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Delay in the Initiation of Extra Renal Purification on the Morbi-Mortality of Patients with Acute Renal Aggression in the Surgical Resuscitation of Mulhouse Hospital

Received: 10 July 2023    Accepted: 2 August 2023    Published: 20 September 2023
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Abstract

Introduction: Acute renal failure (ARI) is a sudden onset of the partial or total inability of the kidney to eliminate the products of nitrogen catabolism and to maintain the hydro-electrolyte balance. It results in the installation of an acute uremic syndrome, made up of a constellation of biological and clinical abnormalities, the intensity of which directly defines the therapeutic urgency. The ideal moment to start an ERA remains debated, with studies with sometimes contradictory results. Objective: to determine the effect of the delay in initiation of the RE on the morbidity and mortality of patients in intensive care surgery in Mulhouse, in the context of severe ARI with multi-visceral involvement. Materials and methods: This is a retrospective single-center study, of the professional practice evaluation type, carried out in the surgical intensive care unit of the Groupe Hospitalier de la Région de Mulhouse Sud Alsace (GHRMSA) over a period of 12 months (March 2019 to February 2020). All patients aged at least 18 years and presenting with ARF were included in the study. Diagnosis and severity of renal injury was determined using the DIGO K score. The primary endpoint was mortality. Results: In 122 patients, the diagnosis of ARF was retained. Twenty-six of them benefited from an RRT and among which 18 for an early RRT and 8 for a late RRT. Baseline patient characteristics were similar in the 2 groups. Mortality was 50.0% in the two early RRT groups and 50.0% in the late RRT group, among the patients who received dialytic treatment with a statistically non-significant difference. Conclusion: This study did not show a difference in terms of mortality between the early RRT group and the late RRT group in patients with severe acute renal injury in intensive care. On the other hand, it notes a reduction in the duration of stay in intensive care as well as the duration of the EER in the early group.

Published in Science Journal of Clinical Medicine (Volume 12, Issue 3)
DOI 10.11648/j.sjcm.20231203.11
Page(s) 31-36
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

IRA, Early EER, Late EER, Resuscitation, K DIGO, Mortality

References
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Cite This Article
  • APA Style

    José Mavinga, Christian Meyer, Eric Mafuta, Gibency Mfulani, Sylvie Ndjoko, et al. (2023). Delay in the Initiation of Extra Renal Purification on the Morbi-Mortality of Patients with Acute Renal Aggression in the Surgical Resuscitation of Mulhouse Hospital. Science Journal of Clinical Medicine, 12(3), 31-36. https://doi.org/10.11648/j.sjcm.20231203.11

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    ACS Style

    José Mavinga; Christian Meyer; Eric Mafuta; Gibency Mfulani; Sylvie Ndjoko, et al. Delay in the Initiation of Extra Renal Purification on the Morbi-Mortality of Patients with Acute Renal Aggression in the Surgical Resuscitation of Mulhouse Hospital. Sci. J. Clin. Med. 2023, 12(3), 31-36. doi: 10.11648/j.sjcm.20231203.11

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    AMA Style

    José Mavinga, Christian Meyer, Eric Mafuta, Gibency Mfulani, Sylvie Ndjoko, et al. Delay in the Initiation of Extra Renal Purification on the Morbi-Mortality of Patients with Acute Renal Aggression in the Surgical Resuscitation of Mulhouse Hospital. Sci J Clin Med. 2023;12(3):31-36. doi: 10.11648/j.sjcm.20231203.11

