Journal of Drug Design and Medicinal Chemistry

Volume 6, Issue 1, March 2020

  • Validation of in Silico Docking Analysis of Oligophenylpropanoids to Xanthine Oxidase by Correlation with in Vitro Bioassay and Its Application to Phlorotannins

    Sheau Ling Ho, Sheng-Fa Tsai, Ching-Ting Lin, Hyeung-Rak Kim, Shoei-Sheng Lee

    Issue: Volume 6, Issue 1, March 2020
    Pages: 1-6
    Received: 12 February 2020
    Accepted: 13 March 2020
    Published: 31 March 2020
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    Abstract: The oligo-phenylpropanoids 1−7, isolated from Hyptis rhombodes, have been found to possess potent inhibitory activity against xanthine oxidase (EC 1.2.3.2, bovine milk). To rationalize such activity, computer assisted docking of these compounds and allopurinol, a positive control, on the xanthine oxidase was undertaken in this study. The docking sc... Show More
  • Antimicrobial Resistance Patterns of Salmonella in Ethiopia Since 2009/2010: A Review

    Samuel Chane Teferi

    Issue: Volume 6, Issue 1, March 2020
    Pages: 7-14
    Received: 20 August 2020
    Accepted: 31 August 2020
    Published: 16 September 2020
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    Abstract: Salmonella is one of the major and important foodborne pathogens of humans and animals causing salmonellosis, which have great medical and economical cost. Infections with Salmonella in food-producing animals present a serious public health concern, because food products of animal origin are considered to be a significant source of human infection.... Show More