Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Eze Ejike Daniel; Aliyu Mohammed; Yusuf Tanko; Abubakar Ahmed

doi:doi:10.11648/j.cb.20150301.11

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Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko, Abubakar Ahmed

Received: 22 December 2014 Accepted: 5 January 2015 Published: 12 January 2015

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Abstract

The present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.

DOI	10.11648/j.cb.20150301.11
Published in	Cell Biology (Volume 3, Issue 1, January 2015)
Page(s)	1-13
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetes Mellitus, Lycopene, Streptozotocin, Electrolytes, Antioxidants, Kidney

References

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Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko, Abubakar Ahmed. (2015). Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats. Cell Biology, 3(1), 1-13. https://doi.org/10.11648/j.cb.20150301.11

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ACS Style

Eze Ejike Daniel; Aliyu Mohammed; Yusuf Tanko; Abubakar Ahmed. Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats. Cell Biol. 2015, 3(1), 1-13. doi: 10.11648/j.cb.20150301.11

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AMA Style

Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko, Abubakar Ahmed. Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats. Cell Biol. 2015;3(1):1-13. doi: 10.11648/j.cb.20150301.11

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@article{10.11648/j.cb.20150301.11,
  author = {Eze Ejike Daniel and Aliyu Mohammed and Yusuf Tanko and Abubakar Ahmed},
  title = {Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats},
  journal = {Cell Biology},
  volume = {3},
  number = {1},
  pages = {1-13},
  doi = {10.11648/j.cb.20150301.11},
  url = {https://doi.org/10.11648/j.cb.20150301.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20150301.11},
  abstract = {The present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.},
 year = {2015}
}

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TY  - JOUR
T1  - Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats
AU  - Eze Ejike Daniel
AU  - Aliyu Mohammed
AU  - Yusuf Tanko
AU  - Abubakar Ahmed
Y1  - 2015/01/12
PY  - 2015
N1  - https://doi.org/10.11648/j.cb.20150301.11
DO  - 10.11648/j.cb.20150301.11
T2  - Cell Biology
JF  - Cell Biology
JO  - Cell Biology
SP  - 1
EP  - 13
PB  - Science Publishing Group
SN  - 2330-0183
UR  - https://doi.org/10.11648/j.cb.20150301.11
AB  - The present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.
VL  - 3
IS  - 1
ER  -

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Author Information

Eze Ejike Daniel

Department of Physiology, Faculty of Basic Medical Sciences, Bingham University, Karu, Nasarawa State, Nigeria
Aliyu Mohammed

Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria
Yusuf Tanko

Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria
Abubakar Ahmed

Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria, Nigeria

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Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko, Abubakar Ahmed. (2015). Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats. Cell Biology, 3(1), 1-13. https://doi.org/10.11648/j.cb.20150301.11

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ACS Style

Eze Ejike Daniel; Aliyu Mohammed; Yusuf Tanko; Abubakar Ahmed. Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats. Cell Biol. 2015, 3(1), 1-13. doi: 10.11648/j.cb.20150301.11

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AMA Style

Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko, Abubakar Ahmed. Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats. Cell Biol. 2015;3(1):1-13. doi: 10.11648/j.cb.20150301.11

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@article{10.11648/j.cb.20150301.11,
  author = {Eze Ejike Daniel and Aliyu Mohammed and Yusuf Tanko and Abubakar Ahmed},
  title = {Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats},
  journal = {Cell Biology},
  volume = {3},
  number = {1},
  pages = {1-13},
  doi = {10.11648/j.cb.20150301.11},
  url = {https://doi.org/10.11648/j.cb.20150301.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20150301.11},
  abstract = {The present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.},
 year = {2015}
}

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TY  - JOUR
T1  - Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats
AU  - Eze Ejike Daniel
AU  - Aliyu Mohammed
AU  - Yusuf Tanko
AU  - Abubakar Ahmed
Y1  - 2015/01/12
PY  - 2015
N1  - https://doi.org/10.11648/j.cb.20150301.11
DO  - 10.11648/j.cb.20150301.11
T2  - Cell Biology
JF  - Cell Biology
JO  - Cell Biology
SP  - 1
EP  - 13
PB  - Science Publishing Group
SN  - 2330-0183
UR  - https://doi.org/10.11648/j.cb.20150301.11
AB  - The present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.
VL  - 3
IS  - 1
ER  -

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