Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde

Nasiru Pindiga Yahaya; Muhammad Sani Mukhtar

doi:doi:10.11648/j.sjc.20210901.12

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Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde

Nasiru Pindiga Yahaya, Muhammad Sani Mukhtar

Published in Science Journal of Chemistry (Volume 9, Issue 1)

Received: 8 November 2020 Accepted: 18 November 2020 Published: 10 February 2021

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Abstract

Schiff base ligands were synthesis via a condensation of the ligands in methanol in 1:1:1 molar ratio reactions. The transition metal(II) complexes were formed by the reaction of Co, Cu, Mn, Fe with the Schiff base and ampicillin and they were characterized via FTIR, electronic spectra, melting points, solubility and molar conductance. The invitro antibacterial activities of the complexes were tested using four bacterial strains; gramnegative; (Escherichiacoli, salmonellatyphi) and grampositive; (staphylococcus pyogenes and staphylococcus aureus). The complexes were formed in good yield and they have various shades of colors and sharp melting points. The IR spectrum of the HL (Table4) displays a new at (1651) cm^-1which is due to υ(HC=N) group of the azomethine stretching vibrations of the ligand, on complexation these band has been shifted to lower frequencies (1651), (1621), (1651), and (1627)cm^-1for complexes [Co(Ampi)(3AMPB)Cl], [Cu(Ampi)(3AMPB)], [Mn(Ampi)(3AMP)Cl] and [Fe(Ampi)(3AMPB)] respectively. The overlap band at (1688)cm^-1stretching vibration is due to υ(C=O) for β-Lactam group, these band has been shifted to lower frequency at (1370-1425)cm^-1for complexes showing that the coordination is through the Oxygen atom of β-Lactam group. The band sat (525), (526), (524) and (526)cm^-1were assigned to υ(M–O) for compounds of Co, Cu, Mn, Fe, indicating that to the carbocyclic oxygen, and oxygen of β-Lactam group of the ligand are involved in coordination with metalions. The bands at (659), (669), (660), and (698)cm^-1were assigned to υ(M–N) for compounds Co, Cu, Mn, Fe respectively, indicating that the nitrogen is involved in coordination with metal ions. The electronic spectral data of the complexes suggest an Octahedral and tetrahedral geometry for all the complexes. The molarconductivity indicates that the synthesized complexes are all non-electrolytes and soluble in protic solvent such as methanol and ethanol. The invitro antibacterial screening of Schiff base and its metal complexes showed that they are potential antibacterial agents against the tested microorganisms

Published in	Science Journal of Chemistry (Volume 9, Issue 1)
DOI	10.11648/j.sjc.20210901.12
Page(s)	9-13
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

SchiffBase, 3-aminophenol, Benzaldehyde, Ampiciln, Metal Complexes, Antibacterial Activity

