American Journal of Internal Medicine

Volume 8, Issue 6, November 2020

  • Anti-PCSK9 Vaccines - An Emerging Therapeutic Innovative Game Changer in Dyslipidemia and Beyond

    Mrinal Kanti Das, Tapan Sinha, Mahesh Kumar Chaudhary

    Issue: Volume 8, Issue 6, November 2020
    Pages: 250-253
    Received: 23 September 2020
    Accepted: 15 October 2020
    Published: 26 October 2020
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    This article belongs to the Special Issue Dyslipidemia: Flash Back and Vision Ahead
    Abstract: Proprotein convertase subtilisin/kexin type 9 serine protease (PCSK9) regulates the cholesterol metabolism by genetic mechanism mediating the LDL receptor degradation. Gain of the functions of the PCSK9 variants resulted in high level of LDL-cholesterol and loss of function in low level of the LDL-cholesterol level. The low level of LDL-cholesterol... Show More
  • The Lag Time of Diagnosis of Axial Spondyloarthritis: A Bangladesh Perspective

    Abu Tahir Muhammad Tanveer Hasan, Muhammad Abdul Alim

    Issue: Volume 8, Issue 6, November 2020
    Pages: 254-257
    Received: 24 September 2020
    Accepted: 15 October 2020
    Published: 30 October 2020
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    Abstract: Background & Objective: The lag time of diagnosis of axial spondyloarthrits varies from country to country. The aim of this study was to find out the lag time of diagnosis of axial spondyloarthritis in Bangladesh based on the patients visiting the morning Rheumatology OPD of a tertiary-care hospital. Materials & Methods: This study was conducted in... Show More
  • Risk Factors and Impact of Diagnostic Delay in Patients with Inflammatory Bowel Disease in Bangladesh

    Chanchal Kumar Ghosh, S. M. Ali Hasan, Md Abdur Rahim Miah

    Issue: Volume 8, Issue 6, November 2020
    Pages: 258-262
    Received: 14 October 2020
    Accepted: 23 October 2020
    Published: 30 October 2020
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    Abstract: Background and Aims: A delay in the diagnosis of inflammatory bowel disease (IBD) is a risk of developing complications and surgery. This study was done to evaluate the factors and impact of diagnostic delay on IBD patients in Bangladesh. Methods: This cross-sectional study was carried out in the Department of Gastroenterology of a tertiary care ce... Show More
  • Contribution of Scanner in the Breast Cancer Extension Assessment in the Radiology Department of CNHU-HKM in Benin

    Yekpe Ahouansou Patricia, Adjadohoun Sonia, Lokossou Symphorose, Ngamo Gabriel, Lokossou Andreas, Kiki Miralda, Akanni Djivèdé, Biaou Olivier

    Issue: Volume 8, Issue 6, November 2020
    Pages: 263-266
    Received: 06 October 2020
    Accepted: 27 October 2020
    Published: 04 November 2020
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    Abstract: Objective: Breast cancer is the most common female cancer in the world. The prognosis depends on whether metastasis is present or not. The objective of this study was to provide an overview of the CT scan aspects identified during the evaluation of breast cancer extension in the Radiology department of the Teaching University Hospital of Hubert Kou... Show More
  • Postural Instability in a Young Dyslexic Adult Improved by Hebbian Pulse-width Modulated Lighting

    Albert Le Floch, Samuel Henriat, Rosane Fourage, Guy Ropars

    Issue: Volume 8, Issue 6, November 2020
    Pages: 267-273
    Received: 14 October 2020
    Accepted: 23 October 2020
    Published: 04 November 2020
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    Abstract: Background: Postural stability is linked to vision in everyone, since when the eyes are closed stability decreases by a factor of 2 or more. However, in persons with dyslexia postural stability is often deficient even when the eyes are open, since they show deficits in motor as well as specific cognitive functions. In dyslexics we have shown that a... Show More
  • Dyslipidemia and Atherosclerotic Cardiovascular Disease: Flash Back and Vision Ahead

    Prabhash Chand Manoria, Pankaj Manoria, Rajesh Kumar Shrivastava, Sharad Kumar Parashar

