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Sensitization to Aspergillus Mix Among Atopic Sickle Cell Disease Patients in Abidjan, Côte d’Ivoire
Adou Adjoumanvoule Honoré,
Kabore Saydou,
Dassé Sery Romuald,
Yeboah Opong Richard,
Goran-Kouacou Amah Patricia,
Siransy Kouabla Liliane,
N’Guessan Koffi,
Assi Aya Ursule Aniela,
Memel Lasme Roselle Charline,
Zaho Ouleon Lea,
Yassongui Mamadou Sekongo
Issue:
Volume 9, Issue 1, March 2021
Pages:
1-5
Received:
20 December 2020
Accepted:
28 December 2020
Published:
12 January 2021
Abstract: The objective of this study was to determine the epidemiological characteristics of sensitization to Aspergillus in these atopic sickle cell patients who present respiratory disorders unrelated to taking NSAIDs. This is a prospective study with a descriptive and analytical aim which was conducted at the University Hospital Center (CHU) of Cocody (Abidjan). It took place from September 2017 to May 2018 on 117 atopic sickle cell disease patients, with no known history of allergy to aeroallergens, to any foods or to occupational allergens. These patients were interviewed and clinically examined for an atopic site. They were subsequently subjected to skin tests. Statistical analyzes were performed using Epi info 6.0 software using Fisher's test and odds ratio. The significance level was located at an odds ratio greater than 1. The comparison of the percentages was carried out by Fisher's test with a significance level p = 0.05. The majority of patients with sensitization to Aspergillus mix were over 15 years of age, with a predominance of women (Sex ratio: 0.56). Neither sex nor age appeared to influence the state of sensitization in our study (p> 0.05). The overall prevalence of sensitization to Aspergillus mix was 7.7%. Our results correlated asthma severity with sensitization to Aspergillus mix (p<0.05). However, there was no significant correlation between severity of allergic rhinitis and sensitization to Apergillus mix. This study confirms the low prevalence of sensitization to Aspergillus mix. Allergy to Aspergillus mix is an uncommon phenomenon in sickle cell patients but its monitoring in this population should be given special attention as it is subject to many complications.
Abstract: The objective of this study was to determine the epidemiological characteristics of sensitization to Aspergillus in these atopic sickle cell patients who present respiratory disorders unrelated to taking NSAIDs. This is a prospective study with a descriptive and analytical aim which was conducted at the University Hospital Center (CHU) of Cocody (A...
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Systemic Immunological Responses Among Dental Infection Patients
Zainab Khudher Ahmad Al Mahdi,
Fatima Malik Abood
Issue:
Volume 9, Issue 1, March 2021
Pages:
6-12
Received:
5 December 2020
Accepted:
12 January 2021
Published:
22 January 2021
Abstract: Dental infections are common health problems, evaluating of some systemic immunological responses are the aim of our study. Our study considered isolation of dental infection bacteria and quantitative evaluation of serum. IgA, IL-4, IL-7 and CD4 and CD8 molecules among dental plaque patients and control group. Oral bacteria from dental infection patients were isolated in appropriate media and diagnosed by biochemical tests and in vitro quantitative determination of serum IgA, IL-4, IL-7 and CD4 and CD8 molecules using ELISA technique. Single and mixed bacterial isolates were noted, mixed infection were (59.25%), the nature of bacteria was Gram positive cocci Streptococcus viridans, Streptococcus pyogenes and Staphylococcus aureus, and Lactocacilli spps, in addition to Gram negative rods black- pigmented bacteria, Klebsilla pneumonia, and Esherishia coli. Serum IgA was higher in patients (368.8±182.5) ng\ml than in control group (319.92±79.26) ng\ml. Serum IL-4 was higher patients (285.33±86.12) pg/ml than in control group (257.7±94.14) pg\ml. Serum IL-7 was higher in control group (19.59±4.14) pg/ml than in dental plaque patients (17.98±3.18) pg /ml. Serum CD4 molecules was higher in control group (1.371±0.5242) ng/ml than in dental plaque patients (1.326±0.1292) ng/ml. Serum CD8 molecules shows non-significant elevation in patients group 0.5825±0.02717 (ng\ml) than in control group 0.51±0.01643 (ng\ml) P≤0.05. Mean of the CD4/CD8 ratio was higher 2.783±1.126 in control group while it was 2.355±0.24 in dental plaque patients, however the differences were non-significant (P≤0.05). The present study conclude that the bacteria isolated from dental infection patients were mixed more than single infection, there were non-significant elevation in IgA, IL-4, and CD8 in patients while IL-7 and CD4 was lower in patients group than in control group, while CD4\CD8 ratio were lower in patients group, these result reflect the fact that mucosal antigen induce systemic tolerance to some extent since these bacteria present in oral cavity in early childhood. Therefor removing these bacteria always the best way to prevent such infections.
