https://doi.org/10.11648/j.mc.20200804.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.mc.20200804.12},
abstract = {Diseases and infections are two of the most notable health challenges that humans are facing today; these have led to different health impairments, death and other economic damages. To combat these menaces, leaf and stem of Momordicaaugustisepala plant have been noted for their medicinal properties. Ethanol extract of Momordicaaugustisepala leaf and stem was investigated for their phytochemical constituents and antimicrobial activities. M. augustisepala leaf (MAL) andstem (MAS) was collected in Ogbomoso. Exactly 500 g of leafand stem was soaked in 4000 mL of ethanol. It was agitated for 1 hour at room temperature (27°C) in ultrasonic sonicator based on their polarity. The extract was then decanted, combined, filtered and concentrated using Rotary Evaporator at 40°C. The Fourier transforms infrared (FT-IR) spectra and ultraviolet-visible (UV-VIS) spectrophotometer was obtained on a Perkin Elmer Spectrum and Varian Cary ultraviolet-visible. Results of the phytochemical analysis of the Momordicaaugustisepala leaf and stem showed the presence of Alkaloids, Glycosides, Flavonoids, Terpenoids, Tannins, Saponins, Phenols, Steroids and Anthraquinones, and Momordicaaugustisepala stem revealed, Alkaloids, flavonoids, Anthraquinones, Glycoside, Steroids, terpenoids, Tannins, Saponins and Phenols, while reducing sugar and phlobatanins were absent. Maximum inhibition protein denaturation of 86.6% and 89.3%was observed at 500μg/ml for anti-inflammatory activities. As compared to Aspirin standard anti-inflammation drug which gave 85.9% at the same concentration. The results revealed that both seed and stem of M. augustisepala have potential for antimicrobial and anti- inflammatory activities which may be due to the presence of plant secondary metabolites.},
year = {2020}
}
TY - JOUR T1 - Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria AU - Ezekiel Gbadebo Adeyeni AU - Ezekiel Temidayo Ayodele AU - Taofik Adewale Adedosu AU - Olusola Nathaniel Majolagbe AU - Ruth Adeola Adeyeni Y1 - 2020/12/31 PY - 2020 N1 - https://doi.org/10.11648/j.mc.20200804.12 DO - 10.11648/j.mc.20200804.12 T2 - Modern Chemistry JF - Modern Chemistry JO - Modern Chemistry SP - 54 EP - 63 PB - Science Publishing Group SN - 2329-180X UR - https://doi.org/10.11648/j.mc.20200804.12 AB - Diseases and infections are two of the most notable health challenges that humans are facing today; these have led to different health impairments, death and other economic damages. To combat these menaces, leaf and stem of Momordicaaugustisepala plant have been noted for their medicinal properties. Ethanol extract of Momordicaaugustisepala leaf and stem was investigated for their phytochemical constituents and antimicrobial activities. M. augustisepala leaf (MAL) andstem (MAS) was collected in Ogbomoso. Exactly 500 g of leafand stem was soaked in 4000 mL of ethanol. It was agitated for 1 hour at room temperature (27°C) in ultrasonic sonicator based on their polarity. The extract was then decanted, combined, filtered and concentrated using Rotary Evaporator at 40°C. The Fourier transforms infrared (FT-IR) spectra and ultraviolet-visible (UV-VIS) spectrophotometer was obtained on a Perkin Elmer Spectrum and Varian Cary ultraviolet-visible. Results of the phytochemical analysis of the Momordicaaugustisepala leaf and stem showed the presence of Alkaloids, Glycosides, Flavonoids, Terpenoids, Tannins, Saponins, Phenols, Steroids and Anthraquinones, and Momordicaaugustisepala stem revealed, Alkaloids, flavonoids, Anthraquinones, Glycoside, Steroids, terpenoids, Tannins, Saponins and Phenols, while reducing sugar and phlobatanins were absent. Maximum inhibition protein denaturation of 86.6% and 89.3%was observed at 500μg/ml for anti-inflammatory activities. As compared to Aspirin standard anti-inflammation drug which gave 85.9% at the same concentration. The results revealed that both seed and stem of M. augustisepala have potential for antimicrobial and anti- inflammatory activities which may be due to the presence of plant secondary metabolites. VL - 8 IS - 4 ER -
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