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Impact of 5-Alpha Reductase Inhibitors Treatment for Benign Prostatic Hyperplasia on Erectile Dysfunction: A Meta-Analysis
He Xiao,
Hu Lei,
Fang Qing-hua,
Chen Dong
Issue:
Volume 1, Issue 1, December 2017
Pages:
1-6
Received:
28 November 2016
Accepted:
23 December 2016
Published:
24 January 2017
DOI:
10.11648/j.ijcu.20170101.11
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Abstract: Objective To provide a meta-analysis of the available randomized clinical trials (RCTs) reporting the impact of 5-alpha reductase inhibitors treatment for BPH on erectile function. Methods According to the requirements of meta-analysis, a literature search about 5-alpha reductase inhibitors therapy in BPH was performed among PubMed, EMBASE, Science Direct and The Cochrane Library from the establishment of the database till June 2016．Rresults A total of 391 articles were included, 11 RCTs were enrolled for meta-analysis. All articles used randomized, double blind and placebo control. Within 1 year, erectile dysfunction was more common with 5-alpha reductase inhibitors than with placebo (OR=2.18, P<0.00001). In particular, considering Finasteride (OR=2.28, P<0.00001) or Dutasteride (OR=2.06, P<0.00001). Finasteride had no significantly difference with Dutasteride. In more than 1 year, erectile dysfunction was more common with 5-alpha reductase inhibitors than with placebo (OR=1.45, P<0.0001). In particular, considering Finasteride (OR=1.46, P<0.0001); conversely, Dutasteride was associated with a risk similar to placebo. Conclusion Within 1 year, 5-Alpha reductase inhibitors may increase the risk of erectile dysfunction. In more than 1 year, Finasteride was more likely to lead to erectile dysfunction. These data can be relevant both for drug selection and patients counseling.
Abstract: Objective To provide a meta-analysis of the available randomized clinical trials (RCTs) reporting the impact of 5-alpha reductase inhibitors treatment for BPH on erectile function. Methods According to the requirements of meta-analysis, a literature search about 5-alpha reductase inhibitors therapy in BPH was performed among PubMed, EMBASE, Science...
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Bifocal Metanephric Adenoma in a Patient with Non-hodgkin Lymphoma
David S. Rosero,
Celia del Agua,
Isabel Marquina,
Angel Garcia de Jalon,
Francesc Felipo
Issue:
Volume 1, Issue 1, December 2017
Pages:
7-10
Received:
7 December 2016
Accepted:
16 January 2017
Published:
9 February 2017
DOI:
10.11648/j.ijcu.20170101.12
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Abstract: Metanephric adenoma (MA) is a rare benign renal tumor. Radiology does not clearly differentiate between this benign lesion and renal carcinoma accurately. We report the case of a woman with history of non-Hodgkin lymphoma. CT scan showed nodules in one kidney, and radical nephrectomy was performed under the appearance of hypernephroma. Two lesions were identified, and the histopathological diagnosis was MA. No other MA has been reported in patients with non-Hodgkin lymphoma. The correct diagnosis of this tumor prevents radical nephrectomy. In the current report we describe two foci of tumor, and being MA usually solitary, its benign characteristics might be more challenging.
Abstract: Metanephric adenoma (MA) is a rare benign renal tumor. Radiology does not clearly differentiate between this benign lesion and renal carcinoma accurately. We report the case of a woman with history of non-Hodgkin lymphoma. CT scan showed nodules in one kidney, and radical nephrectomy was performed under the appearance of hypernephroma. Two lesions ...
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Treatment of Renal Colic in Emergency Hebron Government Hospital
Mohammad Qtait,
Salah Tamiza
Issue:
Volume 1, Issue 1, December 2017
Pages:
11-14
Received:
19 May 2017
Accepted:
31 May 2017
Published:
18 July 2017
DOI:
10.11648/j.ijcu.20170101.13
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Abstract: The aims the present investigation aimed to point out some data concerning renal colic in Palestine, and to evaluate the practical clinic approach to it. All the renal colic cases treated in three month in the Hebron hospital ED, reviewed to assess the data, diagnostic and treatment patterns, and to compare them with what is reported in the literature. Retrospective study by review of file of emergency department in three month of renal colic or urinary stone. Renal colic were diagnosed in three month 300 cases (1%) from all vister of ED; 66 % of them were recurrent stone formers; the males 61%, female 39%, The age distribution, showed a higher rate from 25 to 44 years of age, Ultrasonography (US) was the examination in 72% cases, 99% lab test urine analysis. Diclofen were always used (90%), association with Hyoscine butylbromide, narcotic as pethidin (10%). The data of our investigation are in a substantial agreement with the reported literature bout features of renal colic and its treatment. The diagnostic approach is mainly based on US and lab test. CT-scan was not used in ED. Conclusion; the data of our investigation agree substantially with those reported in the literature as far as concerns of renal colic and its treatment. The diagnostic approach is mainly based on US whereas urine examination, most of patient given Diclofen, and Hyoscine butylbromide and 10% given narcotic. In pale stain treated the renal colic as national guide.
Abstract: The aims the present investigation aimed to point out some data concerning renal colic in Palestine, and to evaluate the practical clinic approach to it. All the renal colic cases treated in three month in the Hebron hospital ED, reviewed to assess the data, diagnostic and treatment patterns, and to compare them with what is reported in the literat...
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A Case Report of Transfusion-Transmitted Plasmodium malariae in a Non-endemic Country
El Mezouari El Mostafa,
Benjelloun Imane,
Belarbi Marouane,
Ait Ameur Mustapha,
Chakour Mohamed,
Zyani Mohamed,
Zemraoui Nadir,
Moutaj Redouane
Issue:
Volume 1, Issue 1, December 2017
Pages:
15-18
Received:
5 March 2017
Accepted:
22 April 2017
Published:
11 October 2017
DOI:
10.11648/j.ijcu.20170101.14
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Abstract: A 57-year-old woman with chronic hemodialysis for 16 years, who presented at the Avicenna hospital in Marrakesh with fever and hepatosplenomegaly. Three months earlier, he received 2 units of packed red blood cells. Laboratory studies indicated hemolytic anemia (hemoglobin, 9.5 mg/dl) and thrombocytopenia (platelet count, 105000/mm2). Malaria smear was consistent with Plasmodium malariae. The level of parasetemia was 1% (10 per 1000 erythrocytes). As a result, the patient's antimalarial therapy was continued for a total of 7 days followed by mefloquine for 7 days once the blood smear results revealed P. malariae infection. Evolution was favorable after antimalarial therapy with the disappeanrance of fever and hepatosplenomegaly. The control of parasitaemia remained negative until 28 days. This is the first case of hepatosplenomegaly secondary to blood transfusion related Plasmodium malariae infection in a non-endemic country in chronic hemodialysis.
Abstract: A 57-year-old woman with chronic hemodialysis for 16 years, who presented at the Avicenna hospital in Marrakesh with fever and hepatosplenomegaly. Three months earlier, he received 2 units of packed red blood cells. Laboratory studies indicated hemolytic anemia (hemoglobin, 9.5 mg/dl) and thrombocytopenia (platelet count, 105000/mm2). Malaria smear...
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