The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic

Vechorko Valery Ivanovich; Evgeny Mikhailovich Evsikov; Teplova Natalya Vadimovna

doi:doi:10.11648/j.wjph.20220703.16

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The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic

Vechorko Valery Ivanovich, Evgeny Mikhailovich Evsikov, Teplova Natalya Vadimovna

Published in World Journal of Public Health (Volume 7, Issue 3)

Received: 23 April 2021 Accepted: 13 May 2021 Published: 16 September 2022

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Abstract

Relevance: Currently, COVID-19 is considered as a systemic disease with impaired immune system function, primarily affecting the lungs, as well as the heart, kidneys, and intestines. The nature of changes in liver function in (COVID-19) is still poorly understood and poorly covered in the available literature. There are no publications on the nature of liver and gastrointestinal tract damage in patients with end-stage chronic kidney disease with COVID-19 virus infection complicated by pneumonia, in the available modern literature. Purpose of the work: To assess the structure of liver pathology in patients with end-stage chronic renal failure (CRF), including chronically receiving hemofiltration procedures, hospitalized with a diagnosis of COVID-19 in a converted emergency hospital in Moscow. Material and methods: We studied 72 patients, including 38 men and 34 women aged 23-86 years, with an average of 58.2±4.8, who were admitted to the hospital for diagnosis and treatment in the period from 10.04.2020 to 02.10.2020 with diagnoses according to ICD-10: U07.1 Coronavirus infection caused by the COVID-19 virus. All patients underwent ultrasound examination of the liver, gallbladder, pancreas and spleen. The level of liver enzyme activity in dynamics, serum albumin concentration, prothrombin time and index were evaluated. Results: Biochemical signs of liver cell cytolysis were detected in 25-57% of patients with viral pneumonia in COVID-19, which complicates the course of terminal forms of chronic kidney disease with hemodialysis. Most often, the disease was accompanied by signs of a decrease in the synthesis of hemostatic proteins of the prothrombin complex and serum albumin, which may be associated with an aggravation of the severity of their existing chronic anemia. hematomegaly and changes in the liver structure were diagnosed in 42-85% of patients with this pathology and were combined with ultrasoundsigns of damage to the pancreas and spleen in 26-38%. In 11-19% of patients with COVID-19 infection, chronic liver damage preceded the development of pneumonia. Regardless of the state of renal function, these changes were accompanied by a worsening of the course of pre-existing liver and pancreatic lesions, including hepatitis and pancreatitis. Conclusion: Assessment of the state of enzyme and protein-producing function of the liver and pancreas should be included in the standards of inpatient examination in patients with end-stage renal failure and hemodialysis, with the development of COVID-19 and viral pneumonia, due to the high prevalence of liver, gallbladder and pancreas pathology.

Published in	World Journal of Public Health (Volume 7, Issue 3)
DOI	10.11648/j.wjph.20220703.16
Page(s)	132-140
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

COVID-19, Viral Pneumonia, End-Stage Chronic Kidney Disease, Liver Damage, Pancreas

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Vechorko Valery Ivanovich, Evgeny Mikhailovich Evsikov, Teplova Natalya Vadimovna. (2022). The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic. World Journal of Public Health, 7(3), 132-140. https://doi.org/10.11648/j.wjph.20220703.16

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ACS Style

Vechorko Valery Ivanovich; Evgeny Mikhailovich Evsikov; Teplova Natalya Vadimovna. The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic. World J. Public Health 2022, 7(3), 132-140. doi: 10.11648/j.wjph.20220703.16

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AMA Style

Vechorko Valery Ivanovich, Evgeny Mikhailovich Evsikov, Teplova Natalya Vadimovna. The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic. World J Public Health. 2022;7(3):132-140. doi: 10.11648/j.wjph.20220703.16

