Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis

Hua Wang; Jun-Jie Tang; Qing Zhou; Jian Chen

doi:doi:10.11648/j.sjcm.20211004.12

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Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis

Hua Wang, Jun-Jie Tang, Qing Zhou, Jian Chen

Published in Science Journal of Clinical Medicine (Volume 10, Issue 4)

Received: 10 October 2021 Accepted: 28 October 2021 Published: 5 November 2021

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Abstract

Background: Ocular burns is a serious eye injury with a high rate of blindness, efforts should be made to eliminate the serious complications, prevent from lifelong disability, and improve emergency interventions and treatment. Objective: To evaluate the effectiveness of amniotic membrane transplantation (AMT) in ocular burns. Methods: The following electronic databases were searched: PubMed, Web of Science, and Cochrane Library. With the keyword “amniotic membrane” and “ocular burn”. No limitation of year, language, gender, age, nationality, etc. Animal trials, patients with other ocular surface diseases, and amniotic membrane transplantation combined with other surgeries were excluded. We evaluated the corneal epithelium healing time (CEHT), tear break-up time (TBUT), Schirmer test (ST), corneal neovascularization, the formation of symblepharon, and lid abnormalities after conventional treatment (CT) and AMT. The differences were tested by referring to the Cochrane Handbook. Pooled estimates were determined with RevMan software, version 5.3. Results: 5 studies with 310 eyes of 282 participants suffering from ocular burns were included. There was no significant difference between CT and AMT among the following outcomes: CEHT, TBUT, ST, formation of symblepharon, and lid abnormalities, except the extent of corneal neovascularization, which was less in patients treated with AMT (RR 0.81; 95% CI 0.68, 0.96; I² = 40%, p = 0.02). Conclusions: Compared to CT, AMT does not show better advantages in promoting epithelial healing, improving tear film status, and preventing complications such as symblepharon formation and eyelid abnormalities except reducing corneal neovascularization.

Published in	Science Journal of Clinical Medicine (Volume 10, Issue 4)
DOI	10.11648/j.sjcm.20211004.12
Page(s)	89-96
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Ocular Burn, Amniotic Membrane Transplantation, Complications, Meta-analysis

References

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APA Style

Hua Wang, Jun-Jie Tang, Qing Zhou, Jian Chen. (2021). Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis. Science Journal of Clinical Medicine, 10(4), 89-96. https://doi.org/10.11648/j.sjcm.20211004.12

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ACS Style

Hua Wang; Jun-Jie Tang; Qing Zhou; Jian Chen. Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis. Sci. J. Clin. Med. 2021, 10(4), 89-96. doi: 10.11648/j.sjcm.20211004.12

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AMA Style

Hua Wang, Jun-Jie Tang, Qing Zhou, Jian Chen. Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis. Sci J Clin Med. 2021;10(4):89-96. doi: 10.11648/j.sjcm.20211004.12

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@article{10.11648/j.sjcm.20211004.12,
  author = {Hua Wang and Jun-Jie Tang and Qing Zhou and Jian Chen},
  title = {Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis},
  journal = {Science Journal of Clinical Medicine},
  volume = {10},
  number = {4},
  pages = {89-96},
  doi = {10.11648/j.sjcm.20211004.12},
  url = {https://doi.org/10.11648/j.sjcm.20211004.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211004.12},
  abstract = {Background: Ocular burns is a serious eye injury with a high rate of blindness, efforts should be made to eliminate the serious complications, prevent from lifelong disability, and improve emergency interventions and treatment. Objective: To evaluate the effectiveness of amniotic membrane transplantation (AMT) in ocular burns. Methods: The following electronic databases were searched: PubMed, Web of Science, and Cochrane Library. With the keyword “amniotic membrane” and “ocular burn”. No limitation of year, language, gender, age, nationality, etc. Animal trials, patients with other ocular surface diseases, and amniotic membrane transplantation combined with other surgeries were excluded. We evaluated the corneal epithelium healing time (CEHT), tear break-up time (TBUT), Schirmer test (ST), corneal neovascularization, the formation of symblepharon, and lid abnormalities after conventional treatment (CT) and AMT. The differences were tested by referring to the Cochrane Handbook. Pooled estimates were determined with RevMan software, version 5.3. Results: 5 studies with 310 eyes of 282 participants suffering from ocular burns were included. There was no significant difference between CT and AMT among the following outcomes: CEHT, TBUT, ST, formation of symblepharon, and lid abnormalities, except the extent of corneal neovascularization, which was less in patients treated with AMT (RR 0.81; 95% CI 0.68, 0.96; I2 = 40%, p = 0.02). Conclusions: Compared to CT, AMT does not show better advantages in promoting epithelial healing, improving tear film status, and preventing complications such as symblepharon formation and eyelid abnormalities except reducing corneal neovascularization.},
 year = {2021}
}