References

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[2]	Neelima M., Kavitan P and Dinesh K (2013). An overview of biological aspects of Schiff base metal complexes. International Journal of Advancements in Research & Technology 2 (8), 52.
[3]	Fugu, M. B., Ndahi, N. P., Paul, B. B and Mustapha, A. N (2013). Synthesis, characterization, and antimicrobial studies of some vanillin Schiff base metal (II) complexes Journal of Chemical and Pharmaceutical Research, 5 (4): 22-28.
[4]	Taghreed, H., Al-Noor, M. R., and Aziz, A. T (2014). synthesis, characterization and antimicrobial activities of [Fe(II), Co(II), Ni(II), Cu(II), and Zn(II)] mixed ligand complexes schiff base derived from ampicillin drug and 4(dimethylamino)benzaldehyde with nicotinamide. International Journal of Technical Research and Applications e-2 (4): 187-192.
[5]	Cox, P. A., (2004). Inorganic chemistry laboratory new college oxford UK scientific publisher 2 (2): 111-230.
[6]	Emad Y., Ahmed M., Khulood A., Nadia S., Jumat S., Bashar A (2013). Metal complexes of Schiff base: Preparation, characterization and antibacterial activity. Arabian Journal of Chemistry 1 (1) 56-70.
[7]	Ahmed, A. A., Umar, H. A, Yunusa, Y. and Adegbemiga, B (2017), Synthesis and Characterization of Cobalt (II) and Nickel (II) Complexes with a Schiff Base Derived from 2-aminophenol and 4-(n,n-dimethylamino)benzaldehyde. International Journal of Science and Applied Research (IJSAR) 2 (3) 587-593.
[8]	Rehman, W., Baloch, M., and Badshah, A (2008). Synthesis, Spectral Characterization and Bio-Analysis of some Organotin(IV) Complexes. European Journal of Medicinal Chemistry, 43: 2380-2385.
[9]	Mukhtar, H. U., Sani, M. H., Shagal L and Joseph, J. I (2018). Synthesis, Characterization and Antimicrobial Studies of Schiff base Derived from Salicyldehyde and 2,4-dinitrophenyl hydrazine and its Metal (II) Complexes. IOSR Journal of Applied Chemistry (IOSR-JAC) 11 (9):49-53.
[10]	Oluwatoosin B., Agbaje, A., Sherifat, M. W., Osowole, A. A (2014). Synthesis, spectroscopic characterisation and antimicrobial activities of some mixed drug metal(II) complexes of Sulfamethoxazole and Paracetamol. Academic editor JC 2 (1) 140-143.
[11]	Lever A. B. P., (1984)” Inorganic electronic spectroscopy”. Elsevier, New york.
[12]	Dhivyapriya, D., Akila, E., Usharani M and. Rajavel R (2012). Synthesis, spectral and biological activity of mixed ligand schiff base complexes derived from salicylaldehyde, Journal of international journal of pharmacy & technology, (IJPT) 4 (1) 11-12.
[13]	Fayad, N. K., Taghreed H. A and Ghanim F. H (2012). Synthesis, characterization and antibacterial activities of Manganese, Cobalt, Iron, Nickel, Zinc, and Cadmium Mixed ligand complexes containing amino acid (L-Valine) and saccharin. Journal of advances in physics theories and application. 9 pp12.
[14]	Walaa H., Mahmoud, G. G., Mohamed, M., and El-Dessouky, M. I (2014). Synthesis, Characterization and in vitro Biological Activity of Mixed Transition Metal Complexes of Lornoxicam with 1,10 phenanthroline. Int. J. Electrochem. Sci., (9) 1415–1438.
[15]	Nasiru, P. Y., Ndahi, N. P., Bako, L., Mohamad, L. M., Abdullahi,. Z and Yusuf, M (2018). Synthesis and partial characterization of two schiff base ligands with (2 and 4-nitroaniline) and their transition metal (II) (Co and Cu) complexes. Dutse journal of pure and applied science, 1 (2):584-591.

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Nasiru Pindiga Yahaya, Muhammad Sani Mukhtar. (2021). Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde. Science Journal of Chemistry, 9(1), 9-13. https://doi.org/10.11648/j.sjc.20210901.12

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Nasiru Pindiga Yahaya; Muhammad Sani Mukhtar. Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde. Sci. J. Chem. 2021, 9(1), 9-13. doi: 10.11648/j.sjc.20210901.12

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Nasiru Pindiga Yahaya, Muhammad Sani Mukhtar. Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde. Sci J Chem. 2021;9(1):9-13. doi: 10.11648/j.sjc.20210901.12

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@article{10.11648/j.sjc.20210901.12,
  author = {Nasiru Pindiga Yahaya and Muhammad Sani Mukhtar},
  title = {Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde},
  journal = {Science Journal of Chemistry},
  volume = {9},
  number = {1},
  pages = {9-13},
  doi = {10.11648/j.sjc.20210901.12},
  url = {https://doi.org/10.11648/j.sjc.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20210901.12},
  abstract = {Schiff base ligands were synthesis via a condensation of the ligands in methanol in 1:1:1 molar ratio reactions. The transition metal(II) complexes were formed by the reaction of Co, Cu, Mn, Fe with the Schiff base and ampicillin and they were characterized via FTIR, electronic spectra, melting points, solubility and molar conductance. The invitro antibacterial activities of the complexes were tested using four bacterial strains; gramnegative; (Escherichiacoli, salmonellatyphi) and grampositive; (staphylococcus pyogenes and staphylococcus aureus). The complexes were formed in good yield and they have various shades of colors and sharp melting points. The IR spectrum of the HL (Table4) displays a new at (1651) cm-1 which is due to υ(HC=N) group of the azomethine stretching vibrations of the ligand, on complexation these band has been shifted to lower frequencies (1651), (1621), (1651), and (1627)cm-1 for complexes [Co(Ampi)(3AMPB)Cl], [Cu(Ampi)(3AMPB)], [Mn(Ampi)(3AMP)Cl] and [Fe(Ampi)(3AMPB)] respectively. The overlap band at (1688)cm-1 stretching vibration is due to υ(C=O) for β-Lactam group, these band has been shifted to lower frequency at (1370-1425)cm-1 for complexes showing that the coordination is through the Oxygen atom of β-Lactam group. The band sat (525), (526), (524) and (526)cm-1 were assigned to υ(M–O) for compounds of Co, Cu, Mn, Fe, indicating that to the carbocyclic oxygen, and oxygen of β-Lactam group of the ligand are involved in coordination with metalions. The bands at (659), (669), (660), and (698)cm-1 were assigned to υ(M–N) for compounds Co, Cu, Mn, Fe respectively, indicating that the nitrogen is involved in coordination with metal ions. The electronic spectral data of the complexes suggest an Octahedral and tetrahedral geometry for all the complexes. The molarconductivity indicates that the synthesized complexes are all non-electrolytes and soluble in protic solvent such as methanol and ethanol. The invitro antibacterial screening of Schiff base and its metal complexes showed that they are potential antibacterial agents against the tested microorganisms},
 year = {2021}
}