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@article{10.11648/j.wjph.20220703.16,
  author = {Vechorko Valery Ivanovich and Evgeny Mikhailovich Evsikov and Teplova Natalya Vadimovna},
  title = {The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic},
  journal = {World Journal of Public Health},
  volume = {7},
  number = {3},
  pages = {132-140},
  doi = {10.11648/j.wjph.20220703.16},
  url = {https://doi.org/10.11648/j.wjph.20220703.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20220703.16},
  abstract = {Relevance: Currently, COVID-19 is considered as a systemic disease with impaired immune system function, primarily affecting the lungs, as well as the heart, kidneys, and intestines. The nature of changes in liver function in (COVID-19) is still poorly understood and poorly covered in the available literature. There are no publications on the nature of liver and gastrointestinal tract damage in patients with end-stage chronic kidney disease with COVID-19 virus infection complicated by pneumonia, in the available modern literature. Purpose of the work: To assess the structure of liver pathology in patients with end-stage chronic renal failure (CRF), including chronically receiving hemofiltration procedures, hospitalized with a diagnosis of COVID-19 in a converted emergency hospital in Moscow. Material and methods: We studied 72 patients, including 38 men and 34 women aged 23-86 years, with an average of 58.2±4.8, who were admitted to the hospital for diagnosis and treatment in the period from 10.04.2020 to 02.10.2020 with diagnoses according to ICD-10: U07.1 Coronavirus infection caused by the COVID-19 virus. All patients underwent ultrasound examination of the liver, gallbladder, pancreas and spleen. The level of liver enzyme activity in dynamics, serum albumin concentration, prothrombin time and index were evaluated. Results: Biochemical signs of liver cell cytolysis were detected in 25-57% of patients with viral pneumonia in COVID-19, which complicates the course of terminal forms of chronic kidney disease with hemodialysis. Most often, the disease was accompanied by signs of a decrease in the synthesis of hemostatic proteins of the prothrombin complex and serum albumin, which may be associated with an aggravation of the severity of their existing chronic anemia. hematomegaly and changes in the liver structure were diagnosed in 42-85% of patients with this pathology and were combined with ultrasoundsigns of damage to the pancreas and spleen in 26-38%. In 11-19% of patients with COVID-19 infection, chronic liver damage preceded the development of pneumonia. Regardless of the state of renal function, these changes were accompanied by a worsening of the course of pre-existing liver and pancreatic lesions, including hepatitis and pancreatitis. Conclusion: Assessment of the state of enzyme and protein-producing function of the liver and pancreas should be included in the standards of inpatient examination in patients with end-stage renal failure and hemodialysis, with the development of COVID-19 and viral pneumonia, due to the high prevalence of liver, gallbladder and pancreas pathology.},
 year = {2022}
}

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TY  - JOUR
T1  - The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic
AU  - Vechorko Valery Ivanovich
AU  - Evgeny Mikhailovich Evsikov
AU  - Teplova Natalya Vadimovna
Y1  - 2022/09/16
PY  - 2022
N1  - https://doi.org/10.11648/j.wjph.20220703.16
DO  - 10.11648/j.wjph.20220703.16
T2  - World Journal of Public Health
JF  - World Journal of Public Health
JO  - World Journal of Public Health
SP  - 132
EP  - 140
PB  - Science Publishing Group
SN  - 2637-6059
UR  - https://doi.org/10.11648/j.wjph.20220703.16
AB  - Relevance: Currently, COVID-19 is considered as a systemic disease with impaired immune system function, primarily affecting the lungs, as well as the heart, kidneys, and intestines. The nature of changes in liver function in (COVID-19) is still poorly understood and poorly covered in the available literature. There are no publications on the nature of liver and gastrointestinal tract damage in patients with end-stage chronic kidney disease with COVID-19 virus infection complicated by pneumonia, in the available modern literature. Purpose of the work: To assess the structure of liver pathology in patients with end-stage chronic renal failure (CRF), including chronically receiving hemofiltration procedures, hospitalized with a diagnosis of COVID-19 in a converted emergency hospital in Moscow. Material and methods: We studied 72 patients, including 38 men and 34 women aged 23-86 years, with an average of 58.2±4.8, who were admitted to the hospital for diagnosis and treatment in the period from 10.04.2020 to 02.10.2020 with diagnoses according to ICD-10: U07.1 Coronavirus infection caused by the COVID-19 virus. All patients underwent ultrasound examination of the liver, gallbladder, pancreas and spleen. The level of liver enzyme activity in dynamics, serum albumin concentration, prothrombin time and index were evaluated. Results: Biochemical signs of liver cell cytolysis were detected in 25-57% of patients with viral pneumonia in COVID-19, which complicates the course of terminal forms of chronic kidney disease with hemodialysis. Most often, the disease was accompanied by signs of a decrease in the synthesis of hemostatic proteins of the prothrombin complex and serum albumin, which may be associated with an aggravation of the severity of their existing chronic anemia. hematomegaly and changes in the liver structure were diagnosed in 42-85% of patients with this pathology and were combined with ultrasoundsigns of damage to the pancreas and spleen in 26-38%. In 11-19% of patients with COVID-19 infection, chronic liver damage preceded the development of pneumonia. Regardless of the state of renal function, these changes were accompanied by a worsening of the course of pre-existing liver and pancreatic lesions, including hepatitis and pancreatitis. Conclusion: Assessment of the state of enzyme and protein-producing function of the liver and pancreas should be included in the standards of inpatient examination in patients with end-stage renal failure and hemodialysis, with the development of COVID-19 and viral pneumonia, due to the high prevalence of liver, gallbladder and pancreas pathology.
VL  - 7
IS  - 3
ER  -