Abstract: Dental infections are common health problems, evaluating of some systemic immunological responses are the aim of our study. Our study considered isolation of dental infection bacteria and quantitative evaluation of serum. IgA, IL-4, IL-7 and CD4 and CD8 molecules among dental plaque patients and control group. Oral bacteria from dental infection pa...
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The Association of IgA Deficiency and Celiac Disease: What Hides Under the Iceberg
Hajar Saffour,
Hassan Ouaya,
Raihane Bahri,
Fadoua Elfarssani,
Karima Benjouad,
Adil Aiterrami,
Soufia Oubaha,
Zouhour Samlani,
Khadija Krati,
Brahim Admou
Issue:
Volume 9, Issue 1, March 2021
Pages:
13-15
Received:
9 November 2020
Accepted:
20 November 2020
Published:
3 March 2021
Abstract: Celiac disease is an autoimmune enteropathy, secondary to an allergy to gluten in genetically predisposed subjects, results in clinical polymorphism, with the presence of malabsorption syndrome, is a villous atrophy demonstrated using gastroscopy, which allows to biopsy the duodenal mucosa in order to demonstrate this atrophy at the histological level and also the demonstration of basal lymphocytosis, its associated clinical, endoscopic and histological abnormalities are positive for anti- ACs. IgA-type transglutaminase, the latter may be deficient, the chosen which is frequent in celiac patients compared to the general population, making sometimes the diagnosis is a challenge for the clinician. We report the case of an association between an IgA deficiency and celiac disease in a 20-year-old patient with no personal or family pathological history, revealed by diarrhea with signs of deficiency in connection with malabsorption and the presence of the sign suggestive at endoscopy. digestive system, with an analysis of the relationship between seronegative celiac disease (SNCD) and immunoglobulin A deficiency through a review of the literature on the main medical databases
Abstract: Celiac disease is an autoimmune enteropathy, secondary to an allergy to gluten in genetically predisposed subjects, results in clinical polymorphism, with the presence of malabsorption syndrome, is a villous atrophy demonstrated using gastroscopy, which allows to biopsy the duodenal mucosa in order to demonstrate this atrophy at the histological le...
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Associated Autoimmunity and Lead Exposure in Childhood
Deyanira Pacheco-Tovar,
María-Guadalupe Pacheco-Tovar,
Esperanza Avalos-Díaz,
Juan-José Bollain-y-Goytia,
María-Elena Pérez-Pérez,
Roxana Ramírez-Sandoval,
Argelia López-Luna,
Rafael Herrera-Esparza
Issue:
Volume 9, Issue 1, March 2021
Pages:
16-21
Received:
28 February 2021
Accepted:
15 March 2021
Published:
26 March 2021
Abstract: Background: The autoimmunity associated with environmental pollutants such as heavy metals is a phenomenon that has been described previously. The aim of the present study investigated the relationship between autoimmunity and lead pollutants in a cohort of children who lived in a mining settlement. Methods: Children were studied clinically and serologically. The serum lead concentration was measured by atomic absorption spectrometry, and antinuclear antibodies were analysed by immunofluorescence, ELISA and Western blot. Results: None of the studied children displayed any autoimmune disease. The lead concentration in the control group was negligible, at 0.10 ± 011 μg. L-1. In contrast, the study group had values of 12.72 ± 0.5 μg. L-1. The differences between the groups were significant (p < 0.0001). In addition, control sera were negative for antinuclear antibodies (ANA), while the sera of children living near the mining settlement showed ANA-positive titres (p < 0.001). These autoantibodies mainly recognized antigens associated with dividing cells, such as the mitotic apparatus and centrioles. Conclusion: The present results show how metallic pollutants induce environmentally associated autoimmunity and are reflected by antinuclear antibodies. This research should prompt us to take greater caution and implement permanent monitoring to ensure a healthy environment.
Abstract: Background: The autoimmunity associated with environmental pollutants such as heavy metals is a phenomenon that has been described previously. The aim of the present study investigated the relationship between autoimmunity and lead pollutants in a cohort of children who lived in a mining settlement. Methods: Children were studied clinically and ser...
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