Study on Mutation Resistance to Imatinib in Chronic Myeloid Leukemia Patients from West India
Ankit Darji,
Praful Bharadia
Issue:
Volume 9, Issue 1, March 2021
Pages:
1-17
Received:
6 March 2020
Accepted:
1 April 2020
Published:
4 January 2021
Abstract: Imatinib is a type of protein tyrosine kinase inhibitor which inhibits the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome i.e. the BCR-ABL tyrosine kinase, abnormality in CML patient. The aim of the study is to assess the response of imatinib in CML patients and to observe resistance to imatinib. Study was performed at Ahmedabad, Gujarat, India. Dose of 400, 600, 800 mg of Imatinib was found to be prescribed to all patients during the study. Comparison of laboratory parameters and PCR data were done after measurement by RT-PCR method. Total 256 patients with CML were enrolled in the study. 196 patients had completed study as per protocol. 38 patients were newly diagnosed whereas 158 patients were already diagnosed with CML. 89.29% (n = 175) of patients achieved complete haematological response, Complete MolR were achieved in n = 41 at 6th months, n = 1 at 12th month & 18th month and no patient was found with none CyR out of 196 patients; no patient were found with minimal CyR at 6th month, 2 patient were at 12th month and 3 patients were at 18th month. Mean PCR value (BCR-ABL/ABL ratio) in patient was found 0.245±1.16 at Day 0, 0.824±1.51 at 6th month, 4.086±9.58 at 12th month and 6.713±11.32 at 18th month visit. In conclusion, it was observed that resistance to imatinib might be developed within an average time of 12 months in the patients due to which survival rate was drastically reduced.
Abstract: Imatinib is a type of protein tyrosine kinase inhibitor which inhibits the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome i.e. the BCR-ABL tyrosine kinase, abnormality in CML patient. The aim of the study is to assess the response of imatinib in CML patients and to observe resistance to imatinib. Study was performed at...
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Rainwater Quality Index of Selected Communities in Langtang North and South Local Government Areas, Plateau State North-Central Nigeria
Badamasi Jamda Saidu,
Daniel Davou Dabi,
Augustine Chukwuma Eziashi,
Mahmud Mohammed Bose
Issue:
Volume 9, Issue 1, March 2021
Pages:
18-25
Received:
11 June 2020
Accepted:
29 July 2020
Published:
12 January 2021
Abstract: This study examines the portability of rainwater in Langtang north and south LGAs of Plateau State-Nigeria using arithmetic water quality index method with 10 samples collected directly from zinc and aluminum rooftops in 10 selected communities. Twenty-six water quality parameters were analyzed in the field and laboratory. Temperature, pH, EC, TDS and turbidity were analyzed in the field using appropriate equipment as well as color, odour and taste. The most probable number was used to determine the presence of bacteria, while photometric and the Atomic Absorption Spectrophotometer (AAS) were used to determine the concentration of the various chemical parameters (USEPA, 2012). The results revealed unobjectionable taste, color and odour, temperature (26.8-27.5), pH (6.5-7.8), Turbidity (1.8-2.7), Conductivity (20-30), TDS (10-15), Caco3 (5-10), Ca (2-8), Mg (1-4), SO4 (1-7), NO3 (1.3-8.6), Fe (0.01-0.15), Cl (10-32), F (0.001-0.002), Cu (0.01-0.2), Zn (0-1.5), Mn (0-0.02), Cr (0-0.01), Al (0.01-0.06), and total coliform (0-4). Cadmium, Arsenic, Lead, phenols, pesticides, faecal coliform and e-coli were not detected. All parameters tested were within acceptable limits for drinking water. While aluminium catchments do not show any difference in parameter concentrations, zinc catchment revealed increase in Zn concentration with age of materials. Calculated water quality index of samples ranged from 2 to 12 with an overall value of 4.7 indicating excellent water quality for all samples. Based on these results, the paper concludes that the rainwater is of good quality suitable for drinking. However, age of catchment materials may influence rainwater quality in due course through leaching, and therefore recommended regular maintenance of catchments, observance of first flush and avoid use of old roof for RWH.
Abstract: This study examines the portability of rainwater in Langtang north and south LGAs of Plateau State-Nigeria using arithmetic water quality index method with 10 samples collected directly from zinc and aluminum rooftops in 10 selected communities. Twenty-six water quality parameters were analyzed in the field and laboratory. Temperature, pH, EC, TDS ...
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Bioaccumulation of Mercury in Marine Algae from Dakar Coast (Senegal) and Galician Rias (Spain)
Birame Ndiaye,
Momar Ndiaye,
Benita Perez Cid,
Abdoulaye Diop,
Ibrahima Diagne,
Dame Cisse,
Cheikh Tidiane Dione,
Maoudo Hane
Issue:
Volume 9, Issue 1, March 2021
Pages:
26-31
Received:
10 February 2021
Accepted:
1 March 2021
Published:
30 March 2021
Abstract: Algae samples from Dakar coast (Senegal) and Galician Rias (Spain) were analyzed by cold vapor atomic absorption spectrometry (CV-AAS) to assess the bioaccumulation of mercury in the two aquatic systems. In this work, the contents of inorganic mercury and total mercury were determined. Simplified analytical procedures (microwave digestion and ultrasonic assisted extraction) were used for sample preparation. A reference material (BCR-60) was used to validate the analytical procedures used for sample preparation. The results of the analysis show that the total mercury contents found in algae samples from the Galician Rias are relatively similar to those found in algae samples from the Dakar coast. However, the inorganic mercury content of the algae from Pontevedra Ria was considerably higher than that found in the algae samples from Vigo Ria. The distribution was observed for inorganic mercury and total mercury, indicating that inorganic mercury is the major mercury species that bioaccumulates in marine algae. The inorganic mercury contents were always approximately equal to those of total mercury in the algae samples and a satisfactory correlation (p <0.0001; r = 0.9997) was obtained between them. Finally, the ANOVA analysis indicates that no significant difference (F = 0.165; p = 0.809) was found between the algae of the two aquatic systems (Dakar coast and Galician Rias).
Abstract: Algae samples from Dakar coast (Senegal) and Galician Rias (Spain) were analyzed by cold vapor atomic absorption spectrometry (CV-AAS) to assess the bioaccumulation of mercury in the two aquatic systems. In this work, the contents of inorganic mercury and total mercury were determined. Simplified analytical procedures (microwave digestion and ultra...
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