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Author Information

Vechorko Valery Ivanovich

Department of Health, City Clinical Hospital No. 15 Named After Them Oleg Michailovisch Filatov, Moscow, Russia
Evgeny Mikhailovich Evsikov

Department of Health, City Clinical Hospital No. 15 Named After Them Oleg Michailovisch Filatov, Moscow, Russia
Teplova Natalya Vadimovna

Russian National Research Medical University Named After Them Nikolay Ivanovisch Pirogova, Moscow, Russia

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Vechorko Valery Ivanovich, Evgeny Mikhailovich Evsikov, Teplova Natalya Vadimovna. (2022). The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic. World Journal of Public Health, 7(3), 132-140. https://doi.org/10.11648/j.wjph.20220703.16

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Vechorko Valery Ivanovich; Evgeny Mikhailovich Evsikov; Teplova Natalya Vadimovna. The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic. World J. Public Health 2022, 7(3), 132-140. doi: 10.11648/j.wjph.20220703.16

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AMA Style

Vechorko Valery Ivanovich, Evgeny Mikhailovich Evsikov, Teplova Natalya Vadimovna. The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic. World J Public Health. 2022;7(3):132-140. doi: 10.11648/j.wjph.20220703.16

Copy | Download

@article{10.11648/j.wjph.20220703.16,
  author = {Vechorko Valery Ivanovich and Evgeny Mikhailovich Evsikov and Teplova Natalya Vadimovna},
  title = {The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic},
  journal = {World Journal of Public Health},
  volume = {7},
  number = {3},
  pages = {132-140},
  doi = {10.11648/j.wjph.20220703.16},
  url = {https://doi.org/10.11648/j.wjph.20220703.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20220703.16},
  abstract = {Relevance: Currently, COVID-19 is considered as a systemic disease with impaired immune system function, primarily affecting the lungs, as well as the heart, kidneys, and intestines. The nature of changes in liver function in (COVID-19) is still poorly understood and poorly covered in the available literature. There are no publications on the nature of liver and gastrointestinal tract damage in patients with end-stage chronic kidney disease with COVID-19 virus infection complicated by pneumonia, in the available modern literature. Purpose of the work: To assess the structure of liver pathology in patients with end-stage chronic renal failure (CRF), including chronically receiving hemofiltration procedures, hospitalized with a diagnosis of COVID-19 in a converted emergency hospital in Moscow. Material and methods: We studied 72 patients, including 38 men and 34 women aged 23-86 years, with an average of 58.2±4.8, who were admitted to the hospital for diagnosis and treatment in the period from 10.04.2020 to 02.10.2020 with diagnoses according to ICD-10: U07.1 Coronavirus infection caused by the COVID-19 virus. All patients underwent ultrasound examination of the liver, gallbladder, pancreas and spleen. The level of liver enzyme activity in dynamics, serum albumin concentration, prothrombin time and index were evaluated. Results: Biochemical signs of liver cell cytolysis were detected in 25-57% of patients with viral pneumonia in COVID-19, which complicates the course of terminal forms of chronic kidney disease with hemodialysis. Most often, the disease was accompanied by signs of a decrease in the synthesis of hemostatic proteins of the prothrombin complex and serum albumin, which may be associated with an aggravation of the severity of their existing chronic anemia. hematomegaly and changes in the liver structure were diagnosed in 42-85% of patients with this pathology and were combined with ultrasoundsigns of damage to the pancreas and spleen in 26-38%. In 11-19% of