Advances in Biochemistry
Volume 3, Issue 5, October 2015, Pages: 51-56
Received: Aug. 30, 2015;
Accepted: Sep. 16, 2015;
Published: Sep. 26, 2015
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Showkat Ahmad Bhat, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry (F. V. Sc & AH), Sher-e-Kashmir University of Agricultural Sciences & Technology Kashmir (SKUAST-K), Shuhama, Alustang, Srinagar, Jammu & Kashmir, India
Manzoor R. Mir, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry (F. V. Sc & AH), Sher-e-Kashmir University of Agricultural Sciences & Technology Kashmir (SKUAST-K), Shuhama, Alustang, Srinagar, Jammu & Kashmir, India
Sabhiya Majid, Department of Biochemistry Govt. Medical College Srinagar, Srinagar, Jammu & Kashmir, India
Muneeb U. Rehman, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry (F. V. Sc & AH), Sher-e-Kashmir University of Agricultural Sciences & Technology Kashmir (SKUAST-K), Shuhama, Alustang, Srinagar, Jammu & Kashmir, India
Sonallah Kuchy, Department of Oncology, Govt. Medical College Srinagar, Srinagar, Jammu & Kashmir, India
Bilal Ahmad Sheikh, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry (F. V. Sc & AH), Sher-e-Kashmir University of Agricultural Sciences & Technology Kashmir (SKUAST-K), Shuhama, Alustang, Srinagar, Jammu & Kashmir, India
Ishraq Husain, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry (F. V. Sc & AH), Sher-e-Kashmir University of Agricultural Sciences & Technology Kashmir (SKUAST-K), Shuhama, Alustang, Srinagar, Jammu & Kashmir, India
Bhudev C. Das, Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh Campus, Delhi, India
Among all the cancers Gastric cancer has been reported to be a highly prevalent malignancy In Kashmir valley, constitutes about 30%-40% of all malignancies. Cancer is consistently considered as significant environmental issue besides other etiological factors. In our study the incidence ratio among genders remained 3:1(male to female). More incidents were found in 60-64 years of age, 34.5% patients reported weight loss and the weight difference was about 10kg from stage I to Stage IV, 62% of the patients were illiterate, 59.5% of patients were from poor and middle class and 51% patients had faced the Water pollution. Major portion 53 %of patients belongs to farmers& house wives among these 38.6%, 12.2%, 8.4%, 21.6%& 18.8% had exposure to Pesticides/insecticides, Fungicides, Chemicals, Fertilizer, Manure respectively. At the time of diagnosis patients presented with multiple symptoms like dyspepsia 76.5%, loss of appetite 35.5% and vomiting 42.0%. On physical examination, anaemia was the most common sign and was present in 163 81.5%, ascites was 11.1%, epigastric mass in 9.9% Regarding distribution of cancer within the stomach, distal stomach was involved in 45.5%, proximal stomach in 42.0% of patients; Middle stomach and Whole stomach were involved in 6.0% each. Among the common symptom, ulceroproliferative type was seen in 35.5%, ulcerative lesions were 30% and infiltrative were in 7.0 %.Various perceptible effects during our study provides significant evidence to conclude that in gastric cancer etiology, environment plays an important role.
Showkat Ahmad Bhat,
Manzoor R. Mir,
Muneeb U. Rehman,
Bilal Ahmad Sheikh,
Bhudev C. Das,
Environmental Factors in Etiology of Gastric Cancer, Advances in Biochemistry.
Vol. 3, No. 5,
2015, pp. 51-56.
Azra, Jan, GM. (1990). Pattern of cancer at Srinagar (Kashmir). Indian J Pathol Microbiol, 33, 118-23.
Blair, A., Dosemeci, M., Heineman, EF. (1993) Cancer and other causes of death among male and female farmers from twenty-three states. Am J Ind Med 23:729-42.
Blair, A., Zahm, SH. (1991) Cancer among farmers. Occup Med; 6:335-54.
Bowrey, DJ., Griffin, SM., Wayman, J., Karat, D., Hayes, N., Raimes, SA. (2006) Use of alarm symptoms to select dyspeptics for endoscopy causes patients with curable esophagogastric cancer to be overlooked. SurgEndosc; 20: 1725-1728.
Bulent, Y., Nurullah, Z., Fazli, A. (2006) The clinical and pathological features of patients with gastric cancer in Turkey: A Turkish Oncology Group Study. Turkish Journal of Cancer, 36, 3.
Chow, WH., McLaughlin, JK., Malker, HSR.(1994) Occupation and stomach cancer cohort of Swedish men. Am J Ind Med; 26:511-20.
Coggon, D., Pannett, B., Pippard, EC. (1989) Lung cancer in the meat industry. Br J Ind Med; 46:188-91.