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TY  - JOUR
T1  - Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde
AU  - Nasiru Pindiga Yahaya
AU  - Muhammad Sani Mukhtar
Y1  - 2021/02/10
PY  - 2021
N1  - https://doi.org/10.11648/j.sjc.20210901.12
DO  - 10.11648/j.sjc.20210901.12
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 9
EP  - 13
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20210901.12
AB  - Schiff base ligands were synthesis via a condensation of the ligands in methanol in 1:1:1 molar ratio reactions. The transition metal(II) complexes were formed by the reaction of Co, Cu, Mn, Fe with the Schiff base and ampicillin and they were characterized via FTIR, electronic spectra, melting points, solubility and molar conductance. The invitro antibacterial activities of the complexes were tested using four bacterial strains; gramnegative; (Escherichiacoli, salmonellatyphi) and grampositive; (staphylococcus pyogenes and staphylococcus aureus). The complexes were formed in good yield and they have various shades of colors and sharp melting points. The IR spectrum of the HL (Table4) displays a new at (1651) cm-1 which is due to υ(HC=N) group of the azomethine stretching vibrations of the ligand, on complexation these band has been shifted to lower frequencies (1651), (1621), (1651), and (1627)cm-1 for complexes [Co(Ampi)(3AMPB)Cl], [Cu(Ampi)(3AMPB)], [Mn(Ampi)(3AMP)Cl] and [Fe(Ampi)(3AMPB)] respectively. The overlap band at (1688)cm-1 stretching vibration is due to υ(C=O) for β-Lactam group, these band has been shifted to lower frequency at (1370-1425)cm-1 for complexes showing that the coordination is through the Oxygen atom of β-Lactam group. The band sat (525), (526), (524) and (526)cm-1 were assigned to υ(M–O) for compounds of Co, Cu, Mn, Fe, indicating that to the carbocyclic oxygen, and oxygen of β-Lactam group of the ligand are involved in coordination with metalions. The bands at (659), (669), (660), and (698)cm-1 were assigned to υ(M–N) for compounds Co, Cu, Mn, Fe respectively, indicating that the nitrogen is involved in coordination with metal ions. The electronic spectral data of the complexes suggest an Octahedral and tetrahedral geometry for all the complexes. The molarconductivity indicates that the synthesized complexes are all non-electrolytes and soluble in protic solvent such as methanol and ethanol. The invitro antibacterial screening of Schiff base and its metal complexes showed that they are potential antibacterial agents against the tested microorganisms
VL  - 9
IS  - 1
ER  -

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Author Information

Nasiru Pindiga Yahaya

Department of Chemistry, Faculty of Science, Gombe State University, Gombe, Nigeria
Muhammad Sani Mukhtar

Department of Chemistry, Faculty of Science, Gombe State University, Gombe, Nigeria

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Nasiru Pindiga Yahaya, Muhammad Sani Mukhtar. (2021). Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde. Science Journal of Chemistry, 9(1), 9-13. https://doi.org/10.11648/j.sjc.20210901.12

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Nasiru Pindiga Yahaya; Muhammad Sani Mukhtar. Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde. Sci. J. Chem. 2021, 9(1), 9-13. doi: 10.11648/j.sjc.20210901.12

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AMA Style

Nasiru Pindiga Yahaya, Muhammad Sani Mukhtar. Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde. Sci J Chem. 2021;9(1):9-13. doi: 10.11648/j.sjc.20210901.12