patients with COVID-19 infection, chronic liver damage preceded the development of pneumonia. Regardless of the state of renal function, these changes were accompanied by a worsening of the course of pre-existing liver and pancreatic lesions, including hepatitis and pancreatitis. Conclusion: Assessment of the state of enzyme and protein-producing function of the liver and pancreas should be included in the standards of inpatient examination in patients with end-stage renal failure and hemodialysis, with the development of COVID-19 and viral pneumonia, due to the high prevalence of liver, gallbladder and pancreas pathology.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic
AU  - Vechorko Valery Ivanovich
AU  - Evgeny Mikhailovich Evsikov
AU  - Teplova Natalya Vadimovna
Y1  - 2022/09/16
PY  - 2022
N1  - https://doi.org/10.11648/j.wjph.20220703.16
DO  - 10.11648/j.wjph.20220703.16
T2  - World Journal of Public Health
JF  - World Journal of Public Health
JO  - World Journal of Public Health
SP  - 132
EP  - 140
PB  - Science Publishing Group
SN  - 2637-6059
UR  - https://doi.org/10.11648/j.wjph.20220703.16
AB  - Relevance: Currently, COVID-19 is considered as a systemic disease with impaired immune system function, primarily affecting the lungs, as well as the heart, kidneys, and intestines. The nature of changes in liver function in (COVID-19) is still poorly understood and poorly covered in the available literature. There are no publications on the nature of liver and gastrointestinal tract damage in patients with end-stage chronic kidney disease with COVID-19 virus infection complicated by pneumonia, in the available modern literature. Purpose of the work: To assess the structure of liver pathology in patients with end-stage chronic renal failure (CRF), including chronically receiving hemofiltration procedures, hospitalized with a diagnosis of COVID-19 in a converted emergency hospital in Moscow. Material and methods: We studied 72 patients, including 38 men and 34 women aged 23-86 years, with an average of 58.2±4.8, who were admitted to the hospital for diagnosis and treatment in the period from 10.04.2020 to 02.10.2020 with diagnoses according to ICD-10: U07.1 Coronavirus infection caused by the COVID-19 virus. All patients underwent ultrasound examination of the liver, gallbladder, pancreas and spleen. The level of liver enzyme activity in dynamics, serum albumin concentration, prothrombin time and index were evaluated. Results: Biochemical signs of liver cell cytolysis were detected in 25-57% of patients with viral pneumonia in COVID-19, which complicates the course of terminal forms of chronic kidney disease with hemodialysis. Most often, the disease was accompanied by signs of a decrease in the synthesis of hemostatic proteins of the prothrombin complex and serum albumin, which may be associated with an aggravation of the severity of their existing chronic anemia. hematomegaly and changes in the liver structure were diagnosed in 42-85% of patients with this pathology and were combined with ultrasoundsigns of damage to the pancreas and spleen in 26-38%. In 11-19% of patients with COVID-19 infection, chronic liver damage preceded the development of pneumonia. Regardless of the state of renal function, these changes were accompanied by a worsening of the course of pre-existing liver and pancreatic lesions, including hepatitis and pancreatitis. Conclusion: Assessment of the state of enzyme and protein-producing function of the liver and pancreas should be included in the standards of inpatient examination in patients with end-stage renal failure and hemodialysis, with the development of COVID-19 and viral pneumonia, due to the high prevalence of liver, gallbladder and pancreas pathology.
VL  - 7
IS  - 3
ER  -

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