Journal of Drug Design and Medicinal Chemistry

Volume 2, Issue 4, August 2016

  • Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents

    Rukhsana Gul, Zainab Nawaz, Amin Badshah, Azim Khan, Asif Junaid, Rabia Naz, Muhammad Kamran Rauf, Saima Hayat

    Issue: Volume 2, Issue 4, August 2016
    Pages: 35-39
    Received: 29 February 2016
    Accepted: 29 March 2016
    Published: 1 August 2016
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    Abstract: A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (1H and 13C) NMR and FTIR spectroscopy. The newly synthesized co... Show More
  • Synthesis and Biological Evaluation of 3-Aryl Pyrazoles as CDK2/HDAC Inhibitor for Anticancer Agents

    Xianfeng Huang, Bei Yang, Yuanyuan Liu, Cheng Zhang, Guoqiang Song

    Issue: Volume 2, Issue 4, August 2016
    Pages: 40-46
    Received: 17 May 2016
    Accepted: 20 June 2016
    Published: 1 August 2016
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    Abstract: A novel series of pyrazole derivatives containing hydroxamic acid group were designed and synthesized as multi-target inhibitors targeting CDK2 (cyclin-dependent kinases 2) and HDAC (histone deacetylase). Compounds 6e and 6f exhibited most potent CDK2 inhibition as well as HDAC inhibition. In vitro antiproliferative assay indicated that several com... Show More