    Issue: Volume 8, Issue 6, November 2020
    Pages: 274-278
    Received: 23 September 2020
    Accepted: 26 October 2020
    Published: 16 November 2020
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    This article belongs to the Special Issue Dyslipidemia: Flash Back and Vision Ahead
    Abstract: Dyslipidemia is the most common modifiable risk factor for atherosclerotic cardiovascular disease (ASCVD). There is unequivocal evidence that Low Density Lipoprotein Cholesterol (LDL-C) is the main culprit. Statins, ezetimibe, bempedoic acid and Proprotein Convertase Subtilisin/ Kexin Type 9 (PCSK9) inhibitors are used to target LDL-C. Statin is al... Show More
  • Familial Hypercholesterolemia: Improving Outcomes with Newer Agents

    Saumitra Ray, Biswarup Sarkar

    Issue: Volume 8, Issue 6, November 2020
    Pages: 279-284
    Received: 23 September 2020
    Accepted: 15 October 2020
    Published: 16 November 2020
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    This article belongs to the Special Issue Dyslipidemia: Flash Back and Vision Ahead
    Abstract: Familial hypercholesterolemia (FH) is one of the commonest autosomal dominant genetic disorders which affects lipoprotein metabolism in the body, causing thereby severe hypercholesterolemia, mainly contributed by high level of low density lipoprotein cholesterol (LDLc). This causes polyvascular premature atherosclerosis with significant mortality, ... Show More
  • Remdesivir Induced Liver Injury and Severe COVID-19 Infection

    Chanchal Kumar Ghosh, S. M. Ali Hasan, Suman Dey

    Issue: Volume 8, Issue 6, November 2020
    Pages: 285-288
    Received: 04 November 2020
    Accepted: 13 November 2020
    Published: 23 November 2020
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    Abstract: Background and Aims: Remdesivir is identified as an effective therapeutic option in COVID-19, but its’ hepatic safety has not been well studied. So, we aimed to identify the pattern and severity of hepatotoxicity in remdesivir treated COVID-19 patients. Methods: This cross-sectional study was carried out at a dedicated COVID-19 unit of a university... Show More
  • A Brief Review for Clinicians of Iron Metabolism and the Safety, Efficacy, and Rationale for Use of Intravenous Iron Products

    Marshall Patrick Stagg, Jennifer Miatech, Hailey Tarleton

    Issue: Volume 8, Issue 6, November 2020
    Pages: 289-303
    Received: 02 October 2020
    Accepted: 17 October 2020
    Published: 27 November 2020
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    Abstract: Iron is an abundant element that is essential for multiple biologic processes. Iron metabolism is not entirely understood, but since the discovery of hepcidin, much progress has been made especially in the last five years. This article is intended to enhance clinician understanding of iron metabolism which may inform decisions about parenteral iron... Show More
  • Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone

    Nakul Kumar Datta, Krishna Priya Das, Mohammad Mamun Mia

    Issue: Volume 8, Issue 6, November 2020
    Pages: 304-311
    Received: 31 October 2020
    Accepted: 16 November 2020
    Published: 04 December 2020
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    Abstract: Cystic lesions include Simple bone cyst and Aneurysmal bone cyst, and among cyst like lesions studied Giant cell tumor, fibrous dysplasia and Non-ossifying fibroma. This prospective interventional study was conducted in the Department of orthopaedic surgery Bangubandhu Sheikh Mujib Mdical university (BSMMU) and Biomedical research division, Atomic ... Show More
  • Acquired Hemophilia B Through Liver Transplantation: A Case Report and Literature Review

    Christine Jane Kurian, Douglass Alan Drelich, Sanaa Rizk

    Issue: Volume 8, Issue 6, November 2020
    Pages: 312-315
    Received: 04 October 2020
    Accepted: 28 October 2020
    Published: 16 December 2020
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    Abstract: Hemophilia B, also called Christmas disease, is an X-linked inherited bleeding disorder that predominantly affects males, and it is caused by deficiency of coagulation factor IX. Factor IX is a coagulation factor produced in the liver. Liver transplantation from hemophilia B donors is neither widely documented nor performed due to presumed risk of ... Show More