Serum Calprotectin Level for Diagnosis and detection of Disease Activity in Rheumatoid Arthritis
International Journal of Immunology
Volume 2, Issue 1, February 2014, Pages: 6-10
Received: Mar. 9, 2014; Published: Mar. 30, 2014
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Authors
Nanees Adel, Internal Medicine Departments, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Marcel William, Internal Medicine Departments, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Reham Al Swaff, Internal Medicine Departments, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Sherin Hassan, Clinical Pathology Departments, Faculty of Medicine, Ain Shams University, Cairo, Egypt
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Abstract
Background: Early diagnosis of rheumatoid arthritis and timely detection of progression are global challenges. However, lack of sensitivity and imprecision of the currently available biomarkers have impaired the ability to implement potentially effective therapies in a timely manner. The present study aimed to evaluate the clinical utility of serum calprotectin in diagnosis as well as assessment of rheumatoid arthritis activity. Methods: serum calprotectin levels were measured in 60 Egyptian patients with rheumatoid arthritis (35 patients with active rheumatoid arthritis vs. 25 patients with quiescent disease) and 20 healthy subjects who served as a control group. Results: Serum calprotectin showed a highly significant elevation in patients with rheumatoid arthritis. Moreover, its level showed a highly significant increase during disease activity. Significant positive correlations were found between serum calprotectin and other markers of disease activity (ESR, CRP, WBCs, and platelets). Serum calprotectin at a cut- off level of 450 ng /mL, had 75% sensitivity &90% specificity for diagnosis of rheumatoid arthritis. Optimum cut-off level of calprotectin for prediction of disease activity was 950 ng /mL with 80% sensitivity, 76% specificity. Conclusion: serum calprotectin is a promising marker for diagnosis and monitoring of disease activity in patients with rheumatoid arthritis.
Keywords
Calprotectin, Rheumatoid, Arthritis, CRP
To cite this article
Nanees Adel, Marcel William, Reham Al Swaff, Sherin Hassan, Serum Calprotectin Level for Diagnosis and detection of Disease Activity in Rheumatoid Arthritis, International Journal of Immunology. Vol. 2, No. 1, 2014, pp. 6-10. doi: 10.11648/j.iji.20140201.12
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