Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients

Ezzat Abdalrahman El Etreby; Mohamed Said El-Shorbagy; Al-Sayed Mohamed Rashed; Ahmed Mohamed Alsawy

doi:doi:10.11648/j.sjcm.20211003.12

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Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients

Ezzat Abdalrahman El Etreby, Mohamed Said El-Shorbagy, Al-Sayed Mohamed Rashed, Ahmed Mohamed Alsawy

Published in Science Journal of Clinical Medicine (Volume 10, Issue 3)

Received: 14 May 2021 Accepted: 12 July 2021 Published: 28 October 2021

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Abstract

Background: Despite increasing knowledge of the uraemic syndrome, both morbidity and mortality remain unacceptably high in patients with chronic kidney disease. Aim of the work: investigate the differences between conventional hemodialysis and hemodiafiltration in the context of chronic kidney disease metabolic bone disease findings serum calcium (sCa), phosphate (sPO4) and intact parathyroid hormone (PTHint) concentrations. Patients and methods: This prospective cross over study was approved by Almaadi hospital committee and included 95 patients with CKD5 on regular hemodialysis for at least 6 months. Patients were divided into two groups: Group A: 60 patients scheduled 6 months conventional high flux (hf-HD) (Period1) followed by 6 months of post-dilutional–HDF (Period2). Group B: (controls) included 35 patients were kept on conventional hf-HD for 12 months. (Period3) for 1^st 6 months and (Period4) for 2^nd 6 months. The main variables evaluated at the start as well as at the end of each period were sCa, sPO4 and PTHint. Results: There was highly significant statistical decrease in Phosphorus level in period2 compared to other groups after 2^nd to 6^th month and average of overall (p<0.001). A significant statistical decrease was found in Parathormone level and CRP in period2 compared to other groups after 1 month to 6^th month and average of overall (p<0.05). There was significant statistical decrease in Albumin level in period2 compared to other groups after 2^nd to 6^th month and average of overall (p<0.05). There was a significant statistical increase in kt/v in period2 compared to other groups after 1^st to 6^th month and average of overall (p<0.05). Conclusion: The switch over from conventional Hf-HD to Ol-HDF results in a significant reduction of both PO4 and PTH concentrations, no significant changes in Ca concentrations.

Published in	Science Journal of Clinical Medicine (Volume 10, Issue 3)
DOI	10.11648/j.sjcm.20211003.12
Page(s)	78-84
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

High Volume Hemodiafiltration, Secondary Hyperparathyroidism, Hemodialysis Patients

References

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APA Style

Ezzat Abdalrahman El Etreby, Mohamed Said El-Shorbagy, Al-Sayed Mohamed Rashed, Ahmed Mohamed Alsawy. (2021). Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients. Science Journal of Clinical Medicine, 10(3), 78-84. https://doi.org/10.11648/j.sjcm.20211003.12

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ACS Style

Ezzat Abdalrahman El Etreby; Mohamed Said El-Shorbagy; Al-Sayed Mohamed Rashed; Ahmed Mohamed Alsawy. Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients. Sci. J. Clin. Med. 2021, 10(3), 78-84. doi: 10.11648/j.sjcm.20211003.12

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AMA Style

Ezzat Abdalrahman El Etreby, Mohamed Said El-Shorbagy, Al-Sayed Mohamed Rashed, Ahmed Mohamed Alsawy. Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients. Sci J Clin Med. 2021;10(3):78-84. doi: 10.11648/j.sjcm.20211003.12

