International Journal of Immunology

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Interferon Gamma (IFN-γ) and Soluble Interleukin-2 Receptor (sIL-2R): Combined Diagnostic Markers of Tuberculous Pleural Effusion

Received: 30 March 2013    Accepted:     Published: 02 April 2013
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Abstract

Background: pleural TB is a diagnostic challenge because of its nonspecific clinical manifestation. The efficiency of conventional laboratory method and the reliance on pleural biopsy have motivated the evaluation of alternative diagnostic strategies. The objective of the current study is to evaluate the diagnostic efficiency of IFN-γ and sIL-2R levels in pleural effusion for differential diagnosis of tuberculous pleurisy. Methods: estimated levels of IFN-γ and sIL-2R were compared with the result of conventional PCR and Z-N staining used for detection of M. tuberculosis DNA and acid fast bacilli screening of pleural effusion, respectively. Involved study population included 60 patients with pleural effusion, divided into two groups: Tuberculous group (40 patients: 7 confirmed TB and 33 probable TB cases) and control group (20 patients: 10 cases due to malignancy and 10 cases due to heart failure). Results: our results showed that IFN-γ and sIL-2R levels are significantly higher in tuberculous group than in control group. Conclusion: current study suggested that measurement of IFN-γ and sIL-2R in pleural effusion could be less invasive and quicker diagnostic tools of TPE compared to conventional microbiological diagnostic methods.

DOI 10.11648/j.iji.20130101.12
Published in International Journal of Immunology (Volume 1, Issue 1, April 2013)
Page(s) 7-13
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Interferon Gamma, Soluble Interleukin-2 Receptor, Tuberculosis

References
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Author Information
  • Department of Medical Laboratory Technology, Faculty of Allied Medical Science, Pharos University in Alexandria, Egypt

  • Department of Immunology, Medical Research Institute, University of Alexandria, Egypt

  • Department of Microbiology, Medical Research Institute, University of Alexandria, Egypt

  • Department of Immunology, Medical Research Institute, University of Alexandria, Egypt

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    Mohamed S. Abdel-Latif, Lobna A. Abou-Shamaa, Eglal A. El-Sherbini, Mohamed S. M. Afifi. (2013). Interferon Gamma (IFN-γ) and Soluble Interleukin-2 Receptor (sIL-2R): Combined Diagnostic Markers of Tuberculous Pleural Effusion. International Journal of Immunology, 1(1), 7-13. https://doi.org/10.11648/j.iji.20130101.12

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    ACS Style

    Mohamed S. Abdel-Latif; Lobna A. Abou-Shamaa; Eglal A. El-Sherbini; Mohamed S. M. Afifi. Interferon Gamma (IFN-γ) and Soluble Interleukin-2 Receptor (sIL-2R): Combined Diagnostic Markers of Tuberculous Pleural Effusion. Int. J. Immunol. 2013, 1(1), 7-13. doi: 10.11648/j.iji.20130101.12

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    AMA Style

    Mohamed S. Abdel-Latif, Lobna A. Abou-Shamaa, Eglal A. El-Sherbini, Mohamed S. M. Afifi. Interferon Gamma (IFN-γ) and Soluble Interleukin-2 Receptor (sIL-2R): Combined Diagnostic Markers of Tuberculous Pleural Effusion. Int J Immunol. 2013;1(1):7-13. doi: 10.11648/j.iji.20130101.12

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  • @article{10.11648/j.iji.20130101.12,
      author = {Mohamed S. Abdel-Latif and Lobna A. Abou-Shamaa and Eglal A. El-Sherbini and Mohamed S. M. Afifi},
      title = {Interferon Gamma (IFN-γ) and Soluble Interleukin-2 Receptor (sIL-2R): Combined Diagnostic Markers of Tuberculous Pleural Effusion},
      journal = {International Journal of Immunology},
      volume = {1},
      number = {1},
      pages = {7-13},
      doi = {10.11648/j.iji.20130101.12},
      url = {https://doi.org/10.11648/j.iji.20130101.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.iji.20130101.12},
      abstract = {Background: pleural TB is a diagnostic challenge because of its nonspecific clinical manifestation. The efficiency of conventional laboratory method and the reliance on pleural biopsy have motivated the evaluation of alternative diagnostic strategies. The objective of the current study is to evaluate the diagnostic efficiency of IFN-γ and sIL-2R levels in pleural effusion for differential diagnosis of tuberculous pleurisy. Methods: estimated levels of IFN-γ and sIL-2R were compared with the result of conventional PCR and Z-N staining used for detection of M. tuberculosis DNA and acid fast bacilli screening of pleural effusion, respectively. Involved study population included 60 patients with pleural effusion, divided into two groups: Tuberculous group (40 patients: 7 confirmed TB and 33 probable TB cases) and control group (20 patients: 10 cases due to malignancy and 10 cases due to heart failure). Results: our results showed that IFN-γ and sIL-2R levels are significantly higher in tuberculous group than in control group. Conclusion: current study suggested that measurement of IFN-γ and sIL-2R in pleural effusion could be less invasive and quicker diagnostic tools of TPE compared to conventional microbiological diagnostic methods.},
     year = {2013}
    }
    

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  • TY  - JOUR
    T1  - Interferon Gamma (IFN-γ) and Soluble Interleukin-2 Receptor (sIL-2R): Combined Diagnostic Markers of Tuberculous Pleural Effusion
    AU  - Mohamed S. Abdel-Latif
    AU  - Lobna A. Abou-Shamaa
    AU  - Eglal A. El-Sherbini
    AU  - Mohamed S. M. Afifi
    Y1  - 2013/04/02
    PY  - 2013
    N1  - https://doi.org/10.11648/j.iji.20130101.12
    DO  - 10.11648/j.iji.20130101.12
    T2  - International Journal of Immunology
    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
    SP  - 7
    EP  - 13
    PB  - Science Publishing Group
    SN  - 2329-1753
    UR  - https://doi.org/10.11648/j.iji.20130101.12
    AB  - Background: pleural TB is a diagnostic challenge because of its nonspecific clinical manifestation. The efficiency of conventional laboratory method and the reliance on pleural biopsy have motivated the evaluation of alternative diagnostic strategies. The objective of the current study is to evaluate the diagnostic efficiency of IFN-γ and sIL-2R levels in pleural effusion for differential diagnosis of tuberculous pleurisy. Methods: estimated levels of IFN-γ and sIL-2R were compared with the result of conventional PCR and Z-N staining used for detection of M. tuberculosis DNA and acid fast bacilli screening of pleural effusion, respectively. Involved study population included 60 patients with pleural effusion, divided into two groups: Tuberculous group (40 patients: 7 confirmed TB and 33 probable TB cases) and control group (20 patients: 10 cases due to malignancy and 10 cases due to heart failure). Results: our results showed that IFN-γ and sIL-2R levels are significantly higher in tuberculous group than in control group. Conclusion: current study suggested that measurement of IFN-γ and sIL-2R in pleural effusion could be less invasive and quicker diagnostic tools of TPE compared to conventional microbiological diagnostic methods.
    VL  - 1
    IS  - 1
    ER  - 

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