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TY - JOUR
T1 - Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis
AU - Hua Wang
AU - Jun-Jie Tang
AU - Qing Zhou
AU - Jian Chen
Y1 - 2021/11/05
PY - 2021
N1 - https://doi.org/10.11648/j.sjcm.20211004.12
DO - 10.11648/j.sjcm.20211004.12
T2 - Science Journal of Clinical Medicine
JF - Science Journal of Clinical Medicine
JO - Science Journal of Clinical Medicine
SP - 89
EP - 96
PB - Science Publishing Group
SN - 2327-2732
UR - https://doi.org/10.11648/j.sjcm.20211004.12
AB - Background: Ocular burns is a serious eye injury with a high rate of blindness, efforts should be made to eliminate the serious complications, prevent from lifelong disability, and improve emergency interventions and treatment. Objective: To evaluate the effectiveness of amniotic membrane transplantation (AMT) in ocular burns. Methods: The following electronic databases were searched: PubMed, Web of Science, and Cochrane Library. With the keyword “amniotic membrane” and “ocular burn”. No limitation of year, language, gender, age, nationality, etc. Animal trials, patients with other ocular surface diseases, and amniotic membrane transplantation combined with other surgeries were excluded. We evaluated the corneal epithelium healing time (CEHT), tear break-up time (TBUT), Schirmer test (ST), corneal neovascularization, the formation of symblepharon, and lid abnormalities after conventional treatment (CT) and AMT. The differences were tested by referring to the Cochrane Handbook. Pooled estimates were determined with RevMan software, version 5.3. Results: 5 studies with 310 eyes of 282 participants suffering from ocular burns were included. There was no significant difference between CT and AMT among the following outcomes: CEHT, TBUT, ST, formation of symblepharon, and lid abnormalities, except the extent of corneal neovascularization, which was less in patients treated with AMT (RR 0.81; 95% CI 0.68, 0.96; I2 = 40%, p = 0.02). Conclusions: Compared to CT, AMT does not show better advantages in promoting epithelial healing, improving tear film status, and preventing complications such as symblepharon formation and eyelid abnormalities except reducing corneal neovascularization.
VL - 10
IS - 4
ER -

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Author Information

Hua Wang

First School of Clinical Medicine, Jinan University, Guangzhou, China
Jun-Jie Tang

First School of Clinical Medicine, Jinan University, Guangzhou, China
Qing Zhou

Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou, China
Jian Chen

Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou, China

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APA Style

Hua Wang, Jun-Jie Tang, Qing Zhou, Jian Chen. (2021). Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis. Science Journal of Clinical Medicine, 10(4), 89-96. https://doi.org/10.11648/j.sjcm.20211004.12

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ACS Style

Hua Wang; Jun-Jie Tang; Qing Zhou; Jian Chen. Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis. Sci. J. Clin. Med. 2021, 10(4), 89-96. doi: 10.11648/j.sjcm.20211004.12

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AMA Style

Hua Wang, Jun-Jie Tang, Qing Zhou, Jian Chen. Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis. Sci J Clin Med. 2021;10(4):89-96. doi: 10.11648/j.sjcm.20211004.12

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@article{10.11648/j.sjcm.20211004.12,
  author = {Hua Wang and Jun-Jie Tang and Qing Zhou and Jian Chen},
  title = {Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis},
  journal = {Science Journal of Clinical Medicine},
  volume = {10},
  number = {4},
  pages = {89-96},
  doi = {10.11648/j.sjcm.20211004.12},
  url = {https://doi.org/10.11648/j.sjcm.20211004.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211004.12},
  abstract = {Background: Ocular burns is a serious eye injury with a high rate of blindness, efforts should be made to eliminate the serious complications, prevent from lifelong disability, and improve emergency interventions and treatment. Objective: To evaluate the effectiveness of amniotic membrane transplantation (AMT) in ocular burns. Methods: The following electronic databases were searched: PubMed, Web of Science, and Cochrane Library. With the keyword “amniotic membrane” and “ocular burn”. No limitation of year, language, gender, age, nationality, etc. Animal trials, patients with other ocular surface diseases, and amniotic membrane transplantation combined with other surgeries were excluded. We evaluated the corneal epithelium healing time (CEHT), tear break-up time (TBUT), Schirmer test (ST), corneal neovascularization, the formation of symblepharon, and lid abnormalities after conventional treatment (CT) and AMT. The differences were tested by referring to the Cochrane Handbook. Pooled estimates were determined with RevMan software, version 5.3. Results: 5 studies with 310 eyes of 282 participants suffering from ocular burns were included. There was no significant difference between CT and AMT among the following outcomes: CEHT, TBUT, ST, formation of symblepharon, and lid abnormalities, except the extent of corneal neovascularization, which was less in patients treated with AMT (RR 0.81; 95% CI 0.68, 0.96; I2 = 40%, p = 0.02). Conclusions: Compared to CT, AMT does not show better advantages in promoting epithelial healing, improving tear film status, and preventing complications such as symblepharon formation and eyelid abnormalities except reducing corneal neovascularization.},
 year = {2021}
}

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