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@article{10.11648/j.sjcm.20211003.12,
  author = {Ezzat Abdalrahman El Etreby and Mohamed Said El-Shorbagy and Al-Sayed Mohamed Rashed and Ahmed Mohamed Alsawy},
  title = {Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients},
  journal = {Science Journal of Clinical Medicine},
  volume = {10},
  number = {3},
  pages = {78-84},
  doi = {10.11648/j.sjcm.20211003.12},
  url = {https://doi.org/10.11648/j.sjcm.20211003.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211003.12},
  abstract = {Background: Despite increasing knowledge of the uraemic syndrome, both morbidity and mortality remain unacceptably high in patients with chronic kidney disease. Aim of the work: investigate the differences between conventional hemodialysis and hemodiafiltration in the context of chronic kidney disease metabolic bone disease findings serum calcium (sCa), phosphate (sPO4) and intact parathyroid hormone (PTHint) concentrations. Patients and methods: This prospective cross over study was approved by Almaadi hospital committee and included 95 patients with CKD5 on regular hemodialysis for at least 6 months. Patients were divided into two groups: Group A: 60 patients scheduled 6 months conventional high flux (hf-HD) (Period1) followed by 6 months of post-dilutional–HDF (Period2). Group B: (controls) included 35 patients were kept on conventional hf-HD for 12 months. (Period3) for 1st 6 months and (Period4) for 2nd 6 months. The main variables evaluated at the start as well as at the end of each period were sCa, sPO4 and PTHint. Results: There was highly significant statistical decrease in Phosphorus level in period2 compared to other groups after 2nd to 6th month and average of overall (pth month and average of overall (pnd to 6th month and average of overall (pst to 6th month and average of overall (pConclusion: The switch over from conventional Hf-HD to Ol-HDF results in a significant reduction of both PO4 and PTH concentrations, no significant changes in Ca concentrations.},
 year = {2021}
}

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TY  - JOUR
T1  - Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients
AU  - Ezzat Abdalrahman El Etreby
AU  - Mohamed Said El-Shorbagy
AU  - Al-Sayed Mohamed Rashed
AU  - Ahmed Mohamed Alsawy
Y1  - 2021/10/28
PY  - 2021
N1  - https://doi.org/10.11648/j.sjcm.20211003.12
DO  - 10.11648/j.sjcm.20211003.12
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 78
EP  - 84
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20211003.12
AB  - Background: Despite increasing knowledge of the uraemic syndrome, both morbidity and mortality remain unacceptably high in patients with chronic kidney disease. Aim of the work: investigate the differences between conventional hemodialysis and hemodiafiltration in the context of chronic kidney disease metabolic bone disease findings serum calcium (sCa), phosphate (sPO4) and intact parathyroid hormone (PTHint) concentrations. Patients and methods: This prospective cross over study was approved by Almaadi hospital committee and included 95 patients with CKD5 on regular hemodialysis for at least 6 months. Patients were divided into two groups: Group A: 60 patients scheduled 6 months conventional high flux (hf-HD) (Period1) followed by 6 months of post-dilutional–HDF (Period2). Group B: (controls) included 35 patients were kept on conventional hf-HD for 12 months. (Period3) for 1st 6 months and (Period4) for 2nd 6 months. The main variables evaluated at the start as well as at the end of each period were sCa, sPO4 and PTHint. Results: There was highly significant statistical decrease in Phosphorus level in period2 compared to other groups after 2nd to 6th month and average of overall (pth month and average of overall (pnd to 6th month and average of overall (pst to 6th month and average of overall (pConclusion: The switch over from conventional Hf-HD to Ol-HDF results in a significant reduction of both PO4 and PTH concentrations, no significant changes in Ca concentrations.
VL  - 10
IS  - 3
ER  -

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Author Information

Ezzat Abdalrahman El Etreby

Department of Internal Medicine and Nephrology, Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt
Mohamed Said El-Shorbagy

Department of Internal Medicine and Nephrology, Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt
Al-Sayed Mohamed Rashed

Department of Internal Medicine and Nephrology, Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt
Ahmed Mohamed Alsawy

Department of Internal Medicine and Nephrology, Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt

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Ezzat Abdalrahman El Etreby, Mohamed Said El-Shorbagy, Al-Sayed Mohamed Rashed, Ahmed Mohamed Alsawy. (2021). Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients. Science Journal of Clinical Medicine, 10(3), 78-84. https://doi.org/10.11648/j.sjcm.20211003.12

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ACS Style

Ezzat Abdalrahman El Etreby; Mohamed Said El-Shorbagy; Al-Sayed Mohamed Rashed; Ahmed Mohamed Alsawy. Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients. Sci. J. Clin. Med. 2021, 10(3), 78-84. doi: 10.11648/j.sjcm.20211003.12