Delzell, E., Grufferman, S. (1985) Mortality among white and nonwhite farmers in North Carolina, 1976-1978. Am J Epidemiol; 121:391 402.
Eskandar. H., Hossein, SS., Rahim, M. (2006) Clinical profile of gastric cancer in Khuzestan, southwest of Iran. World J Gastroenterol; 12:48325.
Everett, SM., Axon, AT. (1997) Early gastric cancer in Europe. Gut; 41: 142-150.
Fincham, SM., Hanson, J., Berkel, J. (1992) Patterns and risks of cancer in farmers in Alberta. Cancer; 69:1276-85.
Hagmar, L., Linden, K., Nilsson, A. (1992) Cancer incidence and mortality among Swedish Baltic Sea fishermen. Scand J Work Environ Health; 18:217–24.
Inoue, M., Tsugane, S. (2005) Epidemiology of gastric cancer in Japan. Postgrad Med J ;81:41924.
Khuroo, MS., Zargar, ZA., Mahajan, R. (1992) High incidence of esophageal and gastric cancer in Kashmir - in a population with special personal and dietary habit. Gut, 33, 11-5.
Kim, DY., Ryu, SY., Kim, YJ. (2003) Clinicopathological characteristics of gastric carcinoma in young patients. Langenbecks Arch Surg; 388.
Koutros, S., Alavanja, MC., Lubin, JH. (2010) An update of cancer incidence in the Agricultural Health Study. Journal of Occupational and Environmental Medicine; 52(11):1098–1105.
Koutros, S., Lynch, CF., Ma, X. (2009) Heterocyclic aromatic amine pesticide use and human cancer risk: results from the U.S. Agricultural Health Study. International Journal of Cancer; 24(5):1206–1212.
Kwong, MF., Nick T., Paul M., Richard H., Takeshi A., Kentaro, S. (2008) Asia-Pacific Consensus Guidelines on Gastric Cancer Prevention. J Gastroenterol Hepatol.; 23(3):351-365.
Maconi, G., Kurihara, H., Panizzo, V., Russo, A., Cristaldi, M., Marrelli, D., Roviello, F. (2003) Gastric cancer in young patients with no alarm symptoms: focus on delay in diagnosis, stage of neoplasm and survival. Scand J Gastroenterol; 38: 1249-1255.
Mariya, AQ., Muneer, AH., Showkat AH. (2006) Gastric Cancer in Kashmir. Asian Pacific J Cancer Prev, 12, 303-307.
MedinaFranco, H., Heslin, MJ., CortesGonzalez, R. (2000) Clinicopathological characteristics of gastric carcinoma in young and elderly patients: a comparative study. Ann Surg Oncol; 7:5159.
Nawroz, H., Koch, W., Anker, P., Stroun, M., Sidransky, D. (1996) Microsatellite alterations in serum DNA of head and neck cancer patients. Nat Med. 2:9:1035-7.
Phukan, RK., Zomawia, E., Narain, K. (2005). Tobacco use and stomach cancer in Mizoram, India. Cancer Epidemiol Biomarkers Prev, 14, 1892-6.
PierluigiCocco, Mary, H., Ward. Occupational Risk Factors for Gastric Cancer. Epidemiologic Reviews by the Johns Hopkins University School of Hygiene and Public Health, Vol. 18, No. 2.
Plummer, JM., Gibson, TN., McFarlane, ME. (2005) Clinicopathologic profile of gastric carcinomas at the University Hospital of the West Indies. West Indian Med J; 54:3648.
Prakash, S., Sarran, L., Socci, N., DeMatteo, RP., Eisenstat, J., Greco, AM., Maki, RG., Wexler, LH. (2005) gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature. Journal Pediatric Hematol Oncol. 27:4:179-87.
Raj, A., Mayberry, JF., Podas, T. (2003) occupation and gastric cancer. Postgrad Med J ; 79:252–258
Safaee, A., Moghimi, DB., Fatemi, SR. (2009) Clinicopathological Features of Gastric Cancer: A Study Based on Cancer Registry Data. IJCP ;2:6770.
Sambasivaiah, K., Ibrarullah, M., Reddy, MK. (2004) Clinical profile of carcinoma stomach at a tertiary care hospital in south India. Trop Gastroenterol; 25:216.
Sinha, R., Anderson, DE., McDonald, SS., Greenwald, P. (2003) Cancer risk and diet in India. J postgrad Med; 49; 222-228.
Stephens, MR., Lewis, WG., White, S., Blackshaw, GR., Edwards, P., Barry, JD., Allison, C. (2005) Prognostic significance of alarm symptoms in patients with gastric cancer. Br J Surg; 92: 840-846.