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  • @article{10.11648/j.sjcm.20231203.11,
      author = {José Mavinga and Christian Meyer and Eric Mafuta and Gibency Mfulani and Sylvie Ndjoko and Julie Pembe and Roddy Bengono and Eric Amisi and John Nsiala and Medard Bula Bula and Berthe Barhayiga},
      title = {Delay in the Initiation of Extra Renal Purification on the Morbi-Mortality of Patients with Acute Renal Aggression in the Surgical Resuscitation of Mulhouse Hospital},
      journal = {Science Journal of Clinical Medicine},
      volume = {12},
      number = {3},
      pages = {31-36},
      doi = {10.11648/j.sjcm.20231203.11},
      url = {https://doi.org/10.11648/j.sjcm.20231203.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20231203.11},
      abstract = {Introduction: Acute renal failure (ARI) is a sudden onset of the partial or total inability of the kidney to eliminate the products of nitrogen catabolism and to maintain the hydro-electrolyte balance. It results in the installation of an acute uremic syndrome, made up of a constellation of biological and clinical abnormalities, the intensity of which directly defines the therapeutic urgency. The ideal moment to start an ERA remains debated, with studies with sometimes contradictory results. Objective: to determine the effect of the delay in initiation of the RE on the morbidity and mortality of patients in intensive care surgery in Mulhouse, in the context of severe ARI with multi-visceral involvement. Materials and methods: This is a retrospective single-center study, of the professional practice evaluation type, carried out in the surgical intensive care unit of the Groupe Hospitalier de la Région de Mulhouse Sud Alsace (GHRMSA) over a period of 12 months (March 2019 to February 2020). All patients aged at least 18 years and presenting with ARF were included in the study. Diagnosis and severity of renal injury was determined using the DIGO K score. The primary endpoint was mortality. Results: In 122 patients, the diagnosis of ARF was retained. Twenty-six of them benefited from an RRT and among which 18 for an early RRT and 8 for a late RRT. Baseline patient characteristics were similar in the 2 groups. Mortality was 50.0% in the two early RRT groups and 50.0% in the late RRT group, among the patients who received dialytic treatment with a statistically non-significant difference. Conclusion: This study did not show a difference in terms of mortality between the early RRT group and the late RRT group in patients with severe acute renal injury in intensive care. On the other hand, it notes a reduction in the duration of stay in intensive care as well as the duration of the EER in the early group.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Delay in the Initiation of Extra Renal Purification on the Morbi-Mortality of Patients with Acute Renal Aggression in the Surgical Resuscitation of Mulhouse Hospital
    AU  - José Mavinga
    AU  - Christian Meyer
    AU  - Eric Mafuta
    AU  - Gibency Mfulani
    AU  - Sylvie Ndjoko
    AU  - Julie Pembe
    AU  - Roddy Bengono
    AU  - Eric Amisi
    AU  - John Nsiala
    AU  - Medard Bula Bula
    AU  - Berthe Barhayiga
    Y1  - 2023/09/20
    PY  - 2023
    N1  - https://doi.org/10.11648/j.sjcm.20231203.11
    DO  - 10.11648/j.sjcm.20231203.11
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
    SP  - 31
    EP  - 36
    PB  - Science Publishing Group
    SN  - 2327-2732
    UR  - https://doi.org/10.11648/j.sjcm.20231203.11
    AB  - Introduction: Acute renal failure (ARI) is a sudden onset of the partial or total inability of the kidney to eliminate the products of nitrogen catabolism and to maintain the hydro-electrolyte balance. It results in the installation of an acute uremic syndrome, made up of a constellation of biological and clinical abnormalities, the intensity of which directly defines the therapeutic urgency. The ideal moment to start an ERA remains debated, with studies with sometimes contradictory results. Objective: to determine the effect of the delay in initiation of the RE on the morbidity and mortality of patients in intensive care surgery in Mulhouse, in the context of severe ARI with multi-visceral involvement. Materials and methods: This is a retrospective single-center study, of the professional practice evaluation type, carried out in the surgical intensive care unit of the Groupe Hospitalier de la Région de Mulhouse Sud Alsace (GHRMSA) over a period of 12 months (March 2019 to February 2020). All patients aged at least 18 years and presenting with ARF were included in the study. Diagnosis and severity of renal injury was determined using the DIGO K score. The primary endpoint was mortality. Results: In 122 patients, the diagnosis of ARF was retained. Twenty-six of them benefited from an RRT and among which 18 for an early RRT and 8 for a late RRT. Baseline patient characteristics were similar in the 2 groups. Mortality was 50.0% in the two early RRT groups and 50.0% in the late RRT group, among the patients who received dialytic treatment with a statistically non-significant difference. Conclusion: This study did not show a difference in terms of mortality between the early RRT group and the late RRT group in patients with severe acute renal injury in intensive care. On the other hand, it notes a reduction in the duration of stay in intensive care as well as the duration of the EER in the early group.
    VL  - 12
    IS  - 3
    ER  - 

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Author Information
  • Department of Anesthesia and Resuscitation, University Clinics of Kinshasa, Kinshasa, DRC

  • Surgical Resuscitation Department, Emile Muller Hospital, Mulhouse, France

  • Department of Statistics, School of Public Health, Kinshasa, DRC

  • Department of Anesthesia and Resuscitation, University Clinics of Kinshasa, Kinshasa, DRC

  • Department of Anesthesia and Resuscitation, University Clinics of Kinshasa, Kinshasa, DRC

  • Department of Anesthesia and Resuscitation, University Clinics of Kinshasa, Kinshasa, DRC

  • Surgical Resuscitation Department, Emile Muller Hospital, Mulhouse, France

  • Department of Anesthesia and Resuscitation, University Clinics of Kinshasa, Kinshasa, DRC

  • Department of Anesthesia and Resuscitation, University Clinics of Kinshasa, Kinshasa, DRC

  • Department of Anesthesia and Resuscitation, University Clinics of Kinshasa, Kinshasa, DRC

  • Department of Anesthesia and Resuscitation, University Clinics of Kinshasa, Kinshasa, DRC

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