Pyruvate Application Indicates an Important Medical Advance

Zhou Fangqiang

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Pyruvate Application Indicates an Important Medical Advance

Zhou Fangqiang

Published in Asia-Pacific Journal of Medicine (Volume 1, Issue 1)

Received: 6 November 2018 Accepted: 3 January 2019 Published: 4 January 2019

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Abstract

On the occasion of the 50th anniversary of WHO-guided oral rehydration salts (ORS) clinical application, this review mainly discussed recent findings in ORS, a novel pyruvate-enriched ORS (Pyr-ORS), in animal experiments. Since past several decades, numerous pieces of evidence have shown that pyruvate owns superior biological and pharmacological characteristics that benefit critical care patients: enhancement of anoxia/hypoxia tolerance, correction of hypoxic lactic acidosis, antagonism of oxidative stress and inflammation, protection of mitochondrial structure and function and anti-apoptosis, etc. Therefore, pyruvate prevents from multi-organ dysfunction and corrects disturbances of glucose metabolism and acid-base balance in patients subjected with various pathogen insults. In recent years, investigations of intravenous pyruvate and oral pyruvate in ORS demonstrated properties above and a double increase of survival in animals subjected to hemorrhagic or burn shock. In the review, biological properties of pyruvate and the high efficiency, underlying mechanisms and vast potential clinical indications of Pyr-ORS were illustrated. The review points out that pyruvate-enriched fluids may be the third generation of fluid therapy, not only a volume expander, but also a therapeutic agent for organ dysfunction and metabolic disturbance; pyruvate may be the first-line drug for fluid therapy: Pyr-ORS becomes the first choice for patients who require fluid rehydration alone or in combination with intravenous pyruvate. Pyruvate applications would improve overall clinical outcomes of various diseases, particularly critical illnesses, potentiating a new most important medical advance this century.

Published in	Asia-Pacific Journal of Medicine (Volume 1, Issue 1)
Page(s)	14-20
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Fluid Therapy, Hypoxic Lactic Acidosis, Oral Rehydration Salts, Pyruvate, Resuscitation, Shock

References

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Zhou Fangqiang. (2019). Pyruvate Application Indicates an Important Medical Advance. Asia-Pacific Journal of Medicine, 1(1), 14-20.

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Zhou Fangqiang. Pyruvate Application Indicates an Important Medical Advance. Asia-Pac. J. Med. 2019, 1(1), 14-20.

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Zhou Fangqiang. Pyruvate Application Indicates an Important Medical Advance. Asia-Pac J Med. 2019;1(1):14-20.

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@article{10034930,
  author = {Zhou Fangqiang},
  title = {Pyruvate Application Indicates an Important Medical Advance},
  journal = {Asia-Pacific Journal of Medicine},
  volume = {1},
  number = {1},
  pages = {14-20},
  url = {https://www.sciencepublishinggroup.com/article/10034930},
  abstract = {On the occasion of the 50th anniversary of WHO-guided oral rehydration salts (ORS) clinical application, this review mainly discussed recent findings in ORS, a novel pyruvate-enriched ORS (Pyr-ORS), in animal experiments. Since past several decades, numerous pieces of evidence have shown that pyruvate owns superior biological and pharmacological characteristics that benefit critical care patients: enhancement of anoxia/hypoxia tolerance, correction of hypoxic lactic acidosis, antagonism of oxidative stress and inflammation, protection of mitochondrial structure and function and anti-apoptosis, etc. Therefore, pyruvate prevents from multi-organ dysfunction and corrects disturbances of glucose metabolism and acid-base balance in patients subjected with various pathogen insults. In recent years, investigations of intravenous pyruvate and oral pyruvate in ORS demonstrated properties above and a double increase of survival in animals subjected to hemorrhagic or burn shock. In the review, biological properties of pyruvate and the high efficiency, underlying mechanisms and vast potential clinical indications of Pyr-ORS were illustrated. The review points out that pyruvate-enriched fluids may be the third generation of fluid therapy, not only a volume expander, but also a therapeutic agent for organ dysfunction and metabolic disturbance; pyruvate may be the first-line drug for fluid therapy: Pyr-ORS becomes the first choice for patients who require fluid rehydration alone or in combination with intravenous pyruvate. Pyruvate applications would improve overall clinical outcomes of various diseases, particularly critical illnesses, potentiating a new most important medical advance this century.},
 year = {2019}
}