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AMA Style

Ezzat Abdalrahman El Etreby, Mohamed Said El-Shorbagy, Al-Sayed Mohamed Rashed, Ahmed Mohamed Alsawy. Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients. Sci J Clin Med. 2021;10(3):78-84. doi: 10.11648/j.sjcm.20211003.12

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@article{10.11648/j.sjcm.20211003.12,
  author = {Ezzat Abdalrahman El Etreby and Mohamed Said El-Shorbagy and Al-Sayed Mohamed Rashed and Ahmed Mohamed Alsawy},
  title = {Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients},
  journal = {Science Journal of Clinical Medicine},
  volume = {10},
  number = {3},
  pages = {78-84},
  doi = {10.11648/j.sjcm.20211003.12},
  url = {https://doi.org/10.11648/j.sjcm.20211003.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211003.12},
  abstract = {Background: Despite increasing knowledge of the uraemic syndrome, both morbidity and mortality remain unacceptably high in patients with chronic kidney disease. Aim of the work: investigate the differences between conventional hemodialysis and hemodiafiltration in the context of chronic kidney disease metabolic bone disease findings serum calcium (sCa), phosphate (sPO4) and intact parathyroid hormone (PTHint) concentrations. Patients and methods: This prospective cross over study was approved by Almaadi hospital committee and included 95 patients with CKD5 on regular hemodialysis for at least 6 months. Patients were divided into two groups: Group A: 60 patients scheduled 6 months conventional high flux (hf-HD) (Period1) followed by 6 months of post-dilutional–HDF (Period2). Group B: (controls) included 35 patients were kept on conventional hf-HD for 12 months. (Period3) for 1st 6 months and (Period4) for 2nd 6 months. The main variables evaluated at the start as well as at the end of each period were sCa, sPO4 and PTHint. Results: There was highly significant statistical decrease in Phosphorus level in period2 compared to other groups after 2nd to 6th month and average of overall (pth month and average of overall (pnd to 6th month and average of overall (pst to 6th month and average of overall (pConclusion: The switch over from conventional Hf-HD to Ol-HDF results in a significant reduction of both PO4 and PTH concentrations, no significant changes in Ca concentrations.},
 year = {2021}
}

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TY  - JOUR
T1  - Effect of High Volume Hemodiafiltration on Secondary Hyperparathyroidism Among Hemodialysis Patients
AU  - Ezzat Abdalrahman El Etreby
AU  - Mohamed Said El-Shorbagy
AU  - Al-Sayed Mohamed Rashed
AU  - Ahmed Mohamed Alsawy
Y1  - 2021/10/28
PY  - 2021
N1  - https://doi.org/10.11648/j.sjcm.20211003.12
DO  - 10.11648/j.sjcm.20211003.12
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 78
EP  - 84
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20211003.12
AB  - Background: Despite increasing knowledge of the uraemic syndrome, both morbidity and mortality remain unacceptably high in patients with chronic kidney disease. Aim of the work: investigate the differences between conventional hemodialysis and hemodiafiltration in the context of chronic kidney disease metabolic bone disease findings serum calcium (sCa), phosphate (sPO4) and intact parathyroid hormone (PTHint) concentrations. Patients and methods: This prospective cross over study was approved by Almaadi hospital committee and included 95 patients with CKD5 on regular hemodialysis for at least 6 months. Patients were divided into two groups: Group A: 60 patients scheduled 6 months conventional high flux (hf-HD) (Period1) followed by 6 months of post-dilutional–HDF (Period2). Group B: (controls) included 35 patients were kept on conventional hf-HD for 12 months. (Period3) for 1st 6 months and (Period4) for 2nd 6 months. The main variables evaluated at the start as well as at the end of each period were sCa, sPO4 and PTHint. Results: There was highly significant statistical decrease in Phosphorus level in period2 compared to other groups after 2nd to 6th month and average of overall (pth month and average of overall (pnd to 6th month and average of overall (pst to 6th month and average of overall (pConclusion: The switch over from conventional Hf-HD to Ol-HDF results in a significant reduction of both PO4 and PTH concentrations, no significant changes in Ca concentrations.
VL  - 10
IS  - 3
ER  -

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