Copy | Download

@article{10.11648/j.sjc.20210901.12,
  author = {Nasiru Pindiga Yahaya and Muhammad Sani Mukhtar},
  title = {Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde},
  journal = {Science Journal of Chemistry},
  volume = {9},
  number = {1},
  pages = {9-13},
  doi = {10.11648/j.sjc.20210901.12},
  url = {https://doi.org/10.11648/j.sjc.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20210901.12},
  abstract = {Schiff base ligands were synthesis via a condensation of the ligands in methanol in 1:1:1 molar ratio reactions. The transition metal(II) complexes were formed by the reaction of Co, Cu, Mn, Fe with the Schiff base and ampicillin and they were characterized via FTIR, electronic spectra, melting points, solubility and molar conductance. The invitro antibacterial activities of the complexes were tested using four bacterial strains; gramnegative; (Escherichiacoli, salmonellatyphi) and grampositive; (staphylococcus pyogenes and staphylococcus aureus). The complexes were formed in good yield and they have various shades of colors and sharp melting points. The IR spectrum of the HL (Table4) displays a new at (1651) cm-1 which is due to υ(HC=N) group of the azomethine stretching vibrations of the ligand, on complexation these band has been shifted to lower frequencies (1651), (1621), (1651), and (1627)cm-1 for complexes [Co(Ampi)(3AMPB)Cl], [Cu(Ampi)(3AMPB)], [Mn(Ampi)(3AMP)Cl] and [Fe(Ampi)(3AMPB)] respectively. The overlap band at (1688)cm-1 stretching vibration is due to υ(C=O) for β-Lactam group, these band has been shifted to lower frequency at (1370-1425)cm-1 for complexes showing that the coordination is through the Oxygen atom of β-Lactam group. The band sat (525), (526), (524) and (526)cm-1 were assigned to υ(M–O) for compounds of Co, Cu, Mn, Fe, indicating that to the carbocyclic oxygen, and oxygen of β-Lactam group of the ligand are involved in coordination with metalions. The bands at (659), (669), (660), and (698)cm-1 were assigned to υ(M–N) for compounds Co, Cu, Mn, Fe respectively, indicating that the nitrogen is involved in coordination with metal ions. The electronic spectral data of the complexes suggest an Octahedral and tetrahedral geometry for all the complexes. The molarconductivity indicates that the synthesized complexes are all non-electrolytes and soluble in protic solvent such as methanol and ethanol. The invitro antibacterial screening of Schiff base and its metal complexes showed that they are potential antibacterial agents against the tested microorganisms},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Synthesis, Characterization and Antibacterial Activity of Mixed Ligands of Schiff Base and It’s Metal(II) Complexes Derived from Ampicilin, 3-Aminophenol and Benzaldehyde
AU  - Nasiru Pindiga Yahaya
AU  - Muhammad Sani Mukhtar
Y1  - 2021/02/10
PY  - 2021
N1  - https://doi.org/10.11648/j.sjc.20210901.12
DO  - 10.11648/j.sjc.20210901.12
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 9
EP  - 13
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20210901.12
AB  - Schiff base ligands were synthesis via a condensation of the ligands in methanol in 1:1:1 molar ratio reactions. The transition metal(II) complexes were formed by the reaction of Co, Cu, Mn, Fe with the Schiff base and ampicillin and they were characterized via FTIR, electronic spectra, melting points, solubility and molar conductance. The invitro antibacterial activities of the complexes were tested using four bacterial strains; gramnegative; (Escherichiacoli, salmonellatyphi) and grampositive; (staphylococcus pyogenes and staphylococcus aureus). The complexes were formed in good yield and they have various shades of colors and sharp melting points. The IR spectrum of the HL (Table4) displays a new at (1651) cm-1 which is due to υ(HC=N) group of the azomethine stretching vibrations of the ligand, on complexation these band has been shifted to lower frequencies (1651), (1621), (1651), and (1627)cm-1 for complexes [Co(Ampi)(3AMPB)Cl], [Cu(Ampi)(3AMPB)], [Mn(Ampi)(3AMP)Cl] and [Fe(Ampi)(3AMPB)] respectively. The overlap band at (1688)cm-1 stretching vibration is due to υ(C=O) for β-Lactam group, these band has been shifted to lower frequency at (1370-1425)cm-1 for complexes showing that the coordination is through the Oxygen atom of β-Lactam group. The band sat (525), (526), (524) and (526)cm-1 were assigned to υ(M–O) for compounds of Co, Cu, Mn, Fe, indicating that to the carbocyclic oxygen, and oxygen of β-Lactam group of the ligand are involved in coordination with metalions. The bands at (659), (669), (660), and (698)cm-1 were assigned to υ(M–N) for compounds Co, Cu, Mn, Fe respectively, indicating that the nitrogen is involved in coordination with metal ions. The electronic spectral data of the complexes suggest an Octahedral and tetrahedral geometry for all the complexes. The molarconductivity indicates that the synthesized complexes are all non-electrolytes and soluble in protic solvent such as methanol and ethanol. The invitro antibacterial screening of Schiff base and its metal complexes showed that they are potential antibacterial agents against the tested microorganisms
VL  - 9
IS  - 1
ER  -

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