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TY  - JOUR
T1  - Pyruvate Application Indicates an Important Medical Advance
AU  - Zhou Fangqiang
Y1  - 2019/01/04
PY  - 2019
T2  - Asia-Pacific Journal of Medicine
JF  - Asia-Pacific Journal of Medicine
JO  - Asia-Pacific Journal of Medicine
SP  - 14
EP  - 20
PB  - Science Publishing Group
UR  - http://www.sciencepg.com/article/10034930
AB  - On the occasion of the 50th anniversary of WHO-guided oral rehydration salts (ORS) clinical application, this review mainly discussed recent findings in ORS, a novel pyruvate-enriched ORS (Pyr-ORS), in animal experiments. Since past several decades, numerous pieces of evidence have shown that pyruvate owns superior biological and pharmacological characteristics that benefit critical care patients: enhancement of anoxia/hypoxia tolerance, correction of hypoxic lactic acidosis, antagonism of oxidative stress and inflammation, protection of mitochondrial structure and function and anti-apoptosis, etc. Therefore, pyruvate prevents from multi-organ dysfunction and corrects disturbances of glucose metabolism and acid-base balance in patients subjected with various pathogen insults. In recent years, investigations of intravenous pyruvate and oral pyruvate in ORS demonstrated properties above and a double increase of survival in animals subjected to hemorrhagic or burn shock. In the review, biological properties of pyruvate and the high efficiency, underlying mechanisms and vast potential clinical indications of Pyr-ORS were illustrated. The review points out that pyruvate-enriched fluids may be the third generation of fluid therapy, not only a volume expander, but also a therapeutic agent for organ dysfunction and metabolic disturbance; pyruvate may be the first-line drug for fluid therapy: Pyr-ORS becomes the first choice for patients who require fluid rehydration alone or in combination with intravenous pyruvate. Pyruvate applications would improve overall clinical outcomes of various diseases, particularly critical illnesses, potentiating a new most important medical advance this century.
VL  - 1
IS  - 1
ER  -

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Zhou Fangqiang

Dialysis Centers, Fresenius Medical Care, Chicago, USA

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Zhou Fangqiang. (2019). Pyruvate Application Indicates an Important Medical Advance. Asia-Pacific Journal of Medicine, 1(1), 14-20.

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Zhou Fangqiang. Pyruvate Application Indicates an Important Medical Advance. Asia-Pac. J. Med. 2019, 1(1), 14-20.

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@article{10034930,
  author = {Zhou Fangqiang},
  title = {Pyruvate Application Indicates an Important Medical Advance},
  journal = {Asia-Pacific Journal of Medicine},
  volume = {1},
  number = {1},
  pages = {14-20},
  url = {https://www.sciencepublishinggroup.com/article/10034930},
  abstract = {On the occasion of the 50th anniversary of WHO-guided oral rehydration salts (ORS) clinical application, this review mainly discussed recent findings in ORS, a novel pyruvate-enriched ORS (Pyr-ORS), in animal experiments. Since past several decades, numerous pieces of evidence have shown that pyruvate owns superior biological and pharmacological characteristics that benefit critical care patients: enhancement of anoxia/hypoxia tolerance, correction of hypoxic lactic acidosis, antagonism of oxidative stress and inflammation, protection of mitochondrial structure and function and anti-apoptosis, etc. Therefore, pyruvate prevents from multi-organ dysfunction and corrects disturbances of glucose metabolism and acid-base balance in patients subjected with various pathogen insults. In recent years, investigations of intravenous pyruvate and oral pyruvate in ORS demonstrated properties above and a double increase of survival in animals subjected to hemorrhagic or burn shock. In the review, biological properties of pyruvate and the high efficiency, underlying mechanisms and vast potential clinical indications of Pyr-ORS were illustrated. The review points out that pyruvate-enriched fluids may be the third generation of fluid therapy, not only a volume expander, but also a therapeutic agent for organ dysfunction and metabolic disturbance; pyruvate may be the first-line drug for fluid therapy: Pyr-ORS becomes the first choice for patients who require fluid rehydration alone or in combination with intravenous pyruvate. Pyruvate applications would improve overall clinical outcomes of various diseases, particularly critical illnesses, potentiating a new most important medical advance this century.},
 year = {2019}
}

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TY  - JOUR
T1  - Pyruvate Application Indicates an Important Medical Advance
AU  - Zhou Fangqiang
Y1  - 2019/01/04
PY  - 2019
T2  - Asia-Pacific Journal of Medicine
JF  - Asia-Pacific Journal of Medicine
JO  - Asia-Pacific Journal of Medicine
SP  - 14
EP  - 20
PB  - Science Publishing Group
UR  - http://www.sciencepg.com/article/10034930
AB  - On the occasion of the 50th anniversary of WHO-guided oral rehydration salts (ORS) clinical application, this review mainly discussed recent findings in ORS, a novel pyruvate-enriched ORS (Pyr-ORS), in animal experiments. Since past several decades, numerous pieces of evidence have shown that pyruvate owns superior biological and pharmacological characteristics that benefit critical care patients: enhancement of anoxia/hypoxia tolerance, correction of hypoxic lactic acidosis, antagonism of oxidative stress and inflammation, protection of mitochondrial structure and function and anti-apoptosis, etc. Therefore, pyruvate prevents from multi-organ dysfunction and corrects disturbances of glucose metabolism and acid-base balance in patients subjected with various pathogen insults. In recent years, investigations of intravenous pyruvate and oral pyruvate in ORS demonstrated properties above and a double increase of survival in animals subjected to hemorrhagic or burn shock. In the review, biological properties of pyruvate and the high efficiency, underlying mechanisms and vast potential clinical indications of Pyr-ORS were illustrated. The review points out that pyruvate-enriched fluids may be the third generation of fluid therapy, not only a volume expander, but also a therapeutic agent for organ dysfunction and metabolic disturbance; pyruvate may be the first-line drug for fluid therapy: Pyr-ORS becomes the first choice for patients who require fluid rehydration alone or in combination with intravenous pyruvate. Pyruvate applications would improve overall clinical outcomes of various diseases, particularly critical illnesses, potentiating a new most important medical advance this century.
VL  - 1
IS  - 1
ER  -

Copy | Download